R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy.

abstract：:The developmental stages and the role of protein tyrosine kinases (PTK) in the maturation of CD3+CD8 alpha alpha+ intraepithelial lymphocytes (IEL) have not been extensively characterized. However, comparisons of thymic and extrathymic T cell development indicate that these processes involve some distinct signaling an...

journal_title：European journal of immunology

authors： Page ST,van Oers NS,Perlmutter RM,Weiss A,Pullen AM

更新日期：1997-02-01 00:00:00

abstract：:Two major histocompatibility complex (MHC) class I-reactive T cell clones derived from H-2b mice, generated against the allogeneic Ld molecule, were found to recognize the H-2b class II mutant Abm12 molecule as well. In addition, these clones also recognize the class II A(s) molecule, and display a class II-dependent ...

journal_title：European journal of immunology

authors： Frangoulis B,Urbero B,Pla M

更新日期：1993-08-01 00:00:00

abstract：:In a search for proteins involved in signal transduction through the T cell receptor (TcR/CD3 complex), a recently developed highly efficient method for labeling of nucleotide binding proteins in permeabilized cells was applied. Here, we report that human CD3-gamma could be labeled by periodate-oxidized [alpha-32P] GT...

journal_title：European journal of immunology

authors： Peter ME,Wileman T,Terhorst C

更新日期：1993-02-01 00:00:00

abstract：:Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa g...

journal_title：European journal of immunology

authors： Sharpe MJ,Neuberger M,Pannell R,Surani MA,Milstein C

更新日期：1990-06-01 00:00:00

abstract：:The crucial role of interleukin (IL)-4 in the induction of murine IgG1 and IgE responses, which are coupled through the process of sequential isotype switching, has been well documented. Whereas IL-4 is obligatory for the induction of IgE responses, it enhances IgG1 responses. In this study, using neutralizing antibod...

journal_title：European journal of immunology

authors： van Ommen R,Vredendaal AE,Savelkoul HF

更新日期：1994-06-01 00:00:00

abstract：:Myeloid dendritic cells (DC) and macrophages evolve from a common precursor. However, factors controlling monocyte differentiation toward DC or macrophages are poorly defined. We report that the surface density of the GM-CSF receptor (GM-CSFR) alpha subunit in human peripheral blood monocytes varies among donors. Alth...

journal_title：European journal of immunology

authors： Conti L,Cardone M,Varano B,Puddu P,Belardelli F,Gessani S

更新日期：2008-03-01 00:00:00

abstract：:CD4+CD25(hi)CD127(lo/-) regulatory T cells (Treg) have been implicated in the resolution of asthma-associated inflammation while the opposite role of CD4+ invariant NKT (iNKT) cells has been the subject of recent investigations. Studies here focused on mechanisms of interaction between CD4+ iNKT cells and Treg to furt...

journal_title：European journal of immunology

authors： Nguyen KD,Vanichsarn C,Nadeau KC

更新日期：2008-07-01 00:00:00

abstract：:The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, and plays crucial roles in numerous neurological diseases. Activation of the NLRP3 inflammasome leads to caspase-1 dependent cleavage of pro-IL-1β to form mature IL-1β. By acting on the P...

journal_title：European journal of immunology

authors： Suzuki T,Kohyama K,Moriyama K,Ozaki M,Hasegawa S,Ueno T,Saitoe M,Morio T,Hayashi M,Sakuma H

更新日期：2020-02-01 00:00:00

abstract：:The effect of anti-Ia antibody on the development of murine neonatal self-Ia-reactive T lymphocytes in the thymus was studied. A C57BL/6 (B6) mouse pregnant with (B6 X C3H/He)F1 (B6C3F1) embryos was injected with monoclonal anti-I-Ek (m alpha I-Ek) antibody every other day starting from the 12th day of gestation. The ...

journal_title：European journal of immunology

authors： Kimoto M,Kishimoto S

更新日期：1986-07-01 00:00:00

abstract：:Cold agglutinins (CA) are autoantibodies that bind to erythrocyte carbohydrates at low temperatures and induce complement-mediated cell lysis, thus causing hemolytic anemia. Tolerance mechanisms towards CA-expressing B cells and the factors inducing pathogenic CA production are unknown. In order to develop an animal m...

journal_title：European journal of immunology

authors： Havouis S,Dumas G,Avé P,Pritsch O,Huerre M,Dighiero G,Pourcel C

更新日期：2000-08-01 00:00:00

abstract：:Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...

journal_title：European journal of immunology

authors： Kelly KA,Scollay R

更新日期：1992-02-01 00:00:00

abstract：:Subcutaneous immunization with hen egg-white lysozyme (HEL) in complete Freund's adjuvant induces, both in antibody responder and nonresponder mice, a classical delayed-type hypersensitivity (DTH) reaction evaluated as footpad swelling. This response can be specifically transferred to naive recipients by Lyt-1+2- T ce...

journal_title：European journal of immunology

authors： Colizzi V,Doria G,Adorini L

更新日期：1984-09-01 00:00:00

abstract：:To study the biological consequences of cytokine production and apoptosis by intraepithelial lymphocytes (IEL), we have studied these characteristics in both the high and low density CD3+ IEL populations. Stimulation of low- or high-density CD3+ IEL via the T cell receptor (TCR)-CD3 complex using monoclonal anti-CD3, ...

journal_title：European journal of immunology

authors： Yamamoto M,Fujihashi K,Amano M,McGhee JR,Beagley KW,Kiyono H

更新日期：1994-06-01 00:00:00

abstract：:Autophagy is an intracellular degradation system that plays an important role in T-cell survival. However, the precise mechanism linking autophagy and cell death in primary human T cells is unclear because methods for monitoring autophagy in small numbers of primary human cells remain controversial. We established a n...

journal_title：European journal of immunology

authors： Watanabe R,Fujii H,Shirai T,Saito S,Ishii T,Harigae H

更新日期：2014-08-01 00:00:00

abstract：:A large panel of T cell clones (TCC) specific for the recombinant form of Poa pratensis allergen (rKBG7.2 or Poa p9) were established from the peripheral blood of grass pollen-sensitive donor in the absence or presence of recombinant interferon-alpha (IFN-alpha) in bulk culture and their pattern of cytokine secretion,...

journal_title：European journal of immunology

authors： Parronchi P,Mohapatra S,Sampognaro S,Giannarini L,Wahn U,Chong P,Mohapatra S,Maggi E,Renz H,Romagnani S

更新日期：1996-03-01 00:00:00

abstract：:The delivery of T-cell help to B cells is antigen-specific, MHC-restricted, and CD40L (CD154) dependent. It has been thought that when a T cell recognizes an antigen-presenting B cell, CD40L expressed on the T-cell surface engages with CD40 on the surface of B cells as long as the cells remain conjugated. By adding fl...

journal_title：European journal of immunology

authors： Gardell JL,Parker DC

更新日期：2017-01-01 00:00:00

abstract：:A T3 complex-bearing subpopulation was characterized within an in vivo cycling T4-8- early thymocyte compartment which contains cells constitutively expressing interleukin 2 and transferrin receptors. We show differentiation in vitro of both mature subsets of thymocytes (T3+4+8- and T3+4-8+) from the above T4-8- compa...

journal_title：European journal of immunology

authors： De la Hera A,Toribio ML,Marquez C,Marcos MA,Cabrero E,Martinez-A C

更新日期：1986-06-01 00:00:00

abstract：:Cells from the monoclonal B cell lymphoma I.29 expressing surface IgM (mu +) are capable of differentiating in vitro to IgM secretion and of switching to IgA or IgE production in response to lipopolysaccharide (LPS) stimulation. To determine whether a single mu + B cell is capable of undertaking both differentiative p...

journal_title：European journal of immunology

authors： Alberini C,Biassoni R,DeAmbrosis S,Vismara D,Sitia R

更新日期：1987-04-01 00:00:00

abstract：:The functional half-life, a measure of the persistence of lymphocytes in an antigen-free environment, has been estimated and found to be about 7 days for virgin 2,4,6-trinitrophenyl (TNP)-reactive mouse B cells, and 2--3 times longer for TNP-primed B cells. Using allotype-congenic mice, lymph node cells were transferr...

journal_title：European journal of immunology

authors： Elson CJ,Jablonska KF,Taylor RB

更新日期：1976-09-01 00:00:00

abstract：:Restriction fragment length polymorphism has been compared between the Igh loci of C57BL/6 and MOLF/EI (Mus musculus molossinus) mice utilizing probes which detect the C gamma 2b gene and genes from nine VH-gene families. Distinct restriction site patterns were found for the CH genes and for VH families PC7183, Q52 an...

journal_title：European journal of immunology

authors： Blankenstein T,Krawinkel U

更新日期：1987-09-01 00:00:00

abstract：:AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 also mobilizes most mature leukocyte subsets to blood; however, their source and trafficking potential have not been fully delineated. Here, ...

journal_title：European journal of immunology

authors： Liu Q,Li Z,Gao JL,Wan W,Ganesan S,McDermott DH,Murphy PM

更新日期：2015-06-01 00:00:00

abstract：:We have proposed earlier that the poor capacity of the lipocalin allergen Bos d 2 to stimulate highly allergic subjects' peripheral blood mononuclear cells could be ascribed to endogenous lipocalins and could be related to the allergenic potential of the molecule. Here, we have characterized the proliferative and cyto...

journal_title：European journal of immunology

authors： Kinnunen T,Buhot C,Närvänen A,Rytkönen-Nissinen M,Saarelainen S,Pouvelle-Moratille S,Rautiainen J,Taivainen A,Maillère B,Mäntyjärvi R,Virtanen T

更新日期：2003-06-01 00:00:00

abstract：:Upon treatment with lipopolysaccharide (LPS), primary B cells proliferate and differentiate into plasma cells with concomitant up-regulation of immunoglobulin (Ig) gene expression. Here we examine the role of the Igkappa 3' enhancer in this process using a kappa3'-enhancer-driven beta-globin reporter gene in transgeni...

journal_title：European journal of immunology

authors： Meyer KB

更新日期：1999-03-01 00:00:00

abstract：:The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and d...

journal_title：European journal of immunology

authors： Behrens EM,Gadue P,Gong SY,Garrett S,Stein PL,Cohen PL

更新日期：2003-08-01 00:00:00

abstract：:Riboflavin, also known as vitamin B2 , is converted by riboflavin kinase (RFK) into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential cofactors of dehydrogenases, reductases, and oxidases including the phagocytic NADPH oxidase 2 (Nox2). Riboflavin deficiency is common in young adul...

journal_title：European journal of immunology

authors： Schramm M,Wiegmann K,Schramm S,Gluschko A,Herb M,Utermöhlen O,Krönke M

更新日期：2014-03-01 00:00:00

abstract：:Normal human peripheral blood lymphocytes were shown to activate complement in normal human serum (NHS). This activation led to C3 fixation on the cell membrane, which in turn was visualized by fluorescence. The reaction occurred in the absence of detectable amounts of antibodies, since an agammaglobulinemic patient's...

journal_title：European journal of immunology

authors： Gutiérrez C,Vega J,Kreisler M

更新日期：1979-01-01 00:00:00

abstract：:Antibodies against bacterial capsular polysaccharides play a critical protective role. Responses to these antigens can occur without the help or control of T cells and are associated with marginal zone (MZ) B cells. Capsular antigens are diverse and some cross-react with self-carbohydrate epitopes. This diversity may ...

journal_title：European journal of immunology

authors： Vinuesa CG,Sze DM,Cook MC,Toellner KM,Klaus GG,Ball J,MacLennan IC

更新日期：2003-02-01 00:00:00

abstract：:Spleen cells from chickens injected with sheep erythrocytes (SE) intravenously 2 to 14 days prior to culture were found to give faster and higher plaque-forming cell responses upon addition of antigen on day 2 rather than on day 0 of culture. Cell mixture experiments showed that this was due to the induction of suppre...

journal_title：European journal of immunology

authors： Chi DS,Grebenau MD,Thorbecke GJ

更新日期：1980-03-01 00:00:00

abstract：:Anchor residues in peptides determine the specificity of binding to major histocompatibility complex class I molecules through interactions of their side chains with pockets in the peptide-binding groove. We have compared the kinetics of association of a Sendai virus nucleoprotein-derived peptide (FAPGNYPAL, termed SV...

journal_title：European journal of immunology

authors： Neefjes JJ,Dierx J,Ploegh HL

更新日期：1993-04-01 00:00:00

abstract：:Inhibition of growth or eradication of experimentally induced tumors has been shown to be accompanied by infiltration of eosinophils and macrophages into the tumor mass. Since macrophages are important mediators of host antitumor activity, the possibility arises that a collaboration may exist between these two cell ty...

journal_title：European journal of immunology

authors： Spessotto P,Dri P,Bulla R,Zabucchi G,Patriarca P

更新日期：1995-05-01 00:00:00