当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis.

CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis.

Abstract：

:Chemokine receptors are important for recruiting leukocytes to sites of infection and may contribute to immune cell activation. The present study investigated the role of the chemokine receptor CCR2 in polymicrobial septic peritonitis. The results showed that peritoneal production of the CCR2 ligands CCL2 and CCL12 in septic mice was largely independent of the common Toll-like receptor signaling adaptor MyD88. Antibody blockade of CCR2 reduced the recruitment of macrophages and neutrophils to the infected peritoneal cavities of both wild-type and MyD88-deficient mice, suggesting that CCR2 engagement contributes to the MyD88-independent cellular response against polymicrobial septic peritonitis. Notably, administration of blocking CCR2 antibodies markedly increased local and systemic IL-10 levels in septic wild-type mice, whereas IL-10 was not detected in MyD88-deficient mice irrespective of whether CCR2 was blocked or not. Inhibition of CCR2 directly augmented Toll-like receptor-induced IL-10, but not TNF and IL-6, production of macrophages in vitro. Concomitant with enhanced IL-10 production, CCR2 blockade caused impaired bacterial clearance and aggravated kidney injury in wild-type, but not MyD88-null mice. These results indicate that CCR2 engagement modulates the innate immune response to polymicrobial septic peritonitis by both MyD88-dependent and -independent processes and suggest that a major function of CCR2 in sepsis is to attenuate IL-10 production and IL-10-mediated suppression of host defense.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Feterowski C,Mack M,Weighardt H,Bartsch B,Kaiser-Moore S,Holzmann B

doi

10.1002/eji.200425294

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

3664-73

issue

12

eissn

0014-2980

issn

1521-4141

journal_volume

34

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Ligand motif of the autoimmune disease-associated mouse MHC class II molecule H2-A(s).

    abstract：:The MHC class II molecule H2-A(s), expressed in the SJL mouse strain, is the principle restriction element of autoreactive CD4(+) T cells mediating experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. We deduced the H2-A(s) ligand motif from the analysis of naturally processed self peptide...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200102)31:2<551::aid-immu551>3.0

    authors： Kalbus M,Fleckenstein BT,Offenhäusser M,Blüggel M,Melms A,Meyer HE,Rammensee HG,Martin R,Jung G,Sommer N

    更新日期：2001-02-01 00:00:00

  • Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection.

    abstract：:To investigate negative selection events during intrathymic ontogeny, we established T cell receptor (TCR)-transgenic mice [N15tg/RAG-2-/- (H-2b)] expressing a single TCR specific for vesicular stomatitis virus nuclear octapeptide N52-59 (VSV8) in the context of the major histocompatibility complex (MHC) class I molec...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270923

    authors： Ghendler Y,Hussey RE,Witte T,Mizoguchi E,Clayton LK,Bhan AK,Koyasu S,Chang HC,Reinherz EL

    更新日期：1997-09-01 00:00:00

  • T cell-specific gene targeting reveals that alpha4 is required for early T cell development.

    abstract：:Alpha4-mediated signaling is involved in a variety of functions in mammalian cells. To determine whether this is true for immunocompetent cells, we generated mutant (Lck-alpha4-) mice in which the alpha4 gene was deleted in a T cell-specific manner using the Cre/loxP system. These mice showed impaired early T cell dev...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200323720

    authors： Hua DR,Inui S,Yamashita T,Maeda K,Takagi K,Takeda J,Sakaguchi N

    更新日期：2003-07-01 00:00:00

  • The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation and function.

    abstract：:Myeloid leukocytes form actin-based plasma membrane protrusions, called podosomes, that are implicated in myeloid cell recruitment into tissues and cell migration within the interstitium. In this study, we show that tyrosine kinases of the Abl family are present in podosomes formed by murine and human macrophages. Sil...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201142270

    authors： Baruzzi A,Berton G

    更新日期：2012-10-01 00:00:00

  • B lineage-restricted rearrangement of a human Ig kappa transgene.

    abstract：:To study the control of immunoglobulin kappa light chain gene rearrangement, we generated transgenic mice carrying a germ-line human kappa minilocus (HK) containing the J kappa-proximal V gene, V kappa IV, the V-J intergenic region, the five J kappa segments and the C kappa gene. This construct includes the intronic, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：

    authors： Cavelier P,Nato F,Coquilleau I,Rolink A,Rougeon F,Goodhardt M

    更新日期：1997-07-01 00:00:00

  • All the small things: How virus-like particles and liposomes modulate allergic immune responses.

    abstract：:Recent years have seen a dramatic increase in the range of applications of virus-like nanoparticle (VNP)- and liposome-based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert virus-backbones or distinct lipid formulations and intend to engage the host's innate a...

    journal_title：European journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1002/eji.201847810

    authors： Kratzer B,Hofer S,Zabel M,Pickl WF

    更新日期：2020-01-01 00:00:00

  • The gene expression profile of phosphoantigen-specific human γδ T lymphocytes is a blend of αβ T-cell and NK-cell signatures.

    abstract：:Global transcriptional technologies have revolutionised the study of lymphoid cell populations, but human γδ T lymphocytes specific for phosphoantigens remain far less deeply characterised by these methods despite the great therapeutic potential of these cells. Here we analyse the transcriptome of circulating TCRVγ(+)...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201141870

    authors： Pont F,Familiades J,Déjean S,Fruchon S,Cendron D,Poupot M,Poupot R,L'faqihi-Olive F,Prade N,Ycart B,Fournié JJ

    更新日期：2012-01-01 00:00:00

  • Regulation of I-309 gene expression in human monocytes by endogenous interleukin-1.

    abstract：:Activated human monocytes are a source of numerous beta-chemokines. The present study was conducted to determine whether these cells produce the human beta-chemokine I-309 and to compare the induction requirements of I-309 to those of other beta-chemokines. We demonstrate that appropriately stimulated adherence-purifi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270317

    authors： Selvan RS,Zhou LJ,Krangel MS

    更新日期：1997-03-01 00:00:00

  • The Tregs' world according to GARP.

    abstract：:Naturally occurring CD4+CD25(high) regulatory T cells (nTreg) are essential for maintaining tolerance. FOXP3 has been established as a molecular marker of nTreg; however, FOXP3 cannot be used as a reliable marker for bona fide human nTreg since effector T cells also up-regulate FOXP3 expression upon activation. Despit...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.200940117

    authors： Battaglia M,Roncarolo MG

    更新日期：2009-12-01 00:00:00

  • The macrophage: past, present and future.

    abstract：:As we approach the centenary of Elie Metchnikoff's Nobel Prize (1908), it is opportune to reflect upon the history of macrophage immunobiology, take stock of current knowledge and anticipate questions for the future. Starting from his appreciation of phagocytosis as an important determinant of host defence against inf...

    journal_title：European journal of immunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1002/eji.200737638

    authors： Gordon S

    更新日期：2007-11-01 00:00:00

  • Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells.

    abstract：:The human T cell leukemia virus type-1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). Since the HTLV-I-encoded transactivator Tax has been shown to activate many cellular genes including cytokine genes interleukin (IL-)1alpha, 2, 5, 6, 8, 10 and 15, we ask whether Tax also affects IL-4 expression. In ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200109)31:9<2623::aid-immu2623>3

    authors： Li-Weber M,Giaisi M,Chlichlia K,Khazaie K,Krammer PH

    更新日期：2001-09-01 00:00:00

  • Pathogenesis of Lyme neuroborreliosis: Borrelia burgdorferi lipoproteins induce both proliferation and apoptosis in rhesus monkey astrocytes.

    abstract：:Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200323872

    authors： Ramesh G,Alvarez AL,Roberts ED,Dennis VA,Lasater BL,Alvarez X,Philipp MT

    更新日期：2003-09-01 00:00:00

  • The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes.

    abstract：:The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830231117

    authors： Fung-Leung WP,Louie MC,Limmer A,Ohashi PS,Ngo K,Chen L,Kawai K,Lacy E,Loh DY,Mak TW

    更新日期：1993-11-01 00:00:00

  • CD4⁺ T-cell immunity in the female genital tract is critically dependent on local mucosal immunization.

    abstract：:Immunizations via the i.n. and intravaginal (ivag) routes effectively generate strong genital tract antibody-mediated immunity. To what extent the same is true for T-cell responses is incompletely known. Therefore, we set out to investigate optimal conditions for stimulation of genital tract CD4(+) T-cell responses, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201041297

    authors： Marks E,Helgeby A,Andersson JO,Schön K,Lycke NY

    更新日期：2011-09-01 00:00:00

  • B cells latently infected with murine gammaherpesvirus 68 (MHV-68) are present in the mouse thymus-A step toward immune evasion?

    abstract：:We show that latently gammaherpesvirus-infected B cells are present in the thymus. This could result in a functional T-cell tolerance against certain viral epitopes. It is conceivable that also antigens from other viruses or pathogens may be conveyed to the thymus for their immune evasion. ...

    journal_title：European journal of immunology

    pub_type： 信件

    doi：10.1002/eji.201847886

    authors： Yamano T,Steinert M,Steer B,Klein L,Hammerschmidt W,Adler H

    更新日期：2019-02-01 00:00:00

  • Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma.

    abstract：:We have investigated the role of TNF-alpha in mast cell-mediated late airway hyperresponsiveness (AHR) using mast cell-deficient WBB6F1-W/W(v) (W/W(v)) mice in a murine model of asthma, which exhibits a biphasic increase in AHR. TNF-alpha levels in the airway and magnitude of late AHR in response to airway allergen ch...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200636612

    authors： Kim YS,Ko HM,Kang NI,Song CH,Zhang X,Chung WC,Kim JH,Choi IH,Park YM,Kim GY,Im SY,Lee HK

    更新日期：2007-04-01 00:00:00

  • Regulation of thymocyte proliferative response by macrophage-derived prostaglandin E2 and interleukin 1.

    abstract：:The antagonistic effects of macrophage (M phi)-derived interleukin 1 (IL 1) and prostaglandin E2 (PGE2) on thymocyte proliferation were uncoupled and studied. Elimination of PGE2 from the culture medium of prostaglandin E2-stimulated M phi was achieved by dialysis of the media or by indomethacin treatment of the M phi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830150109

    authors： Hayari Y,Kukulansky T,Globerson A

    更新日期：1985-01-01 00:00:00

  • Leptin: nourishment for the immune system.

    abstract：:Leptin, a protein produced by adipocytes, exerts several functions, including modulation of the immune response. A report in this issue of the European Journal of Immunology describes for the first time the effect of either leptin receptor deficiency or blockade on murine dendritic cell (DC) maturation, survival and f...

    journal_title：European journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1002/eji.200636770

    authors： Fantuzzi G

    更新日期：2006-12-01 00:00:00

  • Multifocal structure of the T cell - dendritic cell synapse.

    abstract：:The structure of immunological synapses formed between murine naive T cells and mature dendritic cells has been subjected to a quantitative analysis. Immunofluorescence images of synapses formed in the absence of antigen show a diffuse synaptic accumulation of CD3 and LFA-1. In electron microscopy, these antigen-free ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425857

    authors： Brossard C,Feuillet V,Schmitt A,Randriamampita C,Romao M,Raposo G,Trautmann A

    更新日期：2005-06-01 00:00:00

  • NK cell-extrinsic IL-18 signaling is required for efficient NK-cell activation by vaccinia virus.

    abstract：:NK cells are important for the control of vaccinia virus (VV) in vivo. Recent studies have shown that multiple pathways are required for effective activation of NK cells. These include both TLR-dependent and -independent pathways, as well as the NKG2D activating receptor that recognizes host stress-induced NKG2D ligan...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201344134

    authors： Brandstadter JD,Huang X,Yang Y

    更新日期：2014-09-01 00:00:00

  • Application of phage display peptide library to autoimmune diabetes: identification of IA-2/ICA512bdc dominant autoantigenic epitopes.

    abstract：:Autoantigenic epitope mapping represents a critical issue in autoimmune diseases. The islet tyrosine phosphatase-like protein IA-2/ICA512bdc is a major autoantigen in type 1 diabetes (IDDM), but the epitopes responsible for autoantibody binding have been only partially defined. The aim of our study was to identify ICA...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200205)32:5<1420::AID-IMMU1420>3

    authors： Farilla L,Tiberti C,Luzzago A,Yu L,Eisenbarth GS,Cortese R,Dotta F,Di Mario U

    更新日期：2002-05-01 00:00:00

  • CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained.

    abstract：:Cellular immune responses are likely to play a key role in determining the clinical outcome in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their relationship to viral clearance are poorly understood. In a previous study we have shown highly activated, multispecific cytotoxic T ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200009)30:9<2479::AID-IMMU2479>3

    authors： Lechner F,Gruener NH,Urbani S,Uggeri J,Santantonio T,Kammer AR,Cerny A,Phillips R,Ferrari C,Pape GR,Klenerman P

    更新日期：2000-09-01 00:00:00

  • Target structure for natural killer cells: evidence against a unique role for transferrin receptor.

    abstract：:The transferrin receptor (TfR) was recently proposed as putative natural killer (NK) cell target structure. Here data are presented against this hypothesis and it is shown that low TfR expression and high NK sensitivity can occur concommitantly . K562 cells were studied at various stages of cell proliferation. No chan...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830140412

    authors： Dokhélar MC,Garson D,Testa U,Tursz T

    更新日期：1984-04-01 00:00:00

  • Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family.

    abstract：:The causative agents of Lyme disease, Borrelia burgdorferi s.s., B. garinii, and B. afzelii, differ in their susceptibility to complement-mediated lysis. This phenomenon apparently depends on the expression of proteins termed complement regulator-acquiring surface proteins (CRASP) and their binding to the inhibitory p...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200323571

    authors： Kraiczy P,Hellwage J,Skerka C,Kirschfink M,Brade V,Zipfel PF,Wallich R

    更新日期：2003-03-01 00:00:00

  • Recombinant interleukin (IL) 2-induced human B cell differentiation is mediated by autocrine IL6.

    abstract：:The molecular mechanism of the interleukin (IL) 2-induced differentiation of human B cells has been investigated. The experimental results show that Staphylococcus aureus Cowan strain I (SAC) activation alone induces IL6 secretion from B cells. When B cells were activated by SAC, there was an increased transcription o...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830191215

    authors： Xia X,Lee HK,Clark SC,Choi YS

    更新日期：1989-12-01 00:00:00

  • Both membrane-bound and soluble forms of CD14 bind to gram-negative bacteria.

    abstract：:Tissue macrophages and their precursors-the blood monocytes-respond rapidly to a bacterial infection with the release of inflammatory mediators. These mediators are involved in the recruitment of phagocytic cells, principally neutrophils, from the blood to the site of infection. To initiate this process macrophages an...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250545

    authors： Jack RS,Grunwald U,Stelter F,Workalemahu G,Schütt C

    更新日期：1995-05-01 00:00:00

  • Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.

    abstract：:Only activated and effector memory T cells are thought to access non-lymphoid tissues. In contrast, naive T cells are thought to circulate only between the blood, lymph and secondary lymphoid organs. We examined the phenotype of endogenous T cells in various non-lymphoid organs and showed that a subset of cells exhibi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200535539

    authors： Cose S,Brammer C,Khanna KM,Masopust D,Lefrançois L

    更新日期：2006-06-01 00:00:00

  • B cell activation regulates exosomal HLA production.

    abstract：:Exosomes are nanovesicles produced constitutively and inducibly by several types of cells. They are generated as intraluminal vesicles of multivesicular bodies and express MHC and several endosomal/lysosomal proteins. In spite of their potential role in cellular immunity, the regulatory mechanisms of exosome productio...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200737694

    authors： Arita S,Baba E,Shibata Y,Niiro H,Shimoda S,Isobe T,Kusaba H,Nakano S,Harada M

    更新日期：2008-05-01 00:00:00

  • The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro.

    abstract：:Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the Btk SH3 domain bin...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199907)29:07<2269::AID-IMM

    authors： Morrogh LM,Hinshelwood S,Costello P,Cory GO,Kinnon C

    更新日期：1999-07-01 00:00:00

  • Negative regulation of autoreactive B cells in transgenic mice expressing a human pathogenic cold agglutinin.

    abstract：:Cold agglutinins (CA) are autoantibodies that bind to erythrocyte carbohydrates at low temperatures and induce complement-mediated cell lysis, thus causing hemolytic anemia. Tolerance mechanisms towards CA-expressing B cells and the factors inducing pathogenic CA production are unknown. In order to develop an animal m...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(2000)30:8<2290::AID-IMMU2290>3.0

    authors： Havouis S,Dumas G,Avé P,Pritsch O,Huerre M,Dighiero G,Pourcel C

    更新日期：2000-08-01 00:00:00