Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population.

abstract：:Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development of Th2-dependent airw...

journal_title：European journal of immunology

authors： Jung YW,Zindl CL,Lai JF,Weaver CT,Chaplin DD

更新日期：2009-08-01 00:00:00

abstract：:CD40 ligand (CD40L) and IL-4 are sufficient to induce resting murine B cells to divide and switch isotypes from IgM and IgD to IgG1 and IgE. Tracking of cell division following (5- and 6) carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling revealed that B cells expressed IgG1 after three cell divisions, an...

journal_title：European journal of immunology

authors： Hasbold J,Lyons AB,Kehry MR,Hodgkin PD

更新日期：1998-03-01 00:00:00

abstract：:The expression of IgG Fc receptor (FcR) molecules was examined on Ly-1+ B cells and B cells tumors. FcR molecules were found on a representative Ly-1+ B cell lymphoma of the pre-B and as well as of the mature cell B phenotypes. The expression of the FcR did not change on these cells during their differentiation to B c...

journal_title：European journal of immunology

authors： Dexter CM,Corley RB

更新日期：1987-06-01 00:00:00

abstract：:The viral CC chemokine macrophage inhibitory protein-II (vMIP-II) encoded by human herpes virus 8 (HHV-8) binds to multiple chemokine receptors, however, its ability to control the initial recruitment of specific leukocyte subtypes from the peripheral circulation has not been fully clarified. Here we show that vMIP-II...

journal_title：European journal of immunology

authors： Weber KS,Gröne HJ,Röcken M,Klier C,Gu S,Wank R,Proudfoot AE,Nelson PJ,Weber C

更新日期：2001-08-01 00:00:00

abstract：:CD72 has been reported to regulate BCR-mediated signals both positively and negatively. SHP-1 and Grb2 bind, respectively, to ITIM1 and ITIM2 of CD72. We generated transformed B cell lines with an immature phenotype following J2 virus infection of splenocytes from CD72(-/-) and wild-type (Wt) mice. The transformed lin...

journal_title：European journal of immunology

authors： Baba T,Fusaki N,Aoyama A,Li DH,Okamura RM,Parnes JR,Hozumi N

更新日期：2005-05-01 00:00:00

abstract：:T cell activation and cytokine secretion are important mediators of inflammation in allergic asthma. The costimulatory pathway CD28/CD80/CD86 has been shown to play an important role in T cell activation in allergic asthma, but less is known about the effect of other costimulatory molecules in allergy. The costimulato...

journal_title：European journal of immunology

authors： Arestides RS,He H,Westlake RM,Chen AI,Sharpe AH,Perkins DL,Finn PW

更新日期：2002-10-01 00:00:00

abstract：:Previous studies have suggested that T-lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS). In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell signaling, activation, and migration. ...

journal_title：European journal of immunology

authors： Kasic T,Colombo P,Soldani C,Wang CM,Miranda E,Roncalli M,Bronte V,Viola A

更新日期：2011-07-01 00:00:00

abstract：:CD27 is a lymphocyte-specific member of the TNF receptor (TNFR) family. It is a costimulatory molecule for peripheral T cells, as defined by its ability to enhance the TCR-induced proliferative response. We show here that CD27 augments TCR-induced Jun N-terminal kinase (JNK) activity in primary murine lymph node T cel...

journal_title：European journal of immunology

authors： Gravestein LA,Amsen D,Boes M,Calvo CR,Kruisbeek AM,Borst J

更新日期：1998-07-01 00:00:00

abstract：:RNA from 170 different Ig-secreting hybridomas was hybridized with VH gene probes 7183, QUPC52, S107, J558, J606, 36-60, V31, X-24 and V-GAM 3.8, with the aim of comparing xid to non-xid mice, neonatal NZB to adult NZB, and the peritoneal cavity with the splenic compartments for VH gene family expression. Our results ...

journal_title：European journal of immunology

authors： Dighiero G,Lim A,Lembezat MP,Kaushik A,Andrade L,Freitas A

更新日期：1988-12-01 00:00:00

abstract：:LIGHT is a recently identified member of the TNF superfamily that is up-regulated on activated T cells and can cooperate with CD40L to condition DC for the priming of CTL. In this report, we show that an intracellular pool of LIGHT is found selectively in some CD45RA-CD27+CD4+ "central" memory T cells and to a greater...

journal_title：European journal of immunology

authors： Morel Y,Truneh A,Costello RT,Olive D

更新日期：2003-11-01 00:00:00

abstract：:Leukosialin (CD43) is a major glycoprotein of T lymphocytes which has an extracellular domain of 45 nm in length that is heavily O-glycosylated. Monoclonal antibodies (mAb) to the extracellular domain of human leukosialin induce aggregation of T lymphocytes, monocytes and some cell lines that express leukosialin. The ...

journal_title：European journal of immunology

authors： Cyster JG,Williams AF

更新日期：1992-10-01 00:00:00

abstract：:T lymphocytes derived from peripheral blood of a patient with adenosine deaminase (ADA) deficiency were expanded in vitro. The human ADA (hADA) gene was introduced into these replicating ADA- T cells with the use of an amphotropic recombinant retrovirus carrying the hADA gene. Subsequently, infected T cells were selec...

journal_title：European journal of immunology

authors： Braakman E,Van Beusechem VW,Van Krimpen BA,Fischer A,Bolhuis RL,Valerio D

更新日期：1992-01-01 00:00:00

abstract：:Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus (EBV)-transformed B cells is mediated by CD2/lymphocyte function-associated antigen (LFA)-3 and LFA-1/intracellular adhesion molecule (ICAM)-1. Although some anti-CD4 antibodies block the antigen-independent adhesion of CD4+ T lymphocytes, the CD...

journal_title：European journal of immunology

authors： Mazerolles F,Amblard F,Lumbroso C,Lecomte O,Van de Moortele PF,Barbat C,Piatier-Tonneau D,Auffray C,Fischer A

更新日期：1990-03-01 00:00:00

abstract：:Cells from the monoclonal B cell lymphoma I.29 expressing surface IgM (mu +) are capable of differentiating in vitro to IgM secretion and of switching to IgA or IgE production in response to lipopolysaccharide (LPS) stimulation. To determine whether a single mu + B cell is capable of undertaking both differentiative p...

journal_title：European journal of immunology

authors： Alberini C,Biassoni R,DeAmbrosis S,Vismara D,Sitia R

更新日期：1987-04-01 00:00:00

abstract：:The MRC OX-47 monoclonal antibody recognizes a membrane antigen present at low levels on many lymphocytes but whose expression is markedly increased on activation with mitogens. cDNA clones for the OX-47 antigen were isolated from an expression library and the protein sequence deduced. It contains a leader sequence gi...

journal_title：European journal of immunology

authors： Fossum S,Mallett S,Barclay AN

更新日期：1991-03-01 00:00:00

abstract：:Tissue distribution and expression on mitogen and virally stimulated lymphocytes render the ACT35 molecule a human lymphocyte activation antigen which as yet could not be clustered. Expression cloning of the ACT35 antigen from a pCDM8 library of the HUT-102 cell line revealed strong homology of the cDNA and its encode...

journal_title：European journal of immunology

authors： Latza U,Dürkop H,Schnittger S,Ringeling J,Eitelbach F,Hummel M,Fonatsch C,Stein H

更新日期：1994-03-01 00:00:00

abstract：:In this study, we investigated whether the phenotype-related differentiation of human 2H4+ (CD45R) naive cells to 2H4- (CDw29) memory CD4 cells corresponded to modulation of interleukin (IL) 2, IL 4, interferon (IFN)-gamma and granulocyte-monocyte colony-stimulating factor (GM-CSF) gene expression, a phenomenon which ...

journal_title：European journal of immunology

authors： Bettens F,Walker C,Gauchat JF,Gauchat D,Wyss T,Pichler WJ

更新日期：1989-09-01 00:00:00

abstract：:An important aspect of clinical immunity to malaria is the ability to down-regulate inflammatory responses, once parasitaemia is under control, in order to avoid immune-mediated pathology. The role of classical (CD4(+)CD25(+)CD127(lo/-)FOXP3(+)) Treg in this process, however, remains controversial. Thus, we have chara...

journal_title：European journal of immunology

authors： Finney OC,Nwakanma D,Conway DJ,Walther M,Riley EM

更新日期：2009-05-01 00:00:00

abstract：:The MHC class II molecule H2-A(s), expressed in the SJL mouse strain, is the principle restriction element of autoreactive CD4(+) T cells mediating experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. We deduced the H2-A(s) ligand motif from the analysis of naturally processed self peptide...

journal_title：European journal of immunology

authors： Kalbus M,Fleckenstein BT,Offenhäusser M,Blüggel M,Melms A,Meyer HE,Rammensee HG,Martin R,Jung G,Sommer N

更新日期：2001-02-01 00:00:00

abstract：:To study the biological consequences of cytokine production and apoptosis by intraepithelial lymphocytes (IEL), we have studied these characteristics in both the high and low density CD3+ IEL populations. Stimulation of low- or high-density CD3+ IEL via the T cell receptor (TCR)-CD3 complex using monoclonal anti-CD3, ...

journal_title：European journal of immunology

authors： Yamamoto M,Fujihashi K,Amano M,McGhee JR,Beagley KW,Kiyono H

更新日期：1994-06-01 00:00:00

abstract：:The biochemical behavior and peptide binding properties of a soluble form of the human class II DR4Dw4 molecule (PI-DR4Dw4) were compared to DR4Dw4 molecules containing the transmembrane and cytoplasmic domains that were purified both from B and transfected chinese hamster ovary cells. Recombinant and B cell-derived D...

journal_title：European journal of immunology

authors： Buelow R,Paborsky LR,van Schooten WC,Kummerehl TJ,Schreifels R,Marshall K,Mayer J,Rothbard JB

更新日期：1993-01-01 00:00:00

abstract：:T cell receptor (TCR) down-regulation is a consequence of specific receptor engagement and plays an important role in modulating the T cell response. We have investigated the role of protein kinase C (PKC) and protein tyrosine kinases (PTK) in the induction of TCR down-regulation. We report that the mutation of S126 i...

journal_title：European journal of immunology

authors： Salio M,Valitutti S,Lanzavecchia A

更新日期：1997-07-01 00:00:00

abstract：:It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an ongoing debate regarding the reverse plasticity (conversion from Th1 to Th17). We show here that ectopic ROR-γt expression can re...

journal_title：European journal of immunology

authors： Mazzoni A,Maggi L,Siracusa F,Ramazzotti M,Rossi MC,Santarlasci V,Montaini G,Capone M,Rossettini B,De Palma R,Kruglov A,Chang HD,Cimaz R,Maggi E,Romagnani S,Liotta F,Cosmi L,Annunziato F

更新日期：2019-01-01 00:00:00

abstract：:High-dose infusion of IgG (IVIG) is used to treat autoimmune and inflammatory diseases, including Kawasaki disease (KD). Although the immunomodulatory effects of IVIG on blood cells such as macrophages have been well studied, its effects on tissue cells remain unclear. Here, we show that high-dose IgG specifically and...

journal_title：European journal of immunology

authors： Matsuda A,Morita H,Unno H,Saito H,Matsumoto K,Hirao Y,Munechika K,Abe J

更新日期：2012-08-01 00:00:00

abstract：:Thapsigargin (TG), which inhibits endoplasmic reticulum-dependent Ca(2 +)-ATPase and thereby increases cytosolic Ca(2 +), has been reported to cause apoptosis in T lymphocytes another cell types. In this study, we investigated the molecular mechanisms that are involved in the apoptosis induced by TG in T cell hybridom...

journal_title：European journal of immunology

authors： Liu W,Youn HD,Liu JO

更新日期：2001-06-01 00:00:00

abstract：:Infection with parasitic worms (helminths) alters host immune responses and can inhibit pathogenic inflammation. Helminth infection promotes a strong Th2 and T regulatory response while suppressing Th1 and Th17 function. Th2 responses are largely dependent on transcriptional programs directed by Stat6-signaling. We ex...

journal_title：European journal of immunology

authors： Metwali A,Winckler S,Urban JF Jr,Kaplan MH,Ince MN,Elliott DE

更新日期：2020-10-16 00:00:00

abstract：:Accumulating evidence suggests that Th17 cells and Tregs may exhibit development plasticity and that CD4(+) Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described. In this study, we generated Th17 clones from tumor-infiltrating T lym...

journal_title：European journal of immunology

authors： Ye J,Su X,Hsueh EC,Zhang Y,Koenig JM,Hoft DF,Peng G

更新日期：2011-04-01 00:00:00

abstract：:Recent years have seen a dramatic increase in the range of applications of virus-like nanoparticle (VNP)- and liposome-based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert virus-backbones or distinct lipid formulations and intend to engage the host's innate a...

journal_title：European journal of immunology

authors： Kratzer B,Hofer S,Zabel M,Pickl WF

更新日期：2020-01-01 00:00:00

abstract：:IL-12, IL-23, and IL-27, which are produced by APC, modulate innate and adaptive immunities. Human beta-defensin-2 (hBD-2) produced by epidermal keratinocytes promotes cutaneous antimicrobial defense and inflammation. We examined the in vitro effects of IL-12, IL-23, and IL-27 on hBD-2 production in human keratinocyte...

journal_title：European journal of immunology

authors： Kanda N,Watanabe S

更新日期：2008-05-01 00:00:00

abstract：:Immunoglobulin A (IgA) is transported by the polymeric immunoglobulin receptor (pIgR) through epithelial cells of the gut, the airways, the tear and salivary glands, and the lactating mammary gland, and IgA accumulates in serum and the intestinal lamina propria of pIgR-deficient (pIgR(-/-)) mice. Intraepithelial lymph...

journal_title：European journal of immunology

authors： Yamazaki K,Shimada S,Kato-Nagaoka N,Soga H,Itoh T,Nanno M

更新日期：2005-04-01 00:00:00