Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a+ CD49b- natural killer cells.


:Natural Killer (NK) cell-based immunotherapy is a promising approach to treat hepatocellular carcinoma (HCC). The mechanisms underlying the regulation of NK cell activity are not completely understood. In this research, we identified the expression of taste receptor type 1 member 1 (T1R1) and taste receptor type 1 member 3 (T1R3) in a subset of hepatic NK cells in a mouse HCC model. T1R1 and T1R3 were selectively expressed in CD49a+ CD49b- NK cells in livers with HCC. In the in vitro cytotoxicity assay, amino acids promoted the tumoricidal effect of CD49a+ CD49b- NK cells through increasing the production of perforin, granzyme B and IFN-γ. Furthermore, using a lentivirus to induce the expression of exogenous T1R1 and T1R3 in normal hepatic NK cells, we found that amino acids enhanced NK cell-mediated cytotoxicity on tumor cells through the T1R1/T1R3 receptor, as demonstrated by more tumor cell lysis, up-regulation of perforin and granzyme B in comparison with control NK cells. In addition, amino acids activated Akt and mechanistic target of rapamycin complex 1 (mTORC1) signaling in NK cells through T1R1/T1R3 receptor. T-bet expression in NK cells was also increased by amino acid treatment. Therefore, T1R1/T1R3 receptor promotes the tumoricidal activity of hepatic CD49a+ CD49b- NK cells.


Eur J Immunol


Liu S,Xu M,Zhu C,Zhao Q,Zhou F




Has Abstract


2018-12-01 00:00:00












  • Murine macrophage precursor characterization. I. Production, phenotype and differentiation of macrophage precursor hybrids.

    abstract::This study reports on the earliest stages of mononuclear phagocyte differentiation. A crucial question in this developmental process is whether mature macrophage (M phi) heterogeneity is already appointed at the precursor cell level. For this purpose, we produced clonal populations of mononuclear phagocytes from bone ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Leenen PJ,Slieker WA,Melis M,Van Ewijk W

    更新日期:1990-01-01 00:00:00

  • GL7 defines the cycling stage of pre-B cells in murine bone marrow.

    abstract::We have identified a novel subset of early B lineage cells in the mouse bone marrow (BM) by GL7 expression on cell surface. GL7(+)B220(low) BM cells have a large cell size and are CD43(-to low), CD95(-), Sca-1(-), I-A(low), IgM(-) and IgD(-), suggesting that they are large pre-B cells. These BM cells express lambda5 a...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Murasawa M,Okada S,Obata S,Hatano M,Moriya H,Tokuhisa T

    更新日期:2002-01-01 00:00:00

  • The aryl hydrocarbon receptor modulates the function of human CD56bright NK cells.

    abstract::Human natural killer (NK) cells are divided into two subsets: CD56bright and CD56dim NK cells, which differ in maturation, function and distribution. Mechanisms regulating NK cell functions are not completely understood. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, that binds to a variet...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Moreno-Nieves UY,Mundy DC,Shin JH,Tam K,Sunwoo JB

    更新日期:2018-05-01 00:00:00

  • CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice.

    abstract::Inflammatory bowel disease (IBD) is characterized by a dysregulated intestinal immune response with elevated levels of the Th1 cytokines TNF, IL-12 and IFN-gamma. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic intestinal inflammation by as yet unknown...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Obermeier F,Dunger N,Deml L,Herfarth H,Schölmerich J,Falk W

    更新日期:2002-07-01 00:00:00

  • CD8+ T cell responses to human immunodeficiency viruses type 2 (HIV-2) and type 1 (HIV-1) gag proteins are distinguishable by magnitude and breadth but not cellular phenotype.

    abstract::The mechanisms underlying the relatively slow progression of human immunodeficiency virus type 2 (HIV-2) compared with HIV-1 infection are undefined and could be a result of more effective immune responses. We used HIV-2 and HIV-1 IFN-gamma enzyme-linked immunospot assays to evaluate CD8(+) T cell responses in antiret...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Gillespie GM,Pinheiro S,Sayeid-Al-Jamee M,Alabi A,Kaye S,Sabally S,Sarge-Njie R,Njai H,Joof K,Jaye A,Whittle H,Rowland-Jones S,Dorrell L

    更新日期:2005-05-01 00:00:00

  • Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats.

    abstract::The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. In vivo, it has a dramatic protective effect against ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kiely PD,Gillespie KM,Oliveira DB

    更新日期:1995-10-01 00:00:00

  • Immunization through dermal delivery of protein-encoding DNA: a role for migratory dendritic cells.

    abstract::The early mechanisms by which DNA-dependent immunization occurs remain poorly understood. We determined whether intradermal injection of a cytomegalovirus (CMV) promoter-driven plasmid encoding hen egg lysozyme (pCMV:HEL) induced sensitization against the encoded protein, and whether cutaneous dendritic cells (DC) wer...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Bouloc A,Walker P,Grivel JC,Vogel JC,Katz SI

    更新日期:1999-02-01 00:00:00

  • KLRG1 activity is regulated by association with the transferrin receptor.

    abstract::The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells. Here, we surprisingly found that a fraction of KLRG1 molecules expressed in the murine A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the tra...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Schweier O,Hofmann M,Pircher H

    更新日期:2014-06-01 00:00:00

  • Suppression of polyclonal and antigen-specific murine IgG1 but not IgE responses by neutralizing interleukin-6 in vivo.

    abstract::The crucial role of interleukin (IL)-4 in the induction of murine IgG1 and IgE responses, which are coupled through the process of sequential isotype switching, has been well documented. Whereas IL-4 is obligatory for the induction of IgE responses, it enhances IgG1 responses. In this study, using neutralizing antibod...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: van Ommen R,Vredendaal AE,Savelkoul HF

    更新日期:1994-06-01 00:00:00

  • The nature of active and passive thyroglobulin binding lymphoid cells in Obese strain (OS) chickens.

    abstract::Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Richter E,Wick G,Schauenstein K

    更新日期:1975-08-01 00:00:00

  • The glycosylphosphatidylinositol-anchored CD59 protein stimulates both T cell receptor zeta/ZAP-70-dependent and -independent signaling pathways in T cells.

    abstract::The glycosylphosphatidylinositol (GPI)-anchored CD59 protein (human protectin) protects cells against complement-induced lysis, binds to CD2 and also transduces activation signals within T cells. We have further examined the biochemical signals transduced by CD59 and addressed its role in regard to the CD3-mediated si...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Deckert M,Ticchioni M,Mari B,Mary D,Bernard A

    更新日期:1995-07-01 00:00:00

  • SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.

    abstract::Nonhematopoietic stromal cells contribute to the organization and homeostasis of secondary lymphoid organs by producing cytokines and chemokines. The development and maintenance of these stromal cells are thought to be regulated by innate immune cells. Indeed, we recently showed that signal regulatory protein α (SIRPα...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Komori S,Saito Y,Respatika D,Nishimura T,Kotani T,Murata Y,Matozaki T

    更新日期:2019-09-01 00:00:00

  • A human lymphoid cell line with an IgG-like membrane component.

    abstract::A human lymphoid cell ine (S95) with surface-located IgG is described. The line was derived from a patient with Hodgkin's disease and is aneuploid. Its characteristics are suggestive of a malignant B lymphocyte derivation, but no ultimate proof of malignancy can be forwarded. The line produces immunoglobulin (IgG) whi...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Nilsson K,Ghetie V,Sjöquist J

    更新日期:1975-08-01 00:00:00

  • Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens.

    abstract::Antibodies against bacterial capsular polysaccharides play a critical protective role. Responses to these antigens can occur without the help or control of T cells and are associated with marginal zone (MZ) B cells. Capsular antigens are diverse and some cross-react with self-carbohydrate epitopes. This diversity may ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Vinuesa CG,Sze DM,Cook MC,Toellner KM,Klaus GG,Ball J,MacLennan IC

    更新日期:2003-02-01 00:00:00

  • Antigen-independent binding of IgG dimers to C 1 q as studied by sedimentation equilibrium, complement fixation and electron microscopy.

    abstract::Rabbit anti-SII pneumococcal polysaccharide IgG antibody was cross-linked by dithiobis (succinimidyl propionate). The IgG dimers were visualized by electronmicroscopy and resembled two Y-shaped structures connected in random orientations. The three arms of the Y's were of equal length. The six globular domains of the ...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Tschopp J,Villiger W,Lustig A,Jaton JC,Engel J

    更新日期:1980-07-01 00:00:00

  • The B cell antigen receptor of class IgD can be expressed on the cell surface in two different forms.

    abstract::Membrane-bound immunoglobulins of the IgM and IgD class are expressed on the B cell surface in association with a disulfide-linked heterodimer consisting of alpha and beta subunits. While the alpha component of the IgM antigen receptor (IgM-alpha, 34 kDa) is encoded by the B cell-specific gene mb-1, the gene coding fo...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Wienands J,Reth M

    更新日期:1991-10-01 00:00:00

  • IFN-gamma induces the high-affinity Fc receptor I for IgG (CD64) on human glomerular mesangial cells.

    abstract::The deposition of immune complexes, followed by activation of complement and/or Fc receptors and generation of chemoattractants, is the most common feature of human glomerulonephritis. Recently we have shown that primary cultured human glomerular mesangial cells (HMC), which are normally negative for IgG Fc receptors,...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Uciechowski P,Schwarz M,Gessner JE,Schmidt RE,Resch K,Radeke HH

    更新日期:1998-09-01 00:00:00

  • Surface expression of beta 2-microglobulin-associated thymus-leukemia antigen is independent of TAP2.

    abstract::Mouse thymus-leukemia antigen (TL), like other major histocompatibility complex (MHC) class I-b antigens, displays signs of a specialized function. It is normally expressed at high levels on immature thymocytes and at moderate levels on gut epithelium and activated mature T cells. A promoter/enhancer region unique amo...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Rodgers JR,Mehta V,Cook RG

    更新日期:1995-04-01 00:00:00

  • Immunoglobulin VH region genes of the mouse are organized in overlapping clusters.

    abstract::Restriction fragment length polymorphism has been compared between the Igh loci of C57BL/6 and MOLF/EI (Mus musculus molossinus) mice utilizing probes which detect the C gamma 2b gene and genes from nine VH-gene families. Distinct restriction site patterns were found for the CH genes and for VH families PC7183, Q52 an...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Blankenstein T,Krawinkel U

    更新日期:1987-09-01 00:00:00

  • TCR-beta chains derived from peripheral gammadelta T cells can take part in alphabeta T-cell development.

    abstract::Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defi...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Bosco N,Engdahl C,Bénard A,Rolink J,Ceredig R,Rolink AG

    更新日期:2008-12-01 00:00:00

  • Production of interleukin 2 and interleukin 4 by immune CD4-CD8+ and their role in the generation of antigen-specific cytotoxic T cells.

    abstract::In this report we investigated the production and role of interleukin (IL)2 and IL4 in the generation of antigen-specific cytotoxic T cells (CTL). We used as our model the ultraviolet-light-induced epithelial tumor 1591, a highly immunogenic regressor tumor which evokes a strong cell-mediated immune response leading t...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Horvat B,Loukides JA,Anandan L,Brewer E,Flood PM

    更新日期:1991-08-01 00:00:00

  • Self-reactive T cells are activated by the 65-kDa mycobacterial heat-shock protein in neonatally thymectomized mice.

    abstract::To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self-reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing V beta...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Iwasaki A,Yoshikai Y,Yuuki H,Takimoto H,Nomoto K

    更新日期:1991-03-01 00:00:00

  • Interleukin-2 is essential for CD4+CD25+ regulatory T cell function.

    abstract::Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: de la Rosa M,Rutz S,Dorninger H,Scheffold A

    更新日期:2004-09-01 00:00:00

  • Murine macrophage scavenger receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs.

    abstract::Macrophage scavenger receptors are trimeric integral membrane glycoproteins which have been implicated in various macrophage functions including uptake of oxidized lipoprotein and the serum-dependent, divalent cation-independent adhesion of macrophages to tissue culture-treated plastic. In this study we have used a re...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Hughes DA,Fraser IP,Gordon S

    更新日期:1995-02-01 00:00:00

  • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.

    abstract::IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial cells. Here we demonstrate that IL-22, in contrast to its relative IFN-gamma, regulates the expression of only a few genes in keratinocytes. This is due to varied signal transduction. Gene exp...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Wolk K,Witte E,Wallace E,Döcke WD,Kunz S,Asadullah K,Volk HD,Sterry W,Sabat R

    更新日期:2006-05-01 00:00:00

  • HuR keeps interferon-β mRNA stable.

    abstract::The expression of interferon (IFN) β is highly induced in immune and nonimmune cells in response to virus infection. This upregulation is mediated at both transcriptional and posttranscriptional levels. Whereas the signaling pathways triggered by innate virus receptors leading to transcription factor activation have b...

    journal_title:European journal of immunology

    pub_type: 评论,杂志文章


    authors: Takeuchi O

    更新日期:2015-05-01 00:00:00

  • Development of a novel Ag-specific immunotherapy using CpG oligodeoxynucleotides in a new, unique mouse cutaneous eosinophilic inflammation model.

    abstract::The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Kootiratrakarn T,Fujimura T,Sano K,Okuyama R,Aiba S,Tagami H,Terui T

    更新日期:2005-11-01 00:00:00

  • Identity of PB76 differentiation antigen and lymphocyte alkaline phosphatase.

    abstract::Alkaline phosphatases (APases, EC are ecto-enzymes bound to cell membranes by a phosphatidyl-inositol anchor. We have previously shown that APase is present on activated murine B cells and its expression correlates with the process of B cell differentiation into immunoglobulin secretion. Recently, a monoclona...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Márquez C,De la Hera A,Leonardo E,Pezzi L,Strasser A,Martínez-A C

    更新日期:1990-04-01 00:00:00

  • Update on animal models for HIV research.

    abstract::Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Haigwood NL

    更新日期:2009-08-01 00:00:00

  • T90/44 (9.3 antigen). A cell surface molecule with a function in human T cell activation.

    abstract::T90/44 is a cell surface antigen which is present on human T cells of the helper and cytotoxic subsets and which binds the 9.3 monoclonal antibody (9.3 mAb). It is expressed in the form of 90-kDa disulfide-bonded dimers of a 44-kDa polypeptide and of free 44-kDa subunits. The function of T90/44 was investigated in a s...

    journal_title:European journal of immunology

    pub_type: 杂志文章


    authors: Lesslauer W,Koning F,Ottenhoff T,Giphart M,Goulmy E,van Rood JJ

    更新日期:1986-10-01 00:00:00