Abstract:
:Treatment of human peripheral blood lymphocytes with cloned N alpha-desacetylthymosin alpha 1 induced interferon production. The kinetics is similar to that of mitogen-induced interferon induction. N alpha-desacetylthymosin alpha 1, in combination with mitogen, augments the amount of interferon produced. This interferon is immune interferon (IFN-gamma) as determined by sensitivity to pH 2, lack of neutralization by antibodies to IFN-alpha or IFN-beta and absence of activity of MDBK cells. Although the mechanism of induction of IFN-gamma by N alpha-desacetylthymosin alpha 1 is unclear, this compound is not mitogenic at concentrations causing IFN-gamma production. These results indicate that thymic factors may also participate in the regulation of IFN-gamma-production.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Svedersky LP,Hui A,May L,McKay P,Stebbing Ndoi
10.1002/eji.1830120314subject
Has Abstractpub_date
1982-03-01 00:00:00pages
244-7issue
3eissn
0014-2980issn
1521-4141journal_volume
12pub_type
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journal_title:European journal of immunology
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