PKCε promotes human Th17 differentiation: Implications in the pathophysiology of psoriasis.

abstract：:The functional half-life, a measure of the persistence of lymphocytes in an antigen-free environment, has been estimated and found to be about 7 days for virgin 2,4,6-trinitrophenyl (TNP)-reactive mouse B cells, and 2--3 times longer for TNP-primed B cells. Using allotype-congenic mice, lymph node cells were transferr...

journal_title：European journal of immunology

authors： Elson CJ,Jablonska KF,Taylor RB

更新日期：1976-09-01 00:00:00

abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

journal_title：European journal of immunology

authors： Bauer A,Rutenfranz I,Kirchner H

更新日期：1988-12-01 00:00:00

abstract：:Osteopontin (OPN) and CD44 have been implicated in the development of autoimmune diseases, including arthritis and multiple sclerosis, as well as chronic inflammatory diseases, such as atherosclerosis and colitis. To investigate their roles in autoimmune myocarditis induced by immunization with heart alpha-myosin (MyH...

journal_title：European journal of immunology

authors： Abel B,Kurrer M,Shamshiev A,Marty RR,Eriksson U,Günthert U,Kopf M

更新日期：2006-02-01 00:00:00

abstract：:In mouse Peyer's patches (PP), dendritic cells (DC) are localized in T cell areas as NLDC145+ CD11c+ cells, and in the dome and corona region of the follicle as NLDC145- CD11c+ cells, respectively, suggesting the presence of two different DC populations with distinct roles in antigen uptake, processing, and presentati...

journal_title：European journal of immunology

authors： Ruedl C,Hubele S

更新日期：1997-06-01 00:00:00

abstract：:Allogeneic bone marrow transplantation in the neonate is an effective way of inducing permanent tolerance to donor tissue. To do the same in the immunocompetent adult requires immunosuppression to counter host-versus-graft alloreactivity. Conditioning with monoclonal antibodies (mAb) to CD4 and CD8 has been sufficient...

journal_title：European journal of immunology

authors： Leong LY,Qin S,Cobbold SP,Waldmann H

更新日期：1992-11-01 00:00:00

abstract：:Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the mole...

journal_title：European journal of immunology

authors： End C,Bikker F,Renner M,Bergmann G,Lyer S,Blaich S,Hudler M,Helmke B,Gassler N,Autschbach F,Ligtenberg AJ,Benner A,Holmskov U,Schirmacher P,Nieuw Amerongen AV,Rosenstiel P,Sina C,Franke A,Hafner M,Kioschis P,Schre

更新日期：2009-03-01 00:00:00

abstract：:Human plasmacytoid dendritic cells (PDC) are believed to link innate and adaptive immunity by producing type I interferon (IFN-I) and triggering adaptive T cell-mediated immunity. However, it remains elusive to which degree both PDC functions are linked. Here we show that CMV antigen targeted to PDC using a CD303 (blo...

journal_title：European journal of immunology

authors： Jaehn PS,Zaenker KS,Schmitz J,Dzionek A

更新日期：2008-07-01 00:00:00

abstract：:To investigate negative selection events during intrathymic ontogeny, we established T cell receptor (TCR)-transgenic mice [N15tg/RAG-2-/- (H-2b)] expressing a single TCR specific for vesicular stomatitis virus nuclear octapeptide N52-59 (VSV8) in the context of the major histocompatibility complex (MHC) class I molec...

journal_title：European journal of immunology

authors： Ghendler Y,Hussey RE,Witte T,Mizoguchi E,Clayton LK,Bhan AK,Koyasu S,Chang HC,Reinherz EL

更新日期：1997-09-01 00:00:00

abstract：:Although in vivo evidence supports a role for the murine intestinal epithelium in the extrathymic generation of certain intraepithelial T lymphocytes (IEL), no intraepithelial cells with in vitro lymphoid progenitor potential have yet been demonstrated. Using reaggregate fetal thymic organ culture techniques, we show ...

journal_title：European journal of immunology

authors： Woodward J,Jenkinson E

更新日期：2001-11-01 00:00:00

abstract：:Vitamin A and its metabolite retinoic acid influence various aspects of immunity. Although the capacity of vitamin A to condition intestinal CD103(+) DCs to imprint tissue-specific homing programs onto activated lymphocytes is well documented, it is unclear whether vitamin A also regulates DC populations in other tiss...

journal_title：European journal of immunology

authors： Stock AT,Bedoui S

更新日期：2013-06-01 00:00:00

abstract：:Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surfact of activating substances. Using sulfated polyanions as model substances, an efficient fluid-phase activation of complement is d...

journal_title：European journal of immunology

authors： Bitter-Suermann D,Burger R,Hadding U

更新日期：1981-04-01 00:00:00

abstract：:The ligand for the B cell surface antigen CD40 was recently cloned from a murine thymoma cDNA library and shown to be expressed on activated T cells. In this study, we investigate the biological effects of murine recombinant CD40 ligand. The recombinant CD40 ligand expressed on the CV-1/EBNA monkey fibroblast cell lin...

journal_title：European journal of immunology

authors： Maliszewski CR,Grabstein K,Fanslow WC,Armitage R,Spriggs MK,Sato TA

更新日期：1993-05-01 00:00:00

abstract：:The spleen is anatomically and functionally divided into two compartments: the red pulp, where particles are effectively removed from the blood, and the white pulp, where specific immune responses are generated. Here the isolation of white pulp from red pulp is described, allowing a detailed analysis of the cellular c...

journal_title：European journal of immunology

authors： Nolte MA,Hoen EN,van Stijn A,Kraal G,Mebius RE

更新日期：2000-02-01 00:00:00

abstract：:The role of CD8(+) T cells in the development of allergic airway disease is controversial. On the one hand, CD8(+) T cells are known to inhibit the development of airway hyperreactivity (AHR) in murine models of asthma. In humans, IL-10-producing CD8(+) T cells were shown to act as regulatory cells, inhibiting both pr...

journal_title：European journal of immunology

authors： Stock P,Kallinich T,Akbari O,Quarcoo D,Gerhold K,Wahn U,Umetsu DT,Hamelmann E

更新日期：2004-07-01 00:00:00

abstract：:Soluble HLA class I (sHLA-I) molecules can regulate survival of NK cells and their anti-tumor killing activity. Herein, we have analysed whether interaction of sHLA-I with CD8 and/or different isoforms of killer Ig-like receptors (KIR) induced secretion of transforming growth factor (TGF)-beta1. CD8+KIR- NK cell clone...

journal_title：European journal of immunology

authors： Ghio M,Contini P,Negrini S,Boero S,Musso A,Poggi A

更新日期：2009-12-01 00:00:00

abstract：:It has been reported that Thy-1+CD3+CD4-CD8- cells as well as Langerhans cells migrate from organ-cultured murine skin into culture medium. We examined whether these Thy-1+ populations of migrating cells were derived from Thy-1+ dendritic epidermal T cells (Thy-1+ DEC) and found that they were Thy-1+CD3+CD4-CD8-gamma/...

journal_title：European journal of immunology

authors： Nakagawa S,Hara M,Seki M,Yagita H,Tagami H,Aiba S

更新日期：1993-07-01 00:00:00

abstract：:A cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152-residue protein that was 77% identical to human IL 1Ra. The cellular and tissue dist...

journal_title：European journal of immunology

authors： Shuck ME,Eessalu TE,Tracey DE,Bienkowski MJ

更新日期：1991-11-01 00:00:00

abstract：:Vgamma9/Vdelta2+ T cells specifically recognize Mycobacterium tuberculosis in vitro and are precociously recruited in early mycobacterial lesions. Even if gammadelta T cells are only fortuitously detected in granulomas or bronchoalveolar lavages of patients with active pulmonary tuberculosis, a role in shaping the mat...

journal_title：European journal of immunology

authors： Manfredi AA,Heltai S,Rovere P,Sciorati C,Paolucci C,Galati G,Rugarli C,Vaiani R,Clementi E,Ferrarini M

更新日期：1998-06-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II products are specialized to present antigens via different intracellular processing routes. Peptides originating from proteins in the cytoplasm can gain access to class I peptide-binding grooves, most likely in the rough endoplasmic reticulum. Peptides from protein...

journal_title：European journal of immunology

authors： Zaghouani H,Kuzu Y,Kuzu H,Brumeanu TD,Swiggard WJ,Steinman RM,Bona CA

更新日期：1993-11-01 00:00:00

abstract：:The interaction of KB-V1, a multidrug resistant (MDR) variant of the KB-3-1 human oral carcinoma, with human complement was investigated. KB-V1 cells were found to be more sensitive than KB-3-1 cells to complement-mediated lysis. Detailed analysis of the capacity of KB cells to activate human complement demonstrated t...

journal_title：European journal of immunology

authors： Bomstein Y,Fishelson Z

更新日期：1997-09-01 00:00:00

abstract：:T-follicular helper (TFH) cells represent the subpopulation of CD4(+) T cells that provides help for antigen-specific B cells in the GC response. They are generated from naïve T cells during an immune response and are imprinted by their master transcription factor Bcl-6. It has been a long-standing question if TFH ce...

journal_title：European journal of immunology

authors： Weber JP,Fuhrmann F,Hutloff A

更新日期：2012-08-01 00:00:00

abstract：:Production of indoleamine 2,3-dioxygenase (IDO) by tumor cells, leading to tryptophan depletion and production of immunosuppressive metabolites, may facilitate immune tolerance of cancer. IDO gene is also expressed in dendritic cells (DC) upon maturation induced by lipopolysaccarides or IFN. We investigated IDO gene e...

journal_title：European journal of immunology

authors： Weber WP,Feder-Mengus C,Chiarugi A,Rosenthal R,Reschner A,Schumacher R,Zajac P,Misteli H,Frey DM,Oertli D,Heberer M,Spagnoli GC

更新日期：2006-02-01 00:00:00

abstract：:Regulatory T (T(reg)) cells play a key role in the maintenance of the immune system homeostasis. T(reg) cells can be generated in the periphery under control of TGF-beta, a cytokine involved in the negative control of the immune system. However, TGF-beta cooperates with IL-6 in the generation of Th17 cells, a novel cl...

journal_title：European journal of immunology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Becker C,Neurath MF,Macdonald TT,Pallone F,Monteleone G

更新日期：2007-11-01 00:00:00

abstract：:Biopsy specimens were obtained from the bronchial or the nasal mucosa of three patients with grass pollen-induced bronchial asthma or rhinitis 48 h after positive bronchial or nasal provocation test with grass pollen extract. T cell clones (TCC), derived from these and control specimens, were then assessed for their p...

journal_title：European journal of immunology

authors： Del Prete GF,De Carli M,D'Elios MM,Maestrelli P,Ricci M,Fabbri L,Romagnani S

更新日期：1993-07-01 00:00:00

abstract：:The murine monoclonal antibody (mAb) CB43, raised against the K-562 erythroleukemia line, reacts with monocytes, tissue macrophages, thymocytes and with all the human lines tested but not with resting lymphocytes, large granular lymphocytes, granulocytes and erythrocytes. However, activated lymphocytes and natural kil...

journal_title：European journal of immunology

authors： Bellone G,Alloatti G,Levi R,Geuna M,Tetta C,Peruzzi L,Letarte M,Malavasi F

更新日期：1989-01-01 00:00:00

abstract：:B cells isolated from germinal centers (GC) of immune mice 2-5 days after antigen (Ag) challenge migrate in response to chemotactic signals, whereas GC B cells isolated at other times and resting B cells do not. Since B cells are in direct contact with follicular dendritic cells (FDC) in GC we reasoned that FDC might ...

journal_title：European journal of immunology

authors： Burton GF,Kupp LI,McNalley EC,Tew JG

更新日期：1995-04-01 00:00:00

abstract：:During their development, B and T lymphocytes are thought to undergo several cycles of chromatin remodeling at their antigen receptor loci that serve to regulate access of a common V(D)J recombinase to particular gene segments. We used germ-line transcription and susceptibility to DNasel as markers to examine tissue a...

journal_title：European journal of immunology

authors： Haines BB,Brodeur PH

更新日期：1998-12-01 00:00:00

abstract：:The expression of IgG Fc receptor (FcR) molecules was examined on Ly-1+ B cells and B cells tumors. FcR molecules were found on a representative Ly-1+ B cell lymphoma of the pre-B and as well as of the mature cell B phenotypes. The expression of the FcR did not change on these cells during their differentiation to B c...

journal_title：European journal of immunology

authors： Dexter CM,Corley RB

更新日期：1987-06-01 00:00:00

abstract：:The major histocompatibility complex (MHC)-encoded transporter associated with antigen processing (TAP) delivers cytosolic peptides to the lumen of the endoplasmic reticulum (ER) for presentation by MHC class I molecules. For the rat, it has been demonstrated that TAP polymorphism results in the selection of different...

journal_title：European journal of immunology

authors： Obst R,Armandola EA,Nijenhuis M,Momburg F,Hämmerling GJ

更新日期：1995-08-01 00:00:00

abstract：:The major leukocyte population in the decidua during the first trimester of pregnancy consists of NK cells that express receptors capable of recognizing MHC class I molecules expressed by placental trophoblast. These include members of the killer immunoglobulin-like receptor (KIR) family, the two-domain KIR (KIR2D), w...

journal_title：European journal of immunology

authors： Male V,Sharkey A,Masters L,Kennedy PR,Farrell LE,Moffett A

更新日期：2011-10-01 00:00:00