Abstract:
:It is now recognized that Th17 cells constitute the third effector arm of Th cells, complementing the Th1 and Th2 lineages. Although secretion of IL-17 is a primary defining characteristic of Th17 cells, the expression profile of specific chemokine receptors, cell surface molecules and cytokines are also part of the Th17 cell differentiation program. The orphan nuclear receptor ROR gamma t/RORC2 (mice/humans) is the master transcription factor that can drive Th17 cell differentiation in both mice and humans; however, it is not completely clear how much of the human Th17 lineage function and phenotype can be recapitulated by only RORC2 expression. In this issue of the European Journal of Immunology, a study reports that ectopic expression of RORC2 in primary human T cells induces, in addition to IL-17 production, a cytokine and chemokine receptor profile consistent with bona fide human Th17 cells. In addition, programming of human Th17 cells by RORC2 results in partial resistance of these T cells to suppression by Tregs. These findings support the notion that RORC2 is a master switch that initiates a wide range of phenotypic and functional programming during Th17 cell differentiation.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Unutmaz Ddoi
10.1002/eji.200939540subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1452-5issue
6eissn
0014-2980issn
1521-4141journal_volume
39pub_type
评论,杂志文章abstract::Human lamina propria lymphocytes were recovered from surgical specimens of unaffected large bowel and compared with peripheral blood lymphocytes (PBL) from the same individual. We investigated their capacities to respond to triggering stimuli delivered by mitogenic monoclonal antibodies directed at the T cell receptor...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830201025
更新日期:1990-10-01 00:00:00
abstract::Nonhematopoietic stromal cells contribute to the organization and homeostasis of secondary lymphoid organs by producing cytokines and chemokines. The development and maintenance of these stromal cells are thought to be regulated by innate immune cells. Indeed, we recently showed that signal regulatory protein α (SIRPα...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948103
更新日期:2019-09-01 00:00:00
abstract::Stem cell factor (SCF) is encoded at the Sl locus of the mouse and is the ligand for the c-kit receptor. Recombinant rat SCF164 (rrSCF164) induces proliferation and promotes maturation of mouse mast cells in vitro and in vivo and can also induce c-kit receptor-dependent mouse mast cell degranulation. We now report tha...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230415
更新日期:1993-04-01 00:00:00
abstract::Pre-graft priming of heart allograft recipients with donor strain blood induces tolerance in 100% of adult rats in the congenic LEW.1W to LEW.1A combination. This tolerant state is specific for donor MHC antigens as third-party blood transfusions fail to induce tolerance, and third-party skin grafts are promptly rejec...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200105)31:5<1333::AID-IMMU1333>3
更新日期:2001-05-01 00:00:00
abstract::The role of redox regulation in immune-mediated arthritis has been previously described. However, the relationship between innate immune cells, including innate lymphoid cells (ILCs) and phagocyte-derived ROS, in this process remains unclear. Here, we characterize ILCs and measure the IL-1 family cytokines along with ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948141
更新日期:2019-11-01 00:00:00
abstract::Lipoproteins or lipopeptides (LP) are bacterial cell wall components detected by the innate immune system. For LP, it has been shown that TLR2 is the essential receptor in cellular activation. However, molecular mechanisms of LP recognition are not yet clear. We used a FLAG-labeled derivative of the synthetic lipopept...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425336
更新日期:2005-03-01 00:00:00
abstract::Treg subsets play a role in sustaining peripheral tolerance, are characterized by markers such as forkhead winged-helix transcription factor (FOXP3) and CD25, and produce suppressive cytokines, such as IL-10 and TGF-β. Glucocorticoid-induced TNF receptor family-related (GITR) protein has been suggested to regulate Tre...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040943
更新日期:2011-08-01 00:00:00
abstract::The murine monoclonal antibody (mAb) CB43, raised against the K-562 erythroleukemia line, reacts with monocytes, tissue macrophages, thymocytes and with all the human lines tested but not with resting lymphocytes, large granular lymphocytes, granulocytes and erythrocytes. However, activated lymphocytes and natural kil...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190102
更新日期:1989-01-01 00:00:00
abstract::A mouse T cell hybrid specific for pigeon cytochrome c in the context of I-Ek responds by secreting interleukin 2 when co-cultured with the native antigen and the B cell lymphoma, LK-35.2, or naive splenic B cells as antigen-presenting cells (APC). Cytochromes c and their corresponding C-terminal fragments which are n...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830160702
更新日期:1986-07-01 00:00:00
abstract::The lymph node cells (LNC) activated in vivo by liver regeneration following partial hepatectomy of mice (primed lymph node cells) respond to regenerating liver cells in vitro with typical secondary immune response characteristics (Miyahara, S. et al., Eur. J. Immunol. 1983. 13: 878). These LNC activated in vivo suppr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830131105
更新日期:1983-11-01 00:00:00
abstract::CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830271231
更新日期:1997-12-01 00:00:00
abstract::The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, gp33 residues 33-41 (KAVYNFATC), presented in the ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636743
更新日期:2007-03-01 00:00:00
abstract::Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses in intestinal infection models. Mice were held on iron-deficient, normal iron, or high iron di...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201545642
更新日期:2015-09-01 00:00:00
abstract::The third component of complement C3 has been implied in the stimulation of B lymphocytes to proliferation and maturation for Ig secretion. We have reinvestigated the extent of this activation with either activated or resting murine splenic lymphocytes in serum-substituted cultures. Human C3 was used in either soluble...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150214
更新日期:1985-02-01 00:00:00
abstract::Rat CD4+ T cells are divided phenotypically by the anti-CD45RC monoclonal antibody OX22 into subsets with contrasting functions. Stimulation of T cells in vitro is known to induce a change in isoform from CD45RC+ to CD45RC-. We have investigated the in vitro conditions which promote a switch in isoform in the opposite...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230117
更新日期:1993-01-01 00:00:00
abstract::We report here the identification and characterization of murine CCX-CKR, a high affinity receptor for the murine beta-chemokines SLC/mCCL21, MIP-3beta/mCCL19 and TECK/mCCL25. Unlike most other chemokine receptors, CCX-CKR is unable to mediate Ca(2+) fluxes upon ligand binding when expressed in HEK293 cells. Murine CC...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3
更新日期:2002-05-01 00:00:00
abstract::The murine T cell response to heterologous insulins provides a good model system for studying the mechanism of immune response (Ir)-gene function, since insulin is a small, chemically well-defined molecule. H-2b mice respond predominantly to A chain loop determinants of beef insulin, presented by the I-A epitope Ia. W...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830141208
更新日期:1984-12-01 00:00:00
abstract::B cell development is dependent on both direct interactions with stromal cells and their secreted cytokines. The precise mechanisms by which these interactions regulate B cell differentiation are currently unknown. We report here that a novel growth factor thymic stromal-derived lymphopoietin (TSLP) can replace the ac...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260103
更新日期:1996-01-01 00:00:00
abstract::Induction of optimal HIV-1-specific T-cell responses, which can contribute to controlling viral infection in vivo, depends on antigen processing and presentation processes occurring in DCs. Opsonization can influence the routing of antigen processing and pathways used for presentation. We studied antigen proteolysis a...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201242935
更新日期:2013-06-01 00:00:00
abstract::Activated human monocytes are a source of numerous beta-chemokines. The present study was conducted to determine whether these cells produce the human beta-chemokine I-309 and to compare the induction requirements of I-309 to those of other beta-chemokines. We demonstrate that appropriately stimulated adherence-purifi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270317
更新日期:1997-03-01 00:00:00
abstract::Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which ar...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040671
更新日期:2010-11-01 00:00:00
abstract::Hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8+ or CD4+ T cell epitope. Immunization of mice with a single dose of these hybrid pseudo-particles, without adjuvant, induced strong cytotoxic T lymphocyte and T helper (Th) respon...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199804)28:04<1401::AID-IMM
更新日期:1998-04-01 00:00:00
abstract::We investigated here the potential role of Toll-like receptors (TLR) and the adaptor protein MyD88 in innate immunity responses to Cryptococcus neoformans, a pathogenic encapsulated yeast. Peritoneal macrophages from MyD88(-/-) or TLR2(-/-) mice released significantly less TNF-alpha, compared with wild-type controls, ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425799
更新日期:2005-03-01 00:00:00
abstract::Influenza matrix peptide 58-66 is shown to be the optimal nonamer for binding to HLA-A2 and presentation to cytotoxic T lymphocytes (CTL). If titered out to 2 x 10(-10) - 4 x 10(-10) M in CTL-mediated lysis assays and to 3 x 10(-9) M in an HLA-A2 assembly-stabilization assay in cell lysates. The peptide was shown to m...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220404
更新日期:1992-04-01 00:00:00
abstract::The human promyelocytic U937 cells express detectable levels of MHC class II (MHC-II) molecules. Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425378
更新日期:2005-02-01 00:00:00
abstract::T-cell death is a fundamental process that is intricately regulated at multiple phases during T-cell differentiation, tolerance induction and the decline of the immune response. Caspase 3 is a crucial molecule regulating both mitochondrial and death receptor apoptotic pathways and therefore we were interested in exami...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040475
更新日期:2010-12-01 00:00:00
abstract::The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240530
更新日期:1994-05-01 00:00:00
abstract::The viral CC chemokine macrophage inhibitory protein-II (vMIP-II) encoded by human herpes virus 8 (HHV-8) binds to multiple chemokine receptors, however, its ability to control the initial recruitment of specific leukocyte subtypes from the peripheral circulation has not been fully clarified. Here we show that vMIP-II...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200108)31:8<2458::aid-immu24
更新日期:2001-08-01 00:00:00
abstract::Activated human T cells via the CD2 or the CD3 pathways exhibited a higher capacity than resting T lymphocytes to incorporate and metabolize [3H]pafacether (paf) at 37 degrees C. Resting T lymphocytes lacked specific binding capacity for paf, yet high-affinity paf receptors (paf-R) were induced on CD3- or CD2-dependen...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220604
更新日期:1992-06-01 00:00:00
abstract::The pathogenesis of the decline of CD4 lymphocyte counts accompanying the typical course of HIV-1 infection is not completely defined and might be related to a differential susceptibility of naive and memory cells to HIV-1 exposure. Here, we examined the effects induced by heat-inactivated HIV-1 virions on these lymph...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199906)29:06<1879::AID-IMM
更新日期:1999-06-01 00:00:00