Abstract:
:Specific monoclonal antibodies (mAb) directed against the CD23 antigen were used to study human interleukin 4 (hIL4)-induced IgE production by blood and tonsillar mononuclear cells. Both peripheral blood and tonsillar mononuclear cells stimulated by hIL4 expressed membrane CD23 as detected by the binding of all anti-CD23 mAb. Nevertheless, two sets of anti-CD23 mAb could be distinguished. The first set, including mAb 25, was able to decrease significantly hIL4-induced IgE synthesis by mononuclear cells. The second set, including EBVCS#1, did not affect hIL4-induced IgE synthesis. All the anti-CD23 mAb were able to bind specifically to a human B cell line expressing recombinant CD23. Inhibition experiments revealed that the two sets of anti-CD23 mAb did not recognize the same epitope on the CD23 antigen. In fact, all the anti-CD23 mAb, except EBVCS#1, were able to inhibit IgE binding to CD23 on RPMI 8866 cells. Moreover, the first set of antibodies, which decreased IgE production, was able to up-regulate membrane CD23 expression on hIL4-stimulated tonsillar mononuclear cells. Conversely, EBVCS#1, which had no effect on IgE production, did not affect hIL4-induced CD23 expression. These results indicate that CD23 plays a key role in human IgE synthesis.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Bonnefoy JY,Shields J,Mermod JJdoi
10.1002/eji.1830200120subject
Has Abstractpub_date
1990-01-01 00:00:00pages
139-44issue
1eissn
0014-2980issn
1521-4141journal_volume
20pub_type
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200102)31:2<369::aid-immu369
更新日期:2001-02-01 00:00:00
abstract::Immunotherapy generally fails to induce tumour regression in spontaneously arising tumours. Failure is attributed to both tumour-related factors and an ineffective immune response. As a model of tumour immunotherapy, without the confounding effects of potential tumour-determined mechanisms of immune evasion, we studie...
journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190303
更新日期:1989-03-01 00:00:00
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journal_title:European journal of immunology
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更新日期:2012-08-01 00:00:00
abstract::Lymphocyte infiltration to pancreatic islets is associated to chemoattraction, as are other inflammatory autoimmune processes. We examined whether development of insulitis and diabetes depends on chemoattraction of lymphocytes via the CCR5 chemokine receptor. In non-obese diabetic (NOD) mice, a substantial fraction of...
journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/eji.201040827
更新日期:2011-05-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830110412
更新日期:1981-04-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160816
更新日期:1986-08-01 00:00:00
abstract::Anti-peroxidase antibody (Ab)-secreting hybrids have been produced by fusion of peroxidase (PO)-immunized mouse lymph node cells and immunoglobulin (Ig)-secreting P3-X63-Ag8 (X63) myeloma cells. Identification of Ab-secreting hybrids can be performed as early as day 5 after cell fusion by the hemolytic plaque assay. I...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830090102
更新日期:1979-01-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260431
更新日期:1996-04-01 00:00:00
abstract::The liver and activation-regulated chemokine (LARC), also termed MIP-3alpha and Exodus, is a novel human CC chemokine with a selective chemotactic activity for lymphocytes and dendritic cells. Here we describe genomic and cDNA clones encoding the murine orthologue of LARC (mLARC). The gene consists of four exons and t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199902)29:02<633::AID-IMMU
更新日期:1999-02-01 00:00:00
abstract::Tumor-specific helper T cell activity was detected in the spleens of tumor-bearing mice using a sensitive, simple and reproducible in vitro assay based on those previously described for soluble hapten-carrier antigens. Helper activity disappears when the tumor is large. This is coincident with the appearance of two di...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120809
更新日期:1982-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160211
更新日期:1986-02-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251029
更新日期:1995-10-01 00:00:00
abstract::Rodents are significantly less sensitive to enterotoxin-induced shock, and are thus not valid human disease models. Here, we describe a mouse strain carrying the human CD4 and human major histocompatibility complex (MHC) class II (DQ6) transgenes in an endogenous CD4- and CD8-deficient background. T lymphocytes from t...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260518
更新日期:1996-05-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200102)31:2<551::aid-immu551>3.0
更新日期:2001-02-01 00:00:00
abstract::Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD103(+) DCs to imprint tissue-specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A also regulates DC populations in other tiss...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201343631
更新日期:2013-06-01 00:00:00
abstract::There is limited insight into the mechanisms involved in the counterregulation of TLR. Given the important role of TLR3/TIR domain-containing adaptor-inducing IFN-β (TRIF)-dependent signalling in innate immunity, novel insights into its modulation is of significance in the context of many physiological and pathologica...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040547
更新日期:2010-11-01 00:00:00
abstract::Using a culture system which supports primary T cell proliferative responses to various antigens we have detected mouse red blood cell (RBC)-reactive T cells in lymphoid tissues from untreated mice. The release of significant amounts of interleukin 2 (IL2) indicates that T helper (or helper/inducer) cells are activate...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830170610
更新日期:1987-06-01 00:00:00
abstract::In this study we examined the effect of interleukin 4 (IL 4) on T cell activation and proliferation via the alternative CD2 pathway. To this end highly purified human resting T cells were cultured with a stimulating pair of anti-CD2 monoclonal antibodies in the absence of accessory signals from monocytes. Addition of ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200724
更新日期:1990-07-01 00:00:00
abstract::The binding of antigen to the multicomponent T cell antigen receptor (TcR)-CD3 complex leads to the activation of several signal transduction pathways which result in T lymphocyte proliferation and lymphokine secretion by molecular mechanisms and catalytic molecules as yet poorly defined. One of the earliest events th...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220142
更新日期:1992-01-01 00:00:00
abstract::Low zone tolerance (LZT) to contact allergens is induced by epicutaneous exposure to haptens in subsensitizing doses resulting in an inhibition of contact hypersensitivity (CHS), which, in contrast, occurs after sensitization with immunogenic doses of allergens. Performing the protocol of tolerance induction resulted ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425402
更新日期:2004-11-01 00:00:00
abstract::The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells, monocytes and dendritic cells is essential for humoral immunity and for up-regulation of antigen-presenting cell (APC) functions, as a result of signaling through CD40. There are also some indications that after interaction with CD40, CD...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260732
更新日期:1996-07-01 00:00:00
abstract::CD4+CD25(hi)CD127(lo/-) regulatory T cells (Treg) have been implicated in the resolution of asthma-associated inflammation while the opposite role of CD4+ invariant NKT (iNKT) cells has been the subject of recent investigations. Studies here focused on mechanisms of interaction between CD4+ iNKT cells and Treg to furt...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200738082
更新日期:2008-07-01 00:00:00
abstract::To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self-reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing V beta...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210310
更新日期:1991-03-01 00:00:00