Hepatic dendritic cell subsets in the mouse.

abstract：:A conditionally immortalized dendritic cell line was established from bone marrow of mice transgenic for a thermolabile mutant of the SV40 large T antigen under the control of the class I Kb promoter. At the permissive temperature of 33 degrees-37 degrees C, the line divides in the absence of granulocyte/macrophage co...

journal_title：European journal of immunology

authors： Volkmann A,Neefjes J,Stockinger B

更新日期：1996-11-01 00:00:00

abstract：:B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell...

journal_title：European journal of immunology

authors： Hoehlig K,Shen P,Lampropoulou V,Roch T,Malissen B,O'Connor R,Ries S,Hilgenberg E,Anderton SM,Fillatreau S

更新日期：2012-05-01 00:00:00

abstract：:Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which ar...

journal_title：European journal of immunology

authors： Jones ND,Brook MO,Carvalho-Gaspar M,Luo S,Wood KJ

更新日期：2010-11-01 00:00:00

abstract：:The nonobese diabetic (NOD) mouse is a relevant model for studying human insulin-dependent diabetes mellitus (IDDM). The selective destruction of insulin-secreting cells in this model is subsequent to an autoimmune reaction directed towards the beta cells inside the islets of Langerhans of the pancreas. Given the key ...

journal_title：European journal of immunology

authors： Sempé P,Bédossa P,Richard MF,Villà MC,Bach JF,Boitard C

更新日期：1991-05-01 00:00:00

abstract：:Sequential development of antibody titer, functional avidity, helper and suppressor activities were investigated in rhesus monkeys. These were immunized with a single dose of 0.1 microgram to 10 mg of a streptococcal protein antigen (SA) in aluminium hydroxide. The IgG antibody titers followed the classical pattern fi...

journal_title：European journal of immunology

authors： Lehner T,Caldwell J,Avery J

更新日期：1984-09-01 00:00:00

abstract：:Cognate interactions between major histocompatibility complex class II antigen (Ag)-reactive CD4+ T helper (Th) and Ag-presenting B cells induce first the activation of B cells and their subsequent differentiation into Ig-secreting cells (IgSC). The Th cell-associated homodimeric glycoprotein CD28 has been implicated ...

journal_title：European journal of immunology

authors： Damle NK,Linsley PS,Ledbetter JA

更新日期：1991-05-01 00:00:00

abstract：:TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

journal_title：European journal of immunology

authors： Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

更新日期：1999-06-01 00:00:00

abstract：:Epidermal keratinocytes differentiate and form a multilayered epidermis, which is the primary barrier between the body and the outer environment. As the epidermis is constantly exposed to a variety of microbial pathogens, its function of resisting microbial pathogens is vital. This characteristic feature is formed dur...

journal_title：European journal of immunology

authors： Sayama K,Komatsuzawa H,Yamasaki K,Shirakata Y,Hanakawa Y,Ouhara K,Tokumaru S,Dai X,Tohyama M,Ten Dijke P,Sugai M,Ichijo H,Hashimoto K

更新日期：2005-06-01 00:00:00

abstract：:Multi-component glycopeptide libraries and single glycopeptides were used for immunization of mice with the aim of inducing strong T helper cell responses to the repetitive sequence of MUC1 expressed by human tumor cells. The glycopeptides and glycopeptide libraries were modeled upon the native human MUC1 amino acid v...

journal_title：European journal of immunology

authors： Gad M,Jensen T,Gagne R,Komba S,Daugaard S,Kroman N,Meldal M,Werdelin O

更新日期：2003-06-01 00:00:00

abstract：:IL-7 plays many fundamental roles during murine B lineage development. One reported function is to maintain progenitors in a developmentally immature state by preventing differentiation to the surface IgM (sIgM)(+) stage. Withdrawal of IL-7 from cultures has been shown to lead to increases in mature traits such as RAG...

journal_title：European journal of immunology

authors： Milne CD,Fleming HE,Paige CJ

更新日期：2004-10-01 00:00:00

abstract：:Recently activated peripheral T cells treated with IL-2 for 4 days expressed Fas ligand (FasL)-mediated cytotoxicity. These IL-2-treated T cells had high nuclear expression of SP1 and NFAT, but lacked the Egr-2 and Egr-3 that could be induced by anti-CD3 stimulation and had been implicated in FasL gene activation. A m...

journal_title：European journal of immunology

authors： Xiao S,Matsui K,Fine A,Zhu B,Marshak-Rothstein A,Widom RL,Ju ST

更新日期：1999-11-01 00:00:00

abstract：:PKCε is implicated in T cell activation and proliferation and is overexpressed in CD4+ -T cells from patients with autoimmune Hashimoto's thyroiditis. Although this might induce the suspicion that PKCε takes part in autoimmunity, its role in the molecular pathophysiology of immune-mediated disorders is still largely u...

journal_title：European journal of immunology

authors： Martini S,Pozzi G,Carubbi C,Masselli E,Galli D,Di Nuzzo S,Banchini A,Gobbi G,Vitale M,Mirandola P

更新日期：2018-04-01 00:00:00

abstract：:It was previously observed that MOPC-315EL, a subline of the BALB/c myeloma tumor MOPC-315, varies in its ability to interact with primary anti-H-2d cytotoxic thymus-derived lymphocytes (CTL) while remaining invariant in its expression of cell surface antigens recognized by anti-H-2d sera. This paper demonstrates (a) ...

journal_title：European journal of immunology

authors： Russel JH,Hale AH,Inbar D,Eisen HN

更新日期：1978-09-01 00:00:00

abstract：:The proteins p40 (Mr = 40 000), p32 (Mr = 32 000), p28 (Mr = 28 000), p20 (Mr = 20 000) and p10 (Mr = 10 000) are described which occur in noncovalent association with the polymorphic alpha, beta heterodimer of class II antigens. They were investigated with respect to their molecular characteristics and their mutual s...

journal_title：European journal of immunology

authors： Zecher R,Ballhausen W,Reske K,Linder D,Schlüter M,Stirm S

更新日期：1984-06-01 00:00:00

abstract：:Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...

journal_title：European journal of immunology

authors： Matthes M,Schrezenmeier H,Homfeld J,Fleischer S,Malissen B,Kirchner H,Fleischer B

更新日期：1988-11-01 00:00:00

abstract：:Interleukin-15 (IL-15) is an inflammatory cytokine whose role in autoimmune diseases has not been fully elucidated. Th17 cells have been shown to play critical roles in experimental autoimmune encephalomyelitis (EAE) models. In this study, we demonstrate that blockade of IL-15 signaling by TMβ-1 mAb treatment aggravat...

journal_title：European journal of immunology

authors： Yu P,Bamford RN,Waldmann TA

更新日期：2014-11-01 00:00:00

abstract：:The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high-affinity peptides onto MHC class I molecules. It mediates peptide editing, i.e. the binding of peptides of successively higher affinity until class I molecules pass ER quality control and exit to the cell surface. The molecular mechani...

journal_title：European journal of immunology

authors： Praveen PV,Yaneva R,Kalbacher H,Springer S

更新日期：2010-01-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:Previous studies have shown that the fecal flora of patients with Crohn's disease (CD) differed from the flora of healthy subjects by a higher number of anaerobic gram-positive coccoid rods. Sera from patients with CD agglutinated four strains of coccoid rods (Me44, C18, Me46 and Me47) more frequently and stronger tha...

journal_title：European journal of immunology

authors： Van de Merwe JP,Stegeman JH

更新日期：1985-08-01 00:00:00

abstract：:Normal BALB/c spleen cells incubated for 2 days with Streptococcus pneumoniae R 36 a (Pn) vaccine in vitro acquired the specific ability to inhibit the T-independent anti-Pn response of fresh lymphocytes. The activated suppressor cells were susceptible to cytotoxic treatment with mouse anti-theta serum plus complement...

journal_title：European journal of immunology

authors： Cerny J,Caulfield MJ,Siat M

更新日期：1980-09-01 00:00:00

abstract：:Interferon-gamma inducing factor (IGIF) is a recently identified cytokine which stimulates the production of interferon-gamma (IFN-gamma) by T cells and enhances natural killer (NK) cell cytolytic activity. Protein fold recognition, structure prediction and comparative modeling have revealed that IGIF is a member of t...

journal_title：European journal of immunology

authors： Hunter CA,Timans J,Pisacane P,Menon S,Cai G,Walker W,Aste-Amezaga M,Chizzonite R,Bazan JF,Kastelein RA

更新日期：1997-11-01 00:00:00

abstract：:From several years, the anticancer effects of Vγ9 T lymphocytes make these cells good candidates for cancer immunotherapies. However, the proved efficacy of γδ Τ cell-based cancer immunotherapies in some clinical trials was minimized due to the inherent toxicity of IL-2, which is essential for the combination therapy ...

journal_title：European journal of immunology

authors： Duault C,Betous D,Bezombes C,Roga S,Cayrol C,Girard JP,Fournié JJ,Poupot M

更新日期：2017-12-01 00:00:00

abstract：:Limited studies have addressed the ability of gammadelta T cells to become memory populations. We previously demonstrated that WC1.1(+) gammadelta T cells from ruminants vaccinated with killed Leptospira borgpetersenii proliferate and produce IFN-gamma in recall responses. Here we show that this response is dependent ...

journal_title：European journal of immunology

authors： Blumerman SL,Herzig CT,Baldwin CL

更新日期：2007-05-01 00:00:00

abstract：:Spleen cells from chickens injected with sheep erythrocytes (SE) intravenously 2 to 14 days prior to culture were found to give faster and higher plaque-forming cell responses upon addition of antigen on day 2 rather than on day 0 of culture. Cell mixture experiments showed that this was due to the induction of suppre...

journal_title：European journal of immunology

authors： Chi DS,Grebenau MD,Thorbecke GJ

更新日期：1980-03-01 00:00:00

abstract：:Human plasmacytoid dendritic cells (PDC) are believed to link innate and adaptive immunity by producing type I interferon (IFN-I) and triggering adaptive T cell-mediated immunity. However, it remains elusive to which degree both PDC functions are linked. Here we show that CMV antigen targeted to PDC using a CD303 (blo...

journal_title：European journal of immunology

authors： Jaehn PS,Zaenker KS,Schmitz J,Dzionek A

更新日期：2008-07-01 00:00:00

abstract：:After ingestion, oral antigens distribute systemically and provoke T cell stimulation outside the gastrointestinal tract. Within the liver, scavenger liver sinusoidal endothelial cells (LSEC) eliminate blood-borne antigens and induce T cell tolerance. Here we investigated whether LSEC contribute to oral tolerance. Ora...

journal_title：European journal of immunology

authors： Limmer A,Ohl J,Wingender G,Berg M,Jüngerkes F,Schumak B,Djandji D,Scholz K,Klevenz A,Hegenbarth S,Momburg F,Hämmerling GJ,Arnold B,Knolle PA

更新日期：2005-10-01 00:00:00

abstract：:MicroRNAs control developmental pathways and effector functions in immune cells. Previous studies have studied the role of microRNAs in natural killer (NK) cells. However, the mouse models of microRNA depletion used were nonNK-specific and only partially depleting, hampering the interpretation of the data obtained. To...

journal_title：European journal of immunology

authors： Degouve S,Tavares A,Viel S,Walzer T,Marçais A

更新日期：2016-08-01 00:00:00

abstract：:We show that, in vitro, the response of thymocytes to certain stimuli, and their survival largely depend on the nature of the culture environment, i.e. whether thymocytes are stimulated within intact thymus lobes or in cell suspension. Exposure of isolated thymocytes to 12-O-tetra-decanoylphorbol 13-acetate (TPA)+iono...

journal_title：European journal of immunology

authors： Moore NC,Jenkinson EJ,Owen JJ

更新日期：1992-10-01 00:00:00

abstract：:An inhibitor of the cytotoxic functions (ICF) mediated by human immunodeficiency virus (HIV)- or HLA-specific cytotoxic T lymphocytes, natural killer and lymphokine-activated killer (LAK) cells is secreted by CD8+CD57+ T lymphocytes, a subset expanded during infection with HIV and after bone marrow transplantation. We...

journal_title：European journal of immunology

authors： Sadat-Sowti B,Debré P,Mollet L,Quint L,Hadida F,Leblond V,Bismuth G,Autran B

更新日期：1994-11-01 00:00:00

abstract：:A simple and efficient procedure for the construction of bifunctional molecules is described and their use in a variety of applications documented. This procedure is based on our observation that mouse IgG1 monoclonal antibodies, when mixed with equimolar amounts of a high-affinity rat monoclonal antibody specific for...

journal_title：European journal of immunology

authors： Lansdorp PM,Aalberse RC,Bos R,Schutter WG,Van Bruggen EF

更新日期：1986-06-01 00:00:00