Resistance of MRL/Mp-lpr/lpr mice to tolerance induction.

abstract：:The TCR structure of T cell hybridomas recognizing a tumor glycan-defined epitope has been studied using reverse transcriptase-PCR and gene sequencing. The hybridomas had been raised against a glycopeptide, T72(Tn), consisting of the mouse hemoglobin-derived decapeptide Hb(67 - 76), O-glycoslated in position 72 with a...

journal_title：European journal of immunology

authors： Jensen T,Hansen P,Faurskov Nielsen A,Meldal M,Komba S,Werdelin O

更新日期：1999-09-01 00:00:00

abstract：:Despite all the structural and functional data that have been accumulated regarding major histocompatibility complex (MHC) class II molecules during recent years, the relative contribution of putative T cell receptor (TcR)-contacting residues and peptide-binding MHC polymorphisms to MHC-restricted and allospecific T c...

journal_title：European journal of immunology

authors： Coppin HL,Carmichael P,Lombardi G,L'Faqihi FE,Salter R,Parham P,Lechler RI,de Preval C

更新日期：1993-02-01 00:00:00

abstract：:During the chronic phase of infection with the parasite Trypanosoma cruzi, mice develop inflammatory lesions in the heart and skeletal muscles, as well as in peripheral nerves and the liver. We demonstrated the presence, in the blood of chronically infected mice, of L3T4+ T cells able to transfer a specific T. cruzi d...

journal_title：European journal of immunology

authors： Hontebeyrie-Joskowicz M,Said G,Milon G,Marchal G,Eisen H

更新日期：1987-07-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) employs multiple mechanisms to evade the immune system and succeeds to persist lifelong in the host. Human dendritic cells (DC) are the main antigen-presenting cells and play the key role in inducing and maintaining immune responses. Here, we studied the interaction of HCMV with DC. We fou...

journal_title：European journal of immunology

authors： Beck K,Meyer-König U,Weidmann M,Nern C,Hufert FT

更新日期：2003-06-01 00:00:00

abstract：:Tissue macrophages and their precursors-the blood monocytes-respond rapidly to a bacterial infection with the release of inflammatory mediators. These mediators are involved in the recruitment of phagocytic cells, principally neutrophils, from the blood to the site of infection. To initiate this process macrophages an...

journal_title：European journal of immunology

authors： Jack RS,Grunwald U,Stelter F,Workalemahu G,Schütt C

更新日期：1995-05-01 00:00:00

abstract：:The tight-skin (Tsk/+) mutant mouse, a putative murine model of scleroderma, is characterized primarily by the excessive deposition of collagen and other extracellular matrix molecules in the dermis, and also by a developmentally acquired defect in pulmonary architecture. Passive transfer experiments have suggested an...

journal_title：European journal of immunology

authors： Ong C,Wong C,Roberts CR,Teh HS,Jirik FR

更新日期：1998-09-01 00:00:00

abstract：:Mutations in PTEN-induced kinase 1 (PINK1), a serine/threonine kinase linked to familial early-onset Parkinsonism, compromise mitochondrial integrity and metabolism and impair AKT signaling. As the activation of a naïve T cell requires an AKT-dependent reorganization of a cell's metabolic machinery, we sought to deter...

journal_title：European journal of immunology

authors： Ellis GI,Zhi L,Akundi R,Büeler H,Marti F

更新日期：2013-12-01 00:00:00

abstract：:This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. ...

journal_title：European journal of immunology

authors： Hanitsch L,Baumann U,Boztug K,Burkhard-Meier U,Fasshauer M,Habermehl P,Hauck F,Klock G,Liese J,Meyer O,Müller R,Pachlopnik-Schmid J,Pfeiffer-Kascha D,Warnatz K,Wehr C,Wittke K,Niehues T,von Bernuth H

更新日期：2020-10-01 00:00:00

abstract：:Humanized BALB/c mice (termed trimera mice) conditioned by lethal total body irradiation and bone marrow transplantation from SCID mice have been described to support rapid engraftment of human peripheral blood mononuclear cells (PBMC) and the induction of strong B and T cell responses after immunization in vivo. More...

journal_title：European journal of immunology

authors： Böcher WO,Dekel B,Schwerin W,Geissler M,Hoffmann S,Rohwer A,Arditti F,Cooper A,Bernhard H,Berrebi A,Rose-John S,Shaul Y,Galle PR,Löhr HF,Reisner Y

更新日期：2001-07-01 00:00:00

abstract：:Plasma cells secreting IgG, M, and A abound in the synovium of patients with rheumatoid arthritis, yet their immunoglobulin repertoire and clonal relationship remain to be elucidated. Locally synthesized immunoglobulins probably contribute to the chronic joint inflammatory processes which are characteristic of these p...

journal_title：European journal of immunology

authors： Williams DG,Taylor PC

更新日期：1997-02-01 00:00:00

abstract：:A fraction of activated CD8+ T cells expresses CD40 ligand (CD40L), a molecule that plays a key role in T cell-dependent B cell stimulation. CD8+ T cell clones were examined for CD40L expression and for their capacity to allow the growth and differentiation of B cells, upon activation with immobilized anti-CD3. Accord...

journal_title：European journal of immunology

authors： Hermann P,Van-Kooten C,Gaillard C,Banchereau J,Blanchard D

更新日期：1995-10-01 00:00:00

abstract：:Blockade of the immune response, caused by a high dose of Salmonella typhi Vi antigen (200 microgram i.v.) and cyclophosphamide (CY)-induced tolerance to Vi antigen, were analyzed. The results of the study show that blockade of the immune response cannot be attributed to masking of the response resulting from neutrali...

journal_title：European journal of immunology

authors： Prigozhina TB,Fontalin LN

更新日期：1980-08-01 00:00:00

abstract：:Phenotypic classification of human CD8(+) T cells using three cell surface markers, CD27, CD28 and CD45RA, was recently suggested to be useful for identification of naive, memory and effector CD8(+) T cells. However, it still remains unclear whether such classification precisely reflects functional classification of C...

journal_title：European journal of immunology

authors： Tomiyama H,Takata H,Matsuda T,Takiguchi M

更新日期：2004-04-01 00:00:00

abstract：:B1 cells are a subset of B lymphocytes found in many species and are implicated in the development of autoimmunity. B1 cells have previously been shown to be suppressed by the T helper (Th)1 cytokine interferon (IFN)-gamma, and to be stimulated by the Th2 cytokines interleukin (IL)-2, IL-4, IL-5 and IL-10. To examine ...

journal_title：European journal of immunology

authors： Vogel LA,Lester TL,Van Cleave VH,Metzger DW

更新日期：1996-01-01 00:00:00

abstract：:The immune system is tightly regulated by a subset of T cells defined as regulatory T cells (Tregs). Tregs maintain immune homeostasis by restraining unwarranted immune cell activation and effector function. Here, we discuss an important but underappreciated role of proteases in controlling Treg function. Proteases re...

journal_title：European journal of immunology

authors： Amarnath S,Brown ML

更新日期：2020-06-01 00:00:00

abstract：:To evaluate a long peptide-based allergy vaccine in a murine model, CBA/J mice were sensitized with low dose alum-adsorbed phospholipase A2 (PLA2), a major bee venom allergen. Presensitized mice were treated by daily i.p. injections of a mixture of three long overlapping peptides (44- to 60-mer) spanning the entire PL...

journal_title：European journal of immunology

authors： von Garnier C,Astori M,Kettner A,Dufour N,Heusser C,Corradin G,Spertini F

更新日期：2000-06-01 00:00:00

abstract：:Surfactant protein A (SP-A) and surfactant protein D (SP-D) are collectins, and both proteins were shown to interact with influenza A virus and alveolar macrophages. However, it is not known whether SP-A and SP-D can serve as opsonins for the phagocytosis of influenza A virus by alveolar macrophages. In the present st...

journal_title：European journal of immunology

authors： Benne CA,Benaissa-Trouw B,van Strijp JA,Kraaijeveld CA,van Iwaarden JF

更新日期：1997-04-01 00:00:00

abstract：:Current models of lymphocyte traffic suggest that homing specificities of T cells to tissues such as skin are generated outside the thymus as a result of activation of naive T cells by antigen in lymph nodes. Virgin T cells are thought to home to high endothelial venules in lymph nodes, but are thought to be unable to...

journal_title：European journal of immunology

authors： Washington EA,Kimpton WG,Holder JE,Cahill RN

更新日期：1995-03-01 00:00:00

abstract：:It is widely believed that DC, but not macrophages, prime naïve T cells in vivo. Here, we investigated the ability of CD68-expressing cells (commonly defined as macrophages) in priming autoreactive T cells and initiating collagen-induced arthritis (CIA) in the mouse. For this purpose, a transgenic mouse was developed ...

journal_title：European journal of immunology

authors： Pizzolla A,Gelderman KA,Hultqvist M,Vestberg M,Gustafsson K,Mattsson R,Holmdahl R

更新日期：2011-02-01 00:00:00

abstract：:Lymphocyte function-associated-antigen-1 (LFA-1) is able to bind selectively to its ligands intercellular adhesion molecules 1 and 3 (ICAM-1 and ICAM-3), suggesting that LFA-1 can exist in distinct ligand-specific binding states. In the case of ICAM-1, apart from ligand itself and the recently cloned molecule cytohesi...

journal_title：European journal of immunology

authors： Buckley CD,Ferguson ED,Littler AJ,Bossy D,Simmons DL

更新日期：1997-04-01 00:00:00

abstract：:The analysis of an Ia specificity was performed in several H-2 haplotypes by evaluating the affinity of the binding to mouse spleen cells of a monoclonal anti-Ia alloantibody. We used the monoclonal antibody 10-2.16 (Oi et al., Curr. Top. Microbiol. Immunol. 1978. 81: 115.) which recognizes on I-A gene products a publ...

journal_title：European journal of immunology

authors： Birnbaum D,Kourilsky FM

更新日期：1981-09-01 00:00:00

abstract：:Epidermal keratinocytes differentiate and form a multilayered epidermis, which is the primary barrier between the body and the outer environment. As the epidermis is constantly exposed to a variety of microbial pathogens, its function of resisting microbial pathogens is vital. This characteristic feature is formed dur...

journal_title：European journal of immunology

authors： Sayama K,Komatsuzawa H,Yamasaki K,Shirakata Y,Hanakawa Y,Ouhara K,Tokumaru S,Dai X,Tohyama M,Ten Dijke P,Sugai M,Ichijo H,Hashimoto K

更新日期：2005-06-01 00:00:00

abstract：:Mice carrying the H-2b and H-2s haplotypes are genetically nonresponsive to hen egg-white lysozyme (HEL). Analysis of the anti-HEL response patterns of F1, F2 and backcross progeny showed that responsiveness was dominant and H-2 linked. From plaque-forming cell and serum assays in intra-H-2 recombinant mice, it was es...

journal_title：European journal of immunology

authors： Hill SW,Kipp DE,Melchers I,Frelinger JA,Sercarz EE

更新日期：1980-05-01 00:00:00

abstract：:The number of patients with severe atopic dermatitis (AD) has been on the rise recently. We are therefore urgently in need of a treatment that can suppress Th2 cell-mediated responses in an Ag-specific fashion. Oligodeoxynucleotides (ODN)containing CpG motifs (CpG ODN) have been highlighted as immunomodulators that re...

journal_title：European journal of immunology

authors： Kootiratrakarn T,Fujimura T,Sano K,Okuyama R,Aiba S,Tagami H,Terui T

更新日期：2005-11-01 00:00:00

abstract：:Human herpes virus 6B (HHV-6B) is a widespread virus that infects most people early in infancy and establishes a chronic life-long infection with periodic reactivation. CD4 T cells have been implicated in control of HHV-6B, but antigenic targets and functional characteristics of the CD4 T-cell response are poorly unde...

journal_title：European journal of immunology

authors： Becerra-Artiles A,Cruz J,Leszyk JD,Sidney J,Sette A,Shaffer SA,Stern LJ

更新日期：2019-08-01 00:00:00

abstract：:Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multip...

journal_title：European journal of immunology

authors： Jones R,Cosway EJ,Willis C,White AJ,Jenkinson WE,Fehling HJ,Anderson G,Withers DR

更新日期：2018-09-01 00:00:00

abstract：:The liver and activation-regulated chemokine (LARC), also termed MIP-3alpha and Exodus, is a novel human CC chemokine with a selective chemotactic activity for lymphocytes and dendritic cells. Here we describe genomic and cDNA clones encoding the murine orthologue of LARC (mLARC). The gene consists of four exons and t...

journal_title：European journal of immunology

authors： Tanaka Y,Imai T,Baba M,Ishikawa I,Uehira M,Nomiyama H,Yoshie O

更新日期：1999-02-01 00:00:00

abstract：:Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages. We have isolated full-length cDNA clones from a lambda gt 10 library, prepared from phorbol 12-myristate 13-acetate-dif...

journal_title：European journal of immunology

authors： Bellón T,Corbí A,Lastres P,Calés C,Cebrián M,Vera S,Cheifetz S,Massague J,Letarte M,Bernabéu C

更新日期：1993-09-01 00:00:00

abstract：:In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3(+) Treg cells, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg cell-mediated suppression. Cotransfer of polyclonal activated Treg cells into healthy mice attenuated the ind...

journal_title：European journal of immunology

authors： Davidson TS,Shevach EM

更新日期：2011-10-01 00:00:00

abstract：:A significant proportion of memory B cells home to bone marrow (BM) which is a major site of anamnestic antibody responses in mice. We hypothesized that memory T cells likewise accumulate in BM perhaps to provide help for antibody production, and that the compartment of CD4+ T cells in BM of unimmunized mice would be ...

journal_title：European journal of immunology

authors： Price PW,Cerny J

更新日期：1999-03-01 00:00:00