The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies.

abstract：:In the present study, we examined whether anti-CD40+IL-4-mediated B cell proliferation and immunoglobulin synthesis is affected by vitamin D (VD) and its low-hypercalcemic analogue EB1089 in Bcells from healthy donors. Analysis of vitamin D receptor (VDR) expression showed that only anti-CD40+IL-4-stimulated, but not ...

journal_title：European journal of immunology

authors： Heine G,Anton K,Henz BM,Worm M

更新日期：2002-12-01 00:00:00

abstract：:Mutations in PTEN-induced kinase 1 (PINK1), a serine/threonine kinase linked to familial early-onset Parkinsonism, compromise mitochondrial integrity and metabolism and impair AKT signaling. As the activation of a naïve T cell requires an AKT-dependent reorganization of a cell's metabolic machinery, we sought to deter...

journal_title：European journal of immunology

authors： Ellis GI,Zhi L,Akundi R,Büeler H,Marti F

更新日期：2013-12-01 00:00:00

abstract：:We isolated immunoglobulin (Ig) VH4 genes that were rearranged in the genomic DNA of 160 day human fetal spleen. Productively rearranged VH 4-21 genes were cloned into pRTM1, a human IgM expression vector. This allowed us to generate IgM kappa-expressing transfectomas by co-transfecting each of these constructs with p...

journal_title：European journal of immunology

authors： Parr TB,Johnson TA,Silberstein LE,Kipps TJ

更新日期：1994-12-01 00:00:00

abstract：:NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are ...

journal_title：European journal of immunology

authors： Held W

更新日期：2008-11-01 00:00:00

abstract：:Previous work has shown that the primary IgM plaque-forming cell response of inbred mice to xenogeneic red blood cells (RBC) including sheep, horse and chicken RBC is under the control of two polymorphic genes or sets of genes, one linked to the Igh linkage group and the other of unknown linkage but unlinked to H-2 an...

journal_title：European journal of immunology

authors： Saizawa KM,Melchers I,Eichmann K

更新日期：1985-02-01 00:00:00

abstract：:Thymic nurse cells, cortical epithelial cells enclosing 20-200 lymphocytes, were prepared from mouse thymus by enzyme digestion and repetitive sedimentation. Individual nurse cells were then isolated free of any exogenous thymocytes by micromanipulation, and the endogeneous thymocytes released from inside the nurse ce...

journal_title：European journal of immunology

authors： Andrews P,Boyd RL,Shortman K

更新日期：1985-10-01 00:00:00

abstract：:Treatment of systemic lupus erythematosus patients with epratuzumab (Emab), a humanized monoclonal antibody targeting CD22, leads to moderately reduced B-cell numbers but does not completely deplete B cells. Emab appears to induce immunomodulation of B cells, but the exact mode of action has not been defined. In the p...

journal_title：European journal of immunology

authors： Özgör L,Brandl C,Shock A,Nitschke L

更新日期：2016-09-01 00:00:00

abstract：:In M54 mice transgenic for a completely rearranged mu(a) heavy chain there is a decrease in total B cells and the rearrangement of endogenous immunoglobulin genes is partially inhibited. Surprisingly, however, endogenous immunoglobulin gene rearrangement and significant heavy chain polypeptide production does occur. W...

journal_title：European journal of immunology

authors： Rabin E,Cong Y,Imanishi-Kari T,Wortis HH

更新日期：1992-09-01 00:00:00

abstract：:MHC class II molecules present peptides, derived largely from exogenous antigens, to CD4+ T cells. Complex-generation occurs mainly in the specialized late endosomal MHC class II-rich compartment (MIIC) vesicles of antigen-presenting cells (APC). Dendritic cells (DC) have been reported to store intact antigen in MIIC ...

journal_title：European journal of immunology

authors： Colledge L,Bennett CL,Reay PA,Blackburn CC

更新日期：2002-11-01 00:00:00

abstract：:Tyrosine kinase 2 (Tyk2) contributes to the signals triggered by IL-12 for IFN-gamma production by NK cells and T cells. We found in this study that Tyk2-deficient (-/-) mice showed increased susceptibility at the early stage after an i.p. infection with Listeria monocytogenes, accompanied by impaired IFN-gamma produc...

journal_title：European journal of immunology

authors： Aizu K,Li W,Yajima T,Arai T,Shimoda K,Nimura Y,Yoshikai Y

更新日期：2006-11-01 00:00:00

abstract：:We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of ...

journal_title：European journal of immunology

authors： Kirberg J,Bruno L,von Boehmer H

更新日期：1993-08-01 00:00:00

abstract：:The present report describes functional characteristics of a monoclonal antibody (mAb), TA/211, which is reactive with a common determinant of the human CD45 molecules. When added to purified testing human T cells, TA/211, which is itself not mitogenic, leads to a strong proliferative response in combination with subm...

journal_title：European journal of immunology

authors： Schraven B,Roux M,Hutmacher B,Meuer SC

更新日期：1989-02-01 00:00:00

abstract：:Four cell lines derived from spontaneous BALB/c lymphoma tumors were analyzed with regard to the type of their membrane immunoglobulins (Ig). Using lactoperoxidase iodination of membrane proteins combined with immunoprecipitation and electrophoresis on polyacrylamide gel, three of these cell lines (X16c, L10A and K46)...

journal_title：European journal of immunology

authors： Laskov R,Kim JK,Woods VL,McKeever PE,Asofsky R

更新日期：1981-06-01 00:00:00

abstract：:An expanding spectrum of acute and chronic non-infectious inflammatory diseases is uniquely responsive to IL-1β neutralization. IL-1β-mediated diseases are often called "auto-inflammatory" and the dominant finding is the release of the active form of IL-1β driven by endogenous molecules acting on the monocyte/macropha...

journal_title：European journal of immunology

authors： Dinarello CA

更新日期：2011-05-01 00:00:00

abstract：:Thyroglobulin-binding lymphoid cells were identified in the spleen of Obese strain (DS) chickens by their capacity to form rosettes with thyroglobulin-coated chicken red blood cells. The nature of these cells was studied in inhibition experiments using turkey anti-chicken bursa or thymus cell sera and rabbit antisera ...

journal_title：European journal of immunology

authors： Richter E,Wick G,Schauenstein K

更新日期：1975-08-01 00:00:00

abstract：:Cytomegalovirus latently infects myeloid cells; however, the acute effects of the virus on this cell subset are poorly characterised. We demonstrate that systemic cytomegalovirus infection induced rapid activation of monocytes in the bone marrow, characterised by upregulation of CD69, CD11c, Ly6C and M-CSF receptor. A...

journal_title：European journal of immunology

authors： Wikstrom ME,Khong A,Fleming P,Kuns R,Hertzog PJ,Frazer IH,Andoniou CE,Hill GR,Degli-Esposti MA

更新日期：2014-02-01 00:00:00

abstract：:At least two subsets of CD4+ T helper cell lymphocytes termed Th1 and Th2 exist in the mouse and probably in humans. They are characterized by the secretion of different lymphokines and by their functional behavior. Dysregulated expansion of one or the other subset may be one reason for the development of certain dise...

journal_title：European journal of immunology

authors： Germann T,Gately MK,Schoenhaut DS,Lohoff M,Mattner F,Fischer S,Jin SC,Schmitt E,Rüde E

更新日期：1993-08-01 00:00:00

abstract：:Two major histocompatibility complex (MHC) class I-reactive T cell clones derived from H-2b mice, generated against the allogeneic Ld molecule, were found to recognize the H-2b class II mutant Abm12 molecule as well. In addition, these clones also recognize the class II A(s) molecule, and display a class II-dependent ...

journal_title：European journal of immunology

authors： Frangoulis B,Urbero B,Pla M

更新日期：1993-08-01 00:00:00

abstract：:To determine whether antigen (Ag)-specific cytotoxic T lymphocytes are generated during experimental Candida albicans infection, purified L3T4+ and Ly-2+ lymphocytes from immunized mice were cultured in the presence of syngeneic accessory cells, C. albicans Ag, and interleukin 2. Yeast-infected bone marrow macrophages...

journal_title：European journal of immunology

authors： Romani L,Mocci S,Cenci E,Rossi R,Puccetti P,Bistoni F

更新日期：1991-06-01 00:00:00

abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

journal_title：European journal of immunology

authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

更新日期：1994-05-01 00:00:00

abstract：:Here we demonstrate that components of the entire complement cascade are fixed on the surface of erythrocytes infected with the human malarial parasite Plasmodium falciparum. Despite the activation of lytic complement factors, no complement-mediated lysis of P. falciparum-infected erythrocytes occurred only in the abs...

journal_title：European journal of immunology

authors： Wiesner J,Jomaa H,Wilhelm M,Tony HP,Kremsner PG,Horrocks P,Lanzer M

更新日期：1997-10-01 00:00:00

abstract：:Splenic T cells were primed, after removal of alloreactive cells, to beef insulin on allogeneic antigen-presenting cells (APC). The fine specificity of in vitro secondary response was tested in combinations H-2b (responder) T cell-H-2k (nonresponder) APC, and vice versa, using separated chains of beef and pork insulin...

journal_title：European journal of immunology

authors： Ishii N,Klein J,Nagy ZA

更新日期：1983-08-01 00:00:00

abstract：:The human promyelocytic U937 cells express detectable levels of MHC class II (MHC-II) molecules. Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gen...

journal_title：European journal of immunology

authors： De Lerma Barbaro A,Procopio FA,Mortara L,Tosi G,Accolla RS

更新日期：2005-02-01 00:00:00

abstract：:An abnormal protein, from a petient with mu-chain disease has been studied: protein BUR. It is devoid of the F (ab'')2 mu fragment; molecular weight determinations and immunological data identify the protein as a F(c) 5 mu fragment. Similarly, carbohydrate determinations and proteolysis experiments relate it to a Fcmu...

journal_title：European journal of immunology

authors： Lebreton JP,Ropartz C,Rousseaus J,Roussel P,Dautrevaus M,Biserte G

更新日期：1975-03-01 00:00:00

abstract：:Subcutaneous immunization with hen egg-white lysozyme (HEL) in complete Freund's adjuvant induces, both in antibody responder and nonresponder mice, a classical delayed-type hypersensitivity (DTH) reaction evaluated as footpad swelling. This response can be specifically transferred to naive recipients by Lyt-1+2- T ce...

journal_title：European journal of immunology

authors： Colizzi V,Doria G,Adorini L

更新日期：1984-09-01 00:00:00

abstract：:KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myel...

journal_title：European journal of immunology

authors： Lucas M,Daniel L,Tomasello E,Guia S,Horschowski N,Aoki N,Figarella-Branger D,Gomez S,Vivier E

更新日期：2002-09-01 00:00:00

abstract：:It is now recognized that Th17 cells constitute the third effector arm of Th cells, complementing the Th1 and Th2 lineages. Although secretion of IL-17 is a primary defining characteristic of Th17 cells, the expression profile of specific chemokine receptors, cell surface molecules and cytokines are also part of the T...

journal_title：European journal of immunology

authors： Unutmaz D

更新日期：2009-06-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue 1 (Malt1) regulates immune cell function by mediating the activation of nuclear factor κB (NF-κB) signaling through both its adaptor and proteolytic function. Malt1 is also a target of its own protease activity and this self-cleavage further contributes to NF-κB activity. Until now, t...

journal_title：European journal of immunology

authors： Baens M,Stirparo R,Lampi Y,Verbeke D,Vandepoel R,Cools J,Marynen P,de Bock CE,Bornschein S

更新日期：2018-10-01 00:00:00

abstract：:We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...

journal_title：European journal of immunology

authors： Chen M,Muckersie E,Luo C,Forrester JV,Xu H

更新日期：2010-10-01 00:00:00

abstract：:The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have i...

journal_title：European journal of immunology

authors： Brown JA,Greenwald RJ,Scott S,Schweitzer AN,Satoskar AR,Chung C,Schopf LR,van der Woude D,Sypek JP,Sharpe AH

更新日期：2002-06-01 00:00:00