Comparison of three different forms of HLA-DR4Dw4 proteins.

abstract：:Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...

journal_title：European journal of immunology

authors： Schuhbauer DM,Mitchison NA,Mueller B

更新日期：2000-05-01 00:00:00

abstract：:T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture system in which Lineage(-) Sca1(+)c-kit(+) BM hematopoietic progenitors very efficiently differ...

journal_title：European journal of immunology

authors： Gehre N,Nusser A,von Muenchow L,Tussiwand R,Engdahl C,Capoferri G,Bosco N,Ceredig R,Rolink AG

更新日期：2015-03-01 00:00:00

abstract：:Regulatory T (T(reg)) cells play a key role in the maintenance of the immune system homeostasis. T(reg) cells can be generated in the periphery under control of TGF-beta, a cytokine involved in the negative control of the immune system. However, TGF-beta cooperates with IL-6 in the generation of Th17 cells, a novel cl...

journal_title：European journal of immunology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Becker C,Neurath MF,Macdonald TT,Pallone F,Monteleone G

更新日期：2007-11-01 00:00:00

abstract：:The inositol phospholipid metabolism and the increase in cytosolic free Ca2+ concentration ([Ca2+]i) into the cell are recognized as two important events in the anti-mu-induced B cell activation. The anti-mu stimulation caused the [3H]inositol incorporation and also a rapid increase in [Ca2+]i from 85 nM to 285 nM. Th...

journal_title：European journal of immunology

authors： Dugas B,Calenda A,Delfraissy JF,Vazquez A,Bach JF,Galanaud P

更新日期：1987-09-01 00:00:00

abstract：:The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high-affinity peptides onto MHC class I molecules. It mediates peptide editing, i.e. the binding of peptides of successively higher affinity until class I molecules pass ER quality control and exit to the cell surface. The molecular mechani...

journal_title：European journal of immunology

authors： Praveen PV,Yaneva R,Kalbacher H,Springer S

更新日期：2010-01-01 00:00:00

abstract：:Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can...

journal_title：European journal of immunology

authors： Goodier MR,Jonjić S,Riley EM,Juranić Lisnić V

更新日期：2018-01-01 00:00:00

abstract：:F liver protein occurs in serum at low concentration, and therefore induces tolerance of self only in T cells. T cells which mature in cultured thymus lobes in the absence of this protein become reactive towards it but can be prevented from doing so by exposure to the protein while in culture. The threshold of toleran...

journal_title：European journal of immunology

authors： Robertson K,Simon K,Schneider S,Timms E,Mitchison A

更新日期：1992-01-01 00:00:00

abstract：:In chickens, the pre-B cell development takes place in a specialized organ, the bursa of Fabricius. In this study, we show that fibronectin can be detected in the bursa at least from the day 15 of embryonic incubation up to 10 weeks of age after which the bursa starts to involute. During the embryonic incubation, fibr...

journal_title：European journal of immunology

authors： Palojoki E,Toivanen P,Jalkanen S

更新日期：1993-03-01 00:00:00

abstract：:Inhibition of leukocyte trafficking via alpha4-integrin antibody blockade has recently become a validated therapeutic approach for several inflammatory diseases, including multiple sclerosis, ulcerative colitis and Crohn's disease. In the midst of this recent success, 3 patients receiving chronic treatment with the an...

journal_title：European journal of immunology

authors： Engelhardt B,Briskin MJ

更新日期：2005-08-01 00:00:00

abstract：:Following antigen encounter and subsequent resolution of the immune response, a single naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic and functional properties and gene expression profiles. Single-cell technologies, first and foremost flow cytometry, have revealed the com...

journal_title：European journal of immunology

authors： Mahnke YD,Brodie TM,Sallusto F,Roederer M,Lugli E

更新日期：2013-11-01 00:00:00

abstract：:NK cells are important for the control of vaccinia virus (VV) in vivo. Recent studies have shown that multiple pathways are required for effective activation of NK cells. These include both TLR-dependent and -independent pathways, as well as the NKG2D activating receptor that recognizes host stress-induced NKG2D ligan...

journal_title：European journal of immunology

authors： Brandstadter JD,Huang X,Yang Y

更新日期：2014-09-01 00:00:00

abstract：:The adoptive transfer of CD4(+)CD25(+) natural regulatory T cells (Treg) is a promising strategy for the treatment of autoimmune diseases and the prevention of alloresponses after transplantation. Clinical trials exploring this strategy require efficient in vitro expansion of this rare cell population. Protocols devel...

journal_title：European journal of immunology

authors： Hoffmann P,Boeld TJ,Eder R,Huehn J,Floess S,Wieczorek G,Olek S,Dietmaier W,Andreesen R,Edinger M

更新日期：2009-04-01 00:00:00

abstract：:The responses of resting human B lymphocytes to a variety of activation signals were studied. Human tonsillar B lymphocytes were separated according to size by countercurrent elutriation. The small B lymphocytes were then stimulated in vitro with various concentrations of anti-mu antibody in the presence or absence of...

journal_title：European journal of immunology

authors： Kehrl JH,Muraguchi A,Fauci AS

更新日期：1984-02-01 00:00:00

abstract：:ME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. We used the concanavalin A (Con A) model to elucidate the molecular mechanisms of ME3738 to block liver cell damage. Pretreatment of BALB/c mice with ME3738 prior to Con A injection resulted in a significa...

journal_title：European journal of immunology

authors： Klein C,Wüstefeld T,Heinrich PC,Streetz KL,Manns MP,Trautwein C

更新日期：2003-08-01 00:00:00

abstract：:Type B T cells recognize peptide-MHC class II (pMHCII) isoforms that are structurally distinct from those recognized by conventional type A T cells. These alternative type B conformers result from peptide loading in the absence of HLA-DM. Type A conformers are more stable than type B pMHCII conformers but bind the sam...

journal_title：European journal of immunology

authors： Jackson N,Compton E,Trowsdale J,Kelly AP

更新日期：2014-04-01 00:00:00

abstract：:Current concepts on the pathogenesis of chronic asthma emphasize the role of several inflammatory cell populations and their respective mediators that interact in a complex network. However, beside inflammatory cells, lymphocytes are also present in asthmatic airways. Although little is known about their involvement i...

journal_title：European journal of immunology

authors： Lassalle P,Delneste Y,Gosset P,Gras-Masse H,Wallaert B,Tonnel AB

更新日期：1993-04-01 00:00:00

abstract：:IL-10 plays an important role in the regulation of immune responses. We and others have demonstrated recently that cyclic adenosine monophosphate (cAMP)-elevating substances up-regulate monocytic IL-10 expression in vitro and in vivo. Computer analysis of the IL-10 promoter/enhancer region localized four putative cAMP...

journal_title：European journal of immunology

authors： Platzer C,Fritsch E,Elsner T,Lehmann MH,Volk HD,Prösch S

更新日期：1999-10-01 00:00:00

abstract：:Interleukin-5 (IL-5) plays a critical role in the pathogenesis of eosinophil-associated allergic disorders, such as asthma. IL-5 may also play a major role in the development of eosinophilia-associated lymphoproliferative disorders caused by human T lymphotropic virus type I (HTLV-I). In this study, we have investigat...

journal_title：European journal of immunology

authors： Li-Weber M,Giaisi M,Krammer PH

更新日期：2001-12-01 00:00:00

abstract：:Delivery of foreign antigens to mucosal surfaces, such as the pulmonary airways, has been shown to preferentially induce Th2-mediated responses in humans and in mice. What is not clear from these studies is whether this preferential skewing in responses is the result of the limited types of antigen being administered ...

journal_title：European journal of immunology

authors： Constant SL,Lee KS,Bottomly K

更新日期：2000-03-01 00:00:00

abstract：:In this study we have investigated the specificity of bioassays in which interleukin (IL) 1 and/or IL 6 are active. The thymocyte assay cannot be used to discriminate between IL 1 and IL 6; both monokines are active in this assay. Moreover the detection limit for both IL 1 and IL 6 is around 100 pg/ml. IL 6 activity c...

journal_title：European journal of immunology

authors： Helle M,Boeije L,Aarden LA

更新日期：1988-10-01 00:00:00

abstract：:Transcriptional up-regulation of the VCAM-1 gene, induced by proinflammatory cytokines such as IL-1beta and TNF-alpha, requires activation of not only NF-kappaB, but also involves interferon regulatory factor (IRF)-1. During a study of gene induction by mechanical stimuli in cultured human endothelial cells, we noted ...

journal_title：European journal of immunology

authors： Ochi H,Masuda J,Gimbrone MA

更新日期：2002-07-01 00:00:00

abstract：:We previously demonstrated that cholera toxin (CT) is highly efficient as a combined carrier and adjuvant for dendritic cell (DC) vaccination, inducing strong Th1-dominated B cell and CD4(+) T cell responses. In this study we show that vaccination with DC pre-pulsed ex vivo with CT-conjugated OVA (OVA-CT) gives rise t...

journal_title：European journal of immunology

authors： Eriksson K,Sun JB,Nordström I,Fredriksson M,Lindblad M,Li BL,Holmgren J

更新日期：2004-05-01 00:00:00

abstract：:By immunizing Lewis rats with myelin basic protein (MBP) peptide variants derived from the major encephalitogenic epitope of guinea pig (MBP(68-88) and then isolating encephalitogenic T cells from these animals, we demonstrated that the variant peptides do not elicit the same encephalitogenic T cell subsets as those i...

journal_title：European journal of immunology

authors： Sun D,Coleclough C,Hu XZ

更新日期：1995-06-01 00:00:00

abstract：:The expression of an X-linked defect in the CBA/N strain of mice has been found to result in a number of immune abnormalities. These include low responsiveness to antigens and a greatly reduced ability to respond to many of the common B cell mitogens. An in vitro manifestation of this condition is the virtual inabilit...

journal_title：European journal of immunology

authors： Narendran A,Cumano A,Dorshkind K,Paige CJ

更新日期：1992-04-01 00:00:00

abstract：:CD40 ligand (CD40L) and IL-4 are sufficient to induce resting murine B cells to divide and switch isotypes from IgM and IgD to IgG1 and IgE. Tracking of cell division following (5- and 6) carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling revealed that B cells expressed IgG1 after three cell divisions, an...

journal_title：European journal of immunology

authors： Hasbold J,Lyons AB,Kehry MR,Hodgkin PD

更新日期：1998-03-01 00:00:00

abstract：:B cell abnormalities are a prominent feature of the immunologic derangement in NZB and NZB / W mice. We recently demonstrated that these mice have an increased proportion of splenic B cells expressing B7.1 and elevated levels of B7.2 and ICAM-1 that possess the characteristics of marginal zone B cells (CD23(low / -) C...

journal_title：European journal of immunology

authors： Wither JE,Paterson AD,Vukusic B

更新日期：2000-02-01 00:00:00

abstract：:CD27 is a lymphocyte-specific member of the TNF receptor (TNFR) family. It is a costimulatory molecule for peripheral T cells, as defined by its ability to enhance the TCR-induced proliferative response. We show here that CD27 augments TCR-induced Jun N-terminal kinase (JNK) activity in primary murine lymph node T cel...

journal_title：European journal of immunology

authors： Gravestein LA,Amsen D,Boes M,Calvo CR,Kruisbeek AM,Borst J

更新日期：1998-07-01 00:00:00

abstract：:Tissue factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium ...

journal_title：European journal of immunology

authors： Venkatasubramanian S,Tripathi D,Tucker T,Paidipally P,Cheekatla S,Welch E,Raghunath A,Jeffers A,Tvinnereim AR,Schechter ME,Andrade BB,Mackman N,Idell S,Vankayalapati R

更新日期：2016-02-01 00:00:00

abstract：:Membrane-bound immunoglobulins of the IgM and IgD class are expressed on the B cell surface in association with a disulfide-linked heterodimer consisting of alpha and beta subunits. While the alpha component of the IgM antigen receptor (IgM-alpha, 34 kDa) is encoded by the B cell-specific gene mb-1, the gene coding fo...

journal_title：European journal of immunology

authors： Wienands J,Reth M

更新日期：1991-10-01 00:00:00

abstract：:The expression of human leukocyte function-associated antigens (HLFA, equivalents of murine LFA-1) was studied on early lympho-hemopoietic cells in infant thymus and normal bone marrow by double immunofluorescence methods, cell sorting and colony-forming assays. Monoclonal antibodies MHM-24 recognizing the alpha chain...

journal_title：European journal of immunology

authors： Campana D,Sheridan B,Tidman N,Hoffbrand AV,Janossy G

更新日期：1986-05-01 00:00:00