Abstract:
:The analysis of an Ia specificity was performed in several H-2 haplotypes by evaluating the affinity of the binding to mouse spleen cells of a monoclonal anti-Ia alloantibody. We used the monoclonal antibody 10-2.16 (Oi et al., Curr. Top. Microbiol. Immunol. 1978. 81: 115.) which recognizes on I-A gene products a public specificity common to several H-2 haplotypes (f, ja, k, r, s and u). One parameter of the affinity (dissociation rate constant) was determined by the kinetics of the dissociation of cellbound 125 I-labeled Fab fragments in the presence of homologous antibodies. The dissociation rate constants thus obtained were different when the antibody reacted with cells from mice bearing different haplotypes and were similar for reactions with different mouse strains bearing the same haplotype. These data strongly suggest that the Ia public determinants involved are not strictly identical in different haplotypes, and support the concept that a serological cross-reaction does not necessarily mean structural identity between public antigenic determinants.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Birnbaum D,Kourilsky FMdoi
10.1002/eji.1830110912subject
Has Abstractpub_date
1981-09-01 00:00:00pages
734-8issue
9eissn
0014-2980issn
1521-4141journal_volume
11pub_type
杂志文章abstract::Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830181112
更新日期:1988-11-01 00:00:00
abstract::The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain. Treatment of the human leukemic T cell line Jurkat with PMA increased the synthesis of the Ti alpha, CD3 gamma and CG3 zeta...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230625
更新日期:1993-06-01 00:00:00
abstract::CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939887
更新日期:2010-01-01 00:00:00
abstract::The autoimmune disease systemic lupus erythematosus is characterized by loss of tolerance to nuclear Ags and a heightened inflammatory environment, which together result in end organ damage. Lyn-deficient mice, a model of systemic lupus erythematosus, lack an inhibitor of B-cell and myeloid cell activation. This resul...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142095
更新日期:2013-02-01 00:00:00
abstract::Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130611
更新日期:1983-06-01 00:00:00
abstract::Dendritic cells (DC) play an essential role in the induction of primary immune responses; however, very little information is available on cytokine production by DC. Here we determined the cytokine gene expression profile of two immortalized DC clones, CB1 and D2SC/1, both generated from mouse spleen but differing in ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830241039
更新日期:1994-10-01 00:00:00
abstract::Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during s...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190113
更新日期:1989-01-01 00:00:00
abstract::The transforming protein of mouse polyomavirus, the mouse middle T antigen (MomT), and its counterpart in the hamster polyomavirus, the hamster middle T antigen (HamT), interact with a number of cellular proteins. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3-kinase, the ser...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250212
更新日期:1995-02-01 00:00:00
abstract::Aging is accompanied by altered immunity, resulting in a variable state of poorly understood immunodeficiency. While both the numbers and the functionality of naïve T cells are decreased by aging, the impact of these changes upon immune defense against bacterial pathogens in vivo remains understudied. Using a model of...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201041141
更新日期:2011-05-01 00:00:00
abstract::Antimicrobial peptides human beta-defensins (hBD) are mainly produced by epithelia of several organs including skin, and participate in innate immunity by killing invading pathogens. Besides their microbicidal activities, hBD activate several inflammatory and immune cells. Since hBD are generated by tissues where mast...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636379
更新日期:2007-02-01 00:00:00
abstract::AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 also mobilizes most mature leukocyte subsets to blood; however, their source and trafficking potential have not been fully delineated. Here, ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201445245
更新日期:2015-06-01 00:00:00
abstract::The infiltration and activation of monocytes is a hallmark of chronic inflammation, including that associated with a variety of disease states such as rheumatoid arthritis, atherosclerosis, and various autoimmune conditions. Recently, a family of small molecular mass proteins has been described which appear to have in...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220621
更新日期:1992-06-01 00:00:00
abstract::Previous studies have demonstrated that immunization of BALB/c mice with alpha(1----3) dextran (Dex) is accompanied by a reduction in the subsequent immune response to the acetylcholine receptor (AChR), depending on the timing of the Dex administration relative to AChR challenge. Here, we report that suppression of th...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200803
更新日期:1990-08-01 00:00:00
abstract::Autophagy is an intracellular degradation system that plays an important role in T-cell survival. However, the precise mechanism linking autophagy and cell death in primary human T cells is unclear because methods for monitoring autophagy in small numbers of primary human cells remain controversial. We established a n...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201344248
更新日期:2014-08-01 00:00:00
abstract::The C-terminal fragment of merozoite surface protein-1 (MSP-1) of the mouse malaria parasite Plasmodium chabaudi chabaudi (AS) stimulates a weak CD4 T cell response when compared to the response to a more structurally simple region of the molecule. The tertiary structure of the C-terminal region of MSP-1 is maintained...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200101)31:1<72::aid-immu72
更新日期:2001-01-01 00:00:00
abstract::Bone marrow-derived macrophages were stained with a variety of monoclonal antibodies (mAb) with specificity for the mycobacterial heat shock protein (hsp) 60 or with specific rabbit antiserum raised against mycobacterial hsp 60. The mAb ML30 as well as the specific antiserum brightly stained bone marrow-derived macrop...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210437
更新日期:1991-04-01 00:00:00
abstract::Adoptive T-cell therapy (ATCT) can result in tumor rejection, yet the behavior and fate of the introduced T cells remain unclear. We developed a novel bioluminescence mouse model, which enabled highly sensitive detection of T-cell signals at the single-cell level. Transferred T cells preferentially accumulated within ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141452
更新日期:2011-11-01 00:00:00
abstract::We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251019
更新日期:1995-10-01 00:00:00
abstract::Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimul...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210816
更新日期:1991-08-01 00:00:00
abstract::Treatment of human peripheral blood lymphocytes with cloned N alpha-desacetylthymosin alpha 1 induced interferon production. The kinetics is similar to that of mitogen-induced interferon induction. N alpha-desacetylthymosin alpha 1, in combination with mitogen, augments the amount of interferon produced. This interfer...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830120314
更新日期:1982-03-01 00:00:00
abstract::E-selectin is an endothelium-specific inducible adhesion molecule which binds several inflammatory cell types, including neutrophils, monocytes, natural killer cells and a subset of memory T cells. E-selectin is important in the initial rolling interaction of these cells on inflamed endothelium. The transient kinetics...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830261221
更新日期:1996-12-01 00:00:00
abstract::Naturally occurring CD4+CD25(high) regulatory T cells (nTreg) are essential for maintaining tolerance. FOXP3 has been established as a molecular marker of nTreg; however, FOXP3 cannot be used as a reliable marker for bona fide human nTreg since effector T cells also up-regulate FOXP3 expression upon activation. Despit...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.200940117
更新日期:2009-12-01 00:00:00
abstract::The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on p...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830140407
更新日期:1984-04-01 00:00:00
abstract::HLA-A2.1-binding peptides (n = 38) were screened for immunogenicity with human peripheral blood mononuclear cells in cytotoxic T lymphocyte (CTL) induction experiments in vitro and with splenocytes from HLA-A2.1/Kb transgenic mice following immunization in vivo. These data were compiled and analyzed to determine the l...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260115
更新日期:1996-01-01 00:00:00
abstract::By means of a novel technique for identification and isolation of MHC class II-restricted antigen-specific T cells, we describe here in non-transgenic BALB / c mice physiological positive selection of an oligoclonal population of T cells which recognizes both a self MHC-derived peptide (Ialpha52) and a bacterial homol...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199912)29:12<3826::AID-IMM
更新日期:1999-12-01 00:00:00
abstract::This study describes a CD5+ B cell that differs from the majority of the CD5+ B cells from human tonsils. This cell, isolated from in vivo activated B cells, expressed activation markers and featured a CD23-, IgMhigh, IgDlow surface phenotype, responded to T cell-independent type-2 antigens in vitro, and was detected ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636887
更新日期:2007-08-01 00:00:00
abstract::CTLA-4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble CTLA-4 isoform (sC...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242529
更新日期:2013-05-01 00:00:00
abstract::The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199812)28:12<4138::AID-IMM
更新日期:1998-12-01 00:00:00
abstract::Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747431
更新日期:2018-10-01 00:00:00
abstract::An immunoglobulin epsilon-chain fragment was synthesized in E. coli by cloning and expression of the gene coding for the second, third and fourth constant domains of the human IgE heavy chain. The bacterial CH2-4 polypeptide product was assembled by oxidation into a covalently linked dimeric epsilon-chain molecule pre...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150920
更新日期:1985-09-01 00:00:00