Abstract:
:CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsils, CD70 is only expressed on part of the IgD-, CD38- B cell population, which have been described as memory B cells. However, in 10% of the tonsils tested, CD70+ IgD+ GC were found. The CD70+ GC B cells were small cells that also expressed CD44 and CD39, but were CD10- and CD38-, suggesting that they represent very recent immigrants that are in the process of forming a GC. The concordant expression of CD27 and its ligand CD70 on this primordial subset of GC B cells suggests an important role for CD27/CD70 interaction at this stage of GC formation.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Lens SM,Keehnen RM,van Oers MH,van Lier RA,Pals ST,Koopman Gdoi
10.1002/eji.1830260508subject
Has Abstractpub_date
1996-05-01 00:00:00pages
1007-11issue
5eissn
0014-2980issn
1521-4141journal_volume
26pub_type
杂志文章abstract::Induction of optimal HIV-1-specific T-cell responses, which can contribute to controlling viral infection in vivo, depends on antigen processing and presentation processes occurring in DCs. Opsonization can influence the routing of antigen processing and pathways used for presentation. We studied antigen proteolysis a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242935
更新日期:2013-06-01 00:00:00
abstract::The induction of cytotoxic T lymphocytes (CTL) specific for alloantigen in a primary mixed lymphocyte culture (MLC) was used as a model system to study the potential usefulness of monoclonal antibodies directed against the murine transferrin receptor in eliminating antigen-activated T cells. Two monoclonal antibodies ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150709
更新日期:1985-07-01 00:00:00
abstract::A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...
journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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journal_title:European journal of immunology
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更新日期:2002-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240519
更新日期:1994-05-01 00:00:00
abstract::The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancing the average affinity of the antibodies produced. The molecular mechanism underlying these B cell hypermutations remains ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251210
更新日期:1995-12-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/eji.1830271107
更新日期:1997-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201545929
更新日期:2016-04-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1991-07-01 00:00:00
abstract::The role of redox regulation in immune-mediated arthritis has been previously described. However, the relationship between innate immune cells, including innate lymphoid cells (ILCs) and phagocyte-derived ROS, in this process remains unclear. Here, we characterize ILCs and measure the IL-1 family cytokines along with ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948141
更新日期:2019-11-01 00:00:00
abstract::Immunizations via the i.n. and intravaginal (ivag) routes effectively generate strong genital tract antibody-mediated immunity. To what extent the same is true for T-cell responses is incompletely known. Therefore, we set out to investigate optimal conditions for stimulation of genital tract CD4(+) T-cell responses, ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201041297
更新日期:2011-09-01 00:00:00
abstract::IFN-gamma produced by CD4+ T helper 1 (Th1) cells promotes protection against intracellular pathogens. Antigen activation of Th1 cells is an important mode of IFN-gamma induction, but here we analyze a second, antigen-nonspecific pathway capable of inducing full IFN-gamma transcription. IL-12 or IL-18 alone do not ind...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199902)29:02<548::AID-IMMU
更新日期:1999-02-01 00:00:00
abstract::The problem of the structural relationship between suppressive IgG-binding factor and low-affinity receptors for the Fc portion of IgG (Fc gamma RII) has not yet been solved. In the present work we have isolated a recombinant soluble Fc gamma RII containing only the two external domains of Fc gamma RII, and analyzed i...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191213
更新日期:1989-12-01 00:00:00
abstract::The 4-1BB is a costimulatory molecule similar to the receptor activator of NF-kappaB ligand (RANKL), both of which are key factors for the differentiation of osteoclasts and are expressed mainly by activated T cells. The 4-1BB shares common signaling pathways with RANK, suggesting a potential role in osteoclastogenesi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200737650
更新日期:2008-06-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250647
更新日期:1995-06-01 00:00:00
abstract::Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine kinase and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD8(+) T-cell differentiation, a process that changes from the metabolically active state of effector T cells to one of quiescence in memory cells is...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201343483
更新日期:2013-04-01 00:00:00
abstract::Previous reports suggested that lethal toxin (LT)-induced caspase-1 activity and/or IL-1beta accounted for Bacillus anthracis (BA) infection lethality. In contrast, we now report that caspase-1-mediated IL-1beta expression in response to BA spores is required for anti-BA host defenses. Caspase-1(-/-) and IL-1beta(-/-)...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838141
更新日期:2008-06-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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journal_title:European journal of immunology
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更新日期:1999-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231049
更新日期:1993-10-01 00:00:00
abstract::IL-12 is an important immunomodulatory cytokine that induces tyrosine phosphorylation and activation of the signal transducer and activator of transcription (STAT)4. IL-12 induces sustained activation and nuclear translocation of STAT4 and this regulatory process is coupled to both tyrosine and serine phosphorylation ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(200005)30:5<1425::AID-IMMU
更新日期:2000-05-01 00:00:00
abstract::Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation. Experimental evidence shows that BMSC are able to suppress the activation of the immune response by mechanisms that are still not completely understood. Thus...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425405
更新日期:2005-05-01 00:00:00
abstract::Mice carrying the lpr gene, SCG and MRL-lpr/lpr mice, were used to characterize the phenotype and lpr gene of abnormally proliferating T cells in these mice. A major population which expanded in these mice were T cells expressing intermediate (int) levels of T cell receptor (TCR) (and CD3) and the phenotype of interle...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260702
更新日期:1996-07-01 00:00:00
abstract::Alkaline phosphatases (APases, EC 3.1.3.1) are ecto-enzymes bound to cell membranes by a phosphatidyl-inositol anchor. We have previously shown that APase is present on activated murine B cells and its expression correlates with the process of B cell differentiation into immunoglobulin secretion. Recently, a monoclona...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200436
更新日期:1990-04-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270838
更新日期:1997-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200204
更新日期:1990-02-01 00:00:00
abstract::Cytotoxic T lymphocytes (CTL) generally recognize peptides derived from endogenously expressed proteins in association with nascent major histocompatibility complex (MHC) class I molecules. In contrast, peptides derived from exogenous proteins associate with MHC class II following endocytosis to an endosomal compartme...
journal_title:European journal of immunology
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doi:10.1002/eji.1830240721
更新日期:1994-07-01 00:00:00