当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human.

Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human.

Abstract：

:Expression and function of the fractalkine receptor CX3CR1 by T lymphocyte subpopulations was evaluated in healthy individuals. In CD8(+) T lymphocytes, CX3CR1 was expressed by and functional in both CD45RO(-) and CD45RO(+) cells. In CD4(+) T lymphocytes, CX3CR1 was expressed mainly by CD45RO(+) cells, and almost exclusively by activated HLA-DR(+) T lymphocytes. This receptor was functional in CD45RO(+) cells, but not in CD45RO(-) cells. Expression of fractalkine was detected by in situ hybridization and immunohistochemistry in endothelial cells of normal lung and thymus. In hyperplastic lymph nodes, fractalkine was expressed by endothelial cells of high endothelial venules and of subcapsular vessels, by follicular dendritic cells (FDC) and by some follicle lymphocytes. Fractalkine mRNA was constitutively present in the HK FDC-like cell line, and it was induced in vitro in B lymphocytes stimulated by an anti-micro or by a CD40 mAb. These findings indicate that fractalkine may contribute to the recruitment of effector T helper lymphocytes, either in peripheral tissues or in lymphoid organs. In these tissues, fractalkine and its receptor may favor contact within follicles between activated T helper lymphocytes, activated B lymphocytes and FDC, thus contributing to the maturation of the B lymphocyte response.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Foussat A,Coulomb-L'Hermine A,Gosling J,Krzysiek R,Durand-Gasselin I,Schall T,Balian A,Richard Y,Galanaud P,Emilie D

doi

10.1002/1521-4141(200001)30:1<87::AID-IMMU87>3.0.C

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

87-97

issue

1

eissn

0014-2980

issn

1521-4141

pii

10.1002/(SICI)1521-4141(200001)30:01<87::AID-IMMU8

journal_volume

30

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Pertussis toxin can replace T cell receptor signals that induce positive selection of CD8 T cells.

    abstract：:CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830271231

    authors： Takahama Y,Tokoro Y,Sugawara T,Negishi I,Nakauchi H

    更新日期：1997-12-01 00:00:00

  • Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients.

    abstract：:MicroRNA (miRNA) are a class of post-transcriptional regulators of gene expression targeting mRNA for translational repression and/or degradation. We analyzed the expression of 365 miRNA in lymphocytes in relapsing-remitting MS patients, and show the first evidence for distinct miRNA expression profiles in CD4(+), CD8...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200940032

    authors： Lindberg RL,Hoffmann F,Mehling M,Kuhle J,Kappos L

    更新日期：2010-03-01 00:00:00

  • Functional discrimination between interleukin 6 and interleukin 1.

    abstract：:In this study we have investigated the specificity of bioassays in which interleukin (IL) 1 and/or IL 6 are active. The thymocyte assay cannot be used to discriminate between IL 1 and IL 6; both monokines are active in this assay. Moreover the detection limit for both IL 1 and IL 6 is around 100 pg/ml. IL 6 activity c...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830181010

    authors： Helle M,Boeije L,Aarden LA

    更新日期：1988-10-01 00:00:00

  • Recognition of Salmonella by Dectin-1 induces presentation of peptide antigen to type B T cells.

    abstract：:Type B T cells recognize peptide-MHC class II (pMHCII) isoforms that are structurally distinct from those recognized by conventional type A T cells. These alternative type B conformers result from peptide loading in the absence of HLA-DM. Type A conformers are more stable than type B pMHCII conformers but bind the sam...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201344065

    authors： Jackson N,Compton E,Trowsdale J,Kelly AP

    更新日期：2014-04-01 00:00:00

  • High- and low-affinity receptors for murine interleukin 6. Distinct distribution on B and T cells.

    abstract：:The distribution of the murine receptor for interleukin (IL) 6 was examined on a variety of cells. Binding sites for IL 6 were found on many cell lines including fibroblasts and bone marrow-derived macrophages. The highest density of binding sites was found on B cell hybridomas and plasmacytomas, irrespective of their...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830191121

    authors： Coulie PG,Stevens M,Van Snick J

    更新日期：1989-11-01 00:00:00

  • Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells.

    abstract：:IFN-gamma plays a critical role in protection against Bordetella pertussis, but Th1 cells are only detectable after the infection has started to resolve, suggesting a protective role for innate IFN-gamma early in infection. Here, we demonstrate significant recruitment of NK cells and NKT cells into the lungs following...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425092

    authors： Byrne P,McGuirk P,Todryk S,Mills KH

    更新日期：2004-09-01 00:00:00

  • Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV-1 and cytomegalovirus infections.

    abstract：:In the present study, we have investigated the anatomic distribution and the function of different populations of HIV-1- and cytomegalovirus (CMV)-specific memory CD8 T cells. The different populations of virus-specific memory CD8 T cells were distinguished on the basis of the expression of CD45RA and CCR7, and the co...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200212)32:12<3756::AID-IMMU3756>

    authors： Ellefsen K,Harari A,Champagne P,Bart PA,Sékaly RP,Pantaleo G

    更新日期：2002-12-01 00:00:00

  • Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells.

    abstract：:The multimeric Fc gamma RIIIA (CD16) complex is expressed on the surface of natural killer (NK) cells and is composed of a 50-70-kDa transmembrane glycoprotein Fc gamma receptor (CD16), the T cell receptor (TCR)-zeta chain, and the Fc epsilon RI gamma chain. Cross-linking Fc gamma RIIIA initiates the rapid tyrosine ph...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830231017

    authors： Cone JC,Lu Y,Trevillyan JM,Bjorndahl JM,Phillips CA

    更新日期：1993-10-01 00:00:00

  • Vaccination with plasmacytoid dendritic cells induces protection against infection with Leishmania major in mice.

    abstract：:DC-based vaccination against Leishmania major induces a parasite-specific Th1 response and long-lasting protective immunity in susceptible mice. Since distinct DC subsets have been proposed to direct the predominant development of either Th1 or Th2 cells, we analyzed the capability of plasmacytoid DC (pDC) to induce p...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200636780

    authors： Remer KA,Apetrei C,Schwarz T,Linden C,Moll H

    更新日期：2007-09-01 00:00:00

  • Enzymatic modification of lymphocyte receptors for antigen. III. Resistance of receptors to trypsin at the peak of the immune response.

    abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830050612

    authors： Ashman RF

    更新日期：1976-06-01 00:00:00

  • Deficiency of high-affinity anti-beta-D-galactosidase antibodies in selected low immune responder mice.

    abstract：:Amount and affinity of anti-beta-D-galactosidase-activating antibodies (AAb) were studied in two lines of mice obtained by selective breeding for antibody response to heterologous erythrocytes. These lines, referred to as high (H) and low (L) lines, differ also in their responses to many antigens. Concerning AAb amoun...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830090312

    authors： Conway de Macario E,Heumann AM,Macario AJ,Biozzi G

    更新日期：1979-03-01 00:00:00

  • Alteration of the T cell self-specificity repertoire by treatment with anti-Ia antibody during embryonic life.

    abstract：:The effect of anti-Ia antibody on the development of murine neonatal self-Ia-reactive T lymphocytes in the thymus was studied. A C57BL/6 (B6) mouse pregnant with (B6 X C3H/He)F1 (B6C3F1) embryos was injected with monoclonal anti-I-Ek (m alpha I-Ek) antibody every other day starting from the 12th day of gestation. The ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160719

    authors： Kimoto M,Kishimoto S

    更新日期：1986-07-01 00:00:00

  • Enhanced contact hypersensitivity and antiviral immune responses in vivo by keratinocyte-targeted overexpression of IL-15.

    abstract：:IL-15 is involved in lymphocyte homeostasis. To investigate the role of IL-15 in the skin in vivo, mice were generated that overexpress IL-15 in keratinocytes, resulting in increased IL-15 protein levels in the skin but not elevated IL-15 serum concentrations. Keratin 14 (K14)-IL-15 transgenic (tg) mice showed increas...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200324785

    authors： Loser K,Mehling A,Apelt J,Ständer S,Andres PG,Reinecker HC,Eing BR,Skryabin BV,Varga G,Schwarz T,Beissert S

    更新日期：2004-07-01 00:00:00

  • Specificity and cross-reactive idiotypes of anti-glomerular basement membrane autoantibodies in HgCl2-induced autoimmune glomerulonephritis.

    abstract：:Mercury-induced autoimmune glomerulonephritis in the Brown-Norway (BN) rat is characterized by the successive appearance of linear and granular glomerular IgG deposits. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. Fusions were pe...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200114

    authors： Guéry JC,Druet E,Glotz D,Hirsch F,Mandet C,De Heer E,Druet P

    更新日期：1990-01-01 00:00:00

  • CD8alpha+ DC are not the sole subset cross-presenting cell-associated tumor antigens from a solid tumor.

    abstract：:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-pres...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200940153

    authors： McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

    更新日期：2010-06-01 00:00:00

  • Interleukin 32 promotes hematopoietic progenitor expansion and attenuates bone marrow cytotoxicity.

    abstract：:The identification of soluble factors involved in stem cell renewal is a major goal in the assessment of the BM niche. We have previously shown that human endothelial cell (EC) supernatants can induce the proliferation of hematopoietic progenitor cells (HPCs), especially after stimulation with IL-1β. To identify new p...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040986

    authors： Moldenhauer A,Futschik M,Lu H,Helmig M,Götze P,Bal G,Zenke M,Han W,Salama A

    更新日期：2011-06-01 00:00:00

  • Effective T-cell recall responses require the taurine transporter Taut.

    abstract：:T-cell activation and the subsequent transformation of activated T cells into T-cell blasts require profound changes in cell volume. However, the impact of cell volume regulation for T-cell immunology has not been characterized. Here we studied the role of the cell-volume regulating osmolyte transporter Taut for T-cel...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201141690

    authors： Kaesler S,Sobiesiak M,Kneilling M,Volz T,Kempf WE,Lang PA,Lang KS,Wieder T,Heller-Stilb B,Warskulat U,Häussinger D,Lang F,Biedermann T

    更新日期：2012-04-01 00:00:00

  • Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes.

    abstract：:The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260125

    authors： Kanangat S,Blair P,Reddy R,Daheshia M,Godfrey V,Rouse BT,Wilkinson E

    更新日期：1996-01-01 00:00:00

  • Maintenance of memory CD8 T cells: Divided over division.

    abstract：:Once generated during an infection, memory CD8+ T cells can provide long-lasting protection against reinfection with an intracellular pathogen, but the longevity of this defense depends on the ability of these pathogen-specific memory cells to be maintained. It is generally believed that the bone marrow plays an impor...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.201747249

    authors： Nolte MA,Goedhart M,Geginat J

    更新日期：2017-11-01 00:00:00

  • CD4-positive/heat-stable antigen-positive thymocytes cause graft-versus-host disease across non-major histocompatibility complex incompatibilities.

    abstract：:Single-positive thymocytes are the immediate precursors of peripheral recent thymic emigrants (RTE) which develop into mature peripheral T cells. The functional ability of RTE is unclear but their state of differentiation may be relevant to the development of tolerance to peripheral "self" antigens. Since RTE are diff...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240738

    authors： Charlton B,Meltzer J,Fathman CG

    更新日期：1994-07-01 00:00:00

  • Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression.

    abstract：:Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated the activity of IDO in the cornea, following corneal transplantation and the effect of IDO over-expression in donor corneal endothe...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200535238

    authors： Beutelspacher SC,Pillai R,Watson MP,Tan PH,Tsang J,McClure MO,George AJ,Larkin DF

    更新日期：2006-03-01 00:00:00

  • Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitis.

    abstract：:The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced exp...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040679

    authors： Ko HJ,Kinkel SA,Hubert FX,Nasa Z,Chan J,Siatskas C,Hirubalan P,Toh BH,Scott HS,Alderuccio F

    更新日期：2010-12-01 00:00:00

  • Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes.

    abstract：:Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognat...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0

    authors： Czarneski J,Berguer P,Bekinschtein P,Kim DC,Hakimpour P,Wagner N,Nepomnaschy I,Piazzon I,Ross SR

    更新日期：2002-04-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma ), a member of the nuclear receptor superfamily, has recently been described as a modulator of macrophage functions and as an inhibitor of T cell proliferation. Here, we investigated the role of PPARgamma in dendritic cells (DC), the most potent antigen-prese...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(2001010)31:10<2857::aid-immu2857

    authors： Gosset P,Charbonnier AS,Delerive P,Fontaine J,Staels B,Pestel J,Tonnel AB,Trottein F

    更新日期：2001-10-01 00:00:00

  • α-Galactosylceramide-activated murine NK1.1(+) invariant-NKT cells in the myometrium induce miscarriages in mice.

    abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201545923

    authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

    更新日期：2016-08-01 00:00:00

  • IFN-α-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells.

    abstract：:B cells have multiple functions in adaptive immunity, including antibody production, antigen presentation and regulation of T-cell responses. Recent evidences indicate that B cells have more subsets than previously thought and may have non-classical functions, such as involvement in innate immunity and immune regulati...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040840

    authors： Bao Y,Han Y,Chen Z,Xu S,Cao X

    更新日期：2011-03-01 00:00:00

  • Urtica dioica agglutinin, a V beta 8.3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice.

    abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260807

    authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

    更新日期：1996-08-01 00:00:00

  • The TGF-beta response to Leishmania chagasi in the absence of IL-12.

    abstract：:Cure of leishmaniasis requires a type 1 immune response characterized by IFN-gamma production. Leishmania major infection leads to a type 2 response suppressing cure of susceptible BALB/c mice, and L. major causes an exacerbated type 2 response in mouse strains with a gene knockout (KO) such that they lack IL-12p40 (I...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200212)32:12<3556::AID-IMMU3556>

    authors： Wilson ME,Recker TJ,Rodriguez NE,Young BM,Burnell KK,Streit JA,Kline JN

    更新日期：2002-12-01 00:00:00

  • FcγRIIB regulation of BCR/TLR-dependent autoreactive B-cell responses.

    abstract：:Crosslinking of Fc γ receptor II B (FcγRIIB) and the BCR by immune complexes (IC) can downregulate antigen-specific B-cell responses. Accordingly, FcγRIIB deficiencies have been associated with B-cell hyperactivity in patients with systemic lupus erythematosus and mouse models of lupus. However, we have previously sho...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200940184

    authors： Avalos AM,Uccellini MB,Lenert P,Viglianti GA,Marshak-Rothstein A

    更新日期：2010-10-01 00:00:00

  • A monoclonal anti-HLA antibody recognizes a mouse tumor-associated antigen.

    abstract：:The monoclonal antibody W6/32.1 recognizes a public determinant on the HLA-A, B and C antigens of all tested human haplotypes. Though the antibody does not bind to normal mouse cells of any H-2 haplotype, it does show an unexpected specificity for the T cell leukemia line MBL-2 from a C57BL/6 mouse. It is shown that t...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830130213

    authors： Evan GI,Lennox ES,Alderson T,Croft L

    更新日期：1983-02-01 00:00:00