Abstract:
:The presence of dominant epitopes suppresses generation of CTL activity toward other non-dominant epitopes found on the same antigen-presenting cell (APC). This phenomenon, termed immunodomination, drastically restricts the diversity of the repertoire of CTL responses. Under various experimental conditions we assessed the in vivo expansion by tetramer staining and function by expression of O-glycans and intracellular perforin of CTL specific for a dominant (B6(dom1)) and a non-dominant (HY) H2D(b)-restricted epitope. Immunodomination abrogated expansion rather than differentiation of HY-specific CTL. When immunodomination was precluded because HY was presented alone or because high numbers of antigen-bearing APC were present, the numbers of HY-specific T cells detected after antigen priming were similar to those of B6(dom1)-specific T cells. The main difference between T cells that recognized B6(dom1) versus HY was functional rather than quantitative. The key feature of T cells specific for B6(dom1) is that they show striking up-regulation of molecules involved in CTL effector activity rather than accumulating to particularly high levels, as assessed by tetramer staining. These results support the emerging concept that following antigen priming, CTL populations of similar size can display important differences in effector function, and suggest that these functional differences are instrumental in shaping the repertoire of CTL responses.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Roy-Proulx G,Meunier MC,Lanteigne AM,Brochu S,Perreault Cdoi
10.1002/1521-4141(200108)31:8<2284::aid-immu2284>3keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
2284-92issue
8eissn
0014-2980issn
1521-4141pii
10.1002/1521-4141(200108)31:8<2284::AID-IMMU2284>3journal_volume
31pub_type
杂志文章abstract::NK cells are the main cells of the innate immune system that produce IFN-γ, and they express this cytokine at early stages of maturation in response to cytokine stimulation. Conversely, acquisition of IFN-γ-competence in CD4(+) T helper cells requires a differentiation process from naïve toward type 1 (Th1) cells, whi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201344072
更新日期:2014-07-01 00:00:00
abstract::Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200323872
更新日期:2003-09-01 00:00:00
abstract::Expression and function of the fractalkine receptor CX3CR1 by T lymphocyte subpopulations was evaluated in healthy individuals. In CD8(+) T lymphocytes, CX3CR1 was expressed by and functional in both CD45RO(-) and CD45RO(+) cells. In CD4(+) T lymphocytes, CX3CR1 was expressed mainly by CD45RO(+) cells, and almost excl...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200001)30:1<87::AID-IMMU87>3.0.C
更新日期:2000-01-01 00:00:00
abstract::Activation pathways inducing the expression of the interferon (IFN)-gamma gene in a cytotoxic T lymphocyte (CTL) clone were studied for their effects on transcription and on mRNA stability. IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250405
更新日期:1995-04-01 00:00:00
abstract::Exosomes are nanovesicles produced constitutively and inducibly by several types of cells. They are generated as intraluminal vesicles of multivesicular bodies and express MHC and several endosomal/lysosomal proteins. In spite of their potential role in cellular immunity, the regulatory mechanisms of exosome productio...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737694
更新日期:2008-05-01 00:00:00
abstract::Mercury-induced autoimmune glomerulonephritis in the Brown-Norway (BN) rat is characterized by the successive appearance of linear and granular glomerular IgG deposits. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. Fusions were pe...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200114
更新日期:1990-01-01 00:00:00
abstract::Paxillin is an adaptor protein associated with focal adhesion complex, and is activated by tyrosine phosphorylation through focal adhesion kinase (FAK) and Src kinase. Recent studies reveal that serine phosphorylation of paxillin by JNK and p38 MAPK is essential for cell migration or neurite extension, but their cellu...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142192
更新日期:2012-08-01 00:00:00
abstract::Natural Killer (NK) cell-based immunotherapy is a promising approach to treat hepatocellular carcinoma (HCC). The mechanisms underlying the regulation of NK cell activity are not completely understood. In this research, we identified the expression of taste receptor type 1 member 1 (T1R1) and taste receptor type 1 mem...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201847688
更新日期:2018-12-01 00:00:00
abstract::The activating NK cell receptor NKG2D binds to numerous stress-induced cell surface glycoproteins with MHC class I-related ectodomains. In humans, NKG2D ligands (NKG2DL) are members of the MHC-encoded MIC and non-MHC-encoded ULBP families of proteins. The redundancy of NKG2DL raises questions about unique features ass...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200839074
更新日期:2009-06-01 00:00:00
abstract::MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can prod...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040428
更新日期:2010-09-01 00:00:00
abstract::The antagonistic effects of macrophage (M phi)-derived interleukin 1 (IL 1) and prostaglandin E2 (PGE2) on thymocyte proliferation were uncoupled and studied. Elimination of PGE2 from the culture medium of prostaglandin E2-stimulated M phi was achieved by dialysis of the media or by indomethacin treatment of the M phi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150109
更新日期:1985-01-01 00:00:00
abstract::Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils. ...
journal_title:European journal of immunology
pub_type: 信件
doi:10.1002/eji.201848057
更新日期:2019-09-01 00:00:00
abstract::The invariant chain (Ii) is a chaperone that regulates assembly and transport of class II MHC molecules. In the absence of the lysosomal protease cathepsin S (CatS), degradation of Ii is impaired and an Ii remnant that extends from the N terminus to about residue 110 accumulates in class II MHC-positive endosomal comp...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200526323
更新日期:2005-09-01 00:00:00
abstract::The aim of this study was to investigate the effects of IL-17-producing T cells, including Th17 and Tc17 cells, on acute graft-versus-host disease (aGVHD) in patients who had undergone granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (G-BM) tr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040793
更新日期:2011-02-01 00:00:00
abstract::The study of the immunology of schistosomiasis has allowed a clear understanding of the basic mechanisms of resistance, emphasizing the important role played by cellular and humoral factors. Whereas the production of polyclonal or monoclonal antibodies and the precise inventory of immune effector mechanisms in the rat...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830151205
更新日期:1985-12-01 00:00:00
abstract::The expression of HLA class II genes is under the control of a transcriptional activator, CIITA, encoded by the AIR-1 locus. Here we show that CIITA inhibits HIV-1 LTR transactivation mediated by Tat. The inhibition occurred when CIITA and Tat were transiently expressed in cells after transfection and, most importantl...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(2002010)32:10<2783::AID-IMMU2783
更新日期:2002-10-01 00:00:00
abstract::T cell-depleted B cells from a patient with LFA-1 deficiency were tested in costimulation assays for responsiveness to recombinant human IL4 (BSF-1) and purified low molecular weight B cell growth factor (BCGFlow). In both cases the response of LFA-1-deficient B cells was comparable with normal controls. Monoclonal an...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180212
更新日期:1988-02-01 00:00:00
abstract::The development of preventive or therapeutic recombinant vaccines and the generation of serodiagnostic assays for infectious diseases depend essentially on the availability of molecularly defined antigens. A major bottleneck for the identification of suitable target antigens for many pathogens is the isolation of suff...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200535538
更新日期:2006-04-01 00:00:00
abstract::Proliferating cells require iron and, therefore, express the transferrin receptor (CD71) that mediates cellular iron uptake. Cycling thymocytes, which have the CD4-8-3-, CD4-8+3-, or CD4+8+3- phenotypes, also express CD71. The importance of CD71-mediated iron uptake for proliferation and maturation of thymocytes was s...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830241147
更新日期:1994-11-01 00:00:00
abstract::Rapid IgE desensitization provides temporary tolerization for patients who have presented severe hypersensitivity reactions to food and drugs, protecting them from anaphylaxis, but the underlying mechanisms are still incompletely understood. Thus, here we develop an effective and reproducible in vitro model of rapid I...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040810
更新日期:2011-04-01 00:00:00
abstract::Antisera were prepared in rabbits against the idiotypic (Id) determinants of antiallergen antibodies. These antibodies were isolated from the plasma of 10 unrelated patients by immunoabsorption. Three major allergens isolated from the house dust mite, Dermatophagoides pteronyssinus (DPT), were used. The anti-Id antise...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160520
更新日期:1986-05-01 00:00:00
abstract::A T3 complex-bearing subpopulation was characterized within an in vivo cycling T4-8- early thymocyte compartment which contains cells constitutively expressing interleukin 2 and transferrin receptors. We show differentiation in vitro of both mature subsets of thymocytes (T3+4+8- and T3+4-8+) from the above T4-8- compa...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160611
更新日期:1986-06-01 00:00:00
abstract::Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130611
更新日期:1983-06-01 00:00:00
abstract::Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220207
更新日期:1992-02-01 00:00:00
abstract::Vaccination of mice with irradiated Schistosoma mansoni larvae confers high levels of immunity which is mediated by Th1-type lymphocytes. To investigate a possible role for IL-12 in the induction of protection, we have compared the immune response of IL-12 p40-deficient (KO) mice and their C57BL/6 (WT) counterparts fo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199809)28:09<2827::AID-IMM
更新日期:1998-09-01 00:00:00
abstract::Cartilage-specific proteins are considered potential autoantigens that could continuously fuel autoimmune responses directed to the joints in rheumatoid arthritis (RA). Using recombinant chimeric collagen type II we have identified one major type II collagen (CII) epitope (denoted U1) recognized by RA sera. The U1 epi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200106)31:6<1666::aid-immu1666>3
更新日期:2001-06-01 00:00:00
abstract::Th17 cells are defined by their capacity to produce IL-17, and are important mediators of inflammation and autoimmunity. Human Th17 cells express high levels of the retinoic acid-related orphan receptor variant 2 (RORC2), but it is currently unclear whether expression of this transcription factor alone is sufficient t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838908
更新日期:2009-06-01 00:00:00
abstract::The desire to induce HIV-1-specific responses soon after birth to prevent breast milk transmission of HIV-1 led us to propose a vaccine regimen which primes HIV-1-specific T cells using a recombinant Mycobacterium bovis bacillus Calmette-Guérin (rBCG) vaccine. Because attenuated live bacterial vaccines are typically n...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141962
更新日期:2011-12-01 00:00:00
abstract::The human promyelocytic U937 cells express detectable levels of MHC class II (MHC-II) molecules. Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425378
更新日期:2005-02-01 00:00:00
abstract::The problem of the structural relationship between suppressive IgG-binding factor and low-affinity receptors for the Fc portion of IgG (Fc gamma RII) has not yet been solved. In the present work we have isolated a recombinant soluble Fc gamma RII containing only the two external domains of Fc gamma RII, and analyzed i...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191213
更新日期:1989-12-01 00:00:00