Abstract:
:T helper cell type 2 (Th2) cells when triggered by antibodies to CD3 acquire the capacity to stimulate the polyclonal proliferation of syngeneic, resting B cells. Here, we tested the ability of various monoclonal antibodies (mAb) to block the B cell proliferation-inducing potential of such activated Th2 cells. We demonstrate that anti-interleukin 4, as well as anti-LFA-1 antibodies interfere with the T-B cell interaction. In kinetic studies, anti-LFA-1 was found to be operative during the first half and anti-interleukin 4 during the second half of the 48-h culture period. This defines at least two different steps in B cell triggering by Th2 cells. In addition, the data imply that the T-B cell interaction involves an additional structure, namely an activation molecule, on the T cell surface.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Lohoff M,Koch A,Röllinghoff Mdoi
10.1002/eji.1830220246keywords:
subject
Has Abstractpub_date
1992-02-01 00:00:00pages
599-602issue
2eissn
0014-2980issn
1521-4141journal_volume
22pub_type
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250430
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pub_type: 杂志文章
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
pub_type: 杂志文章
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830261251
更新日期:1996-12-01 00:00:00