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Allogeneic recognition of class I molecules: anti-H-2Ld repertoire of H-2b mice includes T cells recognizing mutant class II H-2b (Abm12) molecules.

Abstract：

:Two major histocompatibility complex (MHC) class I-reactive T cell clones derived from H-2b mice, generated against the allogeneic Ld molecule, were found to recognize the H-2b class II mutant Abm12 molecule as well. In addition, these clones also recognize the class II A(s) molecule, and display a class II-dependent reactivity to staphylococcal enterotoxin B. Neither the class I nor the class II alloreactivities of the clones were found to be dependent on other MHC molecules. Both clones express CD4+CD8- phenotypes. The CD4 molecule appears to be involved in their class II reactivity, while little or no role for CD4 could be detected in the class I reactivity. This is the first report of a class I/class II cross-reactivity being mediated by CD4+ T cells. The structural basis for this cross-reactivity is discussed.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Frangoulis B,Urbero B,Pla M

doi

10.1002/eji.1830230823

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

1884-8

issue

8

eissn

0014-2980

issn

1521-4141

journal_volume

23

pub_type

杂志文章

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