Comparative study of VH gene family usage by newborn xid and non-xid mice, newborn NZB and adult NZB mice, and by splenic and peritoneal cavity B cell compartments.

abstract：:Treatment of systemic lupus erythematosus patients with epratuzumab (Emab), a humanized monoclonal antibody targeting CD22, leads to moderately reduced B-cell numbers but does not completely deplete B cells. Emab appears to induce immunomodulation of B cells, but the exact mode of action has not been defined. In the p...

journal_title：European journal of immunology

authors： Özgör L,Brandl C,Shock A,Nitschke L

更新日期：2016-09-01 00:00:00

abstract：:Lymph node cells derived from A.TH or A.TL mice primed with beef cytochrome c show striking patterns of reactivity when assayed in vitro for antigen-induced T cell proliferation. Whereas cells from A.TH mice respond specifically to beef cytochrome c or peptides composed of amino acids 1-65 and 81-104, cells from A.TL ...

journal_title：European journal of immunology

authors： Corradin G,Chiller JM

更新日期：1981-02-01 00:00:00

abstract：:It has been reported that Thy-1+CD3+CD4-CD8- cells as well as Langerhans cells migrate from organ-cultured murine skin into culture medium. We examined whether these Thy-1+ populations of migrating cells were derived from Thy-1+ dendritic epidermal T cells (Thy-1+ DEC) and found that they were Thy-1+CD3+CD4-CD8-gamma/...

journal_title：European journal of immunology

authors： Nakagawa S,Hara M,Seki M,Yagita H,Tagami H,Aiba S

更新日期：1993-07-01 00:00:00

abstract：:Japanese encephalitis, caused by infection with the neurotropic flavivirus, Japanese encephalitis virus (JEV), is among the most important viral encephalitides in Asia. While previous studies established an essential role of Ab and type I IFN, it is still unclear if the cell-mediated immune responses, through their di...

journal_title：European journal of immunology

authors： Larena M,Regner M,Lobigs M

更新日期：2013-07-01 00:00:00

abstract：:A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...

journal_title：European journal of immunology

authors： Parronchi P,Mohapatra S,Sampognaro S,Giannarini L,Wahn U,Chong P,Mohapatra S,Maggi E,Renz H,Romagnani S

更新日期：1996-03-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:We studied the capacity of human factor H to promote the secretion of a lymphocyte-activating factor (LAF) by human monocytes cultured under serum-free conditions. Presence of LAF in the culture supernatants was assessed with the mouse thymocyte assay. Highly purified factor H alone had no effect on thymocyte prolifer...

journal_title：European journal of immunology

authors： Iferroudjene D,Schouft MT,Lemercier C,Gilbert D,Fontaine M

更新日期：1991-04-01 00:00:00

abstract：:The mechanisms responsible for the down-modulation of the activation of separated CD4(+) or CD8(+) human T cell blasts were studied using cells obtained from healthy donors. In the presence of IL-2, human CD8(+) T cell blasts were more sensitive than CD4(+) T cell blasts to regulation by APO2 ligand/TNF-related apopto...

journal_title：European journal of immunology

authors： Bosque A,Pardo J,Martínez-Lorenzo MJ,Lasierra P,Larrad L,Marzo I,Naval J,Anel A

更新日期：2005-06-01 00:00:00

abstract：:LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1-type T cell response in peripheral blood mononuclear cells (PBMC) from leishmaniasis patients. Moreover, the interferon (IFN)-gamma production by PBMC was found to be interleukin (IL)-12 depend...

journal_title：European journal of immunology

authors： Probst P,Skeiky YA,Steeves M,Gervassi A,Grabstein KH,Reed SG

更新日期：1997-10-01 00:00:00

abstract：:Although the role of interleukin 2 (IL 2) in mature T lymphocyte function is well documented, its effect on hematopoietic progenitor cells is less well characterized. Here we have used recombinant retroviruses to transduce and express a cDNA clone encoding the p55 component of the human IL 2 receptor (h-p55), in a mur...

journal_title：European journal of immunology

authors： Collins MK,Malde P,Miyajima A,Arai K,Smith KA,Mulligan RC

更新日期：1990-03-01 00:00:00

abstract：:The influence of Th2 cytokines in tuberculosis has been a matter of dispute. Here we report that IL-4 has a profound regulatory effect on the infection of BALB/c mice with Mycobacterium tuberculosis. Depletion of IL-4 with a neutralizing mAb caused only evanescent reduction of lung infection, but when combined with i....

journal_title：European journal of immunology

authors： Buccheri S,Reljic R,Caccamo N,Ivanyi J,Singh M,Salerno A,Dieli F

更新日期：2007-03-01 00:00:00

abstract：:Human interdigitating dendritic cells (IDC) were isolated from tonsils based on their CD40+ lineage-negative expression in situ. Isolated IDC displayed a phenotypic profile similar to that of IDC in tonsils and spleen in situ, characterized by high-level expression of major histocompatibility complex class II, the co-...

journal_title：European journal of immunology

authors： Björck P,Flores-Romo L,Liu YJ

更新日期：1997-05-01 00:00:00

abstract：:The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...

journal_title：European journal of immunology

authors： Kanangat S,Blair P,Reddy R,Daheshia M,Godfrey V,Rouse BT,Wilkinson E

更新日期：1996-01-01 00:00:00

abstract：:The murine T cell clone D10.G4.1 can be induced to proliferate by monoclonal antibodies (mAb) to the T cell receptor (TcR) or to Thy-1 molecules. When cells were stimulated by anti-TcR mAb, a group of 4 proteins (19-25 kDa) was specifically phosphorylated. This effect was completely mimicked by the Ca2+ ionophore A231...

journal_title：European journal of immunology

authors： Peyron JF,Pont S,Pierres M,Fehlmann M

更新日期：1988-07-01 00:00:00

abstract：:The monoclonal antibody HC1/6 generated against phorbol 12-myristate 13-acetate-treated U-937 cells recognizes a new cell surface antigen with a broad relative molecular mass ranging from 100 to 150 kDa. This antigen is also present on monocytes, platelets and endothelial cells and is weakly expressed by granulocytes....

journal_title：European journal of immunology

authors： Cabañas C,Sanchez-Madrid F,Bellon T,Figdor CG,Te Velde AA,Fernandez JM,Acevedo A,Bernabeu C

更新日期：1989-08-01 00:00:00

abstract：:Mitogens such as pokeweed mitogen, Staphylococcus aureus Cowan I, concanavalin A and phytohemagglutinin and monoclonal anti-CD antibodies were examined for their capacity to induce IgE synthesis by peripheral blood leukocytes obtained from both atopic and nonatopic individuals. While lectins failed to induce IgE synth...

journal_title：European journal of immunology

authors： Yang XD,De Weck AL,Stadler BM

更新日期：1988-03-01 00:00:00

abstract：:Interferon (IFN) was detected upon co-culture of cloned Sendai virus (SV)-specific T lymphocyte with SV-presenting syngeneic stimulator cells. The antiviral activity was defined as IFN-alpha, beta. The T cell clones, upon contact with antigen-presenting stimulator cells, stimulated adherent cells present in the stimul...

journal_title：European journal of immunology

authors： Ertl HC,Brown EG,Finberg RW

更新日期：1982-12-01 00:00:00

abstract：:CBA/J mice immunized with thyroglobulin (Tg) develop an experimental autoimmune thyroiditis (EAT) with lymphocytic infiltration of the thyroid glands, autoantibodies to Tg and occurrence of EAT-specific T cells. When these mice were treated for 4 weeks after immunization with 1 mg/week of a monoclonal antibody (mAb) t...

journal_title：European journal of immunology

authors： Tang H,Mignon-Godefroy K,Meroni PL,Garotta G,Charreire J,Nicoletti F

更新日期：1993-01-01 00:00:00

abstract：:Specific members of the Rho family of GTPases exert unique influences on thymocyte proliferation, differentiation and deletion. Dbs is a guanine nucleotide exchange factor which is expressed throughout thymocyte development and is able to activate the Rho family GTPases CDC42, RhoA and RhoG. Transgenic mice expressing...

journal_title：European journal of immunology

authors： Klinger MB,Guilbault B,Kay RJ

更新日期：2004-03-01 00:00:00

abstract：:A series of rat monoclonal antibodies (mAb) directed against the Thy-1 molecule have been evaluated for their ability to stimulate immature (CD4-8-) murine thymocytes. CD4-8- thymocytes could be induced to proliferate by several anti-Thy-1 mAb provided that exogenous interleukin 1 or interleukin 2 was provided. Appare...

journal_title：European journal of immunology

authors： MacDonald HR,Miescher GC,Howe RC

更新日期：1987-11-01 00:00:00

abstract：:The presence of dominant epitopes suppresses generation of CTL activity toward other non-dominant epitopes found on the same antigen-presenting cell (APC). This phenomenon, termed immunodomination, drastically restricts the diversity of the repertoire of CTL responses. Under various experimental conditions we assessed...

journal_title：European journal of immunology

authors： Roy-Proulx G,Meunier MC,Lanteigne AM,Brochu S,Perreault C

更新日期：2001-08-01 00:00:00

abstract：:CD22 is a B lymphocyte-specific membrane protein that functions as an adhesion molecule via its interactions with a subset of alpha 2-6-linked sialic acid-containing glycoproteins. Engagement of CD22 with a monoclonal antibody (HB22.23) that blocks the binding of CD22 to its ligands results in rapid CD22 tyrosine phos...

journal_title：European journal of immunology

authors： Tuscano JM,Engel P,Tedder TF,Agarwal A,Kehrl JH

更新日期：1996-06-01 00:00:00

abstract：:We have investigated the vaccine potential of two peptides derived from the 6-kDa early secretory antigenic target (ESAT)-6 antigen in the mouse model of tuberculosis. The peptides were both strongly immunogenic in B6CBAF1 (H-2b,k) mice and primed recall responses of the same intensity after immunization. However, bot...

journal_title：European journal of immunology

authors： Olsen AW,Hansen PR,Holm A,Andersen P

更新日期：2000-06-01 00:00:00

abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

journal_title：European journal of immunology

authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

更新日期：1984-06-01 00:00:00

abstract：:The crucial role of interleukin (IL)-4 in the induction of murine IgG1 and IgE responses, which are coupled through the process of sequential isotype switching, has been well documented. Whereas IL-4 is obligatory for the induction of IgE responses, it enhances IgG1 responses. In this study, using neutralizing antibod...

journal_title：European journal of immunology

authors： van Ommen R,Vredendaal AE,Savelkoul HF

更新日期：1994-06-01 00:00:00

abstract：:Bone morphogenetic proteins (BMP) are multifunctional cytokines that belong to the TGF-beta superfamily. BMP have been shown to regulate haematopoietic stem cells, B lymphopoiesis and early thymocyte differentiation. In the present study we explored the role of BMP-6 in Jurkat TAg cells. BMP-6 rapidly induced phosphor...

journal_title：European journal of immunology

authors： Sivertsen EA,Huse K,Hystad ME,Kersten C,Smeland EB,Myklebust JH

更新日期：2007-10-01 00:00:00

abstract：:An antigen-specific T-T hybridoma was mutagenized with ethylmethane sulfonate and negatively selected by anti-Ly-6 antibody-induced growth inhibition. One of the mutants generated, M4/8, had lost surface expression of a T cell receptor (TcR) V beta 8 epitope detected on the surface of the parental cell line. However, ...

journal_title：European journal of immunology

authors： Reno TA,Ley S,Sugiyama E,Cantagrel A,Blumberg R,Bonventre J,Terhorst C,Yeh ET

更新日期：1990-07-01 00:00:00

abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

journal_title：European journal of immunology

authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

更新日期：1994-02-01 00:00:00

abstract：:Plasma cells secreting IgG, M, and A abound in the synovium of patients with rheumatoid arthritis, yet their immunoglobulin repertoire and clonal relationship remain to be elucidated. Locally synthesized immunoglobulins probably contribute to the chronic joint inflammatory processes which are characteristic of these p...

journal_title：European journal of immunology

authors： Williams DG,Taylor PC

更新日期：1997-02-01 00:00:00

abstract：:In the past 15 years, it became clear that the symbiotic microbiota has an important impact on the development and regulation of the immune system. Consequently, it is incorrect to interpret a phenotype solely as a direct result of the genotype, without considering the impact of the microbiota. In fact, ignorance of t...

journal_title：European journal of immunology

authors： Eberl G,Vieira P

更新日期：2020-06-01 00:00:00