Abstract:
:Responsiveness to IL-13 involves at least two chains, IL-4Ralpha and IL-13Ralpha1. Although mouse B cells express IL-4Ralpha, little is known about their expression of IL-13Ralpha chains. To investigate this topic further, we have generated a monoclonal antibody (C41) specific for murine IL-13Ralpha1. Using C41, IL-13Ralpha1 expression was detected on germinal center (GC) B cells by flow cytometry and immunohistochemistry. In addition, IL-13Ralpha1 was observed on follicular dendritic cells, but not interdigitating dendritic cells in the T cell areas. Furthermore, resting B cells also expressed IL-13Ralpha1, and in the presence of IL-13 produced increased amounts of IgM in response to in vitro CD40 stimulation. However, C41 was unable to neutralize this bioactivity. The distribution of IL-13Ralpha1 on murine B cells and during GC reactions suggests a role for IL-13 during B cell differentiation.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Poudrier J,Graber P,Herren S,Berney C,Gretener D,Kosco-Vilbois MH,Gauchat JFdoi
10.1002/1521-4141(200011)30:11<3157::AID-IMMU3157>keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
3157-64issue
11eissn
0014-2980issn
1521-4141pii
10.1002/1521-4141(200011)30:11<3157::AID-IMMU3157>journal_volume
30pub_type
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