当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes.

Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes.

Abstract：

:Propionibacterium acnes-primed mice develop an IFN-gamma-dependent hypersensitivity towards LPS. Since CD14 plays a key role in LPS-induced cell activation the regulation and function of CD14 in this sensitization process were studied in IFN-gamma R-/- and the respective wild-type (wt) mice. In unprimed mice, CD14 (mRNA and protein) was either absent (liver) or only weakly expressed in organs (spleen, lung) and in plasma. Priming with P. acnes led to a moderate, mainly IFN-gamma-dependent up-regulation of CD14. LPS challenge of unprimed mice induced an IFN-gamma-independent increase in CD14 mRNA and CD14 protein. LPS challenge of P. acnes-primed mice induced a strong CD14 overexpression. This response was completely absent in IFN-gamma R-/- mice and is therefore strictly IFN-gamma-dependent. The requirement for CD14 in LPS hyper-responsiveness was assessed by comparing CD14-/- and the respective wt mice with respect to their ability to produce TNF and IFN-gamma, two recognized indices of LPS activity. LPS challenge without priming led to a weaker cytokine reaction in CD14-/- than in wt mice. However, priming with P. acnes enhanced the cytokine response to LPS in both wt and CD14-/- mice, although in the latter absolute levels of cytokines were lower. Therefore, hyperreactivity to LPS is characterized by an up-regulation of CD14, but the sensitization by P. acnes is not CD14 dependent.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Merlin T,Woelky-Bruggmann R,Fearns C,Freudenberg M,Landmann R

doi

10.1002/1521-4141(200203)32:3<761::AID-IMMU761>3.0

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

761-72

issue

3

eissn

0014-2980

issn

1521-4141

journal_volume

32

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Inhibition of clonal expansion by Foxp3 expression as a mechanism of controlled T-cell responses and autoimmune disease.

    abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939404

    authors： Guo L,Tian J,Marinova E,Zheng B,Han S

    更新日期：2010-01-01 00:00:00

  • A new method of radioiodine labeling of polyanionic macromolecules for radioimmunoassay.

    abstract：:A method is described for radiolabeling polyanionic macromolecules by the formation of an electrostatic complex with a radioiodinated tyramine conjugated DEAE-dextran. Data is presented on the use of this technique for the detection and quantitation of immunospecific binding of polynitrophenylated proteins, deoxyribon...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830050604

    authors： Little JR,Blanke TJ,Little KD

    更新日期：1976-06-01 00:00:00

  • Inhibition of the responses of a cloned CD4+ T cell line to different class II major histocompatibility complex ligands by anti-CD4 and by anti-receptor Fab fragments are directly related.

    abstract：:The responses of a single cloned T cell line to three different class II major histocompatibility complex (MHC) ligands have been compared for avidity, determined by inhibition with anti-T cell receptor Fab fragments directed at two different receptor epitopes, and for ease of inhibition with anti-CD4 antibody. It has...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830190114

    authors： Portoles P,Janeway CA Jr

    更新日期：1989-01-01 00:00:00

  • Induction of interleukin-2 transcription by the hamster polyomavirus middle T antigen: a role for Fyn in T cell signal transduction.

    abstract：:The transforming protein of mouse polyomavirus, the mouse middle T antigen (MomT), and its counterpart in the hamster polyomavirus, the hamster middle T antigen (HamT), interact with a number of cellular proteins. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3-kinase, the ser...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250212

    authors： Brizuela L,Ulug ET,Jones MA,Courtneidge SA

    更新日期：1995-02-01 00:00:00

  • 5'-Ectonucleotidase/CD73 expression on lymph-circulating lymphocytes and lymphatic endothelial cells offers new paths to explore barrier function.

    abstract：:5'-Nucleotidase/CD73 is a key enzyme in the regulation of purinergic signaling, hydrolyzing extracellular AMP to produce adenosine, which is critical in the blood vascular system and in immunosuppression. CD73 is expressed by both blood endothelial cells and lymphatic endothelial cells. Although the role of CD73 on bl...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.201445400

    authors： Sidibé A,Imhof BA

    更新日期：2015-02-01 00:00:00

  • Major histocompatibility complex class I presentation of exogenously acquired minor alloantigens initiates skin allograft rejection.

    abstract：:Major histocompatibility complex (MHC) class I molecules present peptides from endogenous proteins. However, in some cases class I-restricted peptides can also derive from exogenous antigens. This MHC class I exogenous presentation could be involved in minor histocompatibility antigen (mHAg)-disparate allograft reject...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830271251

    authors： Oukka M,Galou M,Belkaid Y,Tricotet V,Riche N,Reynes M,Kosmatopoulos K

    更新日期：1997-12-01 00:00:00

  • Variable region genes of anti-histone autoantibodies from a MRL/Mp-lpr/lpr mouse.

    abstract：:The variable region nucleotide sequences of seven (five IgM and two IgG) anti-histone monoclonal antibodies from a single MRL/Mp-lpr/lpr mouse have been determined. These antibodies are not clonally related and used diverse V, D and J genes. However, six of the seven antibodies have VH segments encoded by genes from t...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210721

    authors： Monestier M

    更新日期：1991-07-01 00:00:00

  • The selective localization of B lymphocytes in the spleen and the role of complement receptors.

    abstract：:The role of complement receptors on the localization of T and B cells in the spleen of mice was studied using short-term homing experiments in cobra venom factor (CoF)-treated animals. The localization ratio of B and T cells in the spleen of CoF-treated mice decreased significantly compared to control recipients. No c...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830150708

    authors： Kraal G,Van Hoogstraten I,Klerx JP,Van Dijk H

    更新日期：1985-07-01 00:00:00

  • Thermostability analysis of major histocompatibility complex class I molecules by temperature gradient gel electrophoresis.

    abstract：:Empty major histocompatibility complex (MHC) class I molecules present on the surface of RMA-S (26 degrees C) cells were loaded with the iodinated peptides APGNYPAL, FAPGNYPAL (SEV-9) and RGYVYQGL (VSV-8), respectively. The thermostability of these peptide-loaded MHC class I molecules was assessed using temperature gr...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830230847

    authors： Tulp A,Verwoerd DJ

    更新日期：1993-08-01 00:00:00

  • Cancer-promoting tumor-associated macrophages: new vistas and open questions.

    abstract：:Tumor-associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer- and host cell-derived signals generally drive the functions of TAMs towards an M2-like polarized, tumor-propelling mode; however, when appropriately re-educated. TAMs also have the potential to elicit tumor destructive reacti...

    journal_title：European journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1002/eji.201141894

    authors： Mantovani A,Germano G,Marchesi F,Locatelli M,Biswas SK

    更新日期：2011-09-01 00:00:00

  • Differential expression of the T cell receptor/CD3 genes and their lymphoid-specific transcription factor genes in murine T cell x fibroblast and T cell x B cell hybrids.

    abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250947

    authors： Yamada T,Hitomi Y,Satake M,Oikawa T

    更新日期：1995-09-01 00:00:00

  • Delayed-type hypersensitivity induced in immunodeficient mice with syngeneic modified self antigens: a suggestive model of autoimmune response.

    abstract：:Previous studies suggested that trinitrophenyl (TNP)-modified syngeneic red cells induced humoral autoimmune response in mice with defective T cell function but not in normal mice. The ability of modified self antigen to induce autoimmune response in immunodeficient mice was further explored using the delayed-type hyp...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830121112

    authors： Tarcic N,Naor D

    更新日期：1982-11-01 00:00:00

  • Differentiation factors for human specific B cell response.

    abstract：:Nonspecific T cell factors produced by lectin-activated human peripheral blood lymphocytes (PBL) were used to restore the T-dependent B cell response to trinitrophenyl-polyacrylamide (TNP-PAA). Preincubation experiments with the particulate antigen TNP-PAA and/or a soluble TNP-protein conjugate show that a first speci...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160714

    authors： Vazquez A,Gerard JP,Delfraissy JF,Dugas B,Auffredou MT,Crevon MC,Fradelizi D,Galanaud P

    更新日期：1986-07-01 00:00:00

  • Microvesicles released by apoptotic human neutrophils suppress proliferation and IL-2/IL-2 receptor expression of resting T helper cells.

    abstract：:Membrane-coated microvesicles (MVs) have been identified as important mediators in intercellular communication. During the process of apoptosis, dying cells dynamically release MVs. Neutrophils are the most abundant type of leukocytes in the circulation. Due to their very short lifespan, it is likely that they are the...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201546203

    authors： Shen G,Krienke S,Schiller P,Nießen A,Neu S,Eckstein V,Schiller M,Lorenz HM,Tykocinski LO

    更新日期：2017-05-01 00:00:00

  • Environmental and allele-specific influences on T cell receptor gene rearrangement: skewed alpha, delta, and gamma gene rearrangement patterns in chimeric mice.

    abstract：:This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a fetal liver or adult b...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830211208

    authors： Larché M,Manzo AR,Hurwitz JL

    更新日期：1991-12-01 00:00:00

  • Guinea pig immunoglobulin light chain isotypes. II. The preferential expression of lambda chain-bearing anti-phenyltrimethylammonium antibodies is associated with restricted variable region expression, but not with any alteration in the proportion of lamb

    abstract：:The inbred strain 13 guinea pig expresses at least three isotypes of immunoglobulin (Ig) lambda chain. The proportion of these isotypes in normal Ig can be estimated by isolating a constant (C) region cyanogen bromide peptide from lambda chains and quantitatively analyzing its component tryptic peptides. Anti-phenyltr...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830081212

    authors： Brunhouse RF,Cebra JJ

    更新日期：1978-12-01 00:00:00

  • Pyk2 is differentially regulated by beta1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes.

    abstract：:Beta1 integrins can provide T cell co-stimulation, but little is known concerning their downstream signaling pathways. We found that Pyk2, a focal adhesion kinase-related tyrosine kinase, is regulated by beta1 integrin signaling in human T cells. Stimulation of Jurkat T cells with the alpha4beta1 integrin ligand VCAM-...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199811)28:11<3867::AID-IMM

    authors： van Seventer GA,Mullen MM,van Seventer JM

    更新日期：1998-11-01 00:00:00

  • B cells activated via CD40 and IL-4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation.

    abstract：:T cell stimulation of B cell proliferation during T-B collaboration requires membrane-bound stimulatory ligands, such as CD40 ligand and the secretion of soluble cytokines, such as IL-4. Nevertheless, it remains unclear whether T cell contact is required to provoke each consecutive B cell division, or whether B cells ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200104)31:4<1150::aid-immu1150>3

    authors： Rush JS,Hodgkin PD

    更新日期：2001-04-01 00:00:00

  • Interaction of cutaneous stromal cells and gamma/delta T cell receptor (TcR)-positive cells. I. V gamma 5-gamma/delta TcR+ T cells migrating from organ-cultured murine skin proliferate by co-culture with cutaneous stromal cells in the presence of interleu

    abstract：:It has been reported that Thy-1+CD3+CD4-CD8- cells as well as Langerhans cells migrate from organ-cultured murine skin into culture medium. We examined whether these Thy-1+ populations of migrating cells were derived from Thy-1+ dendritic epidermal T cells (Thy-1+ DEC) and found that they were Thy-1+CD3+CD4-CD8-gamma/...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830230746

    authors： Nakagawa S,Hara M,Seki M,Yagita H,Tagami H,Aiba S

    更新日期：1993-07-01 00:00:00

  • Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice.

    abstract：:Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process. However, Tfr-cell function in the GC is not well understood. Here, we define Tfr cells as a C...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201546094

    authors： Wu H,Chen Y,Liu H,Xu LL,Teuscher P,Wang S,Lu S,Dent AL

    更新日期：2016-05-01 00:00:00

  • Heterogeneity in the molecular defect leading to the leukocyte adhesion deficiency.

    abstract：:Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of leukocyte adhesion glycoproteins. These proteins, LFA-1, Mac-1 and p150,95, are alpha 1/beta 1 heterodimers...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830181016

    authors： Dimanche-Boitrel MT,Guyot A,De Saint-Basile G,Fischer A,Griscelli C,Lisowska-Grospierre B

    更新日期：1988-10-01 00:00:00

  • A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules.

    abstract：:The heat shock protein (HSP) Hsp90 is known to chaperone cytosolic peptides for MHC class I (MHCI)-restricted antigen presentation to T lymphocytes. We now demonstrate a role for Hsp90 activity in presentation of antigens on MHCII. Treatment of mouse antigen-presenting cells (APC) with the pharmacological Hsp90 inhibi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200535326

    authors： Rajagopal D,Bal V,Mayor S,George A,Rath S

    更新日期：2006-04-01 00:00:00

  • Interaction within clusters of dendritic cells and helper T cells during initial Th1/Th2 commitment.

    abstract：:Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(200005)30:5<1255::AID-IMMU

    authors： Schuhbauer DM,Mitchison NA,Mueller B

    更新日期：2000-05-01 00:00:00

  • Trypanosome-induced suppression of anti-parasite responses during experimental African trypanosomiasis.

    abstract：:The effect of Trypanosoma brucei infections on parasite-specific antibody responses was examined by immunization of infected mice with radio-attenuated trypanosomes of a noncross-reacting clone. Antibody titers (total Ig) against variant surface antigen were determined by indirect immunofluorescence. The suppression r...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830101216

    authors： Sacks DL,Askonas BA

    更新日期：1980-12-01 00:00:00

  • α-Galactosylceramide-activated murine NK1.1(+) invariant-NKT cells in the myometrium induce miscarriages in mice.

    abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201545923

    authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

    更新日期：2016-08-01 00:00:00

  • MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways.

    abstract：:Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development of Th2-dependent airw...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200838985

    authors： Jung YW,Zindl CL,Lai JF,Weaver CT,Chaplin DD

    更新日期：2009-08-01 00:00:00

  • IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells.

    abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200101)31:1<243::AID-IMMU243>3.0

    authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

    更新日期：2001-01-01 00:00:00

  • Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies.

    abstract：:The cytokines interleukin (IL)-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitor factor (LIF), oncostatin M (OSM) and probably the recently cloned cytokine cardiotrophin-1, signal, in combination with their specific receptors, through the common signal transducer gp130. Here, we report that the signalin...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830251240

    authors： Wijdenes J,Heinrich PC,Müller-Newen G,Roche C,Gu ZJ,Clément C,Klein B

    更新日期：1995-12-01 00:00:00

  • Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells.

    abstract：:Accumulating evidence suggest that infection with Chlamydia pneumoniae is associated with atherosclerosis, but the mechanisms involved remain unclear. Inflammation is important in the initial phase of atherogenesis, and cytokines are important in the initiation and progression of inflammation. The aim of this study wa...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200002)30:2<541::AID-IMMU541>3.0

    authors： Netea MG,Selzman CH,Kullberg BJ,Galama JM,Weinberg A,Stalenhoef AF,Van der Meer JW,Dinarello CA

    更新日期：2000-02-01 00:00:00

  • Evidence that the level of the p55 component of the interleukin (IL) 2 receptor can control IL 2 responsiveness in a murine IL 3-dependent cell.

    abstract：:Although the role of interleukin 2 (IL 2) in mature T lymphocyte function is well documented, its effect on hematopoietic progenitor cells is less well characterized. Here we have used recombinant retroviruses to transduce and express a cDNA clone encoding the p55 component of the human IL 2 receptor (h-p55), in a mur...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200317

    authors： Collins MK,Malde P,Miyajima A,Arai K,Smith KA,Mulligan RC

    更新日期：1990-03-01 00:00:00