Abstract:
:The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no detectable antibody or T cell proliferative response to cow insulin, we have been able to clone out responding T cells after priming and restimulating in vitro with this "nonimmunogenic" antigen. These cells are L3T4+, and co-recognize specific antigen and class II MHC gene products. The data demonstrate that "nonresponder" mice to cow insulin have both the capacity to present antigen and T cells capable of recognizing that antigen. The diversity within this population was investigated by analyzing various parameters of cellular activation. These include fine specificity of both antigen and MHC recognition, as well as recognition of allogeneic MHC and M1s determinants. In addition, the antigen-presenting cell requirements were studied. The results demonstrate that this population comprise a surprisingly heterogeneous group in terms of its repertoire of receptors.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Abromson-Leeman S,Laning J,Cantor H,Dorf MEdoi
10.1002/eji.1830180122subject
Has Abstractpub_date
1988-01-01 00:00:00pages
145-52issue
1eissn
0014-2980issn
1521-4141journal_volume
18pub_type
杂志文章abstract::The human T cell leukemia virus type-1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). Since the HTLV-I-encoded transactivator Tax has been shown to activate many cellular genes including cytokine genes interleukin (IL-)1alpha, 2, 5, 6, 8, 10 and 15, we ask whether Tax also affects IL-4 expression. In ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200109)31:9<2623::aid-immu2623>3
更新日期:2001-09-01 00:00:00
abstract::X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the B-cell compartment caused by a defective gene encoding for the tyrosine kinase (btk) essential for B cell differentiation. Affected males undergo recurrent pyogenic infections and deficient immunoglobulin production. Peripheral blood T cells from 6...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200106)31:6<1927::aid-immu1927>3
更新日期:2001-06-01 00:00:00
abstract::Ab-restricted, H-Y-specific T cell clones from C57BL/6 mice were found to use predominantly V beta 6 T cell receptor genes, conferring Mls-1a reactivity. However, the expression of Mls-1a as a self antigen in (DBA/2 x C57BL/6)F1 mice did not turn these mice into nonresponders to H-Y. Instead of V beta 6, they used oth...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190322
更新日期:1989-03-01 00:00:00
abstract::A comparison of the clonal nature of the immune response to phosphorylcholine (PC) was made in nine different inbred mouse strains. Quantitative idiotypic analysis showed that anti-PC antibodies from each strain were composed of antibodies bearing binding-site idiotypic determinants indistinguishable from two differen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830061002
更新日期:1976-10-01 00:00:00
abstract::Type I IFN are cytokines which play a central role in host resistance to viral or microbial infections and are important components linking innate and adaptive immunity. We and others have previously demonstrated that the production of IFN-beta by DC following bacterial infections or TLR triggering influences, in an a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737566
更新日期:2007-12-01 00:00:00
abstract::Previous studies from our laboratory have shown that prolonged exposure of mouse macrophages to IFN-beta interferes with their subsequent ability to become activated for tumor cell killing. Data reported here show that such inhibition is due to reduced production of NO, resulting from decreased transcription of the ge...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200006)30:6<1551::AID-IMMU1551>3
更新日期:2000-06-01 00:00:00
abstract::Somatic hypermutation (SH) in B cells undergoing T cell-dependent immune responses generates high-affinity antibodies that provide protective immunity. Most current models of SH postulate the introduction of a nick into the DNA and subsequent replication-independent, error-prone short-patch synthesis by one or more DN...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200211)32:11<3152::AID-IMMU3152>
更新日期:2002-11-01 00:00:00
abstract::The glycosylphosphatidylinositol (GPI)-anchored CD59 protein (human protectin) protects cells against complement-induced lysis, binds to CD2 and also transduces activation signals within T cells. We have further examined the biochemical signals transduced by CD59 and addressed its role in regard to the CD3-mediated si...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250704
更新日期:1995-07-01 00:00:00
abstract::The spleen is anatomically and functionally divided into two compartments: the red pulp, where particles are effectively removed from the blood, and the white pulp, where specific immune responses are generated. Here the isolation of white pulp from red pulp is described, allowing a detailed analysis of the cellular c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200002)30:2<626::AID-IMMU626>3.0
更新日期:2000-02-01 00:00:00
abstract::The second HLA-DR molecules, which are encoded by loci different from HLA-DRB1 are weakly polymorphic. Predominant alleles such as HLA-DRB3*0101, HLA-DRB4*0101 and HLA-DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, they have been poorly...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200106)31:6<1837::aid-immu1837>3
更新日期:2001-06-01 00:00:00
abstract::We have constructed four different deletion mutants of a chimeric mouse-human IgG3 anti-(4-hydroxy-3-nitrophenyl)acetyl/(5-iodo-4 hydroxy-3 nitrophenyl) acetyl (NP/NIP) antibody lacking one or more of the four exons coding for the hinge region. The mutant variants all retained intact hinge region epitopes since they a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190912
更新日期:1989-09-01 00:00:00
abstract::The CD38 antigen displays restricted functional associations with surface molecules involved in immune system and complement. Capping of the CD38 molecule in normal or neoplastic T cells is followed by rapid and specific co-modulation of the CD3-T cell receptor (TcR) complex. In normal and tumor cells of B lineage, CD...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231005
更新日期:1993-10-01 00:00:00
abstract::The recognition of lipid antigens by T cells is a complex and fascinating phenomenon. The MHC-like molecules of the CD1 family have evolved to present a wide variety of both self and foreign lipids for recognition by T-cell receptors. While much progress has been made in our understanding of the NKT cells that recogni...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201141408
更新日期:2011-03-01 00:00:00
abstract::The CD11c(+) cell population in the non-parenchymal cell population of the mouse liver contains dendritic cells (DC), NK cells, B cells and T cells. In the hepatic CD11c(+) DC population from immunocompetent or immunodeficient [recombinase-activating gene-1 (RAG1)(-/-)] C57BL/6 mice (rigorously depleted of T cells, B ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200324336
更新日期:2004-02-01 00:00:00
abstract::Using the patch-clamp technique in combination with fluorescence microscopy we have found an abnormality in voltage-gated K+ channel expression in T cells that represents the first molecular marker linking three disparate autoimmune diseases in mice. CD4-CD8-Thy-1.2+ (double-negative or DN) lymphocytes from every know...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200406
更新日期:1990-04-01 00:00:00
abstract::The MHC class II molecule H2-A(s), expressed in the SJL mouse strain, is the principle restriction element of autoreactive CD4(+) T cells mediating experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. We deduced the H2-A(s) ligand motif from the analysis of naturally processed self peptide...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200102)31:2<551::aid-immu551>3.0
更新日期:2001-02-01 00:00:00
abstract::In order to characterize the murine anti-human xenogeneic mixed lymphocyte reactions (MLR), we studied T cell proliferative responses against various human lymphoid cells by immunization of mice either with cellular or purified HLA-DR antigens. Data presented here indicated that small amounts of soluble HLA-DR antigen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830171103
更新日期:1987-11-01 00:00:00
abstract::Thapsigargin (TG), which inhibits endoplasmic reticulum-dependent Ca(2 +)-ATPase and thereby increases cytosolic Ca(2 +), has been reported to cause apoptosis in T lymphocytes another cell types. In this study, we investigated the molecular mechanisms that are involved in the apoptosis induced by TG in T cell hybridom...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200106)31:6<1757::aid-immu1757>3
更新日期:2001-06-01 00:00:00
abstract::The development of the antibody repertoire in newborn mice is greatly influenced by idiotype network interactions. It has been demonstrated that anti-idiotypic antibodies either directly injected or transferred from the mother may alter the repertoire for life. For an elucidation of the underlying mechanisms we have a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830241216
更新日期:1994-12-01 00:00:00
abstract::Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.202048978
更新日期:2020-12-12 00:00:00
abstract::The objective of the present investigation was to culture helper or suppressor/cytotoxic T cell subsets after extensive purification in interleukin 2-containing medium to determine whether phenotype changes for OKT4/91d6- or OKT8/Leu-2a-defined antigens do occur with prolonged culture. Repeated and sequential analysis...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830140819
更新日期:1984-08-01 00:00:00
abstract::The interaction between activated T cells and eosinophils has been proposed to play an important role in the pathogenesis of allergic diseases. T cell-derived cytokines such as interleukin-5 and granulocyte/macrophage colony-stimulating factor inhibit eosinophil apoptosis and may therefore contribute to the developmen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260817
更新日期:1996-08-01 00:00:00
abstract::At least two subsets of CD4+ T helper cell lymphocytes termed Th1 and Th2 exist in the mouse and probably in humans. They are characterized by the secretion of different lymphokines and by their functional behavior. Dysregulated expansion of one or the other subset may be one reason for the development of certain dise...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230805
更新日期:1993-08-01 00:00:00
abstract::A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201646738
更新日期:2017-02-01 00:00:00
abstract::Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" Vα24-Jα18 chain (iNKTα) paired to semi-invariant Vβ11 chains (iNKTβ). Single-amino acid variations at position 93 (p93) of iNKTα, immediately upstream of the "invariant" CDR3α region, have been reported in a substantial proportion of huma...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141956
更新日期:2012-01-01 00:00:00
abstract::We investigated the efficacy of a combination of anti-CD80 and CD86 (CD80 + 86) monoclonal antibodies (mAb), anti-interleukin (IL)-12 mAb, or both, for prophylaxis in a mouse acute graft-versus-host-disease (GVHD) model. The treatment with a combination of anti-CD80 + 86 mAb efficiently reduced the lethality of GVHD, ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830261241
更新日期:1996-12-01 00:00:00
abstract::Infection with parasitic worms (helminths) alters host immune responses and can inhibit pathogenic inflammation. Helminth infection promotes a strong Th2 and T regulatory response while suppressing Th1 and Th17 function. Th2 responses are largely dependent on transcriptional programs directed by Stat6-signaling. We ex...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201848072
更新日期:2020-10-16 00:00:00
abstract::The monoclonal antibody HC1/6 generated against phorbol 12-myristate 13-acetate-treated U-937 cells recognizes a new cell surface antigen with a broad relative molecular mass ranging from 100 to 150 kDa. This antigen is also present on monocytes, platelets and endothelial cells and is weakly expressed by granulocytes....
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190804
更新日期:1989-08-01 00:00:00
abstract::It has been shown previously that three different H-2-associated genes control the resistance to viremia and leukemia in Moloney virus-infected mice: Rmv. 1, mapping to the I-A or less probably K regions; Rmv. 2, mapping to the I-C, S or G regions and Rmv. 3, mapping to the D or T regions. Experiments have been perfo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830101205
更新日期:1980-12-01 00:00:00
abstract::The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199804)28:04<1204::AID-IMM
更新日期:1998-04-01 00:00:00