Polyreactive autoantibodies to negatively charged epitopes following Trypanosoma cruzi infection.

Abstract:

:During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite frequently results in autoimmune and inflammatory pathology. We report here on an affinity-purified population of antibodies that bind to a broad class of antigens that contain runs of acidic amino acids, including tubulin. Although these antibodies can be isolated from both uninfected and T. cruzi chronically infected C3H/He mice, the antibodies from the normal mice (the natural autoantibodies) bind to tubulin poorly at physiological pH, whereas the antibodies isolated from the infected animals bind well at physiological pH. We propose that similar processes may occur in humans following other infections accounting for the detection of antibodies to negatively charged epitopes in a variety of autoimmune diseases.

journal_name

Eur J Immunol

authors

Kahn S,Kahn M,Eisen H

doi

10.1002/eji.1830221204

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

3051-6

issue

12

eissn

0014-2980

issn

1521-4141

journal_volume

22

pub_type

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