Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.

abstract：:The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal regio...

journal_title：European journal of immunology

authors： Schnittger S,Hamann J,Dannenberg C,Fiebig H,Strauss M,Fonatsch C

更新日期：1993-10-01 00:00:00

abstract：:Recent studies have suggested that T cell memory for recall antigens resides in clones of primed T cells with a short inter-mitotic half-life. In humans such cells express an isoform of the leukocyte common antigen termed CD45RO. Nevertheless, little is known of the fate of these primed T cells after initial activatio...

journal_title：European journal of immunology

authors： Salmon M,Pilling D,Borthwick NJ,Viner N,Janossy G,Bacon PA,Akbar AN

更新日期：1994-04-01 00:00:00

abstract：:Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

journal_title：European journal of immunology

authors： Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

更新日期：2020-12-12 00:00:00

abstract：:The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells, monocytes and dendritic cells is essential for humoral immunity and for up-regulation of antigen-presenting cell (APC) functions, as a result of signaling through CD40. There are also some indications that after interaction with CD40, CD...

journal_title：European journal of immunology

authors： Peng X,Kasran A,Warmerdam PA,de Boer M,Ceuppens JL

更新日期：1996-07-01 00:00:00

abstract：:Phenotypic classification of human CD8(+) T cells using three cell surface markers, CD27, CD28 and CD45RA, was recently suggested to be useful for identification of naive, memory and effector CD8(+) T cells. However, it still remains unclear whether such classification precisely reflects functional classification of C...

journal_title：European journal of immunology

authors： Tomiyama H,Takata H,Matsuda T,Takiguchi M

更新日期：2004-04-01 00:00:00

abstract：:Although potentially autoreactive T cells are present even in healthy subjects, most individuals do not develop autoimmune disease. It has been well demonstrated that CD4+ CD25+ regulatory T cells play a significant role in controlling the expansion of autoreactive T cells in the periphery. However, some healthy indiv...

journal_title：European journal of immunology

authors： James EA,Kwok WW

更新日期：2007-01-01 00:00:00

abstract：:Spontaneous apoptosis in germinal center (GC) B cells can be arrested either by engaging cell surface immunoglobulin (Ig) with immobilized ligand or, more effectively, by treatment with soluble monoclonal antibody (mAb) directed against CD40. The present study examines the intracellular signal transduction pathways th...

journal_title：European journal of immunology

authors： Knox KA,Gordon J

更新日期：1993-10-01 00:00:00

abstract：:Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...

journal_title：European journal of immunology

authors： Schlunck T,Schraut W,Riethmüller G,Ziegler-Heitbrock HW

更新日期：1990-09-01 00:00:00

abstract：:The murine monoclonal antibody (mAb) CB43, raised against the K-562 erythroleukemia line, reacts with monocytes, tissue macrophages, thymocytes and with all the human lines tested but not with resting lymphocytes, large granular lymphocytes, granulocytes and erythrocytes. However, activated lymphocytes and natural kil...

journal_title：European journal of immunology

authors： Bellone G,Alloatti G,Levi R,Geuna M,Tetta C,Peruzzi L,Letarte M,Malavasi F

更新日期：1989-01-01 00:00:00

abstract：:In mouse Peyer's patches (PP), dendritic cells (DC) are localized in T cell areas as NLDC145+ CD11c+ cells, and in the dome and corona region of the follicle as NLDC145- CD11c+ cells, respectively, suggesting the presence of two different DC populations with distinct roles in antigen uptake, processing, and presentati...

journal_title：European journal of immunology

authors： Ruedl C,Hubele S

更新日期：1997-06-01 00:00:00

abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

journal_title：European journal of immunology

authors： Ashman RF

更新日期：1976-06-01 00:00:00

abstract：:This is the first report on the establishment of the readily identifiable and functioning thymic nurse cell (TNC) clones from the mouse thymus. In the course of the culture of an epithelial cell line using a medium with a low concentration of Ca2+ from the spontaneous BALB/c thymic tumor, lymphocytes as well as thymic...

journal_title：European journal of immunology

authors： Itoh T,Doi H,Chin S,Nishimura T,Kasahara S

更新日期：1988-05-01 00:00:00

abstract：:A cDNA coding for the human interleukin 1 receptor antagonist protein (IL 1Ra) was used to clone the corresponding murine cDNA. The nucleotide sequence of the open reading frame coding for the processed form of mIL 1Ra predicted a 152-residue protein that was 77% identical to human IL 1Ra. The cellular and tissue dist...

journal_title：European journal of immunology

authors： Shuck ME,Eessalu TE,Tracey DE,Bienkowski MJ

更新日期：1991-11-01 00:00:00

abstract：:NK cells are the main cells of the innate immune system that produce IFN-γ, and they express this cytokine at early stages of maturation in response to cytokine stimulation. Conversely, acquisition of IFN-γ-competence in CD4(+) T helper cells requires a differentiation process from naïve toward type 1 (Th1) cells, whi...

journal_title：European journal of immunology

authors： Luetke-Eversloh M,Cicek BB,Siracusa F,Thom JT,Hamann A,Frischbutter S,Baumgrass R,Chang HD,Thiel A,Dong J,Romagnani C

更新日期：2014-07-01 00:00:00

abstract：:The immaturity of the neonatal immune system in mice is associated with defective IFN-gamma production and Th2-biased immune responses. In this study, infants vaccinated at birth with BCG produced similar concentrations of IFN-gamma in response to PPD and showed similar frequencies of IFN-gamma-producing lymphocytes a...

journal_title：European journal of immunology

authors： Vekemans J,Amedei A,Ota MO,D'Elios MM,Goetghebuer T,Ismaili J,Newport MJ,Del Prete G,Goldman M,McAdam KP,Marchant A

更新日期：2001-05-01 00:00:00

abstract：:The invariant chain (Ii) binds to newly synthesized major histocompatibility complex (MHC) class II molecules and is targeted to an acidic compartment where it is degraded. To evaluate its role on the conformation and the subcellular distribution of murine MHC class II molecules we have established stable L cell trans...

journal_title：European journal of immunology

authors： Humbert M,Raposo G,Cosson P,Reggio H,Davoust J,Salamero J

更新日期：1993-12-01 00:00:00

abstract：:Transgenic mice in which mouse interleukin (IL)-7 cDNA is expressed under the control of the mouse major histocompatibility complex (MHC) class II (E alpha) promoter develop a lymphoproliferative disease characterized by the early polyclonal expansion of T cells followed in many cases by the development of lymphomas o...

journal_title：European journal of immunology

authors： Mertsching E,Grawunder U,Meyer V,Rolink T,Ceredig R

更新日期：1996-01-01 00:00:00

abstract：:We have evaluated the life-span of B lymphocytes by measuring the functional reactivity of normal B cells upon transfer into xid mice, which do not respond to anti-mu, fluoresceinated-Ficoll (FL-Ficoll) and 2,4,6-trinitrophenyl aminoethylcarbamylmethyl Ficoll (TNP-Ficoll). After 4 days of transfer only 30-40% of anti-...

journal_title：European journal of immunology

authors： Udhayakumar V,Goud SN,Subbarao B

更新日期：1988-10-01 00:00:00

abstract：:The aim of this study was to investigate malignant lymphomas of donor origin induced in F1 mice undergoing a chronic graft-versus-host reaction (GVHR) after injection of parental strain spleen cells. A total of 3 X 10(8) or 4 X 10(8) C57BL/10 spleen cells were administered to 7-8-week-old H-2 incompatible (C57BL/10 X ...

journal_title：European journal of immunology

authors： Gleichmann E,Peters K,Lattmann E,Gleichmann H

更新日期：1976-06-01 00:00:00

abstract：:A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65-kDa heat-shock protein (hsp) as a putative causal agent. The 65-kDa hsp has over 40% sequence homology with the human hsp 60, and elevated synovial T cell resp...

journal_title：European journal of immunology

authors： Quayle AJ,Wilson KB,Li SG,Kjeldsen-Kragh J,Oftung F,Shinnick T,Sioud M,Førre O,Capra JD,Natvig JB

更新日期：1992-05-01 00:00:00

abstract：:An approach to the preparation of antigen-specific human monoclonal antibodies focuses on mice transgenic for human immunoglobulin gene miniloci; the V gene segments in these miniloci undergo productive rearrangement to yield mouse B cells expressing human immunoglobulin (Ig) chains. The general usefulness of this str...

journal_title：European journal of immunology

authors： Wagner SD,Popov AV,Davies SL,Xian J,Neuberger MS,Brüggemann M

更新日期：1994-11-01 00:00:00

abstract：:A single T cell clone can be activated by many different peptides in the context of a particular HLA molecule. To quantify the number of peptides that can be recognized by a CD4(+) T cell clone, we screened a one-bead-one-peptide synthetic peptide library and a protein database for peptides that stimulate an HLA-DR3-r...

journal_title：European journal of immunology

authors： Hiemstra HS,van Veelen PA,Willemen SJ,Benckhuijsen WE,Geluk A,de Vries RR,Roep BO,Drijfhout JW

更新日期：1999-08-01 00:00:00

abstract：:Stimulation of mixed lymphocyte cultures with ultraviolet (UV)-irradiated stimulator cells leads to selective activation of Lyt-2+ cytotoxic T lymphocyte precursors (CTL-P) to acquire interleukin 2 (IL2) reactivity: (a) no proliferative response, nor IL2 production was observed in these cultures; (b) upon addition of ...

journal_title：European journal of immunology

authors： Gullberg M,Larsson EL

更新日期：1982-12-01 00:00:00

abstract：:IL-33 is a novel cytokine of the IL-1 family and mediates its biological effect via the receptor ST2, which is selectively expressed on Th2 cells but not Th1 cells. IL-33 drives production of Th2-associated cytokines including IL-5 and IL-13 and thereby promotes defense and pathology in mucosal organs. Cell locomotion...

journal_title：European journal of immunology

authors： Komai-Koma M,Xu D,Li Y,McKenzie AN,McInnes IB,Liew FY

更新日期：2007-10-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is one of the key primary response genes in the immune system that can be activated by a variety of stimuli. Previous analysis of chromatin accessibility to DNaseI demonstrated open chromatin conformation of the TNF proximal promoter in T cells. Here, using chromatin probing with restrictio...

journal_title：European journal of immunology

authors： Shebzukhov YV,Horn K,Brazhnik KI,Drutskaya MS,Kuchmiy AA,Kuprash DV,Nedospasov SA

更新日期：2014-01-01 00:00:00

abstract：:The specificity of the IgM receptor expressed by human T cells cultured in IgM-free media has been investigated. IgM receptors have been detected using a rosette system with ox erythrocytes coated with rabbit antibody (EA(IgM)), and the inhibitory capacity of different IgM fragments in the rosette system has been test...

journal_title：European journal of immunology

authors： Ferrarini M,Moretta L,Mingari MC,Tonda P,Pernis B

更新日期：1976-07-01 00:00:00

abstract：:A mouse HER2-derived peptide, HER2p63 (A) (TYLPANASL), can induce K(d)-restricted mouse cytotoxic T lymphocytes (CTL) and also function as a tumor rejection antigen in an in vivo assay. Since the anchor motif of mouse K(d) for peptide binding has much similarity to that of human HLA-A2402, we asked if human HER2p63 (T...

journal_title：European journal of immunology

authors： Okugawa T,Ikuta Y,Takahashi Y,Obata H,Tanida K,Watanabe M,Imai S,Furugen R,Nagata Y,Toyoda N,Shiku H

更新日期：2000-11-01 00:00:00

abstract：:The activation requirements for antigen-dependent proliferation of CD4+ T cells are well documented, while the events leading to the inactivation phase are poorly understood. Here, we tested the hypothesis that the lymphocyte-activation gene 3 (LAG-3), a second major histocompatibility complex (MHC) class II ligand, p...

journal_title：European journal of immunology

authors： Huard B,Tournier M,Hercend T,Triebel F,Faure F

更新日期：1994-12-01 00:00:00

abstract：:Propionibacterium acnes-primed mice develop an IFN-gamma-dependent hypersensitivity towards LPS. Since CD14 plays a key role in LPS-induced cell activation the regulation and function of CD14 in this sensitization process were studied in IFN-gamma R-/- and the respective wild-type (wt) mice. In unprimed mice, CD14 (mR...

journal_title：European journal of immunology

authors： Merlin T,Woelky-Bruggmann R,Fearns C,Freudenberg M,Landmann R

更新日期：2002-03-01 00:00:00

abstract：:Psoriasis is an inflammatory disease of the skin affecting 2-3% of the population, characterized by a thickening of the epidermis and immune infiltrates throughout the dermis and epidermis, causing skin lesions that can seriously affect quality of life. The study of psoriasis has historically been hampered by the lack...

journal_title：European journal of immunology

authors： Flutter B,Nestle FO

更新日期：2013-12-01 00:00:00