Physiology of murine B lymphocytes. I. Life-spans of anti-mu and haptenated Ficoll (thymus-independent antigen)-reactive B cells.

abstract：:Alymphoplasia mice (aly/aly) have been shown to be deficient for a nuclear factor-kappaB-inducing kinase involved in signal transduction of lymphotoxin beta receptor (LT-betaR) and of CD40, resulting in structural defects of secondary lymphoid organs and highly increased susceptibility to viral infections. We analyzed...

journal_title：European journal of immunology

authors： Karrer U,Althage A,Odermatt B,Hengartner H,Zinkernagel RM

更新日期：2000-10-01 00:00:00

abstract：:C57BL/10ScCr (Cr) mice carry a deletion of the Toll-like receptor 4 (tlr4) gene (i.e. they are tlr4(0/0)) and are thus refractory to LPS effects. Insertion of wild-type tlr4 transgene into the tlr4(0/0) Cr germ line endowed LPS susceptibility in the two transgenic lines created, indicating that TLR4 is the only limiti...

journal_title：European journal of immunology

authors： Kalis C,Kanzler B,Lembo A,Poltorak A,Galanos C,Freudenberg MA

更新日期：2003-03-01 00:00:00

abstract：:An expanding spectrum of acute and chronic non-infectious inflammatory diseases is uniquely responsive to IL-1β neutralization. IL-1β-mediated diseases are often called "auto-inflammatory" and the dominant finding is the release of the active form of IL-1β driven by endogenous molecules acting on the monocyte/macropha...

journal_title：European journal of immunology

authors： Dinarello CA

更新日期：2011-05-01 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) has been described as an important autoantigen in rheumatoid arthritis (RA) since it is targeted by autoantibodies, autoreactive T cells, and is aberrantly expressed in synovial cells in patients. To identify hnRNP-A2-specific T-cell epitopes possibly associate...

journal_title：European journal of immunology

authors： Trembleau S,Hoffmann M,Meyer B,Nell V,Radner H,Zauner W,Hammer J,Aichinger G,Fischer G,Smolen J,Steiner G

更新日期：2010-06-01 00:00:00

abstract：:The requirement for cell interactions in T cell activation has been studied with two continuously in vitro growing T cell clones. These clones are specific for minor histocompatibility antigens, are H-2K restricted, and one clone is functionally a cytolytic T lymphocyte. Both can proliferate when interleukin 2 is adde...

journal_title：European journal of immunology

authors： Di Pauli R,Brückner T

更新日期：1984-10-01 00:00:00

abstract：:Lymphocyte function-associated-antigen-1 (LFA-1) is able to bind selectively to its ligands intercellular adhesion molecules 1 and 3 (ICAM-1 and ICAM-3), suggesting that LFA-1 can exist in distinct ligand-specific binding states. In the case of ICAM-1, apart from ligand itself and the recently cloned molecule cytohesi...

journal_title：European journal of immunology

authors： Buckley CD,Ferguson ED,Littler AJ,Bossy D,Simmons DL

更新日期：1997-04-01 00:00:00

abstract：:As we approach the centenary of Elie Metchnikoff's Nobel Prize (1908), it is opportune to reflect upon the history of macrophage immunobiology, take stock of current knowledge and anticipate questions for the future. Starting from his appreciation of phagocytosis as an important determinant of host defence against inf...

journal_title：European journal of immunology

authors： Gordon S

更新日期：2007-11-01 00:00:00

abstract：:Natural killer (NK) cells in normal mouse spleen have so far been found to lack conventional cell surface markers. Recently, neuraminidase treatment has been shown to uncover receptors for the A hemagglutinin of the snail Helix pomatia (HP) on populations (preferentially T cells) of human blood lymphocytes. We have us...

journal_title：European journal of immunology

authors： Haller O,Gidlund M,Hellström U,Hammarström S,Wigzell H

更新日期：1978-11-01 00:00:00

abstract：:NK cells are important for the control of vaccinia virus (VV) in vivo. Recent studies have shown that multiple pathways are required for effective activation of NK cells. These include both TLR-dependent and -independent pathways, as well as the NKG2D activating receptor that recognizes host stress-induced NKG2D ligan...

journal_title：European journal of immunology

authors： Brandstadter JD,Huang X,Yang Y

更新日期：2014-09-01 00:00:00

abstract：:The cell surface molecule CD44, thought to be a cell surface receptor for hyaluronic acid, is expressed by thymocytes and peripheral T cells. Following T cell activation with mitogens or antigens, surface expression of CD44 increases. This increase in CD44 cell surface expression has been used as a means of identifyin...

journal_title：European journal of immunology

authors： Haegel H,Ceredig R

更新日期：1991-06-01 00:00:00

abstract：:Monocyte/macrophage-mediated cytotoxicity requires the generation of activated oxygen radicals, which can be measured by chemiluminescence (CL). To investigate whether natural killer (NK) cell activity required activated oxygen species, both cytotoxicity against K562 target cells and CL were measured in cell populatio...

journal_title：European journal of immunology

authors： Ernst M,Lange A,Flad HD,Havel A,Ennen J,Ulmer AJ

更新日期：1984-07-01 00:00:00

abstract：:The expression of interferon (IFN) β is highly induced in immune and nonimmune cells in response to virus infection. This upregulation is mediated at both transcriptional and posttranscriptional levels. Whereas the signaling pathways triggered by innate virus receptors leading to transcription factor activation have b...

journal_title：European journal of immunology

authors： Takeuchi O

更新日期：2015-05-01 00:00:00

abstract：:Act1 is a negative regulator of B-cell activation factor of the TNF family (BAFF) and CD40L-induced signaling. BALB/C mice lacking Act1 develop systemic autoimmunity resembling systemic lupus erythematosus (SLE) and Sjögren's syndrome (SjS). SLE and SjS are characterized by anti-nuclear IgG autoantibody (ANA-IgG) prod...

journal_title：European journal of immunology

authors： Johnson AC,Davison LM,Giltiay NV,Vareechon C,Li X,Jørgensen TN

更新日期：2012-07-01 00:00:00

abstract：:CTLA-4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble CTLA-4 isoform (sC...

journal_title：European journal of immunology

authors： Ward FJ,Dahal LN,Wijesekera SK,Abdul-Jawad SK,Kaewarpai T,Xu H,Vickers MA,Barker RN

更新日期：2013-05-01 00:00:00

abstract：:B cells get help in the antibody response by presenting antigen to helper T (Th) cells. Upon antigen recognition, T cells produce lymphokines that act as growth and differentiation factors for B cells, but resting B cells require additional helper signals that depend on cell contact with an activated Th cell. Like lym...

journal_title：European journal of immunology

authors： Kawakami K,Parker DC

更新日期：1992-01-01 00:00:00

abstract：:Antigen-presenting cells (APC), including dendritic cells and macrophages, produce a large amount of interferon (IFN)-gamma, a crucial cytokine for the control of infectious diseases. To elucidate the role of IFN-gamma from APC in vivo, we employed cytokine receptor common gamma subunit (gamma c) and recombination-act...

journal_title：European journal of immunology

authors： Suzue K,Asai T,Takeuchi T,Koyasu S

更新日期：2003-10-01 00:00:00

abstract：:To investigate the effect of HIV-specific CD8(+) T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8(+) T cells directed against several HIV epitopes in a total of 54 patients by the use of tetrameric HLA-peptide complexes. In patients with high CD4(+) T cell numbers...

journal_title：European journal of immunology

authors： Kostense S,Ogg GS,Manting EH,Gillespie G,Joling J,Vandenberghe K,Veenhof EZ,van Baarle D,Jurriaans S,Klein MR,Miedema F

更新日期：2001-03-01 00:00:00

abstract：:Both interleukin-7 (IL-7) and IL-7 receptor (R) gene knockout (IL-7-/- and IL-7R-/-) mice were employed in order to directly investigate the importance of the IL-7 and IL-7R signaling pathway for the development of intestinal intraepithelial lymphocytes (IEL). Loss of the IL-7R-specific gene resulted in complete defic...

journal_title：European journal of immunology

authors： Fujihashi K,McGhee JR,Yamamoto M,Peschon JJ,Kiyono H

更新日期：1997-09-01 00:00:00

abstract：:The development of preventive or therapeutic recombinant vaccines and the generation of serodiagnostic assays for infectious diseases depend essentially on the availability of molecularly defined antigens. A major bottleneck for the identification of suitable target antigens for many pathogens is the isolation of suff...

journal_title：European journal of immunology

authors： Sahin U,Türeci O,Graf C,Meyer RG,Lennerz V,Britten CM,Dumrese C,Scandella E,Wölfel T,Ludewig B

更新日期：2006-04-01 00:00:00

abstract：:Cellular immune responses are likely to play a key role in determining the clinical outcome in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their relationship to viral clearance are poorly understood. In a previous study we have shown highly activated, multispecific cytotoxic T ...

journal_title：European journal of immunology

authors： Lechner F,Gruener NH,Urbani S,Uggeri J,Santantonio T,Kammer AR,Cerny A,Phillips R,Ferrari C,Pape GR,Klenerman P

更新日期：2000-09-01 00:00:00

abstract：:Activation of T cells was shown to up-regulate the Fas ligand (FasL) which binds to the CD95 (APO-1/Fas) antigen and mediates activation-induced cell death (AICD) of activated T cells and T lymphoma cells. A recent report showed that mouse B cells express the FasL upon activation with lipopolysaccharide (LPS). We ther...

journal_title：European journal of immunology

authors： Daniel PT,Oettinger U,Mapara MY,Bommert K,Bargou R,Dörken B

更新日期：1997-04-01 00:00:00

abstract：:CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2-cell-mediated disease. In the present study, we investigated the role of CD30 in the maintenance ...

journal_title：European journal of immunology

authors： Polte T,Fuchs L,Behrendt AK,Hansen G

更新日期：2009-07-01 00:00:00

abstract：:Cervical thymus mimics the thoracic thymus in supporting T-cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus can generate T cells that are self-tolerant in the complete absence of signals from the thoracic thymus. Using a fetal liver reconstitution ...

journal_title：European journal of immunology

authors： Smolarchuk C,Zhu LF,Chan WF,Anderson CC

更新日期：2014-08-01 00:00:00

abstract：:Despite the differences in the molecular structure between lipopolysaccharides (LPS) isolated from Escherichia coli, Klebsiella pneumoniae or Salmonella typhimurium, the potential differences in their biological effects in vivo have not been investigated. In the present study, TNF and LT double knock-out (TNF-/-LT-/-)...

journal_title：European journal of immunology

authors： Netea MG,Kullberg BJ,Joosten LA,Sprong T,Verschueren I,Boerman OC,Amiot F,van den Berg WB,Van der Meer JW

更新日期：2001-09-01 00:00:00

abstract：:Immunoglobulin (Ig) production by lipopolysaccharide (LPS)-stimulated cells in the presence of various combinations of interleukin (IL)2, IL4 and IL5 was examined. IgG1, IgM and IgE secretion was studied using a 3T3-fibroblast filler cell-supported B cell culture system, either at low cell density to support maximal I...

journal_title：European journal of immunology

authors： McHeyzer-Williams MG

更新日期：1989-11-01 00:00:00

abstract：:A mouse HER2-derived peptide, HER2p63 (A) (TYLPANASL), can induce K(d)-restricted mouse cytotoxic T lymphocytes (CTL) and also function as a tumor rejection antigen in an in vivo assay. Since the anchor motif of mouse K(d) for peptide binding has much similarity to that of human HLA-A2402, we asked if human HER2p63 (T...

journal_title：European journal of immunology

authors： Okugawa T,Ikuta Y,Takahashi Y,Obata H,Tanida K,Watanabe M,Imai S,Furugen R,Nagata Y,Toyoda N,Shiku H

更新日期：2000-11-01 00:00:00

abstract：:The T cell-dependent differentiation and function of B lymphocytes are tightly regulated by TNF ligands (L) and receptors interactions, such as CD40/CD40L, CD27/CD70 and CD134/CD314L. The LIGHT/HVEM system [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the herpes vir...

journal_title：European journal of immunology

authors： Duhen T,Pasero C,Mallet F,Barbarat B,Olive D,Costello RT

更新日期：2004-12-01 00:00:00

abstract：:The effect of high antigen dose on the activation of cytochrome c peptide-primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide-specific T cells was completely inhibited at high antigen concentration in C57BL/6 but onl...

journal_title：European journal of immunology

authors： Ceredig R,Corradin G

更新日期：1986-01-01 00:00:00

abstract：:Murine Thy-1+, TcR V gamma 3/V delta 1+ dendritic epidermal T cells (DETC) differ from most other T cell subsets by the absence of CD4 and CD8 antigens as well as the lack of CD5 expression. To see whether negativity for those antigens is an intrinsic feature of a given T cell population or if such triple-negative T c...

journal_title：European journal of immunology

authors： Payer E,Kutil R,Stingl G

更新日期：1994-06-01 00:00:00

abstract：:This study describes a CD5+ B cell that differs from the majority of the CD5+ B cells from human tonsils. This cell, isolated from in vivo activated B cells, expressed activation markers and featured a CD23-, IgMhigh, IgDlow surface phenotype, responded to T cell-independent type-2 antigens in vitro, and was detected ...

journal_title：European journal of immunology

authors： Dono M,Burgio VL,Colombo M,Sciacchitano S,Reverberi D,Tarantino V,Cutrona G,Chiorazzi N,Ferrarini M

更新日期：2007-08-01 00:00:00