Abstract:
:Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease inducible in rodents by immunization of brain-specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the immune mechanisms of susceptibility and resistance to EAE, we first examined the T cell repertoire for MBP using thymectomized chimeras that possessed thymuses from EAE-susceptible (LEW) or EAE-resistant (BM) strains. It was revealed that T cell specificity of these chimeras was skewed toward that of the grafted thymus. Very interestingly, the chimeras bearing thymuses from the resistant strain developed severe EAE, keeping a hole in the encephalitogenic 68-88 sequence of MBP. These findings suggest that the strain-specific T cell repertoire itself is not involved in the regulation of EAE susceptibility. Furthermore, the analysis of the chimeras reconstituted with F1 T cells and marrow cells from various strains indicates that the major histocompatibility complex (MHC) molecules expressed on accessory cells primarily determine susceptibility or resistance to EAE. We finally showed, using various inbred and congenic rats carrying RT1l or RT1n, that susceptibility to EAE of rats carrying RT1l is heavily influenced by the background genes, whereas resistance to EAE of rats carrying RT1n is primarily regulated by the MHC molecules expressed on accessory cells without influence of the background genes.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Matsumoto Y,Kawai K,Fujiwara Mdoi
10.1002/eji.1830200934subject
Has Abstractpub_date
1990-09-01 00:00:00pages
2119-26issue
9eissn
0014-2980issn
1521-4141journal_volume
20pub_type
杂志文章abstract::A study was made of the ability of the superantigen staphylococcal enterotoxin B (SEB) to induce relapses of experimental allergic encephalomyelitis (EAE) in SJL mice that had partially or completely recovered from acute EAE. We find that a single injection of 0.05 mg SEB i.v. induces mild relapses in 50% of such mice...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251108
更新日期:1995-11-01 00:00:00
abstract::In this study we have examined the role of small numbers of adherent cells in the stimulation of highly purified resting T lymphocytes by cross-linked monoclonal anti-CD3 antibodies (T3). T cells were obtained by 3 cycles of purification, using adherence to plastic surface, nylon wool column separation and rosetting w...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830171122
更新日期:1987-11-01 00:00:00
abstract::The existence of a functional receptor for secretory component (SC) on the eosinophil membrane might explain the preferential degranulation induced by secretory IgA (sIgA) when compared to serum IgA. Indeed, flow cytometry analysis revealed that purified human SC could bind to a subpopulation (4-59%) of blood eosinoph...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250121
更新日期:1995-01-01 00:00:00
abstract::Persistent polyclonal B cell lymphocytosis (PPBL) is a hematological disorder diagnosed predominantly in women, characterized by a polyclonal increase in the number of peripheral blood B lymphocytes. Abnormality of the B cell population was evidenced by the finding of multiple bcl-2/Ig gene rearrangements and an addit...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200212)32:12<3678::AID-IMMU3678>
更新日期:2002-12-01 00:00:00
abstract::We identified the presence in the Aleutian skate, Bathyraja aleutica, of two classes of immunoglobulins (Ig), a high molecular weight Ig analogous to mammalian IgM and a low molecular weight Ig, similarly to the spiny rasp skate, Raja kenojei, (Kobayashi, K. et al., Mol. Immunol. 1984. 21: 397), using an immunological...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150916
更新日期:1985-09-01 00:00:00
abstract::Ia. W39 is a B cell differentiation antigen whose membrane expression is controlled by the xid gene. In this report we show that, analogous to its B cell expression, Ia. W39 is also present on a subset of Ia+ macrophages, indicating heterogeneity within that cell population. The Ir gene(s) for the antigenic determinan...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120109
更新日期:1982-01-01 00:00:00
abstract::The murine T cell response to heterologous insulins provides a good model system for studying the mechanism of immune response (Ir)-gene function, since insulin is a small, chemically well-defined molecule. H-2b mice respond predominantly to A chain loop determinants of beef insulin, presented by the I-A epitope Ia. W...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830141208
更新日期:1984-12-01 00:00:00
abstract::The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine cor...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141683
更新日期:2011-10-01 00:00:00
abstract::IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial cells. Here we demonstrate that IL-22, in contrast to its relative IFN-gamma, regulates the expression of only a few genes in keratinocytes. This is due to varied signal transduction. Gene exp...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200535503
更新日期:2006-05-01 00:00:00
abstract::Despite all the structural and functional data that have been accumulated regarding major histocompatibility complex (MHC) class II molecules during recent years, the relative contribution of putative T cell receptor (TcR)-contacting residues and peptide-binding MHC polymorphisms to MHC-restricted and allospecific T c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230207
更新日期:1993-02-01 00:00:00
abstract::The expression and action of Fas/Fas ligand (FasL) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination. To formally test this hypothesis, C57BL/6-lpr and -gld mice, which due to gene mutation express Fas and FasL in an inactive form, were immunized with myelin oligodendro...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830271211
更新日期:1997-12-01 00:00:00
abstract::Pulmonary mucosal immune response is critical for preventing opportunistic Aspergillus fumigatus infections. Although fungus-specific CD4+ T cells in blood are described to reflect the actual host-pathogen interaction status, little is known about Aspergillus-specific pulmonary T-cell responses. Here, we exploit the d...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948524
更新日期:2020-11-01 00:00:00
abstract::Interleukin (IL)-4-transgenic mice were used as a model system to study the consequences of low levels of IL-4 expression for the expression of other cytokines examined by quantitative polymerase chain reaction (PCR). For this purpose, a plasmid was constructed which contains, in tandem array, 5' and 3' primer sequenc...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220511
更新日期:1992-05-01 00:00:00
abstract::While the nasal mucosa is a potentially useful site for human immunization, toxin-based nasal adjuvants are generally unsafe and less effective in humans. Safe mucosal adjuvants that activate protective immunity via mucosal administration are highly dependent on barrier antigen sampling by epithelial and DCs. Here, we...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142346
更新日期:2012-08-01 00:00:00
abstract::It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selection). However, we now p...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830201125
更新日期:1990-11-01 00:00:00
abstract::The immunologic mechanisms that protect the fetus from rejection were the subject of numerous investigations. Reports showing the uterus as a favorable site of implantation focused our attention to the decidua which is the maternal tissue intimately attached to fetal structures. Explants of human decidua were cultured...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830111020
更新日期:1981-10-01 00:00:00
abstract::While IL-18 synergizes with IL-12 to induce a Th1 immune response, it also promotes a Th2 response. Here we investigate the modulatory role of IL-18 on the Th1/Th2 cytokine response. The injection of alpha-galactosylceramide (alpha-GalCer), a ligand for NKT cells, elevated mouse serum levels of both IFN-gamma and IL-4...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636465
更新日期:2007-04-01 00:00:00
abstract::A series of rat monoclonal antibodies (mAb) directed against the Thy-1 molecule have been evaluated for their ability to stimulate immature (CD4-8-) murine thymocytes. CD4-8- thymocytes could be induced to proliferate by several anti-Thy-1 mAb provided that exogenous interleukin 1 or interleukin 2 was provided. Appare...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830171127
更新日期:1987-11-01 00:00:00
abstract::Intrathymic deletion of immature thymocytes that express self-reactive TCR specificities is essential in the generation of self tolerance. Medullary thymic epithelial cells (mTEC) expressing the transcriptional regulator Aire play a key role in this process by regulating expression of tissue-restricted antigens to ens...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200738052
更新日期:2008-04-01 00:00:00
abstract::For homeostasis, T cells integrate non-cognate TCR-dependent and -independent signals to survive and weakly proliferate. In contrast to antigen-specific, stable, and long-lived contacts, signaling in short-lived homeostatic interactions depends upon the coordination of ongoing T-cell migration on the surface of DC and...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040575
更新日期:2010-10-01 00:00:00
abstract::The mechanism of synergistic complement-mediated lysis of rat red cells was investigated using rat monoclonal antibodies against class I RT1Aa antigens. The increased lytic activity when using two antibodies simultaneously is due to the increase in the number of activated C1 molecules on the cell surface and this resu...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130806
更新日期:1983-08-01 00:00:00
abstract::Autoantigenic epitope mapping represents a critical issue in autoimmune diseases. The islet tyrosine phosphatase-like protein IA-2/ICA512bdc is a major autoantigen in type 1 diabetes (IDDM), but the epitopes responsible for autoantibody binding have been only partially defined. The aim of our study was to identify ICA...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200205)32:5<1420::AID-IMMU1420>3
更新日期:2002-05-01 00:00:00
abstract::Site-directed mutagenesis of a recombinant Fc hinge fragment has recently been used to localize the site of the mouse IgG1 (mIgG1) molecule that is involved in the intestinal transfer of recombinant Fc hinge fragments in neonatal mice. This site encompasses Ile-253, His-310, Gln-311, His-433 and Asn-434, localized at ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830261038
更新日期:1996-10-01 00:00:00
abstract::Anti-CD3 mAb can modulate graft rejection and attenuate autoimmune diseases but their mechanism(s) of action remain unclear. CD8(+) T cells with regulatory function are induced in vitro by Teplizumab, a humanized anti-CD3 antibody and inhibit responses of autologous and allogeneic T cells. They inhibit CD4(+) T-cell p...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040485
更新日期:2010-10-01 00:00:00
abstract::Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230722
更新日期:1993-07-01 00:00:00
abstract::The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed th...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425246
更新日期:2004-08-01 00:00:00
abstract::Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120908
更新日期:1982-09-01 00:00:00
abstract::Accumulating evidence suggests that Th17 cells and Tregs may exhibit development plasticity and that CD4(+) Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described. In this study, we generated Th17 clones from tumor-infiltrating T lym...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040682
更新日期:2011-04-01 00:00:00
abstract::Human tonsils contain B cells capable of spontaneous and high-rate immunoglobulin (Ig) secretion in vitro. These cells are in vivo induced mature B cells, and, as such, they provide and adequate model for studying tonsil B cell differentiation. The present report analyzes the effect of a variety of factors on purified...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230527
更新日期:1993-05-01 00:00:00
abstract::Induction of the glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a role in their antiinflammatory action, whereas GILZ expression is reduced under inflammatory conditions. The mechanisms regulating GILZ expression during inflammation, however, have not yet been characterized. Here, we investigate...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142081
更新日期:2012-05-01 00:00:00