Stimulation and suppression of rat mast cell functions by alloantibodies.

abstract：:Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*...

journal_title：European journal of immunology

authors： Lewis JW,Sewell A,Price D,Elliott T

更新日期：1998-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the emergence of autoreactive T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these cells in its immunopathogenesis. This subset uses an invariant TC...

journal_title：European journal of immunology

authors： Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A

更新日期：2007-02-01 00:00:00

abstract：:It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selection). However, we now p...

journal_title：European journal of immunology

authors： Jenkinson EJ,Kingston R,Owen JJ

更新日期：1990-11-01 00:00:00

abstract：:Induction of the glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a role in their antiinflammatory action, whereas GILZ expression is reduced under inflammatory conditions. The mechanisms regulating GILZ expression during inflammation, however, have not yet been characterized. Here, we investigate...

journal_title：European journal of immunology

authors： Hoppstädter J,Diesel B,Eifler LK,Schmid T,Brüne B,Kiemer AK

更新日期：2012-05-01 00:00:00

abstract：:HIV controllers are a valuable source for the identification of HIV-neutralizing antibodies, as chronic infection over decades allows extensive affinity maturation of antibodies for improved Ag recognition. We analyzed a small cohort of elite controllers (ECs) for HIV-neutralizing antibodies using a panel of standardi...

journal_title：European journal of immunology

authors： Zhou M,Meyer T,Koch S,Koch J,von Briesen H,Benito JM,Soriano V,Haberl A,Bickel M,Dübel S,Hust M,Dietrich U

更新日期：2013-02-01 00:00:00

abstract：:Activation of the alternative complement pathway by human B cell lymphoma lines is correlated with the presence of Epstein Barr virus (EBV) in the cell genome. EBV-negative B cell lymphoma lines produce little activation of the alternative pathway as measured either by C3 deposition on the cell surface or C3 conversio...

journal_title：European journal of immunology

authors： McConnell I,Klein G,Lint TF,Lachmann PJ

更新日期：1978-07-01 00:00:00

abstract：:Activation of naive T cells is tightly controlled and depends on cognate interactions with professional antigen-presenting cells. We analyzed dependency on secondary lymphoid tissues for the activation of naive and memory CD4(+) and CD8(+) T cells following primary and secondary Listeria monocytogenes infection, respe...

journal_title：European journal of immunology

authors： Kursar M,Jänner N,Pfeffer K,Brinkmann V,Kaufmann SH,Mittrücker HW

更新日期：2008-01-01 00:00:00

abstract：:We isolated immunoglobulin (Ig) VH4 genes that were rearranged in the genomic DNA of 160 day human fetal spleen. Productively rearranged VH 4-21 genes were cloned into pRTM1, a human IgM expression vector. This allowed us to generate IgM kappa-expressing transfectomas by co-transfecting each of these constructs with p...

journal_title：European journal of immunology

authors： Parr TB,Johnson TA,Silberstein LE,Kipps TJ

更新日期：1994-12-01 00:00:00

abstract：:Good responder (C57/Br/cd) and poor responder (C57BL/10) mice were immunized with mouse thyroid extract in Freund's complete adjuvant. The good responder mice first showed antibody to thyroglobulin on the seventh day while the poor responder animals had slightly lower titers and antibody did not appear until day 12. T...

journal_title：European journal of immunology

authors： Tomazic V,Rose NR

更新日期：1977-01-01 00:00:00

abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

journal_title：European journal of immunology

authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

更新日期：1996-08-01 00:00:00

abstract：:The distribution of the murine receptor for interleukin (IL) 6 was examined on a variety of cells. Binding sites for IL 6 were found on many cell lines including fibroblasts and bone marrow-derived macrophages. The highest density of binding sites was found on B cell hybridomas and plasmacytomas, irrespective of their...

journal_title：European journal of immunology

authors： Coulie PG,Stevens M,Van Snick J

更新日期：1989-11-01 00:00:00

abstract：:Physical exercise, mental stress, or infusion of beta-adrenergic agonists result in an increase in the number of natural killer (NK) cells in the peripheral circulation. In view of the specific migration pattern of NK cells in vivo, it has been suggested that these cells may be released from the marginating pool in bl...

journal_title：European journal of immunology

authors： Benschop RJ,Oostveen FG,Heijnen CJ,Ballieux RE

更新日期：1993-12-01 00:00:00

abstract：:The monoclonal antibody W6/32.1 recognizes a public determinant on the HLA-A, B and C antigens of all tested human haplotypes. Though the antibody does not bind to normal mouse cells of any H-2 haplotype, it does show an unexpected specificity for the T cell leukemia line MBL-2 from a C57BL/6 mouse. It is shown that t...

journal_title：European journal of immunology

authors： Evan GI,Lennox ES,Alderson T,Croft L

更新日期：1983-02-01 00:00:00

abstract：:Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

journal_title：European journal of immunology

authors： de la Rosa M,Rutz S,Dorninger H,Scheffold A

更新日期：2004-09-01 00:00:00

abstract：:Antigen-induced stimulation of T cells is mediated via the CD3 antigen receptor (Ti) complex and monoclonal antibodies (mAb) reacting with CD3 and Ti result in rapid intracellular Ca2+ mobilization, followed by monocyte-dependent proliferation. Combinations of mAb to CD2, the sheep red blood cell receptor, also mobili...

journal_title：European journal of immunology

authors： O'Flynn K,Knott LJ,Russul-Saib M,Abdul-Gaffar R,Morgan G,Beverley PC,Linch DC

更新日期：1986-05-01 00:00:00

abstract：:Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detect...

journal_title：European journal of immunology

authors： Smith LJ,Sogh JA,Kindt TJ,Mandy WJ

更新日期：1979-01-01 00:00:00

abstract：:Human NK cells can be subdivided into CD56(dim) and CD56(bright) NK cells, which exhibit different phenotypical and functional characteristics. As murine NK cells lack CD56 or a distinct correlate, direct comparative studies of NK cells in mice and humans are limited. Although CD27 is currently proposed as a feasible ...

journal_title：European journal of immunology

authors： Marquardt N,Wilk E,Pokoyski C,Schmidt RE,Jacobs R

更新日期：2010-05-01 00:00:00

abstract：:Persistent polyclonal B cell lymphocytosis (PPBL) is a hematological disorder diagnosed predominantly in women, characterized by a polyclonal increase in the number of peripheral blood B lymphocytes. Abnormality of the B cell population was evidenced by the finding of multiple bcl-2/Ig gene rearrangements and an addit...

journal_title：European journal of immunology

authors： Loembé MM,Néron S,Delage R,Darveau A

更新日期：2002-12-01 00:00:00

abstract：:This study describes a CD5+ B cell that differs from the majority of the CD5+ B cells from human tonsils. This cell, isolated from in vivo activated B cells, expressed activation markers and featured a CD23-, IgMhigh, IgDlow surface phenotype, responded to T cell-independent type-2 antigens in vitro, and was detected ...

journal_title：European journal of immunology

authors： Dono M,Burgio VL,Colombo M,Sciacchitano S,Reverberi D,Tarantino V,Cutrona G,Chiorazzi N,Ferrarini M

更新日期：2007-08-01 00:00:00

abstract：:Chemokine receptors are important for recruiting leukocytes to sites of infection and may contribute to immune cell activation. The present study investigated the role of the chemokine receptor CCR2 in polymicrobial septic peritonitis. The results showed that peritoneal production of the CCR2 ligands CCL2 and CCL12 in...

journal_title：European journal of immunology

authors： Feterowski C,Mack M,Weighardt H,Bartsch B,Kaiser-Moore S,Holzmann B

更新日期：2004-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI-induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased >20-fold the day after i...

journal_title：European journal of immunology

authors： Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE

更新日期：2013-08-01 00:00:00

abstract：:The immunosuppressor sanglifehrin A (SfA) is a member of a family of immunophilin cyclophilin A-binding molecules and does not inhibit calcineurin activity. Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability. This immunosuppre...

journal_title：European journal of immunology

authors： Sànchez-Tilló E,Wojciechowska M,Comalada M,Farrera C,Lloberas J,Celada A

更新日期：2006-09-01 00:00:00

abstract：:The molecular mimicry represented by cross-recognition of determinants shared by unrelated antigens by antibodies or T cells is of broad immunological interest. In this study, we analyzed the cross-recognition by CD4+ T cells of a peptide epitope shared by two mycobacterial proteins of diverse sequence, represented by...

journal_title：European journal of immunology

authors： Harris DP,Vordermeier HM,Singh M,Moreno C,Jurcevic S,Ivanyi J

更新日期：1995-11-01 00:00:00

abstract：:A method is described for achieving the efficient production of proteins of biological interest by the establishment of hybridomas from lymphocytes of transgenic animals carrying a fusion gene having promoter-regulatory sequences functional in lymphocytes fused to the coding sequences of the protein to be produced. Wh...

journal_title：European journal of immunology

authors： Babinet C,Morello D,Rougeot C,Rouyre S

更新日期：1986-08-01 00:00:00

abstract：:Human antibodies against HIV-1 have been sought to study neutralization events on the molecular level, and for possible use in passive immune intervention. The development of phage display techniques has opened the possibility of rapidly generating human monoclonal antibodies with desired specificities. We and others ...

journal_title：European journal of immunology

authors： Samuelsson A,Yari F,Hinkula J,Ersoy O,Norrby E,Persson MA

更新日期：1996-12-01 00:00:00

abstract：:Intravenous immunoglobulin G (IVIg) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti-inflammatory activity of IVIg in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (ITP)...

journal_title：European journal of immunology

authors： Schwab I,Biburger M,Krönke G,Schett G,Nimmerjahn F

更新日期：2012-04-01 00:00:00

abstract：:Four cell lines derived from spontaneous BALB/c lymphoma tumors were analyzed with regard to the type of their membrane immunoglobulins (Ig). Using lactoperoxidase iodination of membrane proteins combined with immunoprecipitation and electrophoresis on polyacrylamide gel, three of these cell lines (X16c, L10A and K46)...

journal_title：European journal of immunology

authors： Laskov R,Kim JK,Woods VL,McKeever PE,Asofsky R

更新日期：1981-06-01 00:00:00

abstract：:Cholesterol- and sphingolipid-rich membrane microdomains termed lipid rafts appear to play a central role in B cell activation. In mature B cells, signaling through the B cell antigen receptor(BCR) is initiated from within rafts and leads to activation. In immature B cells, the BCR is excluded from rafts and signaling...

journal_title：European journal of immunology

authors： Malapati S,Pierce SK

更新日期：2001-12-01 00:00:00

abstract：:The second HLA-DR molecules, which are encoded by loci different from HLA-DRB1 are weakly polymorphic. Predominant alleles such as HLA-DRB3*0101, HLA-DRB4*0101 and HLA-DRB5*0101 are therefore interesting targets to define antigenic peptides with major impact for the entire population. Strikingly, they have been poorly...

journal_title：European journal of immunology

authors： Texier C,Pouvelle-Moratille S,Busson M,Charron D,Ménez A,Maillère B

更新日期：2001-06-01 00:00:00

abstract：:Even after repeated immunizations with alpha(1-3)dextran (Dex) male (CBA/N x BALB/c)F1 mice fail to produce specific antibodies whereas nondefective female littermates express an idiotype-positive anti-Dex immune response. This failure of xid mice to express serum anti-Dex immunoglobulins is not only limited to immuni...

journal_title：European journal of immunology

authors： Selinka HC,Bösing-Schneider R

更新日期：1988-11-01 00:00:00