Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock.

abstract：:Soluble HLA class I (sHLA-I) molecules can regulate survival of NK cells and their anti-tumor killing activity. Herein, we have analysed whether interaction of sHLA-I with CD8 and/or different isoforms of killer Ig-like receptors (KIR) induced secretion of transforming growth factor (TGF)-beta1. CD8+KIR- NK cell clone...

journal_title：European journal of immunology

authors： Ghio M,Contini P,Negrini S,Boero S,Musso A,Poggi A

更新日期：2009-12-01 00:00:00

abstract：:Multinucleated giant cells (MGC), which are a common feature of various pathologic states, were generated in vitro by cytokine-stimulation of human peripheral blood monocytes. As expected, conditioned medium, i.e. the supernatant of concanavalin A-stimulated peripheral blood mononuclear cells, readily caused generatio...

journal_title：European journal of immunology

authors： Möst J,Neumayer HP,Dierich MP

更新日期：1990-08-01 00:00:00

abstract：:Treatment of human peripheral blood lymphocytes with cloned N alpha-desacetylthymosin alpha 1 induced interferon production. The kinetics is similar to that of mitogen-induced interferon induction. N alpha-desacetylthymosin alpha 1, in combination with mitogen, augments the amount of interferon produced. This interfer...

journal_title：European journal of immunology

authors： Svedersky LP,Hui A,May L,McKay P,Stebbing N

更新日期：1982-03-01 00:00:00

abstract：:Under physiological conditions, activation of CD4+ T cells by major histocompatibility complex (MHC)antigen complexes requires engagement of both the T cell receptor and the CD4 molecule. However, CD4 ligands binding to the CD4 molecule has also been shown to inhibit T cell proliferation and interleukin (IL)-2 product...

journal_title：European journal of immunology

authors： Jabado N,Pallier A,Jauliac S,Fischer A,Hivroz C

更新日期：1997-02-01 00:00:00

abstract：:cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per...

journal_title：European journal of immunology

authors： Chretien I,Marcuz A,Fellah J,Charlemagne J,Du Pasquier L

更新日期：1997-03-01 00:00:00

abstract：:The involvement of the CD2 (T11) molecule, an alternative activation pathway for T lymphocytes, in the regulation of tumor necrosis factor (TNF)-alpha/TNF receptor system in human T lymphocytes has been investigated. It has been found that both TNF-alpha synthesis and secretion were induced after incubation of purifie...

journal_title：European journal of immunology

authors： Santis AG,Campanero MR,Alonso JL,Sánchez-Madrid F

更新日期：1992-12-01 00:00:00

abstract：:Inhibitory anti-antibodies induced in patients by xenogeneic or even by humanized anti-T cell antibodies remain an unresolved problem. Mice also produce anti-antibodies following injection of xeno- or allogeneic anti-T cell antibodies. Here we report a principle based on sequentially applied anti-T cell antibodies gen...

journal_title：European journal of immunology

authors： Mysliwietz J,Thierfelder S,Mocikat R,Kremmer E

更新日期：1994-10-01 00:00:00

abstract：:Cholera toxin (CT) can function as a potent adjuvant in the mucosal immune response. However, we have found that treatment of A20-HL murine B lymphoma cells with CT severely inhibits the presentation of ovalbumin (OVA) to cells of the T cell clone 42-6A specific for OVA(323-339)/I-Ad, whereas it does not affect the pr...

journal_title：European journal of immunology

authors： Tanaka Y,Nakano H,Ishikawa F,Yoshida M,Gyotoku Y,Kakiuchi T

更新日期：1999-05-01 00:00:00

abstract：:Helicobacter pylori is a Gram-negative bacterium that causes a variety of gastrointestinal diseases, such as duodenal ulcer and gastric carcinoma. The T cell response against H. pylori is thought to contribute to the pathogenesis of these diseases. Here, we show that mouse-adapted H. pylori is able to polyclonally act...

journal_title：European journal of immunology

authors： Rosenplänter C,Sommer F,Kleemann P,Belkovets A,Schmidt A,Lohoff M

更新日期：2007-07-01 00:00:00

abstract：:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

journal_title：European journal of immunology

authors： Abromson-Leeman S,Laning J,Cantor H,Dorf ME

更新日期：1988-01-01 00:00:00

abstract：:Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD103(+) DCs to imprint tissue-specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A also regulates DC populations in other tiss...

journal_title：European journal of immunology

authors： Stock AT,Bedoui S

更新日期：2013-06-01 00:00:00

abstract：:Lipid antigens are presented to T cells by the non-polymorphic MHC class I-related CD1 molecules. Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident chaperone that has been shown to lipidate the group 2 CD1 molecule CD1d and thus to regulate its function. We now report that MTP al...

journal_title：European journal of immunology

authors： Kaser A,Hava DL,Dougan SK,Chen Z,Zeissig S,Brenner MB,Blumberg RS

更新日期：2008-08-01 00:00:00

abstract：:Recognition of foreign DNA by cytosolic innate immune receptors triggers the production of IFN-beta. However, it is unclear whether different types of DNA ligands are recognized by similar receptors and whether the resulting response is distinct from the endosomal TLR response. To address these questions, we compared ...

journal_title：European journal of immunology

authors： Karayel E,Bürckstümmer T,Bilban M,Dürnberger G,Weitzer S,Martinez J,Superti-Furga G

更新日期：2009-07-01 00:00:00

abstract：:Increased numbers of eosinophils are found in parasitic infections, autoimmune diseases and allergic diseases such as allergic asthma. They are activated by distinct cytokines and chemokines leading to the immigration in the inflamed tissue and mediate tissue damage by releasing reactive oxygen species. Here, the effe...

journal_title：European journal of immunology

authors： Elsner J,Höchstetter R,Kimmig D,Kapp A

更新日期：1996-08-01 00:00:00

abstract：:New Zealand Black (NZB) mice spontaneously develop an autoimmune hemolytic anemia together with a markedly increased production of polyclonal antibodies. The spontaneous generation of anti-mouse red blood cells (MRBC), anti-bromelain-treated MRBC (BrMRBC) and anti-DNA autoantibodies was compared to the polyclonal anti...

journal_title：European journal of immunology

authors： Reininger L,Shibata T,Schurmans S,Merino R,Fossati L,Lacour M,Izui S

更新日期：1990-11-01 00:00:00

abstract：:IgG complexes bind to Fc receptor family members FcgammaRI (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16), activating cell MAPK and PI3K resulting in increased cytokine production from particular leukocytes. The signaling molecules involved in cytokine production after cross-linking CD16 have not been determined in ...

journal_title：European journal of immunology

authors： Kramer PR,Winger V,Reuben J

更新日期：2009-02-01 00:00:00

abstract：:Macrophage scavenger receptors are trimeric integral membrane glycoproteins which have been implicated in various macrophage functions including uptake of oxidized lipoprotein and the serum-dependent, divalent cation-independent adhesion of macrophages to tissue culture-treated plastic. In this study we have used a re...

journal_title：European journal of immunology

authors： Hughes DA,Fraser IP,Gordon S

更新日期：1995-02-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF-κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease activity and this self-cleavage further contributes to NF-κB activity. Until now, t...

journal_title：European journal of immunology

authors： Baens M,Stirparo R,Lampi Y,Verbeke D,Vandepoel R,Cools J,Marynen P,de Bock CE,Bornschein S

更新日期：2018-10-01 00:00:00

abstract：:Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to stud...

journal_title：European journal of immunology

authors： Li BW,de Bruijn MJ,Tindemans I,Lukkes M,KleinJan A,Hoogsteden HC,Hendriks RW

更新日期：2016-06-01 00:00:00

abstract：:To study the question when and where self peptides become associated with major histocompatibility complex class II molecules for tolerance induction, we recently developed a system in which the intracellular site(s) of antigen expression could be manipulated using gene cloning techniques. We previously constructed a ...

journal_title：European journal of immunology

authors： Bikoff EK

更新日期：1991-06-01 00:00:00

abstract：:Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral blood (PB) FOXP3(+) cells present in CD25(high), CD25(low) and even CD25(-) subsets of CD4(+) cells expressed high levels of TNFR2. Consequently, TNFR2-expressi...

journal_title：European journal of immunology

authors： Chen X,Subleski JJ,Hamano R,Howard OM,Wiltrout RH,Oppenheim JJ

更新日期：2010-04-01 00:00:00

abstract：:We used 5-(and 6-) carboxyfluorescein diacetate succinimidyl ester labeled TCR-transgenic CD4(+) T cells to investigate the contribution of B7 costimulation to T cell activation and clonal expansion. B7 costimulation was blocked with the fusion protein cytotoxic T lymphocyte-associated antigen-4 (CTLA-4)-Ig, which pre...

journal_title：European journal of immunology

authors： Lumsden JM,Prasad SJ,Peach RJ,Ronchese F

更新日期：2003-08-01 00:00:00

abstract：:The Fas antigen (Fas), which is a cell surface protein belonging to the tumor necrosis factor receptor family, mediates apoptosis. To assess the contribution of Fas to the pathogenesis of retrovirus-induced immunodeficiency, we examined the kinetics of Fas expression on the lymphocytes during the course of murine acqu...

journal_title：European journal of immunology

authors： Hiromatsu K,Aoki Y,Makino M,Matsumoto Y,Mizuochi T,Gotoh Y,Nomoto K,Ogasawara J,Nagata S,Yoshikai Y

更新日期：1994-10-01 00:00:00

abstract：:Monoclonal antibodies MRC-OX6 and MRC-OX3 were used to define biosynthetically inter-related subsets of I-A-equivalent class II molecules from Lewis rat spleen cells. MRC-OX6 was shown to recognize specifically multiple forms of the class II molecule arising along its maturation pathway from the origin of polypeptide ...

journal_title：European journal of immunology

authors： Reske K,Weitzel R

更新日期：1985-12-01 00:00:00

abstract：:T-cell activation and the subsequent transformation of activated T cells into T-cell blasts require profound changes in cell volume. However, the impact of cell volume regulation for T-cell immunology has not been characterized. Here we studied the role of the cell-volume regulating osmolyte transporter Taut for T-cel...

journal_title：European journal of immunology

authors： Kaesler S,Sobiesiak M,Kneilling M,Volz T,Kempf WE,Lang PA,Lang KS,Wieder T,Heller-Stilb B,Warskulat U,Häussinger D,Lang F,Biedermann T

更新日期：2012-04-01 00:00:00

abstract：:Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...

journal_title：European journal of immunology

authors： Feng ZY,Louis J,Kindler V,Pedrazzini T,Eliason JF,Behin R,Vassalli P

更新日期：1988-08-01 00:00:00

abstract：:The expression of the Pit-1/GHF-1 transcription factor (hereafter Pit-1), which controls the expression of growth hormone (GH) and prolactin (PRL) in the pituitary gland, has been documented in human and rat hemopoietic and lymphoid tissues and cell lines. Pit-1 mRNA was detected by in situ hybridization in about 1% o...

journal_title：European journal of immunology

authors： Delhase M,Vergani P,Malur A,Hooghe-Peters EL,Hooghe RJ

更新日期：1993-04-01 00:00:00

abstract：:The repertoire of V regions of alpha/beta+ T cell receptor (TcR) on CD4+ and CD8+ T cells from the peripheral blood of six patients with a novel X-linked combined immunodeficiency was investigated by flow cytometry. The relative frequencies of V region subfamilies V alpha 2a on CD4+ T lymphocytes and V beta 5b and V b...

journal_title：European journal of immunology

authors： Goldman AS,Palkowetz KH,Rudloff HE,Brooks EG,Schmalstieg FC

更新日期：1992-04-01 00:00:00

abstract：:Murine splenic T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A stimulation and subsequent down-regulation before the onset of DNA synthesis. Stimulation by leucoagglutinin in the presence or absence of interleukin 2 leads to only low initial levels of c-myc-specific ...

journal_title：European journal of immunology

authors： Schneider-Schaulies J,Hünig T,Schimpl A,Wecker E

更新日期：1986-03-01 00:00:00

abstract：:The presence of dominant epitopes suppresses generation of CTL activity toward other non-dominant epitopes found on the same antigen-presenting cell (APC). This phenomenon, termed immunodomination, drastically restricts the diversity of the repertoire of CTL responses. Under various experimental conditions we assessed...

journal_title：European journal of immunology

authors： Roy-Proulx G,Meunier MC,Lanteigne AM,Brochu S,Perreault C

更新日期：2001-08-01 00:00:00