Abstract:
:Chronic hepatitis C virus (HCV) infection frequently develops into liver disease and is accompanied by extra-hepatic autoimmune manifestations. The tetraspanin CD81 is a putative HCV receptor as it binds the E2 envelope glycoprotein of HCV and bona fide HCV particles. Here we show that HCV E2 binding to CD81 on human cells in vitro lowers the threshold for IL-2 receptor alpha expression and IL-2 production, resulting in strongly increased T cell proliferation. HCV E2-induced co-stimulation also enhances the production of IFN-gamma and IL-4 and causes increased TCR down-regulation. This suggests that binding of HCV particles to CD81 on T cells in vivo may lead to activation by otherwise suboptimal stimuli. Therefore, co-stimulation of autoreactive T cells by HCV may contribute to liver damage and autoimmune phenomena observed in HCV infection.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Wack A,Soldaini E,Tseng C,Nuti S,Klimpel G,Abrignani Sdoi
10.1002/1521-4141(200101)31:1<166::aid-immu166>3.0keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
166-75issue
1eissn
0014-2980issn
1521-4141pii
10.1002/1521-4141(200101)31:1<166::AID-IMMU166>3.0journal_volume
31pub_type
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