Abstract:
:The functional half-life, a measure of the persistence of lymphocytes in an antigen-free environment, has been estimated and found to be about 7 days for virgin 2,4,6-trinitrophenyl (TNP)-reactive mouse B cells, and 2--3 times longer for TNP-primed B cells. Using allotype-congenic mice, lymph node cells were transferred from virgin or primed CBA/Igb donors to normal CBA/Iga recipients, and the proportion of donor B cells estimated at intervals...
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Elson CJ,Jablonska KF,Taylor RBdoi
10.1002/eji.1830060908keywords:
subject
Has Abstractpub_date
1976-09-01 00:00:00pages
634-8issue
9eissn
0014-2980issn
1521-4141journal_volume
6pub_type
杂志文章abstract::Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that diff...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747073
更新日期:2018-01-01 00:00:00
abstract::The extracellular domain of the lymphocyte surface antigen CD38 has been recently shown to share a high sequence homology with a nicotinamide adenine dinucleotide (NAD+)-specific hydrolyzing enzyme cloned from the ovotestis of the gastropod Aplysia (E. States, D.J., Walseth, T.F., Lee, H. C., Trends Biochem. Sci. 1992...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231245
更新日期:1993-12-01 00:00:00
abstract::We have constructed four different deletion mutants of a chimeric mouse-human IgG3 anti-(4-hydroxy-3-nitrophenyl)acetyl/(5-iodo-4 hydroxy-3 nitrophenyl) acetyl (NP/NIP) antibody lacking one or more of the four exons coding for the hinge region. The mutant variants all retained intact hinge region epitopes since they a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190912
更新日期:1989-09-01 00:00:00
abstract::Production of indoleamine 2,3-dioxygenase (IDO) by tumor cells, leading to tryptophan depletion and production of immunosuppressive metabolites, may facilitate immune tolerance of cancer. IDO gene is also expressed in dendritic cells (DC) upon maturation induced by lipopolysaccarides or IFN. We investigated IDO gene e...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200535616
更新日期:2006-02-01 00:00:00
abstract::The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, gp33 residues 33-41 (KAVYNFATC), presented in the ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636743
更新日期:2007-03-01 00:00:00
abstract::Adoptive T-cell therapy (ATCT) can result in tumor rejection, yet the behavior and fate of the introduced T cells remain unclear. We developed a novel bioluminescence mouse model, which enabled highly sensitive detection of T-cell signals at the single-cell level. Transferred T cells preferentially accumulated within ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141452
更新日期:2011-11-01 00:00:00
abstract::Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200913
更新日期:1990-09-01 00:00:00
abstract::Major histocompatibility complex (MHC) class II-associated antigen presentation is mainly linked to processing of exogenous antigens upon cellular uptake by endocytosis, but has also been observed for endogenously synthesized antigens. We have studied the MHC class II-associated presentation of the endogenously synthe...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251230
更新日期:1995-12-01 00:00:00
abstract::In the present study, we sought evidence for a surface nucleosome receptor in the fibroblastic cell line CV-1, and questioned whether anti-double-stranded (ds) DNA and/or anti-histone autoantibodies could recognize and influence the fate of cell surface-bound nucleosomes. 125I-labeled mononucleosomes were shown to bin...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260230
更新日期:1996-02-01 00:00:00
abstract::Human natural killer (NK) cells are divided into two subsets: CD56bright and CD56dim NK cells, which differ in maturation, function and distribution. Mechanisms regulating NK cell functions are not completely understood. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, that binds to a variet...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747289
更新日期:2018-05-01 00:00:00
abstract::LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1-type T cell response in peripheral blood mononuclear cells (PBMC) from leishmaniasis patients. Moreover, the interferon (IFN)-gamma production by PBMC was found to be interleukin (IL)-12 depend...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830271024
更新日期:1997-10-01 00:00:00
abstract::CD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948309
更新日期:2020-05-01 00:00:00
abstract::The purpose of this study was to obtain additional information on the mechanism by which interferon-gamma (IFN-gamma) is able to regulate gene expression in macrophages. The expression of the genes for class II histocompatibility I-A beta, tumor necrosis factor (TNF) and complement component C3 was assayed after treat...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190621
更新日期:1989-06-01 00:00:00
abstract::T cell activation and cytokine secretion are important mediators of inflammation in allergic asthma. The costimulatory pathway CD28/CD80/CD86 has been shown to play an important role in T cell activation in allergic asthma, but less is known about the effect of other costimulatory molecules in allergy. The costimulato...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(2002010)32:10<2874::AID-IMMU2874
更新日期:2002-10-01 00:00:00
abstract::Previous studies from our laboratory have shown that some in vitro maintained Leishmania major-specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180815
更新日期:1988-08-01 00:00:00
abstract::We investigated the effect of recombinant murine interleukin 4 (IL 4) in the absence or presence of recombinant murine interferon-gamma (IFN-gamma) on adherent bone-marrow macrophages (M phi), peritoneal exudate and resident peritoneal M phi from susceptible BALB/c M phi, which were pulse-infected with Leishmania majo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210213
更新日期:1991-02-01 00:00:00
abstract::MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can prod...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040428
更新日期:2010-09-01 00:00:00
abstract::Glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) is a synthetic adjuvant TLR4 agonist that promotes potent poly-functional T(H)1 responses. Different TLR4 agonists may preferentially signal via MyD88 or TIR-domain-containing adapter inducing IFN-beta (TRIF) to exert adjuvant effects; however, the contribution of...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201243124
更新日期:2013-09-01 00:00:00
abstract::In this study, after immunization with NK cells from a KIR2DS5(+) donor and screening on cell transfectants expressing different members of the killer immunoglobulin-like receptor (KIR) family, we generated a mAb, DF200, reacting with several KIR2D receptors including KIR2DL1/L2/L3, KIR2DS1/S2 and KIR2DS5. By the anal...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838434
更新日期:2008-08-01 00:00:00
abstract::Murine Thy-1+, TcR V gamma 3/V delta 1+ dendritic epidermal T cells (DETC) differ from most other T cell subsets by the absence of CD4 and CD8 antigens as well as the lack of CD5 expression. To see whether negativity for those antigens is an intrinsic feature of a given T cell population or if such triple-negative T c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240612
更新日期:1994-06-01 00:00:00
abstract::To further define DNA immunization as a model for anti-DNA production, we investigated the cellular requirements for this response in mice immunized with single-stranded DNA from E. coli. The anti-DNA responses of genetically immune-deficient mice and congenic controls were measured by ELISA after immunization with E....
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200825
更新日期:1990-08-01 00:00:00
abstract::Responsiveness to IL-13 involves at least two chains, IL-4Ralpha and IL-13Ralpha1. Although mouse B cells express IL-4Ralpha, little is known about their expression of IL-13Ralpha chains. To investigate this topic further, we have generated a monoclonal antibody (C41) specific for murine IL-13Ralpha1. Using C41, IL-13...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200011)30:11<3157::AID-IMMU3157>
更新日期:2000-11-01 00:00:00
abstract::Lymphocyte function-associated-antigen-1 (LFA-1) is able to bind selectively to its ligands intercellular adhesion molecules 1 and 3 (ICAM-1 and ICAM-3), suggesting that LFA-1 can exist in distinct ligand-specific binding states. In the case of ICAM-1, apart from ligand itself and the recently cloned molecule cytohesi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270423
更新日期:1997-04-01 00:00:00
abstract::The functional relevance of CD2-mediated signal transduction in triggering T cell receptor/CD3-independent natural killer cell cytotoxicity was investigated by introducing wild-type CD2 or signaling-deficient CD2 with truncated cytoplasmic region into a murine natural killer-like large granular lymphocyte clone lackin...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210345
更新日期:1991-03-01 00:00:00
abstract::Six different cell-mediated lympholysis (CML) combinations were established, four of which generated effector cells against the I-E, and two against the I-A molecule. The cell surface phenotype of effector cells was then determined by depletion of cytotoxic T lymphocyte (CTL) activity with antisera and rabbit compleme...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830110611
更新日期:1981-06-01 00:00:00
abstract::Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise ...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201847527
更新日期:2018-07-01 00:00:00
abstract::Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230907
更新日期:1993-09-01 00:00:00
abstract::This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.202048713
更新日期:2020-10-01 00:00:00
abstract::CTLA-4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble CTLA-4 isoform (sC...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242529
更新日期:2013-05-01 00:00:00
abstract::An antigen-specific T-T hybridoma was mutagenized with ethylmethane sulfonate and negatively selected by anti-Ly-6 antibody-induced growth inhibition. One of the mutants generated, M4/8, had lost surface expression of a T cell receptor (TcR) V beta 8 epitope detected on the surface of the parental cell line. However, ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200702
更新日期:1990-07-01 00:00:00