Abstract:
:We report here the identification and characterization of murine CCX-CKR, a high affinity receptor for the murine beta-chemokines SLC/mCCL21, MIP-3beta/mCCL19 and TECK/mCCL25. Unlike most other chemokine receptors, CCX-CKR is unable to mediate Ca(2+) fluxes upon ligand binding when expressed in HEK293 cells. Murine CCX-CKR is expressed predominantly in the heart and lung, but is detectable in most organs using RT-PCR. Interestingly, in brain and testis, an alternative mRNA form of CCX-CKR exists with a unique 5' untranslated region (5'UTR) that overlaps with a novel acyl-CoA dehydrogenase (ACD) gene. Analysis of human CCX-CKR shows that the expression profiles and alternative 5'UTR are conserved. However, in man, there are two copies of the CCX-CKR gene, one on chromosome 3 nestled within the ACD homologue, and one on chromosome 6. These genes encode proteins with only one amino acid difference, and their expression is independently regulated. This study identifies murine CCX-CKR, reveals complex regulation of CCX-CKR gene expression in mouse and man, and is suggestive of non-leukocytic targets for MIP-3beta/CCL19, SLC/CCL21 and TECK/CCL25.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Townson JR,Nibbs RJdoi
10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
1230-41issue
5eissn
0014-2980issn
1521-4141journal_volume
32pub_type
杂志文章abstract::We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) breaks tolerance induction. The objective of this study was to determine whether GM-CSF breaks established inhalation tolerance. To induce tolerance, BALB/c mice were exposed to aerosolized ovalbumin (OVA) for 10 consecutive days. A co...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425012
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abstract::Cyclosporin A (CSA), an immunosuppressive agent used in organ transplantation and to treat some autoimmune diseases, blocks the Ca2+-dependent steps involved in T cell receptor triggering leading to interleukin (IL)-2 production. Considering that the early steps of T cell activation are insensitive to CSA, we asked wh...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260712
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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abstract::A monoclonal antibody, termed 3-2F1, is specific for the rabbit VH al allotypic marker. This antibody appears to recognize a common al determinant since it reacts with all of the a1 immunoglobulin (Ig) that is bound by polyclonal rabbit anti-a1, and completely inhibits the binding of polyclonal anti-a1 to a1 Ig. When ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830140405
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425294
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journal_title:European journal of immunology
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更新日期:2002-08-01 00:00:00
abstract::It is well established that therapeutic impairment of Foxp3+ Treg in mice and humans favors immune rejection of solid tumors. Less explored is the impact Foxp3 allelic variants may have on tumor incidence, progression and therapy. In this work, we tested and demonstrate that the Foxp3fgfp reporter allele, found previo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948251
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journal_title:European journal of immunology
pub_type: 杂志文章,收录出版
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425562
更新日期:2005-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830211208
更新日期:1991-12-01 00:00:00
abstract::The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD4...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231049
更新日期:1993-10-01 00:00:00
abstract::The T cell-dependent differentiation and function of B lymphocytes are tightly regulated by TNF ligands (L) and receptors interactions, such as CD40/CD40L, CD27/CD70 and CD134/CD314L. The LIGHT/HVEM system [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the herpes vir...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425598
更新日期:2004-12-01 00:00:00
abstract::Autoantibodies in the form of immune complexes are known to be crucial mediators in initiating inflammation in a variety of autoimmune diseases. This has been well documented in the anti-collagen II antibody-induced arthritis animal model for a long time now. Recently, in the K/B x N mouse model (the F1 of the TCR-tra...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200526167
更新日期:2005-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231230
更新日期:1993-12-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250917
更新日期:1995-09-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939493
更新日期:2010-01-01 00:00:00
abstract::Cooperation between B cells specific for an antigen exposed on a viral structure and T helper (Th) cells specific for an internal antigen, as demonstrated with influenza, hepatitis B and rabies viruses, has been termed intrastructural help. Th cells specific for internal proteins of HIV, which are much less mutated th...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250513
更新日期:1995-05-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200001)30:1<272::AID-IMMU272>3.0
更新日期:2000-01-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/eji.1830260220
更新日期:1996-02-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251118
更新日期:1995-11-01 00:00:00
abstract::Profiling antibodies to SARS-CoV-2 can help to assess potential immune response after COVID-19 disease. Luciferase IP system (LIPS) assay is a sensitive method for quantitative detection of antibodies to antigens in their native conformation. We here describe LIPS to detect antibody responses to SARS-CoV-2 spike (S) a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.202048715
更新日期:2020-08-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948141
更新日期:2019-11-01 00:00:00
abstract::The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210518
更新日期:1991-05-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830241024
更新日期:1994-10-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:European journal of immunology
pub_type: 评论,杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830140710
更新日期:1984-07-01 00:00:00
abstract::We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...
journal_title:European journal of immunology
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更新日期:2010-10-01 00:00:00