Analysis of expressed V(H) genes in persistent polyclonal B cell lymphocytosis reveals absence of selection in CD27+IgM+IgD+ memory B cells.

abstract：:In the frog Xenopus, MHC class I antigen presentation and processing genes (the immunoproteasome LMP2 and LMP7 and the transporter TAP1 and TAP2) seem to be closely linked in a primordial organization. Two distinct lineages of class Ia and LMP7 loci were previously identified, thus strongly suggesting co-evolution amo...

journal_title：European journal of immunology

authors： Ohta Y,Powis SJ,Lohr RL,Nonaka M,Pasquier LD,Flajnik MF

更新日期：2003-11-01 00:00:00

abstract：:We show that latently gammaherpesvirus-infected B cells are present in the thymus. This could result in a functional T-cell tolerance against certain viral epitopes. It is conceivable that also antigens from other viruses or pathogens may be conveyed to the thymus for their immune evasion. ...

journal_title：European journal of immunology

authors： Yamano T,Steinert M,Steer B,Klein L,Hammerschmidt W,Adler H

更新日期：2019-02-01 00:00:00

abstract：:Somatic hypermutation in B cells undergoing T cell dependent immune responses generates high affinity antibodies that provide protective immunity. B cells also switch from the expression of immunoglobulin (Ig) M and IgD to that of other Ig classes through somatic DNA recombination. Recent work has implicated DNA stran...

journal_title：European journal of immunology

authors： Klein U,Esposito G,Baudat F,Keeney S,Jasin M

更新日期：2002-02-01 00:00:00

abstract：:The importance of human herpesvirus 6 (HHV-6) species as human pathogens is increasingly appreciated. However, we do not understand how infection is controlled in healthy virus carriers, and why control fails in patients with disease. Other persistent viruses are under continuous surveillance by antigen-specific T cel...

journal_title：European journal of immunology

authors： Martin LK,Schub A,Dillinger S,Moosmann A

更新日期：2012-11-01 00:00:00

abstract：:Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

journal_title：European journal of immunology

authors： Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

更新日期：2019-05-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent inducer of interleukin 1 (IL 1) synthesis and release, and of tumor necrosis factor (TNF) secretion. Many signals can enhance the LPS-induced production of these cytokines. We have previously observed that addition of low amounts of normal human serum to the culture medium enhances...

journal_title：European journal of immunology

authors： Cavaillon JM,Fitting C,Haeffner-Cavaillon N

更新日期：1990-02-01 00:00:00

abstract：:Cervical thymus mimics the thoracic thymus in supporting T-cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus can generate T cells that are self-tolerant in the complete absence of signals from the thoracic thymus. Using a fetal liver reconstitution ...

journal_title：European journal of immunology

authors： Smolarchuk C,Zhu LF,Chan WF,Anderson CC

更新日期：2014-08-01 00:00:00

abstract：:Multinucleated giant cells (MGC), which are a common feature of various pathologic states, were generated in vitro by cytokine-stimulation of human peripheral blood monocytes. As expected, conditioned medium, i.e. the supernatant of concanavalin A-stimulated peripheral blood mononuclear cells, readily caused generatio...

journal_title：European journal of immunology

authors： Möst J,Neumayer HP,Dierich MP

更新日期：1990-08-01 00:00:00

abstract：:Th1 and Th2 cells, which produce distinct sets of cytokines, differentially express several chemokine receptors that may regulate their tissue-specific localization. Although the expression pattern and regulation of chemokines are likely to play a critical role in many immunopathological processes, they remain largely...

journal_title：European journal of immunology

authors： Iellem A,Colantonio L,Bhakta S,Sozzani S,Mantovani A,Sinigaglia F,D'Ambrosio D

更新日期：2000-04-01 00:00:00

abstract：:A rapidly-growing, HAT-sensitive cell line LICR-LON-HMy2 has been derived from the ARH-77 human plasma cell leukemia-derived line. It lacks the enzyme hypoxanthine phosphoribosyltransferase (EC 2.4.2.8). Hybrids have been reproducibly made for more than a year and in independent laboratories with lymphocytes from tons...

journal_title：European journal of immunology

authors： Edwards PA,Smith CM,Neville AM,O'Hare MJ

更新日期：1982-08-01 00:00:00

abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

journal_title：European journal of immunology

authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

更新日期：2019-07-01 00:00:00

abstract：:The murine intestinal epithelium contains a heterogeneous population of intraepithelial leukocytes (IEL) most of which are granulated, Thy-1-CD5-CD8+. In order to assess the lineage relationship of this subgroup of IEL to peripheral T cells, we examined IEL in mice with the severe combined immunodeficiency (scid/scid)...

journal_title：European journal of immunology

authors： Croitoru K,Stead RH,Bienenstock J,Fulop G,Harnish DG,Shultz LD,Jeffery PK,Ernst PB

更新日期：1990-03-01 00:00:00

abstract：:A number of applications of antibodies in diagnosis and therapy require multivalent reagents either because of the polymeric nature of the antigens or because biological activity depends on an effect on the formation of homodimeric species. Here, we report a procedure for mass screening of phage-derived monomeric anti...

journal_title：European journal of immunology

authors： Zaccolo M,Griffiths AP,Prospero TD,Winter G,Gherardi E

更新日期：1997-03-01 00:00:00

abstract：:Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence suggests that crescent formation results from a delayed-type hypersensitivity-like Th1 response. As IL-12 directs Th1 responses, we tested the hypothesis that IL-12 is important in crescentic GN. Neutralization of IL-12 attenuated cre...

journal_title：European journal of immunology

authors： Kitching AR,Tipping PG,Holdsworth SR

更新日期：1999-01-01 00:00:00

abstract：:Immunodominant T cell epitopes from the autoantigen human cartilage glycoprotein 39 have previously been mapped in the context of HLA-DR*0401 and *0402, using mice expressing HLA-DR4 transgenes. We measured the dissociation rates of these epitopes from soluble recombinant DR*0401 and DR*0402 to assess the relationship...

journal_title：European journal of immunology

authors： Hall FC,Rabinowitz JD,Busch R,Visconti KC,Belmares M,Patil NS,Cope AP,Patel S,McConnell HM,Mellins ED,Sonderstrup G

更新日期：2002-03-01 00:00:00

abstract：:We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) breaks tolerance induction. The objective of this study was to determine whether GM-CSF breaks established inhalation tolerance. To induce tolerance, BALB/c mice were exposed to aerosolized ovalbumin (OVA) for 10 consecutive days. A co...

journal_title：European journal of immunology

authors： Swirski FK,Gajewska BU,Robbins CS,D'Sa A,Johnson JR,Pouladi MA,Inman MD,Stämpfli MR

更新日期：2004-09-01 00:00:00

abstract：:In this study we have used cells expressing LFA-3 or T11TS, the human and sheep forms of the ligand of CD2, as well as the purified LFA-3 and T11TS molecules themselves to study their effects on T cell activation via the CD2-mediated "alternative pathway". Sheep red blood cells, which bind to CD2 via T11TS in E-rosett...

journal_title：European journal of immunology

authors： Tiefenthaler G,Hünig T,Dustin ML,Springer TA,Meuer SC

更新日期：1987-12-01 00:00:00

abstract：:Cells expressing the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and the chemokine C receptor (CCR)4 were consistently detected in the circulation of healthy subjects, whereas numbers of cells expressing CCR3 were much lower. While all CCR4+ cells were T cells, a small proportion of CRT...

journal_title：European journal of immunology

authors： Cosmi L,Annunziato F,Galli MIG,Maggi RME,Nagata K,Romagnani S

更新日期：2000-10-01 00:00:00

abstract：:The aim of this study was to investigate malignant lymphomas of donor origin induced in F1 mice undergoing a chronic graft-versus-host reaction (GVHR) after injection of parental strain spleen cells. A total of 3 X 10(8) or 4 X 10(8) C57BL/10 spleen cells were administered to 7-8-week-old H-2 incompatible (C57BL/10 X ...

journal_title：European journal of immunology

authors： Gleichmann E,Peters K,Lattmann E,Gleichmann H

更新日期：1976-06-01 00:00:00

abstract：:Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa g...

journal_title：European journal of immunology

authors： Sharpe MJ,Neuberger M,Pannell R,Surani MA,Milstein C

更新日期：1990-06-01 00:00:00

abstract：:Local graft-vs.-host reaction (GVHR) was induced in rats by injecting parental cells into young F1 recipients. As a consequence of antigenic stimulation in the course of developing GVHR in the responding lymph nodes, the number of interleukin 2-receptor (IL 2R)-bearing T cells increased from less than 1% up to 10% of ...

journal_title：European journal of immunology

authors： Volk HD,Brocke S,Osawa H,Diamantstein T

更新日期：1986-10-01 00:00:00

abstract：:Macrophages are becoming increasingly recognized as key cellular players in intestinal immune homeostasis. However, differentiating between macrophages and dendritic cells (DCs) is often difficult, and finding a specific phenotypic signature for intestinal macrophage identification has remained elusive. In this issue ...

journal_title：European journal of immunology

authors： De Calisto J,Villablanca EJ,Mora JR

更新日期：2012-12-01 00:00:00

abstract：:Strains CBA (M523) (= M523) and CBA differ by a mutation which has been mapped genetically into the K region of the H-2 complex. Similarly, strains B 10.D2 (M504 (= M504) and b 10.D2 differ in a mutation which occurred in the D region. The data presented in this study show that mixed lymphocyte culture in M523 anti-CB...

journal_title：European journal of immunology

authors： Geib RW,Klein J

更新日期：1979-02-01 00:00:00

abstract：:The MHC class Ib molecule H2-M3 presents N-formylated peptides from the N terminus of proteins encoded by the mitochondrial genome to CTL. A panel of CTL specific for a peptide derived from a mitochondrial protein, either COI or ND1, was used to determine the optimal peptide length for sensitizing antigen-deficient ta...

journal_title：European journal of immunology

authors： Dabhi VM,Lindahl KF

更新日期：1998-11-01 00:00:00

abstract：:A monoclonal antibody, termed 3-2F1, is specific for the rabbit VH al allotypic marker. This antibody appears to recognize a common al determinant since it reacts with all of the a1 immunoglobulin (Ig) that is bound by polyclonal rabbit anti-a1, and completely inhibits the binding of polyclonal anti-a1 to a1 Ig. When ...

journal_title：European journal of immunology

authors： Metzger DW

更新日期：1984-04-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein which is one of the ligands for the leukocyte function-associated antigen (LFA-1). It is involved in leukocyte adhesion to endothelial cells as well as in immune functions requiring cell-cell contact. The quantitative expression of ICAM-1 in various cell types can be either induce...

journal_title：European journal of immunology

authors： Geissler D,Gaggl S,Möst J,Greil R,Herold M,Dietrich M

更新日期：1990-12-01 00:00:00

abstract：:B cell development is dependent on both direct interactions with stromal cells and their secreted cytokines. The precise mechanisms by which these interactions regulate B cell differentiation are currently unknown. We report here that a novel growth factor thymic stromal-derived lymphopoietin (TSLP) can replace the ac...

journal_title：European journal of immunology

authors： Ray RJ,Furlonger C,Williams DE,Paige CJ

更新日期：1996-01-01 00:00:00

abstract：:Fas is a cell surface molecule that is expressed on a wide array of cell types and triggers apoptosis. While in most situations Fas ligation activates programmed cell death, on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex. This incongruity suggests that Fas may eli...

journal_title：European journal of immunology

authors： Wilson DJ,Fortner KA,Lynch DH,Mattingly RR,Macara IG,Posada JA,Budd RC

更新日期：1996-05-01 00:00:00

abstract：:Changes in the epigenetic landscape of immune cells are a crucial component of gene activation during the induction of inflammatory responses, therefore it has been hypothesized that epigenetic modulation could be employed to restore homeostasis in inflammatory scenarios. Fungal pathogens cause a large burden of morbi...

journal_title：European journal of immunology

authors： Domínguez-Andrés J,Ferreira AV,Jansen T,Smithers N,Prinjha RK,Furze RC,Netea MG

更新日期：2019-11-01 00:00:00

abstract：:Cartilage-specific proteins are considered potential autoantigens that could continuously fuel autoimmune responses directed to the joints in rheumatoid arthritis (RA). Using recombinant chimeric collagen type II we have identified one major type II collagen (CII) epitope (denoted U1) recognized by RA sera. The U1 epi...

journal_title：European journal of immunology

authors： Kraetsch HG,Unger C,Wernhoff P,Schneider C,Kalden JR,Holmdahl R,Burkhardt H

更新日期：2001-06-01 00:00:00