Urtica dioica agglutinin, a V beta 8.3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice.

abstract：:A number of applications of antibodies in diagnosis and therapy require multivalent reagents either because of the polymeric nature of the antigens or because biological activity depends on an effect on the formation of homodimeric species. Here, we report a procedure for mass screening of phage-derived monomeric anti...

journal_title：European journal of immunology

authors： Zaccolo M,Griffiths AP,Prospero TD,Winter G,Gherardi E

更新日期：1997-03-01 00:00:00

abstract：:The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC class I molecules expressed by placental trophoblast. These include members of the killer immunoglobulin-like receptor (KIR) family, the two-domain KIR (KIR2D), w...

journal_title：European journal of immunology

authors： Male V,Sharkey A,Masters L,Kennedy PR,Farrell LE,Moffett A

更新日期：2011-10-01 00:00:00

abstract：:Osteopontin (OPN) and CD44 have been implicated in the development of autoimmune diseases, including arthritis and multiple sclerosis, as well as chronic inflammatory diseases, such as atherosclerosis and colitis. To investigate their roles in autoimmune myocarditis induced by immunization with heart alpha-myosin (MyH...

journal_title：European journal of immunology

authors： Abel B,Kurrer M,Shamshiev A,Marty RR,Eriksson U,Günthert U,Kopf M

更新日期：2006-02-01 00:00:00

abstract：:We have studied a secondary IgG anti-dinitrophenyl response in dissociated mouse spleen cell cultures which is comparable in magnitude to the responses detected after adoptive transfer. The data indicate that the responsive precursor cell is not a recirculating memory cell but is an intermediate B cell type which appe...

journal_title：European journal of immunology

authors： North JR,Askonas BA

更新日期：1976-01-01 00:00:00

abstract：:C3 is the central component of the complement system. Upon activation, C3 sequentially generates various proteolytic fragments, C3a, C3b, iC3b, C3dg, each of them exposing novel surfaces, which are sites of interaction with other proteins. C3 and its fragments are therapeutic targets and markers of complement activati...

journal_title：European journal of immunology

authors： Subías Hidalgo M,Yébenes H,Rodríguez-Gallego C,Martín-Ambrosio A,Domínguez M,Tortajada A,Rodríguez de Córdoba S,Llorca O

更新日期：2017-03-01 00:00:00

abstract：:Anti-HLA donor-specific antibodies are deleterious for organ transplant survival. Class I HLA donor-specific antibodies are identified by using the Luminex single antigen beads (LSAB) assay, which also detects anti-denatured HLA antibodies (anti-dHLAs). Anti-dHLAs are thought to be unable to recognize native HLA (nHLA...

journal_title：European journal of immunology

authors： Visentin J,Guidicelli G,Moreau JF,Lee JH,Taupin JL

更新日期：2015-07-01 00:00:00

abstract：:Expression and function of the fractalkine receptor CX3CR1 by T lymphocyte subpopulations was evaluated in healthy individuals. In CD8(+) T lymphocytes, CX3CR1 was expressed by and functional in both CD45RO(-) and CD45RO(+) cells. In CD4(+) T lymphocytes, CX3CR1 was expressed mainly by CD45RO(+) cells, and almost excl...

journal_title：European journal of immunology

authors： Foussat A,Coulomb-L'Hermine A,Gosling J,Krzysiek R,Durand-Gasselin I,Schall T,Balian A,Richard Y,Galanaud P,Emilie D

更新日期：2000-01-01 00:00:00

abstract：:Germinal centers support the differentiation of memory B cells and long-lived antibody-secreting cells during infection or upon vaccination. Here, we constructed mice with T cells that selectively lack the chemokine receptor CXCR5 to determine if expression of this receptor by T cells is mandatory for germinal center ...

journal_title：European journal of immunology

authors： Arnold CN,Campbell DJ,Lipp M,Butcher EC

更新日期：2007-01-01 00:00:00

abstract：:In chickens, the pre-B cell development takes place in a specialized organ, the bursa of Fabricius. In this study, we show that fibronectin can be detected in the bursa at least from the day 15 of embryonic incubation up to 10 weeks of age after which the bursa starts to involute. During the embryonic incubation, fibr...

journal_title：European journal of immunology

authors： Palojoki E,Toivanen P,Jalkanen S

更新日期：1993-03-01 00:00:00

abstract：:Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which ar...

journal_title：European journal of immunology

authors： Jones ND,Brook MO,Carvalho-Gaspar M,Luo S,Wood KJ

更新日期：2010-11-01 00:00:00

abstract：:In human T lymphocytes a functional complex is formed between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and a phosphoprotein, pp32, a possible common substrate. Here we demonstrate that the previously described pp32 protein is composed of two distinct molecules (pp29 and pp32) in both r...

journal_title：European journal of immunology

authors： Schraven B,Schirren A,Kirchgessner H,Siebert B,Meuer SC

更新日期：1992-07-01 00:00:00

abstract：:A monoclonal antibody (12-15) reactive with the mouse CD2 was used to study the expression of the antigen in different lymphoid cell subsets. By two-color immunofluorescence using B or T cell-specific reagents and cell sorting in combination with biochemical analysis we provide evidence that the CD2 antigen is present...

journal_title：European journal of immunology

authors： Altevogt P,Michaelis M,Kyewski B

更新日期：1989-08-01 00:00:00

abstract：:Activation of naive T cells is tightly controlled and depends on cognate interactions with professional antigen-presenting cells. We analyzed dependency on secondary lymphoid tissues for the activation of naive and memory CD4(+) and CD8(+) T cells following primary and secondary Listeria monocytogenes infection, respe...

journal_title：European journal of immunology

authors： Kursar M,Jänner N,Pfeffer K,Brinkmann V,Kaufmann SH,Mittrücker HW

更新日期：2008-01-01 00:00:00

abstract：:Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...

journal_title：European journal of immunology

authors： Kelly KA,Scollay R

更新日期：1992-02-01 00:00:00

abstract：:NK cells and cytotoxic T lymphocytes can induce apoptosis in virus-infected and transformed target cells via the granule exocytosis pathway. The key components of the cytolytic granules are perforin and several serine esterases, termed granzymes. While the cellular distribution of human granzymes A (GrA) and B (GrB) h...

journal_title：European journal of immunology

authors： Bratke K,Kuepper M,Bade B,Virchow JC Jr,Luttmann W

更新日期：2005-09-01 00:00:00

abstract：:It is widely accepted that females have superior immune responses than males, but the ways by which sex hormones may enhance T cell responses are still poorly understood. In the present study, we analyzed the effect of estrogens on CD4 T cell activation and differentiation after immunization with exogenous antigens. W...

journal_title：European journal of immunology

authors： Maret A,Coudert JD,Garidou L,Foucras G,Gourdy P,Krust A,Dupont S,Chambon P,Druet P,Bayard F,Guéry JC

更新日期：2003-02-01 00:00:00

abstract：:Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence suggests that crescent formation results from a delayed-type hypersensitivity-like Th1 response. As IL-12 directs Th1 responses, we tested the hypothesis that IL-12 is important in crescentic GN. Neutralization of IL-12 attenuated cre...

journal_title：European journal of immunology

authors： Kitching AR,Tipping PG,Holdsworth SR

更新日期：1999-01-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated the activity of IDO in the cornea, following corneal transplantation and the effect of IDO over-expression in donor corneal endothe...

journal_title：European journal of immunology

authors： Beutelspacher SC,Pillai R,Watson MP,Tan PH,Tsang J,McClure MO,George AJ,Larkin DF

更新日期：2006-03-01 00:00:00

abstract：:The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, and plays crucial roles in numerous neurological diseases. Activation of the NLRP3 inflammasome leads to caspase-1 dependent cleavage of pro-IL-1β to form mature IL-1β. By acting on the P...

journal_title：European journal of immunology

authors： Suzuki T,Kohyama K,Moriyama K,Ozaki M,Hasegawa S,Ueno T,Saitoe M,Morio T,Hayashi M,Sakuma H

更新日期：2020-02-01 00:00:00

abstract：:Bone marrow (BM) stromal cells are important in the development and maintenance of cells of the immune system. Using single cell RNA sequencing, we here explore the functional and phenotypic heterogeneity of individual transcriptomes of 1167 murine BM mesenchymal stromal cells. These cells exhibit a tremendous heterog...

journal_title：European journal of immunology

authors： Addo RK,Heinrich F,Heinz GA,Schulz D,Sercan-Alp Ö,Lehmann K,Tran CL,Bardua M,Matz M,Löhning M,Hauser AE,Kruglov A,Chang HD,Durek P,Radbruch A,Mashreghi MF

更新日期：2019-09-01 00:00:00

abstract：:Human Vγ9Vδ2 T cells are potent anti-tumor lymphocytes that specifically respond to pyrophosphate (phospho-) antigens, which constitute the basis of current γδ T-cell-based immunotherapy strategies. Despite a clear involvement of the TCR, the costimulation requirements of Vγ9Vδ2 T cells remain ill-defined. Here, we sh...

journal_title：European journal of immunology

authors： DeBarros A,Chaves-Ferreira M,d'Orey F,Ribot JC,Silva-Santos B

更新日期：2011-01-01 00:00:00

abstract：:The activation requirements for antigen-dependent proliferation of CD4+ T cells are well documented, while the events leading to the inactivation phase are poorly understood. Here, we tested the hypothesis that the lymphocyte-activation gene 3 (LAG-3), a second major histocompatibility complex (MHC) class II ligand, p...

journal_title：European journal of immunology

authors： Huard B,Tournier M,Hercend T,Triebel F,Faure F

更新日期：1994-12-01 00:00:00

abstract：:It is widely believed that IL-4 exerts its influence by profiling the immune response during priming and expansion of immune cells, and thereby modulates the outcome of chronic inflammation. In the present investigation, collagen antibody-induced arthritis (CAIA) was used to delineate the role of IL-4 in a T cell-inde...

journal_title：European journal of immunology

authors： Nandakumar KS,Holmdahl R

更新日期：2006-06-01 00:00:00

abstract：:Defined tumor-associated antigens (TAA) are attractive targets for anti-tumor immunotherapy. Here, we describe a novel genome-wide approach to identify multiple TAA from any given tumor. A panel of transplantable thymomas was established from an inbred p53-/- mouse strain. The resulting tumors were examined for gene e...

journal_title：European journal of immunology

authors： Mathiassen S,Lauemøller SL,Ruhwald M,Claesson MH,Buus S

更新日期：2001-04-01 00:00:00

abstract：:There is a current need for safe, cheap, and effective vaccine adjuvants, to combine with sub-unit antigens to enhance their immunogenicity. In this study we have used probiotic Bacillus subtilis spores, known to be safe and fully tolerated by ingestion in man, and explored their ability to influence the magnitude and...

journal_title：European journal of immunology

authors： Barnes AG,Cerovic V,Hobson PS,Klavinskis LS

更新日期：2007-06-01 00:00:00

abstract：:The HIV-1 Tat protein plays a critical role in the pathogenesis of HIV and has been considered as a candidate vaccine antigen. In an effort to design a non-invasive vaccination strategy against HIV-1 that stimulates the induction of systemic and mucosal immune responses, we studied the transcutaneous delivery of a syn...

journal_title：European journal of immunology

authors： Partidos CD,Moreau E,Chaloin O,Tunis M,Briand JP,Desgranges C,Muller S

更新日期：2004-12-01 00:00:00

abstract：:Plasmid cassette-transfer vectors pBHuC chi and pBHuC gamma l have been designed which enable the construction of recombinant baculoviruses directing the co-expression of complete immunoglobulin in insect cells. We describe the application of these vectors for the expression of a human/mouse chimeric monoclonal antibo...

journal_title：European journal of immunology

authors： Poul MA,Cerutti M,Chaabihi H,Ticchioni M,Deramoudt FX,Bernard A,Devauchelle G,Kaczorek M,Lefranc MP

更新日期：1995-07-01 00:00:00

abstract：:The inflammatory cytokine IL-17 plays a critical role in immunity to infection and is involved in the inflammatory pathology associated with certain autoimmune diseases, such as psoriasis and rheumatoid arthritis. While CD4(+) and CD8(+) T cells are important sources of this cytokine, recent evidence has suggested tha...

journal_title：European journal of immunology

authors： Sutton CE,Mielke LA,Mills KH

更新日期：2012-09-01 00:00:00

abstract：:Human peripheral blood mononuclear leukocytes (PBL) cocultured with WISH human amnion cells rapidly produced alpha-type interferon (IFN-alpha) and in an IFN-dependent manner protected the WISH cells against the cytopathic effects caused by vesicular stomatitis virus. When the number of PBL per WISH cell monolayer cult...

journal_title：European journal of immunology

authors： Rönnblom L,Alm GV

更新日期：1982-05-01 00:00:00

abstract：:Diacylglycerol kinases (DGKs) play important roles in restraining diacylglycerol (DAG)-mediated signaling. Within the DGK family, the ζ isoform appears to be the most important isoform in T cells for controlling their development and function. DGKζ has been demonstrated to regulate T cell maturation, activation, anerg...

journal_title：European journal of immunology

authors： Xie D,Zhang S,Chen P,Deng W,Pan Y,Xie J,Wang J,Liao B,Sleasman JW,Zhong XP

更新日期：2020-11-01 00:00:00