Dynamic changes in intrathymic ILC populations during murine neonatal development.

abstract：:Natural resistance to hemopoietic allograft results in functional elimination of the graft from the host within 24 to 48 h. The resistance is specific and is directed to the cell surface target structures of an unidentified nature. These determinants are controlled by the major histocompatibility complex-linked hemopo...

journal_title：European journal of immunology

authors： Shimamura K,Kaminsky SG,Nakamura I

更新日期：1989-07-01 00:00:00

abstract：:IL-6-specific autoantibodies (aAb-IL-6) have been reported in diseased and healthy individuals. We recently established a model for aAb-IL-6 in different mouse strains, based on vaccination with immunogenic IL-6 analogues, in which titers of aAb-IL-6 above 1,000 resulted in an in vivo IL-6 deficiency. Here, we examine...

journal_title：European journal of immunology

authors： Galle P,Svenson M,Bendtzen K,Hansen MB

更新日期：2004-11-01 00:00:00

abstract：:Unexpected fetal loss is one of the common complications of pregnancy; however, the pathogenesis of many miscarriages, particularly those not associated with infections, is unknown. We previously found that activated DEC-205+ dendritic cells (DCs) and NK1.1+ invariant natural killer T (iNKT) cells are recruited into t...

journal_title：European journal of immunology

authors： Negishi Y,Ichikawa T,Takeshita T,Takahashi H

更新日期：2018-06-01 00:00:00

abstract：:The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24...

journal_title：European journal of immunology

authors： Claus C,Schlaak J,Dittmayer M,Meyer zum Büschenfelde K,Dippold W

更新日期：1994-05-01 00:00:00

abstract：:A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

journal_title：European journal of immunology

authors： Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

更新日期：1996-12-01 00:00:00

abstract：:To determine whether antigen (Ag)-specific cytotoxic T lymphocytes are generated during experimental Candida albicans infection, purified L3T4+ and Ly-2+ lymphocytes from immunized mice were cultured in the presence of syngeneic accessory cells, C. albicans Ag, and interleukin 2. Yeast-infected bone marrow macrophages...

journal_title：European journal of immunology

authors： Romani L,Mocci S,Cenci E,Rossi R,Puccetti P,Bistoni F

更新日期：1991-06-01 00:00:00

abstract：:AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Folliculin (FLCN) and the FLCN-interacting proteins 1 and 2 (FNIP1, 2) modulate AMPK. FNIP1 deficiency patients have a AMPK-P gain of f...

journal_title：European journal of immunology

authors： Niehues T,Özgür TT,Bickes M,Waldmann R,Schöning J,Bräsen J,Hagel C,Ballmaier M,Klusmann JH,Niedermayer A,Pannicke U,Enders A,Dückers G,Siepermann K,Hempel J,Schwarz K,Viemann D

更新日期：2020-07-01 00:00:00

abstract：:Surfactant protein A (SP-A) and surfactant protein D (SP-D) are collectins, and both proteins were shown to interact with influenza A virus and alveolar macrophages. However, it is not known whether SP-A and SP-D can serve as opsonins for the phagocytosis of influenza A virus by alveolar macrophages. In the present st...

journal_title：European journal of immunology

authors： Benne CA,Benaissa-Trouw B,van Strijp JA,Kraaijeveld CA,van Iwaarden JF

更新日期：1997-04-01 00:00:00

abstract：:To investigate the role of interferon-gamma (IFN-gamma) in experimental autoimmune thyroidits (EAT), H-2k mice with a disrupted IFN-gamma receptor (IFN-gamma R) gene were immunized with porcine thyroglobulin (pTg). We observed that EAT occurred on day 19 and remitted on day 35 in IFN-gamma R-deficient (IFN-gamma R(0/0...

journal_title：European journal of immunology

authors： Alimi E,Huang S,Brazillet MP,Charreire J

更新日期：1998-01-01 00:00:00

abstract：:The existence of a functional receptor for secretory component (SC) on the eosinophil membrane might explain the preferential degranulation induced by secretory IgA (sIgA) when compared to serum IgA. Indeed, flow cytometry analysis revealed that purified human SC could bind to a subpopulation (4-59%) of blood eosinoph...

journal_title：European journal of immunology

authors： Lamkhioued B,Gounni AS,Gruart V,Pierce A,Capron A,Capron M

更新日期：1995-01-01 00:00:00

abstract：:Mucosal boosting of BCG-immunised individuals with a subunit tuberculosis (TB) vaccine would be highly desirable, considering that the lungs are the principal port of entry for Mycobacterium tuberculosis (MTB) and the site of the primary infection and reactivation. However, the main roadblock for subunit TB vaccine de...

journal_title：European journal of immunology

authors： Stylianou E,Diogo GR,Pepponi I,van Dolleweerd C,Arias MA,Locht C,Rider CC,Sibley L,Cutting SM,Loxley A,Ma JK,Reljic R

更新日期：2014-02-01 00:00:00

abstract：:Cycling lymphocytes may express the enzyme telomerase which is involved in maintenance of telomere length and cell proliferation potential. In CD8(+) T cells freshly isolated from peripheral blood, we found that in vivo cycling cells expressed HLA-DR. Furthermore, CD28-positive cells are known to have longer telomeres...

journal_title：European journal of immunology

authors： Speiser DE,Migliaccio M,Pittet MJ,Valmori D,Liénard D,Lejeune F,Reichenbach P,Guillaume P,Lüscher I,Cerottini JC,Romero P

更新日期：2001-02-01 00:00:00

abstract：:Large-scale extravasation of lymphocytes takes place in vivo under physiological conditions in lymph nodes at very specialized vascular segments called high endothelial venules (HEV). When circulating lymphocytes leave the blood, they first bind to endothelial cells of HEV (HE cells) and subsequently enter lymph nodes...

journal_title：European journal of immunology

authors： Ise Y,Yamaguchi K,Sato K,Yamamura Y,Kitamura F,Tamatani T,Miyasaka M

更新日期：1988-08-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated the activity of IDO in the cornea, following corneal transplantation and the effect of IDO over-expression in donor corneal endothe...

journal_title：European journal of immunology

authors： Beutelspacher SC,Pillai R,Watson MP,Tan PH,Tsang J,McClure MO,George AJ,Larkin DF

更新日期：2006-03-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a membrane glycoprotein first identified on rat mucosal type mast cells (line RBL-2H3) and known to inhibit the Fc epsilon RI-mediated secretory response. In its extracellular domain, an amino acid stretch homologous to the carbohydrate binding domain of calcium-depe...

journal_title：European journal of immunology

authors： Binsack R,Pecht I

更新日期：1997-10-01 00:00:00

abstract：:Nonhematopoietic stromal cells contribute to the organization and homeostasis of secondary lymphoid organs by producing cytokines and chemokines. The development and maintenance of these stromal cells are thought to be regulated by innate immune cells. Indeed, we recently showed that signal regulatory protein α (SIRPα...

journal_title：European journal of immunology

authors： Komori S,Saito Y,Respatika D,Nishimura T,Kotani T,Murata Y,Matozaki T

更新日期：2019-09-01 00:00:00

abstract：:The capacity of old (18-24 months) C57BL/6 mice to develop an immune reaction against MC-B6-1 fibrosarcoma cells was studied using in vivo adoptive transfer experiments (Winn assay) and in vitro T cell-mediated cytotoxicity test. Anti-tumor immunity was found to decline with age, as indicated by a decreased anti-tumor...

journal_title：European journal of immunology

authors： Bruley-Rosset M,Payelle B

更新日期：1987-03-01 00:00:00

abstract：:The entry of neutrophils into inflamed tissues is initiated by cell rolling on the blood vessel wall followed by arrest and transendothelial migration. Rolling is mediated by the selectins, while the two subsequent steps require activated beta 2-integrins. We have investigated whether the binding of P-selectin to mous...

journal_title：European journal of immunology

authors： Blanks JE,Moll T,Eytner R,Vestweber D

更新日期：1998-02-01 00:00:00

abstract：:Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which ar...

journal_title：European journal of immunology

authors： Jones ND,Brook MO,Carvalho-Gaspar M,Luo S,Wood KJ

更新日期：2010-11-01 00:00:00

abstract：:We investigated here the potential role of Toll-like receptors (TLR) and the adaptor protein MyD88 in innate immunity responses to Cryptococcus neoformans, a pathogenic encapsulated yeast. Peritoneal macrophages from MyD88(-/-) or TLR2(-/-) mice released significantly less TNF-alpha, compared with wild-type controls, ...

journal_title：European journal of immunology

authors： Biondo C,Midiri A,Messina L,Tomasello F,Garufi G,Catania MR,Bombaci M,Beninati C,Teti G,Mancuso G

更新日期：2005-03-01 00:00:00

abstract：:A majority of immunodominant epitopes of mycobacterial antigens are known to be recognized by murine T cells in the context of several H-2 haplotypes. In this study, we established the frequency of T cells able to recognize these peptides promiscuously, i.e. in the context of allogeneic antigen-presenting cells, using...

journal_title：European journal of immunology

authors： Vordermeier HM,Arya A,Harris DP,Moreno C,Ivanyi J

更新日期：1995-10-01 00:00:00

abstract：:TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor (TNFR)1, as each TNFR1-Fc, neutralizing TNF-specific ...

journal_title：European journal of immunology

authors： Schneider P,Schwenzer R,Haas E,Mühlenbeck F,Schubert G,Scheurich P,Tschopp J,Wajant H

更新日期：1999-06-01 00:00:00

abstract：:The CD4 and CD8 coreceptor molecules on immature thymocytes participate in T cell repertoire selection. To examine more definitively the role of CD4 and CD8 in the negative and positive selection of immature thymocytes, we generated transgenic mice with elevated surface CD4 expression and mated them with mice expressi...

journal_title：European journal of immunology

authors： Van Oers NS,Garvin AM,Davis CB,Forbush KA,Carlow DA,Littman DR,Perlmutter RM,Teh HS

更新日期：1992-03-01 00:00:00

abstract：:It has been reported that the 45-kDa low-affinity Fc epsilon receptor (Fc epsilon RII) on B cells is cleaved spontaneously from the cell surface to release soluble fragments. This study demonstrates an additional fate of the Fc epsilon RII. 125I-labeled CD23+ B cells were cultured for 24 h at 37 degrees C. After lysis...

journal_title：European journal of immunology

authors： Grenier-Brossette N,Bourget I,Akoundi C,Bonnefoy JY,Cousin JL

更新日期：1992-06-01 00:00:00

abstract：:IL-18 was originally described as a cytokine which induced IFN-gamma production by established Th1 cells in an IL-12-independent manner. However, subsequent studies demonstrated that exogenous IL-18 in the absence of IL-12 failed to drive Th1 differentiation of naive cells and induced IFN-gamma from established Th1 ce...

journal_title：European journal of immunology

authors： Chang JT,Segal BM,Nakanishi K,Okamura H,Shevach EM

更新日期：2000-04-01 00:00:00

abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

journal_title：European journal of immunology

authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

更新日期：1994-02-01 00:00:00

abstract：:Dendritic cells (DC) are unique in their ability to present antigen to naive T cells, and therefore play a central role in the initiation of immune responses. Characterization of DC-specific genes may help to unravel the mechanism underlying their potent antigen presenting capacity. Here we describe the identification...

journal_title：European journal of immunology

authors： Hartgers FC,Vissers JL,Looman MW,van Zoelen C,Huffine C,Figdor CG,Adema GJ

更新日期：2000-12-01 00:00:00

abstract：:Membrane-coated microvesicles (MVs) have been identified as important mediators in intercellular communication. During the process of apoptosis, dying cells dynamically release MVs. Neutrophils are the most abundant type of leukocytes in the circulation. Due to their very short lifespan, it is likely that they are the...

journal_title：European journal of immunology

authors： Shen G,Krienke S,Schiller P,Nießen A,Neu S,Eckstein V,Schiller M,Lorenz HM,Tykocinski LO

更新日期：2017-05-01 00:00:00

abstract：:Cellular immune responses are likely to play a key role in determining the clinical outcome in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their relationship to viral clearance are poorly understood. In a previous study we have shown highly activated, multispecific cytotoxic T ...

journal_title：European journal of immunology

authors： Lechner F,Gruener NH,Urbani S,Uggeri J,Santantonio T,Kammer AR,Cerny A,Phillips R,Ferrari C,Pape GR,Klenerman P

更新日期：2000-09-01 00:00:00

abstract：:Macrophage precursor cells were cultured from the bone marrow of mice in a liquid culture system in the presence of conditioned medium. To separate their different maturation stages, they were passed through a discontinuous Ficoll density gradient, treated with iron plus magnet or passed through glass bead columns. Th...

journal_title：European journal of immunology

authors： Domzig W,Lohmann-Matthes ML

更新日期：1979-04-01 00:00:00