Abstract:
:DC not only activate CD4 T (Th) cell and cytotoxic CD8 T cell (CTL) responses against pathogens, but they also tolerize autoreactive T cells in order to avoid autoimmunity. Previous studies have demonstrated that steady-state DC can tolerize naïve CTL, naïve Th cells and memory CTL. A study in this issue of the European Journal of Immunology demonstrates that DC also tolerize memory Th cells. This is arguably most critical for developing therapies against autoimmune disease; first, because Th cells are the central regulators of all adaptive immune responses, and second because memory, rather than naïve T cells are the clinically relevant cells in established autoimmune diseases. This study fosters hope that DC-based specific immunotherapies for common autoimmune diseases are possible.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Kurts Cdoi
10.1002/eji.201040704subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1870-2issue
7eissn
0014-2980issn
1521-4141journal_volume
40pub_type
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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abstract::Dendritic cells (DC) are sentinels of the immune system, transporting antigens from the periphery to secondary lymphoid organs. This study investigates the interactions of DC with B cells for the induction of anti-viral neutralizing antibody responses. Using the vesicular stomatitis virus glycoprotein (VSV-G) as a mod...
journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章,评审
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
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abstract::Intravenous immunoglobulin G (IVIg) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti-inflammatory activity of IVIg in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (ITP)...
journal_title:European journal of immunology
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更新日期:2012-04-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/eji.1830180525
更新日期:1988-05-01 00:00:00
abstract::The migration of immunocytes within the extracellular matrix (ECM) is influenced by the activation state of the incoming cell and its responses to the presence of chemokines and cytokines. We studied the regulatory role of TGF-beta1 on T cell homing to secondary lymphatic organs, such as the spleen, and chemotaxis wit...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200201)32:1<193::AID-IMMU193>3.0
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journal_title:European journal of immunology
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更新日期:1994-08-01 00:00:00
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更新日期:2011-05-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/eji.1830230530
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journal_title:European journal of immunology
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doi:10.1002/(sici)1521-415x(200001)30:1<14::aid-biuz14
更新日期:2000-01-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/eji.1830250731
更新日期:1995-07-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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abstract::In a search for proteins involved in signal transduction through the T cell receptor (TcR/CD3 complex), a recently developed highly efficient method for labeling of nucleotide binding proteins in permeabilized cells was applied. Here, we report that human CD3-gamma could be labeled by periodate-oxidized [alpha-32P] GT...
journal_title:European journal of immunology
pub_type: 杂志文章
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abstract::Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern that effective vaccine adjuvants may similarly rely on widespread DC ...
journal_title:European journal of immunology
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更新日期:2008-05-01 00:00:00