VEGFR2 is selectively expressed by FOXP3high CD4+ Treg.

abstract：:Durch Pflanzenkrankheiten entstehen weltweit hohe Ernteverluste. Eine der häufigsten Infektionen in der Familie der Kreuzb&luml;tengewächse wird durch den Pilz Plasmodiophora brassicae verursacht. Die Krankheit äußert sich in Form von Wurzeltumoren, den "Kohlherniegallen". Da es auf verseuchten Böden zu hohen Ernteaus...

journal_title：European journal of immunology

authors： Ludwig-Müller J

更新日期：2000-01-01 00:00:00

abstract：:The IFN stimulated gene 15 (ISG15) encodes a 15-kDa ubiquitin-like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an antiviral molecule possibly by being covalently conjugated to viral proteins and disturbing virus particle as...

journal_title：European journal of immunology

authors： Held T,Basler M,Knobeloch KP,Groettrup M

更新日期：2020-07-20 00:00:00

abstract：:Gradual depletion of CD4+ T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4+ T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection. ...

journal_title：European journal of immunology

authors： Zhang MX,Zheng HY,Jiang J,Song JH,Chen M,Xiao Y,Lian XD,Song TZ,Tian RR,Pang W,Zheng YT

更新日期：2018-02-01 00:00:00

abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

journal_title：European journal of immunology

authors： Guo L,Tian J,Marinova E,Zheng B,Han S

更新日期：2010-01-01 00:00:00

abstract：:We have determined the cell cycle position of individual mouse leukemia L 1210 cells by cytophotometric and autoradiographic techniques and simultaneously determined the amount of histocompatibility antigens expressed on the surface of individual cells by quantitative immunofluorescence. Interferon treatment of L 1210...

journal_title：European journal of immunology

authors： Killander D,Lindahl P,Lundin L,Leary P,Gresser I

更新日期：1976-01-01 00:00:00

abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

journal_title：European journal of immunology

authors： Walzer T,Galibert L,De Smedt T

更新日期：2005-02-01 00:00:00

abstract：:Fever is associated with improved survival during infection in endothermic and ectothermic species although the protective mechanisms are largely undefined. Previous studies indicate that fever-range thermal stress increases the binding activity of the L-selectin homing receptor in human or mouse leukocytes, thereby p...

journal_title：European journal of immunology

authors： Appenheimer MM,Girard RA,Chen Q,Wang WC,Bankert KC,Hardison J,Bain MD,Ridgley F,Sarcione EJ,Buitrago S,Kothlow S,Kaspers B,Robert J,Rose-John S,Baumann H,Evans SS

更新日期：2007-10-01 00:00:00

abstract：:Using a culture system which supports primary T cell proliferative responses to various antigens we have detected mouse red blood cell (RBC)-reactive T cells in lymphoid tissues from untreated mice. The release of significant amounts of interleukin 2 (IL2) indicates that T helper (or helper/inducer) cells are activate...

journal_title：European journal of immunology

authors： Hooper DC,Taylor RB

更新日期：1987-06-01 00:00:00

abstract：:Cyclosporin A (CSA), an immunosuppressive agent used in organ transplantation and to treat some autoimmune diseases, blocks the Ca2+-dependent steps involved in T cell receptor triggering leading to interleukin (IL)-2 production. Considering that the early steps of T cell activation are insensitive to CSA, we asked wh...

journal_title：European journal of immunology

authors： Bemer V,Truffa-Bachi P

更新日期：1996-07-01 00:00:00

abstract：:Activation of T cells was shown to up-regulate the Fas ligand (FasL) which binds to the CD95 (APO-1/Fas) antigen and mediates activation-induced cell death (AICD) of activated T cells and T lymphoma cells. A recent report showed that mouse B cells express the FasL upon activation with lipopolysaccharide (LPS). We ther...

journal_title：European journal of immunology

authors： Daniel PT,Oettinger U,Mapara MY,Bommert K,Bargou R,Dörken B

更新日期：1997-04-01 00:00:00

abstract：:T lymphocytes can be activated and induced to proliferate through stimulation of the CD2 glycoprotein with functional combinations of CD2 antibodies. However, this mechanism of signal transduction via CD2 is still not fully understood. We have investigated which molecules on the T cell surface preferentially associate...

journal_title：European journal of immunology

authors： Castro MA,Tavares PA,Almeida MS,Nunes RJ,Wright MD,Mason D,Moreira A,Carmo AM

更新日期：2002-05-01 00:00:00

abstract：:The scavenger receptor-A I/II (SR-A) and macrophage receptor with collagenous domain (MARCO) share a common domain organisation and ligand repertoire, including selected polyanions and gram-positive and -negative organisms, but differ in fine specificity of ligand binding, tissue distribution and regulation. Neisseria...

journal_title：European journal of immunology

authors： Mukhopadhyay S,Chen Y,Sankala M,Peiser L,Pikkarainen T,Kraal G,Tryggvason K,Gordon S

更新日期：2006-04-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease inducible in rodents by immunization of brain-specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the...

journal_title：European journal of immunology

authors： Matsumoto Y,Kawai K,Fujiwara M

更新日期：1990-09-01 00:00:00

abstract：:Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a nove...

journal_title：European journal of immunology

authors： Kiss J,Yegutkin GG,Koskinen K,Savunen T,Jalkanen S,Salmi M

更新日期：2007-12-01 00:00:00

abstract：:Proliferation of BCL1 cells, generally used for the measurement of murine interleukin (IL)5, is shown to be strongly suppressed by interferon (IFN)-gamma. This effect can be abrogated by the addition of anti-IFN-gamma antibodies. Thus, the IL5 activity of culture supernatants derived from T cells simultaneously produc...

journal_title：European journal of immunology

authors： Lohoff M,Sommer F,Röllinghoff M

更新日期：1989-07-01 00:00:00

abstract：:Co-infection of HCV with HIV has been associated with more rapid progression of HCV-related disease. HCV-specific T-cell immune responses, which are essential for disease control, are attenuated in co-infection with HIV. T-cell exhaustion has recently been implicated in the deficient control of chronic viral infection...

journal_title：European journal of immunology

authors： Vali B,Jones RB,Sakhdari A,Sheth PM,Clayton K,Yue FY,Gyenes G,Wong D,Klein MB,Saeed S,Benko E,Kovacs C,Kaul R,Ostrowski MA

更新日期：2010-09-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:Despite all the structural and functional data that have been accumulated regarding major histocompatibility complex (MHC) class II molecules during recent years, the relative contribution of putative T cell receptor (TcR)-contacting residues and peptide-binding MHC polymorphisms to MHC-restricted and allospecific T c...

journal_title：European journal of immunology

authors： Coppin HL,Carmichael P,Lombardi G,L'Faqihi FE,Salter R,Parham P,Lechler RI,de Preval C

更新日期：1993-02-01 00:00:00

abstract：:MICA and MICB (MHC-class-I-related chain A/B) are transmembrane proteins expressed in pathological conditions that are ligands for NKG2D, an activating receptor found on cytotoxic lymphocytes. The recognition on target cells of NKG2D ligands leads to the activation of lysis and cytokine secretion by NK cells and T cel...

journal_title：European journal of immunology

authors： Agüera-González S,Gross CC,Fernández-Messina L,Ashiru O,Esteso G,Hang HC,Reyburn HT,Long EO,Valés-Gómez M

更新日期：2011-12-01 00:00:00

abstract：:The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...

journal_title：European journal of immunology

authors： Kelso A,Groves P,Troutt AB,Francis K

更新日期：1995-05-01 00:00:00

abstract：:Gammadelta T cells are expanded in human IgA nephropathy and in a rat model of adriamycin (ADR)-induced nephropathy. Despite different diseases and species, these renal gammadelta T cells use a restricted set of gammadelta T cell receptor (TCR) genes. To explore whether this phenomenon of post injury expansion of gamm...

journal_title：European journal of immunology

authors： Wu H,Knight JF,Alexander SI

更新日期：2004-08-01 00:00:00

abstract：:Cathelicidins are a family of host defence peptides that are known to selectively alter innate immunity in response to infection and other changes in immune status. A study in this issue of the European Journal of Immunology elucidates a new role for mouse cathelin-related antimicrobial peptide in the adaptive immune ...

journal_title：European journal of immunology

authors： Wuerth K,Hancock RE

更新日期：2011-10-01 00:00:00

abstract：:Changes in the migration pattern of lymphocytes represent a key event in the evolution of an immune response since they enable lymphocytes to gain access to infected tissues. We studied the location of virus-specific CD8 T cells in various splenic compartments in response to infection with lymphocytic choriomeningitis...

journal_title：European journal of immunology

authors： Potsch C,Vöhringer D,Pircher H

更新日期：1999-11-01 00:00:00

abstract：:The effect of anti-Ia antibody on the development of murine neonatal self-Ia-reactive T lymphocytes in the thymus was studied. A C57BL/6 (B6) mouse pregnant with (B6 X C3H/He)F1 (B6C3F1) embryos was injected with monoclonal anti-I-Ek (m alpha I-Ek) antibody every other day starting from the 12th day of gestation. The ...

journal_title：European journal of immunology

authors： Kimoto M,Kishimoto S

更新日期：1986-07-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterized by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD...

journal_title：European journal of immunology

authors： Boardman DA,Garcia RV,Ivison SM,Bressler B,Dhar TM,Zhao Q,Levings MK

更新日期：2020-09-01 00:00:00

abstract：:Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cytotoxic CD127+ CD94- , ILC1s, ILC2s, ILC3s, and LTi cells. Here, we identify a previously unrecognized subset within the CD127+ ILC population, characterized by the expression of the cytotoxic marker CD94. These CD94+ I...

journal_title：European journal of immunology

authors： Krabbendam L,Heesters BA,Kradolfer CMA,Spits H,Bernink JH

更新日期：2020-12-09 00:00:00

abstract：:Humanized BALB/c mice (termed trimera mice) conditioned by lethal total body irradiation and bone marrow transplantation from SCID mice have been described to support rapid engraftment of human peripheral blood mononuclear cells (PBMC) and the induction of strong B and T cell responses after immunization in vivo. More...

journal_title：European journal of immunology

authors： Böcher WO,Dekel B,Schwerin W,Geissler M,Hoffmann S,Rohwer A,Arditti F,Cooper A,Bernhard H,Berrebi A,Rose-John S,Shaul Y,Galle PR,Löhr HF,Reisner Y

更新日期：2001-07-01 00:00:00

abstract：:E-selectin is a cytokine-inducible membrane glycoprotein capable of mediating adhesion of leukocytes to endothelial cells. It is highly glycosylated, containing 11 sites for N-linked glycosylation. N-Glycosylation of E-selectin was analyzed by endoglycosidase treatment. Analysis of immunoprecipitated E-selectin from h...

journal_title：European journal of immunology

authors： Påhlsson P,Strindhall J,Srinivas U,Lundblad A

更新日期：1995-09-01 00:00:00

abstract：:This is the first report on the establishment of the readily identifiable and functioning thymic nurse cell (TNC) clones from the mouse thymus. In the course of the culture of an epithelial cell line using a medium with a low concentration of Ca2+ from the spontaneous BALB/c thymic tumor, lymphocytes as well as thymic...

journal_title：European journal of immunology

authors： Itoh T,Doi H,Chin S,Nishimura T,Kasahara S

更新日期：1988-05-01 00:00:00

abstract：:During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite fre...

journal_title：European journal of immunology

authors： Kahn S,Kahn M,Eisen H

更新日期：1992-12-01 00:00:00