Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis.

abstract：:To detect possible differences in immunogenicity between tumors induced in T cell-deficient mice and phenotypically normal congenic mice, 16 sarcomas, 8 having developed in nude BALB/c mice and 8 having developed in congenic normal (nu/+) mice, were transplanted to normal BALB/c recipients and the rates of rejection o...

journal_title：European journal of immunology

authors： Svane IM,Engel AM,Nielsen MB,Ljunggren HG,Rygaard J,Werdelin O

更新日期：1996-08-01 00:00:00

abstract：:The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) have been shown to be primary mediators in the pathogenesis of chronic inflammatory joint diseases. However, the relative contributions of these molecules to the development and progression of disease is not known. In the present study...

journal_title：European journal of immunology

authors： Probert L,Plows D,Kontogeorgos G,Kollias G

更新日期：1995-06-01 00:00:00

abstract：:Foxp3-expressing Tregs play a non-redundant role in protecting against immune pathologies. Foxp3(+) Tregs can arise intra- and extra-thymically, however, the signals directing their differentiation and maintenance in the periphery are not well understood. We show that stimulation of mouse naïve CD4(+) T cells in vitro...

journal_title：European journal of immunology

authors： Gabryšová L,Christensen JR,Wu X,Kissenpfennig A,Malissen B,O'Garra A

更新日期：2011-05-01 00:00:00

abstract：:The second HLA-DR molecules, which are encoded by loci different from HLA-DRB1 are weakly polymorphic. Predominant alleles such as HLA-DRB3*0101, HLA-DRB4*0101 and HLA-DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, they have been poorly...

journal_title：European journal of immunology

authors： Texier C,Pouvelle-Moratille S,Busson M,Charron D,Ménez A,Maillère B

更新日期：2001-06-01 00:00:00

abstract：:The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. In vivo, it has a dramatic protective effect against ...

journal_title：European journal of immunology

authors： Kiely PD,Gillespie KM,Oliveira DB

更新日期：1995-10-01 00:00:00

abstract：:Spleen cells from trypanosome-infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H-2-different) stimulator cells. This suppression was not H-2-restricted, as responses of spleen lymphocytes both allogeneic and syngenei...

journal_title：European journal of immunology

authors： Pearson TW,Roelants GE,Pinder M,Lundin LB,Mayor-Withey KS

更新日期：1979-03-01 00:00:00

abstract：:Regulation of the development of thymocytes into mature T cells within the thymus is now known to involve antigen-induced deletion, by apoptosis, of potentially autoreactive thymocytes, and it can be mimicked either by stimulating the T cell receptor (TcR) complex by monoclonal antibody (mAb) or by ionophore-induced e...

journal_title：European journal of immunology

authors： Conroy LA,Jenkinson EJ,Owen JJ,Michell RH

更新日期：1995-07-01 00:00:00

abstract：:Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...

journal_title：European journal of immunology

authors： Jurk M,Kritzler A,Schulte B,Tluk S,Schetter C,Krieg AM,Vollmer J

更新日期：2006-07-01 00:00:00

abstract：:Dendritic cells (DC) are the main orchestrators of specific immune responses. Depending on microbial information they encounter in peripheral tissues, they promote the development of Th1, Th2 or unpolarized Th cell responses. In this study we have investigated the immunomodulatory effect of non-pathogenic intestinal G...

journal_title：European journal of immunology

authors： Smits HH,van Beelen AJ,Hessle C,Westland R,de Jong E,Soeteman E,Wold A,Wierenga EA,Kapsenberg ML

更新日期：2004-05-01 00:00:00

abstract：:Large-scale extravasation of lymphocytes takes place in vivo under physiological conditions in lymph nodes at very specialized vascular segments called high endothelial venules (HEV). When circulating lymphocytes leave the blood, they first bind to endothelial cells of HEV (HE cells) and subsequently enter lymph nodes...

journal_title：European journal of immunology

authors： Ise Y,Yamaguchi K,Sato K,Yamamura Y,Kitamura F,Tamatani T,Miyasaka M

更新日期：1988-08-01 00:00:00

abstract：:We have fractionated human tonsillar B cells on the basis of CD5 expression and determined the nucleotide sequences of immunoglobin light chain variable (V) regions encoded by the single member of the V chi 4 gene family in both CD5+ and CD5- populations. The majority of cDNA from both CD5+ and CD5- B cells population...

journal_title：European journal of immunology

authors： Ebeling SB,Schutte ME,Logtenberg T

更新日期：1993-06-01 00:00:00

abstract：:The TCR structure of T cell hybridomas recognizing a tumor glycan-defined epitope has been studied using reverse transcriptase-PCR and gene sequencing. The hybridomas had been raised against a glycopeptide, T72(Tn), consisting of the mouse hemoglobin-derived decapeptide Hb(67 - 76), O-glycoslated in position 72 with a...

journal_title：European journal of immunology

authors： Jensen T,Hansen P,Faurskov Nielsen A,Meldal M,Komba S,Werdelin O

更新日期：1999-09-01 00:00:00

abstract：:Membrane-bound IgG was found only on old populations of platelets from normal individuals. This IgG could be dissociated from senescent cells by repeatedly heating the cells. Heat-eluted IgG (He-IgG) prepared from senescent red blood cells was capable of binding to either heat-treated old platelets or Vibrio cholerae ...

journal_title：European journal of immunology

authors： Khansari N,Fudenberg HH

更新日期：1983-12-01 00:00:00

abstract：:Human invariant natural killer T (NKT) cell TCRs bind to CD1d via an "invariant" Vα24-Jα18 chain (iNKTα) paired to semi-invariant Vβ11 chains (iNKTβ). Single-amino acid variations at position 93 (p93) of iNKTα, immediately upstream of the "invariant" CDR3α region, have been reported in a substantial proportion of huma...

journal_title：European journal of immunology

authors： Sanderson JP,Waldburger-Hauri K,Garzón D,Matulis G,Mansour S,Pumphrey NJ,Lissin N,Villiger PM,Jakobsen B,Faraldo-Gómez JD,Gadola SD

更新日期：2012-01-01 00:00:00

abstract：:As shown recently, CD3+/TcR+ functional T lymphocytes can be derived in culture from embryonic liver cell precursors at a gestational age (6-8 weeks) preceding the colonization of the epithelial thymus. In this report, we analyzed the V beta repertoire of T lymphocytes derived from embryonic liver by applying a quanti...

journal_title：European journal of immunology

authors： Poggi A,Demarest JF,Costa P,Biassoni R,Pella N,Pantaleo G,Mingari MC,Moretta L

更新日期：1994-09-01 00:00:00

abstract：:We analyzed the stimulating capacities of malignant B cells from non-Hodgkin's lymphomas (NHL) to induce an allogeneic response in primary mixed lymphocyte reaction (MLR). T cells purified from a single healthy donor (KS) were used to compare the responses induced by either malignant or hyperplastic cells. Malignant B...

journal_title：European journal of immunology

authors： Plumas J,Chaperot L,Jacob MC,Molens JP,Giroux C,Sotto JJ,Bensa JC

更新日期：1995-12-01 00:00:00

abstract：:The role of TGF-beta1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-beta1 has a profound inhibitory effect on naive CD4+ T cell undergoing differentiation...

journal_title：European journal of immunology

authors： Lúdvíksson BR,Seegers D,Resnick AS,Strober W

更新日期：2000-07-01 00:00:00

abstract：:With the aid of a specific rabbit antibody preparation to purified monoclonal murine IgE, two plaque-forming cell (PFC) assays have been developed for the detection and enumeration of mouse IgE-secreting cells. The first assay, utilizing protein A-coated sheep red cells (protein A-SRC), detected antibody-secreting cel...

journal_title：European journal of immunology

authors： Rector ES,Lang GM,Carter BG,Kelly KA,Bundesen PG,Böttcher I,Sehon AH

更新日期：1980-12-01 00:00:00

abstract：:The effector function of activated CD4(+) T cells and secretion of cytokines are important in the establishment of productive immune responses and tolerance. We identified expression by CD4(+) T cells of Notch receptors and ligands and enhanced Notch signaling upon activation. Notch1 expression was up regulated and co...

journal_title：European journal of immunology

authors： Benson RA,Adamson K,Corsin-Jimenez M,Marley JV,Wahl KA,Lamb JR,Howie SE

更新日期：2005-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma ), a member of the nuclear receptor superfamily, has recently been described as a modulator of macrophage functions and as an inhibitor of T cell proliferation. Here, we investigated the role of PPARgamma in dendritic cells (DC), the most potent antigen-prese...

journal_title：European journal of immunology

authors： Gosset P,Charbonnier AS,Delerive P,Fontaine J,Staels B,Pestel J,Tonnel AB,Trottein F

更新日期：2001-10-01 00:00:00

abstract：:CD4+ alpha beta T cell populations that develop in mice deficient in MHC class II (through 'knockout' of either the Aalpha, or the Abeta chain of the I-A(b) molecule) comprise a major 'single-positive' (SP) CD4+ CD8- subset (60-90%) and a minor 'double-positive' (DP) CD4+ CD8alpha beta+ subset (10-40%). Many DP T cell...

journal_title：European journal of immunology

authors： Krajina T,Leithäuser F,Reimann J

更新日期：2004-03-01 00:00:00

abstract：:A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...

journal_title：European journal of immunology

authors： Pircher H,Rebaï N,Groettrup M,Grégoire C,Speiser DE,Happ MP,Palmer E,Zinkernagel RM,Hengartner H,Malissen B

更新日期：1992-02-01 00:00:00

abstract：:The Fc or pFc' fragments of the human IgG were demonstrated to exert different effects on murine T lymphocyte subsets. Thus, murine lymph node (LN) T cells were specifically induced to proliferate in vitro to pFc' after priming in vivo. This proliferation could be inhibited, either by depleting the responding LN popul...

journal_title：European journal of immunology

authors： Baxevanis CN,Ioannides CD,Reclos GJ,Papamichail M

更新日期：1986-08-01 00:00:00

abstract：:The outcomes of many diseases differ between women and men, with women experiencing a higher incidence and more severe pathogenesis of autoimmune and some infectious diseases. It has been suggested that this is partially due to activation of plasmacytoid dendritic cells (pDCs), the main producers of interferon (IFN)-α...

journal_title：European journal of immunology

authors： Ziegler SM,Beisel C,Sutter K,Griesbeck M,Hildebrandt H,Hagen SH,Dittmer U,Altfeld M

更新日期：2017-02-01 00:00:00

abstract：:The molecular mimicry represented by cross-recognition of determinants shared by unrelated antigens by antibodies or T cells is of broad immunological interest. In this study, we analyzed the cross-recognition by CD4+ T cells of a peptide epitope shared by two mycobacterial proteins of diverse sequence, represented by...

journal_title：European journal of immunology

authors： Harris DP,Vordermeier HM,Singh M,Moreno C,Jurcevic S,Ivanyi J

更新日期：1995-11-01 00:00:00

abstract：:DC not only activate CD4 T (Th) cell and cytotoxic CD8 T cell (CTL) responses against pathogens, but they also tolerize autoreactive T cells in order to avoid autoimmunity. Previous studies have demonstrated that steady-state DC can tolerize naïve CTL, naïve Th cells and memory CTL. A study in this issue of the Europe...

journal_title：European journal of immunology

authors： Kurts C

更新日期：2010-07-01 00:00:00

abstract：:NK cells are the main cells of the innate immune system that produce IFN-γ, and they express this cytokine at early stages of maturation in response to cytokine stimulation. Conversely, acquisition of IFN-γ-competence in CD4(+) T helper cells requires a differentiation process from naïve toward type 1 (Th1) cells, whi...

journal_title：European journal of immunology

authors： Luetke-Eversloh M,Cicek BB,Siracusa F,Thom JT,Hamann A,Frischbutter S,Baumgrass R,Chang HD,Thiel A,Dong J,Romagnani C

更新日期：2014-07-01 00:00:00

abstract：:The MHC class II molecule H2-A(s), expressed in the SJL mouse strain, is the principle restriction element of autoreactive CD4(+) T cells mediating experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. We deduced the H2-A(s) ligand motif from the analysis of naturally processed self peptide...

journal_title：European journal of immunology

authors： Kalbus M,Fleckenstein BT,Offenhäusser M,Blüggel M,Melms A,Meyer HE,Rammensee HG,Martin R,Jung G,Sommer N

更新日期：2001-02-01 00:00:00

abstract：:RNA from 170 different Ig-secreting hybridomas was hybridized with VH gene probes 7183, QUPC52, S107, J558, J606, 36-60, V31, X-24 and V-GAM 3.8, with the aim of comparing xid to non-xid mice, neonatal NZB to adult NZB, and the peritoneal cavity with the splenic compartments for VH gene family expression. Our results ...

journal_title：European journal of immunology

authors： Dighiero G,Lim A,Lembezat MP,Kaushik A,Andrade L,Freitas A

更新日期：1988-12-01 00:00:00

abstract：:Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative phosphorylation using pyruvate (derived from glucose and glycolysis) and fatty acids (FAs), both of which are oxidized in the Krebs cycle, as fuel sources. Mitochondria are also an important source of reactive oxygen species (ROS)...

journal_title：European journal of immunology

authors： Mills EL,O'Neill LA

更新日期：2016-01-01 00:00:00