当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Immunologic induction of reticulum cell sarcoma: donor-type lymphomas in the graft-versus-host model.

Immunologic induction of reticulum cell sarcoma: donor-type lymphomas in the graft-versus-host model.

Abstract：

:The aim of this study was to investigate malignant lymphomas of donor origin induced in F1 mice undergoing a chronic graft-versus-host reaction (GVHR) after injection of parental strain spleen cells. A total of 3 X 10(8) or 4 X 10(8) C57BL/10 spleen cells were administered to 7-8-week-old H-2 incompatible (C57BL/10 X HTG)F1 hybrids either as single or fractionated i.p. injections. Recipients were killed at intervals ranging from 1 month to 1 year after the first injection and their lymphoid cells typed for host-derived and donor-derived histocompatibility antigens. In 49% of the 88 GVH F1 mice, cells failed to be killed by a hyperimmune serum against HTG (H-2g) but reacted normally with antisera to C57BL/10 (H-2b) and, in the 9 cases tested, to theta-C3H. The conclusion that the lymphoid cells of these mice were derived from donor cells was supported by the finding that these animals lacked immunoglobulins bearing host-derived Iga allotype in their serum. Forty-three percent of the GVH F1 mice developed reticulum cell sarcomas (RCS), 32% revealed hyperplastic lymphoreticular tissue, and 25% showed no grossly abnormal changes. Mice with donor-type lymphoid tissues were found in all three groups; 50% of the 38 RCS detected were donor-type neoplasms. The induction of donor-type RCS during the GVHR strengthens the concept of lymphomagenesis through persistent stimulation with antigen(s).

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Gleichmann E,Peters K,Lattmann E,Gleichmann H

doi

10.1002/eji.1830050610

keywords:

subject

Has Abstract

pub_date

1976-06-01 00:00:00

pages

406-12

issue

6

eissn

0014-2980

issn

1521-4141

journal_volume

5

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Enhancement of terminal B lymphocyte differentiation in vitro by fibroblast-like stromal cells from human spleen.

    abstract：:Stromal elements are major components of lymphoid tissues contributing to both tissue architecture and function. In this study we report on the phenotype and function of fibroblast-like stromal cells obtained from human spleen. These cells express high levels of CD44 and ICAM-1 and moderate levels of VLA-4, VCAM, CD40...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199812)28:12<3940::AID-IMM

    authors： Skibinski G,Skibinska A,Stewart GD,James K

    更新日期：1998-12-01 00:00:00

  • Immunologically discrete conformation isomers of I-A locus-equivalent class II molecules detected in Lewis rats.

    abstract：:Monoclonal antibodies MRC-OX6 and MRC-OX3 were used to define biosynthetically inter-related subsets of I-A-equivalent class II molecules from Lewis rat spleen cells. MRC-OX6 was shown to recognize specifically multiple forms of the class II molecule arising along its maturation pathway from the origin of polypeptide ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830151216

    authors： Reske K,Weitzel R

    更新日期：1985-12-01 00:00:00

  • Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen.

    abstract：:A panel of HLA-DRB1*0401-restricted CD4+ mouse T cell hybridomas specific for bovine type II collagen were generated from transgenic mice expressing the human HLA-DRA1*0101/-DRB1*0401 and CD4 molecules. The vast majority recognized a single peptide determinant corresponding to residues 261-273 (CII 261-273). This dete...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260431

    authors： Fugger L,Rothbard JB,Sonderstrup-McDevitt G

    更新日期：1996-04-01 00:00:00

  • Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers.

    abstract：:Immunization leads to the generation of both antibody-forming cells (AFC) and memory B cells which are thought to arise in germinal centers within lymphoid follicles. The findings that the precursors to memory B cells reside in the J11Dlo subpopulation of the spleens in non-immune mice and that this subpopulation is d...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220526

    authors： Linton PJ,Lo D,Lai L,Thorbecke GJ,Klinman NR

    更新日期：1992-05-01 00:00:00

  • Reduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions.

    abstract：:The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subsequent extravasation to the tissues is a key step during different physiological and pathological processes. In certain of these pathologies the oxygen tension becomes very low, leading to reduced cellular oxidative statu...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270818

    authors： Montoya MC,Luscinskas FW,del Pozo MA,Aragonés J,de Landázuri MO

    更新日期：1997-08-01 00:00:00

  • CD40 ligand is a T cell growth factor.

    abstract：:CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830230941

    authors： Armitage RJ,Tough TW,Macduff BM,Fanslow WC,Spriggs MK,Ramsdell F,Alderson MR

    更新日期：1993-09-01 00:00:00

  • Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal.

    abstract：:Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199808)28:08<2424::AID-IMM

    authors： Roers A,Montesinos-Rongen M,Hansmann ML,Rajewsky K,Küppers R

    更新日期：1998-08-01 00:00:00

  • Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer.

    abstract：:Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune-related adverse events, most likely due to the breadth of the induced T-cell activation. Here, we investigated the efficacy of a local low-dose...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201646583

    authors： van Hooren L,Sandin LC,Moskalev I,Ellmark P,Dimberg A,Black P,Tötterman TH,Mangsbo SM

    更新日期：2017-02-01 00:00:00

  • Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces.

    abstract：:Maintenance of homeostasis at body barriers that are constantly challenged by microbes, toxins and potentially bioactive (macro)molecules requires complex, highly orchestrated mechanisms of protection. Recent discoveries in respiratory research have shed light on the unprecedented role of airway epithelial cells (AEC)...

    journal_title：European journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1002/eji.201847811

    authors： Smole U,Kratzer B,Pickl WF

    更新日期：2020-05-01 00:00:00

  • The repertoire of serum IgM in normal mice is largely independent of external antigenic contact.

    abstract：:Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270635

    authors： Haury M,Sundblad A,Grandien A,Barreau C,Coutinho A,Nobrega A

    更新日期：1997-06-01 00:00:00

  • Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant.

    abstract：:We recently reported that parenteral injection of malaria palmitoyl-tailed peptides without adjuvant efficiently induces B, Th and CTL responses. We now show that intranasal (IN) or sub-lingual (SL) delivery of such lipopeptides induces strong systemic immune responses, as demonstrated by specific Th cell responses fr...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200208)32:8<2274::AID-IMMU2274>3

    authors： BenMohamed L,Belkaid Y,Loing E,Brahimi K,Gras-Masse H,Druilhe P

    更新日期：2002-08-01 00:00:00

  • Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production.

    abstract：:The effector function of activated CD4(+) T cells and secretion of cytokines are important in the establishment of productive immune responses and tolerance. We identified expression by CD4(+) T cells of Notch receptors and ligands and enhanced Notch signaling upon activation. Notch1 expression was up regulated and co...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425562

    authors： Benson RA,Adamson K,Corsin-Jimenez M,Marley JV,Wahl KA,Lamb JR,Howie SE

    更新日期：2005-03-01 00:00:00

  • Maternal-fetal tolerance is maintained despite transgene-driven trophoblast expression of MHC class I, and defects in Fas and its ligand.

    abstract：:During mammalian pregnancy, one or more semiallogeneic fetuses gestate in direct contact with the maternal circulation and uterine tissue. However, a damaging maternal immune response is not normally provoked. We studied two possible mechanisms for this maternal-fetal tolerance, alone and in combination. First, we dir...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199811)28:11<3479::AID-IMM

    authors： Rogers AM,Boime I,Connolly J,Cook JR,Russell JH

    更新日期：1998-11-01 00:00:00

  • Microfilaments make mast cells migrate (rather than degranulate).

    abstract：:Expression of the high-affinity receptor for IgE (FcεRI) provides mast cells with the ability to react in a proinflammatory manner to antigens (Ags). In particular, the immediate secretion of preformed mediators from secretory lysosomes (degranulation) is typical for FcεRI-mediated mast cell activation. In addition to...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.201343706

    authors： Huber M

    更新日期：2013-07-01 00:00:00

  • NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.

    abstract：:Ig class switch recombination (CSR) is dependent upon the expression of activation-induced deaminase and targeted to specific isotypes by germ-line transcript expression and isotype-specific factors. NF-kappaB plays critical roles in multiple aspects of B cell biology and has been implicated in the mechanism of CSR by...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200636294

    authors： Wang L,Wuerffel R,Kenter AL

    更新日期：2006-12-01 00:00:00

  • An allotype-associated polymorphism in the gamma3 promoter determines the germ-line gamma3 transcriptional rate but does not influence switching and subsequent IgG3 production.

    abstract：:The human IgG3 (b) allotype is associated with a high and the (g) allotype with a low mean serum level of IgG3 which is due to a low frequency of B cell switching in the latter. In the present study, we found a polymorphism in position -73 (C --> A), located in the 4th NF-kappaB site of the germ-line (GL) gamma3 promo...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(2000)30:8<2388::AID-IMMU2388>3.0

    authors： Pan Q,Petit-Frére C,Hammarström L

    更新日期：2000-08-01 00:00:00

  • Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding.

    abstract：:MICA and MICB (MHC-class-I-related chain A/B) are transmembrane proteins expressed in pathological conditions that are ligands for NKG2D, an activating receptor found on cytotoxic lymphocytes. The recognition on target cells of NKG2D ligands leads to the activation of lysis and cytokine secretion by NK cells and T cel...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201141645

    authors： Agüera-González S,Gross CC,Fernández-Messina L,Ashiru O,Esteso G,Hang HC,Reyburn HT,Long EO,Valés-Gómez M

    更新日期：2011-12-01 00:00:00

  • Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70.

    abstract：:CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsi...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260508

    authors： Lens SM,Keehnen RM,van Oers MH,van Lier RA,Pals ST,Koopman G

    更新日期：1996-05-01 00:00:00

  • IgG-binding sites on macrophage cell membrane. II. Mobility of Fc receptors induced by the interaction with their corresponding IgG ligands.

    abstract：:Mouse peritoneal macrophages were charged with IgG molecules in monomeric (mIgG), heat-aggregated (agIgG) or antigen-complexed (acIgG) form. Upon exposure to 37 degrees C, all bound IgG ligand types are redistributed on the cell surface due to the mobilization of their corresponding Fc receptor (FcR). The major findin...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830091213

    authors： Sulica A,Gherman M,Medeşan C,Gheţie V,Sjöquist J

    更新日期：1979-12-01 00:00:00

  • The HLA class II transcriptional activator blocks the function of HIV-1 Tat and inhibits viral replication.

    abstract：:The expression of HLA class II genes is under the control of a transcriptional activator, CIITA, encoded by the AIR-1 locus. Here we show that CIITA inhibits HIV-1 LTR transactivation mediated by Tat. The inhibition occurred when CIITA and Tat were transiently expressed in cells after transfection and, most importantl...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(2002010)32:10<2783::AID-IMMU2783

    authors： Accolla RS,Mazza S,De Lerma Barbaro A,De Maria A,Tosi G

    更新日期：2002-10-01 00:00:00

  • Maternal immunization modulates the primary immune response to 2-phenyl-oxazolone in BALB/c mice.

    abstract：:The development of the antibody repertoire in newborn mice is greatly influenced by idiotype network interactions. It has been demonstrated that anti-idiotypic antibodies either directly injected or transferred from the mother may alter the repertoire for life. For an elucidation of the underlying mechanisms we have a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830241216

    authors： Lemke H,Lange H,Berek C

    更新日期：1994-12-01 00:00:00

  • IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin.

    abstract：:IL-23, a proximal regulator of IL-17, may be a major driving force in the induction of autoimmune inflammation. We have used a model of subdiabetogenic treatment with multiple low doses of streptozotocin (MLD-STZ; 4 x 40 mg/kg body weight) in male C57BL/6 mice to study the effect of IL-23 on immune-mediated beta cell ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200535325

    authors： Mensah-Brown EP,Shahin A,Al-Shamisi M,Wei X,Lukic ML

    更新日期：2006-01-01 00:00:00

  • Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells.

    abstract：:T cell recognition of self antigens is a key event in the pathogenesis of autoimmune diseases. To date, the initial events that trigger autoreactive T cells are unknown. The "molecular mimicry" hypothesis predicts that during an infection T cells that recognize both a microbial antigen and a related self peptide becom...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200002)30:2<448::AID-IMMU448>3.0

    authors： Maier B,Molinger M,Cope AP,Fugger L,Schneider-Mergener J,Sønderstrup G,Kamradt T,Kramer A

    更新日期：2000-02-01 00:00:00

  • Natural T-cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles.

    abstract：:CD4 T cells play a central role as helper cells in adaptive immunity. Presentation of exogenous antigens in MHC class II by professional antigen-presenting cells is a crucial step in induction of specific CD4 T cells in adaptive immune responses. For efficient induction of immunity against intracellular threats such a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201747152

    authors： Kremer AN,Zonneveld MI,Kremer AE,van der Meijden ED,Falkenburg JHF,Wauben MHM,Nolte-'t Hoen ENM,Griffioen M

    更新日期：2018-10-01 00:00:00

  • Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody.

    abstract：:A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220217

    authors： Pircher H,Rebaï N,Groettrup M,Grégoire C,Speiser DE,Happ MP,Palmer E,Zinkernagel RM,Hengartner H,Malissen B

    更新日期：1992-02-01 00:00:00

  • Resistance of MRL/Mp-lpr/lpr mice to tolerance induction.

    abstract：:Mice of strain MRL/Mp-lpr/lpr develop resistance against tolerance induction with aggregate-freed rabbit gamma-globulin as early as 6 weeks of age and show very complete resistance when they are 10 weeks old; congenic mice MRL-Mp+/+ of 6 and 10 weeks can be rendered tolerant. By reconstitution experiments, it was show...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830111113

    authors： Amagai T,Cinader B

    更新日期：1981-11-01 00:00:00

  • Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.

    abstract：:A cDNA encoding the human beta Fc gamma receptor II (FcRII) was isolated from a placental cDNA library. Analysis of the predicted amino acid sequence indicates that this receptor is synthesized with a 42-amino acid leader sequence. The mature protein consists of 249 amino acids. The leader sequence and the cytoplasmic...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200624

    authors： Engelhardt W,Geerds C,Frey J

    更新日期：1990-06-01 00:00:00

  • A role for lymphotoxin beta receptor in host defense against Mycobacterium bovis BCG infection.

    abstract：:To investigate the role of membrane lymphotoxin (LT)alpha1 / beta2 and its LTbeta receptor (LTbetaR) in the protective immune response to Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, we have used a soluble fusion molecule (LTbetaR-IgG1). LTbetaR-Ig treatment interferes with granuloma formation mainly ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199912)29:12<4002::AID-IMM

    authors： Lucas R,Tacchini-Cottier F,Guler R,Vesin D,Jemelin S,Olleros ML,Marchal G,Browning JL,Vassalli P,Garcia I

    更新日期：1999-12-01 00:00:00

  • Differentiation of human mature thymocytes: existence of a T3+4-8- intermediate stage.

    abstract：:A T3 complex-bearing subpopulation was characterized within an in vivo cycling T4-8- early thymocyte compartment which contains cells constitutively expressing interleukin 2 and transferrin receptors. We show differentiation in vitro of both mature subsets of thymocytes (T3+4+8- and T3+4-8+) from the above T4-8- compa...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160611

    authors： De la Hera A,Toribio ML,Marquez C,Marcos MA,Cabrero E,Martinez-A C

    更新日期：1986-06-01 00:00:00

  • A mouse monoclonal antibody against rabbit VH allotype shares the predominant idiotype with a rabbit antibody of the same specificity.

    abstract：:A monoclonal antibody, termed 3-2F1, is specific for the rabbit VH al allotypic marker. This antibody appears to recognize a common al determinant since it reacts with all of the a1 immunoglobulin (Ig) that is bound by polyclonal rabbit anti-a1, and completely inhibits the binding of polyclonal anti-a1 to a1 Ig. When ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830140405

    authors： Metzger DW

    更新日期：1984-04-01 00:00:00