Deciphering allogeneic antibody response against native and denatured HLA epitopes in organ transplantation.

abstract：:MS and EAE are T cell-driven autoimmune diseases of the CNS where IL-17-producing Th17 cells promote damage and are pathogenic. Conversely, tolerogenic DCs induce Treg cells and suppress Th17 cells. Chloroquine (CQ) suppresses EAE through the modulation of DCs by unknown mechanisms. Here, we show that STAT 1 is necess...

journal_title：European journal of immunology

authors： Thome R,Bonfanti AP,Rasouli J,Mari ER,Zhang GX,Rostami A,Verinaud L

更新日期：2018-07-01 00:00:00

abstract：:Tertiary lymphoid organs can form at sites of chronic inflammation. Their presence has been mainly associated with tissue destruction. In transplantation, there is a dynamic immune response as in chronic inflammation. Indeed, the presence of tertiary lymphoid organs has been associated with chronic rejection. In addit...

journal_title：European journal of immunology

authors： Brown K,Sacks SH,Wong W

更新日期：2011-01-01 00:00:00

abstract：:Expression and function of the fractalkine receptor CX3CR1 by T lymphocyte subpopulations was evaluated in healthy individuals. In CD8(+) T lymphocytes, CX3CR1 was expressed by and functional in both CD45RO(-) and CD45RO(+) cells. In CD4(+) T lymphocytes, CX3CR1 was expressed mainly by CD45RO(+) cells, and almost excl...

journal_title：European journal of immunology

authors： Foussat A,Coulomb-L'Hermine A,Gosling J,Krzysiek R,Durand-Gasselin I,Schall T,Balian A,Richard Y,Galanaud P,Emilie D

更新日期：2000-01-01 00:00:00

abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

journal_title：European journal of immunology

authors： Ashman RF

更新日期：1976-06-01 00:00:00

abstract：:Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the sec...

journal_title：European journal of immunology

authors： Müller N,Fischer JC,Yabal M,Haas T,Poeck H,Jost PJ

更新日期：2019-03-01 00:00:00

abstract：:Naive T cells do not proliferate but remain alive in vivo. In contrast, naive T cells rapidly die in an in vitro culture, suggesting that some factors that are present at the sites of naive T cell circulation in vivo but missing in the bovine serum-containing culture medium, are necessary for their survival. The prese...

journal_title：European journal of immunology

authors： Endharti AT,Zhou YW,Nakashima I,Suzuki H

更新日期：2005-01-01 00:00:00

abstract：:Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host response to Mycoba...

journal_title：European journal of immunology

authors： Lachmandas E,Beigier-Bompadre M,Cheng SC,Kumar V,van Laarhoven A,Wang X,Ammerdorffer A,Boutens L,de Jong D,Kanneganti TD,Gresnigt MS,Ottenhoff TH,Joosten LA,Stienstra R,Wijmenga C,Kaufmann SH,van Crevel R,Netea MG

更新日期：2016-11-01 00:00:00

abstract：:The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

journal_title：European journal of immunology

authors： Nordin AA

更新日期：1978-11-01 00:00:00

abstract：:Mouse thymus-leukemia antigen (TL), like other major histocompatibility complex (MHC) class I-b antigens, displays signs of a specialized function. It is normally expressed at high levels on immature thymocytes and at moderate levels on gut epithelium and activated mature T cells. A promoter/enhancer region unique amo...

journal_title：European journal of immunology

authors： Rodgers JR,Mehta V,Cook RG

更新日期：1995-04-01 00:00:00

abstract：:MHC-peptide-specific Fab antibodies binding to HLA-A*0201 complexes presenting the wild-type EAAGIGILTV (EAA) or analogue Melan-A 10-mer ELAGIGILTV (ELA) peptide were generated to study efficacy of peptide processing and presentation. None of the selected Fab antibodies detected the naturally processed EAA/HLA-A*0201 ...

journal_title：European journal of immunology

authors： Held G,Wadle A,Dauth N,Stewart-Jones G,Sturm C,Thiel M,Zwick C,Dieckmann D,Schuler G,Hoogenboom HR,Lévy F,Cerundolo V,Pfreundschuh M,Renner C

更新日期：2007-07-01 00:00:00

abstract：:Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...

journal_title：European journal of immunology

authors： Schlunck T,Schraut W,Riethmüller G,Ziegler-Heitbrock HW

更新日期：1990-09-01 00:00:00

abstract：:Cyclosporin A (CSA), an immunosuppressive agent used in organ transplantation and to treat some autoimmune diseases, blocks the Ca2+-dependent steps involved in T cell receptor triggering leading to interleukin (IL)-2 production. Considering that the early steps of T cell activation are insensitive to CSA, we asked wh...

journal_title：European journal of immunology

authors： Bemer V,Truffa-Bachi P

更新日期：1996-07-01 00:00:00

abstract：:cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per...

journal_title：European journal of immunology

authors： Chretien I,Marcuz A,Fellah J,Charlemagne J,Du Pasquier L

更新日期：1997-03-01 00:00:00

abstract：:Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

journal_title：European journal of immunology

authors： Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

更新日期：2019-05-01 00:00:00

abstract：:Specific monoclonal antibodies (mAb) directed against the CD23 antigen were used to study human interleukin 4 (hIL4)-induced IgE production by blood and tonsillar mononuclear cells. Both peripheral blood and tonsillar mononuclear cells stimulated by hIL4 expressed membrane CD23 as detected by the binding of all anti-C...

journal_title：European journal of immunology

authors： Bonnefoy JY,Shields J,Mermod JJ

更新日期：1990-01-01 00:00:00

abstract：:This study shows that both recombinant human interleukin (rhIL)3 and rhIL4 induced proliferation in bone marrow (BM) cells of myelogenous leukemia patients in a manner similar to that reported using normal BM cells. However, we additionally found that these cytokines also influenced expression of other cytokines. Name...

journal_title：European journal of immunology

authors： Brantschen S,Gauchat JF,De Weck AL,Stadler BM

更新日期：1989-11-01 00:00:00

abstract：:Surfactant protein A (SP-A) and surfactant protein D (SP-D) are collectins, and both proteins were shown to interact with influenza A virus and alveolar macrophages. However, it is not known whether SP-A and SP-D can serve as opsonins for the phagocytosis of influenza A virus by alveolar macrophages. In the present st...

journal_title：European journal of immunology

authors： Benne CA,Benaissa-Trouw B,van Strijp JA,Kraaijeveld CA,van Iwaarden JF

更新日期：1997-04-01 00:00:00

abstract：:Sequential development of antibody titer, functional avidity, helper and suppressor activities were investigated in rhesus monkeys. These were immunized with a single dose of 0.1 microgram to 10 mg of a streptococcal protein antigen (SA) in aluminium hydroxide. The IgG antibody titers followed the classical pattern fi...

journal_title：European journal of immunology

authors： Lehner T,Caldwell J,Avery J

更新日期：1984-09-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates th...

journal_title：European journal of immunology

authors： Youn JI,Gabrilovich DI

更新日期：2010-11-01 00:00:00

abstract：:T cell clones of C57BL/6 origin which recognize porcine lactate dehydrogenase B (LDH-BP) together with the Ab molecule were characterized in terms of fine specificity for both LDH-B and self-major histocompatibility complex determinants. Using antigen-presenting cells from the Ab-mutant strain B6.C-H-2bm12 (bm12), thr...

journal_title：European journal of immunology

authors： Nagy ZA,Servis C,Walden P,Klein J,Goldberg E

更新日期：1985-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a major part in providing innate immunity against pathogenic microorganisms. Recent studies show that these receptors are also expressed on T cells, which are the sentinels of adaptive immunity. Here, we have investigated the regulatory role of the T-cell receptor in the functioning of ...

journal_title：European journal of immunology

authors： Akhade AS,Qadri A

更新日期：2015-09-01 00:00:00

abstract：:It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an ongoing debate regarding the reverse plasticity (conversion from Th1 to Th17). We show here that ectopic ROR-γt expression can re...

journal_title：European journal of immunology

authors： Mazzoni A,Maggi L,Siracusa F,Ramazzotti M,Rossi MC,Santarlasci V,Montaini G,Capone M,Rossettini B,De Palma R,Kruglov A,Chang HD,Cimaz R,Maggi E,Romagnani S,Liotta F,Cosmi L,Annunziato F

更新日期：2019-01-01 00:00:00

abstract：:Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to stud...

journal_title：European journal of immunology

authors： Li BW,de Bruijn MJ,Tindemans I,Lukkes M,KleinJan A,Hoogsteden HC,Hendriks RW

更新日期：2016-06-01 00:00:00

abstract：:HLA class II molecules are involved in the OKT3-induced T cell activation, since monoclonal antibodies (mAb) to monomorphic determinants of class II antigens are able to inhibit T cell proliferation. This effect involves several of the events leading to T cell activation and proliferation, i.e. interleukin (IL) 1, IL ...

journal_title：European journal of immunology

authors： Ruggiero G,Racioppi L,Manzo C,Pirozzi G,D'Oro U,Ferrone S,Zappacosta S,Fontana S

更新日期：1991-01-01 00:00:00

abstract：:Humanized BALB/c mice (termed trimera mice) conditioned by lethal total body irradiation and bone marrow transplantation from SCID mice have been described to support rapid engraftment of human peripheral blood mononuclear cells (PBMC) and the induction of strong B and T cell responses after immunization in vivo. More...

journal_title：European journal of immunology

authors： Böcher WO,Dekel B,Schwerin W,Geissler M,Hoffmann S,Rohwer A,Arditti F,Cooper A,Bernhard H,Berrebi A,Rose-John S,Shaul Y,Galle PR,Löhr HF,Reisner Y

更新日期：2001-07-01 00:00:00

abstract：:Human peripheral blood mononuclear leukocytes (PBL) cocultured with WISH human amnion cells rapidly produced alpha-type interferon (IFN-alpha) and in an IFN-dependent manner protected the WISH cells against the cytopathic effects caused by vesicular stomatitis virus. When the number of PBL per WISH cell monolayer cult...

journal_title：European journal of immunology

authors： Rönnblom L,Alm GV

更新日期：1982-05-01 00:00:00

abstract：:The early mechanisms by which DNA-dependent immunization occurs remain poorly understood. We determined whether intradermal injection of a cytomegalovirus (CMV) promoter-driven plasmid encoding hen egg lysozyme (pCMV:HEL) induced sensitization against the encoded protein, and whether cutaneous dendritic cells (DC) wer...

journal_title：European journal of immunology

authors： Bouloc A,Walker P,Grivel JC,Vogel JC,Katz SI

更新日期：1999-02-01 00:00:00

abstract：:Similar idiotopes are detected on anti-allotypic antibodies synthesized by all rabbits immunized against the b6 allotype. The expression of similar idiotypes on anti-b6 antibodies has been found in rabbits of all VHa allotypic types thus far studies. For their expression, these idiotypes require the interaction betwee...

journal_title：European journal of immunology

authors： Roland J,Cazenave PA

更新日期：1981-06-01 00:00:00

abstract：:Growing evidence suggests that some immune responses are mediated not only by conventional and distinct NK cells and CTL, but also by T cell subsets expressing NK receptors and NK cell-associated molecules. Consistent with our previously published finding that the mAb 1F8 identifies non-T/non-B cells in Xenopus that e...

journal_title：European journal of immunology

authors： Rau L,Gantress J,Bell A,Stewart R,Horton T,Cohen N,Horton J,Robert J

更新日期：2002-06-01 00:00:00

abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

journal_title：European journal of immunology

authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

更新日期：1984-06-01 00:00:00