A cross-reacting human idiotype (B17) associated with antibodies to N-acetyl-D-glucosamine. Specificity, immunoglobulin class association, and distribution in the population.

abstract：:Targeting exogenous antigen into the MHC class I-restricted presentation pathway is a prerequisite for the induction of cytotoxic T lymphocytes (CTL) which have been shown to represent an important component of the protective and therapeutic immune response to viral infections and tumors. In this study, we produced re...

journal_title：European journal of immunology

authors： Lee RS,Tartour E,van der Bruggen P,Vantomme V,Joyeux I,Goud B,Fridman WH,Johannes L

更新日期：1998-09-01 00:00:00

abstract：:The immune system relies on homeostatic mechanisms in order to adapt to the changing requirements encountered during steady-state existence and activation by antigen. For T cells, this involves maintenance of a diverse repertoire of naïve cells, rapid elimination of effector cells after pathogen clearance, and long-te...

journal_title：European journal of immunology

authors： Boyman O,Létourneau S,Krieg C,Sprent J

更新日期：2009-08-01 00:00:00

abstract：:The anti-PC antibodies of BALB/c origin bear predominantly the idiotype characteristic of the phosphorylcholine (PC)-binding T15 idiotype than sera from adult mice, and, unlike the latter, they also contain detectable amounts of anti-T15 antibodies. By 2 weeks of age the anti-T15 antibodies are no longer detectable wh...

journal_title：European journal of immunology

authors： Augustin A,Cosenza H

更新日期：1976-07-01 00:00:00

abstract：:Natural antibodies (Ab) reacting with self antigens have been shown to be present in all individuals. These autoantibodies (auto-Ab) can be either pathogenic or non-pathogenic. Auto-Ab reacting with the alpha-subunit of the high-affinity receptor for IgE (FcepsilonRIalpha) have been implicated in the pathogenesis of a...

journal_title：European journal of immunology

authors： Horn MP,Gerster T,Ochensberger B,Derer T,Kricek F,Jouvin MH,Kinet JP,Tschernig T,Vogel M,Stadler BM,Miescher SM

更新日期：1999-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...

journal_title：European journal of immunology

authors： Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A

更新日期：2007-02-01 00:00:00

abstract：:The involvement of Lyt-2+ T cells in the immunological control of cutaneous leishmaniasis was assessed by studying the course of the disease in mice in which the number of these cells was reduced by treatment with anti-Lyt-2 monoclonal antibody (mAb). Administration of anti-Lyt-2 mAb exacerbated Leishmania major-induc...

journal_title：European journal of immunology

authors： Titus RG,Milon G,Marchal G,Vassalli P,Cerottini JC,Louis JA

更新日期：1987-10-01 00:00:00

abstract：:The transcription factor c-Maf is critical for IL-4 production and the development of Th2 cells, which promote humoral immunity and protect against extracellular parasites. Yet, little else is known of c-Maf function in CD4 cells. Here, we identify a novel role for c-Maf in regulating susceptibility to apoptosis. Over...

journal_title：European journal of immunology

authors： Peng S,Lalani S,Leavenworth JW,Ho IC,Pauza ME

更新日期：2007-10-01 00:00:00

abstract：:Thymic nurse cells, cortical epithelial cells enclosing 20-200 lymphocytes, were prepared from mouse thymus by enzyme digestion and repetitive sedimentation. Individual nurse cells were then isolated free of any exogenous thymocytes by micromanipulation, and the endogeneous thymocytes released from inside the nurse ce...

journal_title：European journal of immunology

authors： Andrews P,Boyd RL,Shortman K

更新日期：1985-10-01 00:00:00

abstract：:Stilbene disulfonates are known to competitively inhibit Cl-/HCO3- flux through Band 3-related anion exchange (AE) proteins. To study the role of AE in lymphocyte activation, stilbene disulfonates were added to cultures of rat splenocytes (SPL). Four different stilbene derivatives were tested and each directly stimula...

journal_title：European journal of immunology

authors： Deane KH,Mannie MD

更新日期：1992-05-01 00:00:00

abstract：:The role of TGF-beta1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-beta1 has a profound inhibitory effect on naive CD4+ T cell undergoing differentiation...

journal_title：European journal of immunology

authors： Lúdvíksson BR,Seegers D,Resnick AS,Strober W

更新日期：2000-07-01 00:00:00

abstract：:CD16-positive (CD14(++) CD16(+) and CD14(+) CD16(++) ) monocytes have unique features with respect to phenotype and function. We have used transcriptional profiling for comparison of CD16-positive monocytes and classical monocytes. We show herein that 187 genes are greater than fivefold differentially expressed, incl...

journal_title：European journal of immunology

authors： Frankenberger M,Hofer TP,Marei A,Dayyani F,Schewe S,Strasser C,Aldraihim A,Stanzel F,Lang R,Hoffmann R,Prazeres da Costa O,Buch T,Ziegler-Heitbrock L

更新日期：2012-04-01 00:00:00

abstract：:We recently reported that parenteral injection of malaria palmitoyl-tailed peptides without adjuvant efficiently induces B, Th and CTL responses. We now show that intranasal (IN) or sub-lingual (SL) delivery of such lipopeptides induces strong systemic immune responses, as demonstrated by specific Th cell responses fr...

journal_title：European journal of immunology

authors： BenMohamed L,Belkaid Y,Loing E,Brahimi K,Gras-Masse H,Druilhe P

更新日期：2002-08-01 00:00:00

abstract：:Peptides associated with HLA-B35 commonly have a proline or occasionally a serine residue in the P2 anchor position of the peptide, with a tyrosine at the C terminus. Based on this motif, we identified an octamer epitope from influenza A matrix protein which is presented by HLA-B35. The requirements for MHC binding an...

journal_title：European journal of immunology

authors： Dong T,Boyd D,Rosenberg W,Alp N,Takiguchi M,McMichael A,Rowland-Jones S

更新日期：1996-02-01 00:00:00

abstract：:TCR degeneracy may facilitate self-reactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC class II alleles of the DR2 haplotype DR2a (DRB5*0101) and DR2b (DRB1*1501) are associated with an increased risk for MS in Caucasian populations. In order to selectively expand an...

journal_title：European journal of immunology

authors： Zhang X,Tang Y,Sujkowska D,Wang J,Ramgolam V,Sospedra M,Adams J,Martin R,Pinilla C,Markovic-Plese S

更新日期：2008-05-01 00:00:00

abstract：:Activated human monocytes are a source of numerous beta-chemokines. The present study was conducted to determine whether these cells produce the human beta-chemokine I-309 and to compare the induction requirements of I-309 to those of other beta-chemokines. We demonstrate that appropriately stimulated adherence-purifi...

journal_title：European journal of immunology

authors： Selvan RS,Zhou LJ,Krangel MS

更新日期：1997-03-01 00:00:00

abstract：:KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myel...

journal_title：European journal of immunology

authors： Lucas M,Daniel L,Tomasello E,Guia S,Horschowski N,Aoki N,Figarella-Branger D,Gomez S,Vivier E

更新日期：2002-09-01 00:00:00

abstract：:Studies of experimental autoimmune encephalomyelitis (EAE) in rodents have revealed that encephalitogenic T cell lines reactive with myelin basic protein (BP) are frequently dominated by clones expressing a restricted T cell receptor repertoire. Using the rat EAE model, we have begun to examine the basis for clonal do...

journal_title：European journal of immunology

authors： Sun D,Hu XZ,Coleclough C

更新日期：1995-01-01 00:00:00

abstract：:We have investigated the complexity of the human gamma delta T cell repertoire by means of a VJ heteroduplex analysis method. cDNA obtained from peripheral blood mononuclear cells was amplified with V delta 1-C delta or V delta 2-C delta primers. The product was denatured and renatured to allow random reannealing of t...

journal_title：European journal of immunology

authors： Giachino C,Granziero L,Modena V,Maiocco V,Lomater C,Fantini F,Lanzavecchia A,Migone N

更新日期：1994-08-01 00:00:00

abstract：:Several recent studies have identified eosinophils as a cellular source of various cytokines, indicating that eosinophils play not only an effector role, but also a regulatory role within the allergic inflammatory cell network. In this study, we demonstrate that eosinophils can generate and secrete monocyte chemoattra...

journal_title：European journal of immunology

authors： Izumi S,Hirai K,Miyamasu M,Takahashi Y,Misaki Y,Takaishi T,Morita Y,Matsushima K,Ida N,Nakamura H,Kasahara T,Ito K

更新日期：1997-04-01 00:00:00

abstract：:In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...

journal_title：European journal of immunology

authors： Lagaudrière-Gesbert C,Lebel-Binay S,Hubeau C,Fradelizi D,Conjeaud H

更新日期：1998-12-01 00:00:00

abstract：:To define activation-specific sequences in human T lymphocytes, a cDNA library was constructed by subtractive hybridization using resting and stimulated peripheral blood lymphocyte pairs. Stimulation of peripheral blood lymphocytes was achieved by triggering with mitogenic anti-CD2 (T11) monoclonal antibodies. Differe...

journal_title：European journal of immunology

authors： Chang HC,Reinherz EL

更新日期：1989-06-01 00:00:00

abstract：:FoxP3(+) Treg cells and anergic T cells are the two regulatory phenotypes of T-cell responses associated with helminth infection. Here, we examine the T-cell responses in mice during Fasciola hepatica infection, and to its tegumental coat antigens (FhTeg) that are shed from the fluke every 2-3 h. FhTeg comprises a ric...

journal_title：European journal of immunology

authors： Aldridge A,O'Neill SM

更新日期：2016-05-01 00:00:00

abstract：:Foxp3-expressing Tregs play a non-redundant role in protecting against immune pathologies. Foxp3(+) Tregs can arise intra- and extra-thymically, however, the signals directing their differentiation and maintenance in the periphery are not well understood. We show that stimulation of mouse naïve CD4(+) T cells in vitro...

journal_title：European journal of immunology

authors： Gabryšová L,Christensen JR,Wu X,Kissenpfennig A,Malissen B,O'Garra A

更新日期：2011-05-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:An immunoglobulin epsilon-chain fragment was synthesized in E. coli by cloning and expression of the gene coding for the second, third and fourth constant domains of the human IgE heavy chain. The bacterial CH2-4 polypeptide product was assembled by oxidation into a covalently linked dimeric epsilon-chain molecule pre...

journal_title：European journal of immunology

authors： Coleman JW,Helm BA,Stanworth DR,Gould HJ

更新日期：1985-09-01 00:00:00

abstract：:The magnitude of the output of lymphocytes from Peyer's patches (PP), the morphology of the lymphocytes and their route of exit from PP has been examined in sheep. An extracorporeal perfusion system was used to selectively label a 3-4 m length of the terminal ileum of lambs at 6-10 weeks of age (the mesenteric lymph n...

journal_title：European journal of immunology

authors： Reynolds JD,Pabst R

更新日期：1984-01-01 00:00:00

abstract：:F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...

journal_title：European journal of immunology

authors： Schofield JP,Vijayakumar RK,Oliveira DB

更新日期：1991-05-01 00:00:00

abstract：:NK cells are important for the control of vaccinia virus (VV) in vivo. Recent studies have shown that multiple pathways are required for effective activation of NK cells. These include both TLR-dependent and -independent pathways, as well as the NKG2D activating receptor that recognizes host stress-induced NKG2D ligan...

journal_title：European journal of immunology

authors： Brandstadter JD,Huang X,Yang Y

更新日期：2014-09-01 00:00:00

abstract：:To determine whether antigen (Ag)-specific cytotoxic T lymphocytes are generated during experimental Candida albicans infection, purified L3T4+ and Ly-2+ lymphocytes from immunized mice were cultured in the presence of syngeneic accessory cells, C. albicans Ag, and interleukin 2. Yeast-infected bone marrow macrophages...

journal_title：European journal of immunology

authors： Romani L,Mocci S,Cenci E,Rossi R,Puccetti P,Bistoni F

更新日期：1991-06-01 00:00:00

abstract：:Interleukin 2 (IL2)-dependent cytolytic hybrids usually loose IL2 dependence and cytolytic activity concomittantly. Here we describe an exceptional IL2-independent variant which lost IL2 receptor but retained cytolytic activity. When the IL2-independent cytolytic hybrid cells were fused with IL2-dependent cytolytic cl...

journal_title：European journal of immunology

authors： Haas W,Kisielow P

更新日期：1985-08-01 00:00:00