Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes.

abstract：:Developing T cells undergo distinct selection processes that determine the T cell receptor (TcR) repertoire. One of these processes is positive selection. Positive selection involves the differentiation to mature T cells of thymocytes bearing TcR capable of recognizing antigens in the context of self-major histocompat...

journal_title：European journal of immunology

authors： Carrera AC,Baker C,Roberts TM,Pardoll DM

更新日期：1992-09-01 00:00:00

abstract：:Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR-dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type-specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by the PRR NLRP3 in muri...

journal_title：European journal of immunology

authors： Chen KW,Bezbradica JS,Groß CJ,Wall AA,Sweet MJ,Stow JL,Schroder K

更新日期：2016-04-01 00:00:00

abstract：:MHC-peptide-specific Fab antibodies binding to HLA-A*0201 complexes presenting the wild-type EAAGIGILTV (EAA) or analogue Melan-A 10-mer ELAGIGILTV (ELA) peptide were generated to study efficacy of peptide processing and presentation. None of the selected Fab antibodies detected the naturally processed EAA/HLA-A*0201 ...

journal_title：European journal of immunology

authors： Held G,Wadle A,Dauth N,Stewart-Jones G,Sturm C,Thiel M,Zwick C,Dieckmann D,Schuler G,Hoogenboom HR,Lévy F,Cerundolo V,Pfreundschuh M,Renner C

更新日期：2007-07-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:Mice of strain MRL/Mp-lpr/lpr develop resistance against tolerance induction with aggregate-freed rabbit gamma-globulin as early as 6 weeks of age and show very complete resistance when they are 10 weeks old; congenic mice MRL-Mp+/+ of 6 and 10 weeks can be rendered tolerant. By reconstitution experiments, it was show...

journal_title：European journal of immunology

authors： Amagai T,Cinader B

更新日期：1981-11-01 00:00:00

abstract：:Interleukin-HP1 (HP1) is a murine T cell-derived lymphokine, originally described as a growth factor for B cell hybridomas and plasmacytomas, that was recently shown to stimulate growth and differentiation of normal B and T lymphocytes. Here, we describe a cDNA for HP1 that was isolated from a library prepared using m...

journal_title：European journal of immunology

authors： Van Snick J,Cayphas S,Szikora JP,Renauld JC,Van Roost E,Boon T,Simpson RJ

更新日期：1988-02-01 00:00:00

abstract：:The fine specificity of murine B 10.A/SgSn (B 10.A) T cells reactive with hen egg-white lysozyme (HEL) has been studied through the use of reduced, carboxymethylated HEL, a set of peptides encompassing the entire molecule, and a set of variant lysozymes from other species. Cells were taken from the lymph nodes drainin...

journal_title：European journal of immunology

authors： Maizels RM,Clarke JA,Harvey MA,Miller A,Sercarz EE

更新日期：1980-07-01 00:00:00

abstract：:MHC class II tetramers are attractive tools to study antigen-specific CD4(+) T cell responses in various clinical situations in humans. HLA-DRA1*0101/DRB1*0401 MHC class II heterodimers were produced as empty molecules using the Drosophila melanogaster expression system. Peptide binding experiments revealed that these...

journal_title：European journal of immunology

authors： Lemaître F,Viguier M,Cho MS,Fourneau JM,Maillère B,Kourilsky P,Van Endert PM,Ferradini L

更新日期：2004-10-01 00:00:00

abstract：:In the bone marrow, the passage of developing B cells through critical checkpoints of differentiation is associated with a reduction of specific categories of CDR3 of the Ig heavy chain (CDR-H3), particularly those with excessive hydrophobic or charged amino acids and those with a length of eight or fewer residues. To...

journal_title：European journal of immunology

authors： Schelonka RL,Tanner J,Zhuang Y,Gartland GL,Zemlin M,Schroeder HW Jr

更新日期：2007-04-01 00:00:00

abstract：:The CD11c(+) cell population in the non-parenchymal cell population of the mouse liver contains dendritic cells (DC), NK cells, B cells and T cells. In the hepatic CD11c(+) DC population from immunocompetent or immunodeficient [recombinase-activating gene-1 (RAG1)(-/-)] C57BL/6 mice (rigorously depleted of T cells, B ...

journal_title：European journal of immunology

authors： Jomantaite I,Dikopoulos N,Kröger A,Leithäuser F,Hauser H,Schirmbeck R,Reimann J

更新日期：2004-02-01 00:00:00

abstract：:Human interdigitating dendritic cells (IDC) were isolated from tonsils based on their CD40+ lineage-negative expression in situ. Isolated IDC displayed a phenotypic profile similar to that of IDC in tonsils and spleen in situ, characterized by high-level expression of major histocompatibility complex class II, the co-...

journal_title：European journal of immunology

authors： Björck P,Flores-Romo L,Liu YJ

更新日期：1997-05-01 00:00:00

abstract：:DC not only activate CD4 T (Th) cell and cytotoxic CD8 T cell (CTL) responses against pathogens, but they also tolerize autoreactive T cells in order to avoid autoimmunity. Previous studies have demonstrated that steady-state DC can tolerize naïve CTL, naïve Th cells and memory CTL. A study in this issue of the Europe...

journal_title：European journal of immunology

authors： Kurts C

更新日期：2010-07-01 00:00:00

abstract：:The lone CX3C chemokine, fractalkine (FK), is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. We now show that FK is associated with dendritic cells (DC) in epidermis and lymphoid organs. In normal human skin, dual-color fl...

journal_title：European journal of immunology

authors： Papadopoulos EJ,Sassetti C,Saeki H,Yamada N,Kawamura T,Fitzhugh DJ,Saraf MA,Schall T,Blauvelt A,Rosen SD,Hwang ST

更新日期：1999-08-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer- and host cell-derived signals generally drive the functions of TAMs towards an M2-like polarized, tumor-propelling mode; however, when appropriately re-educated. TAMs also have the potential to elicit tumor destructive reacti...

journal_title：European journal of immunology

authors： Mantovani A,Germano G,Marchesi F,Locatelli M,Biswas SK

更新日期：2011-09-01 00:00:00

abstract：:Rat CD4+ T cells are divided phenotypically by the anti-CD45RC monoclonal antibody OX22 into subsets with contrasting functions. Stimulation of T cells in vitro is known to induce a change in isoform from CD45RC+ to CD45RC-. We have investigated the in vitro conditions which promote a switch in isoform in the opposite...

journal_title：European journal of immunology

authors： Sarawar SR,Sparshott SM,Sutton P,Yang CP,Hutchinson IV,Bell EB

更新日期：1993-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II-associated antigen presentation is mainly linked to processing of exogenous antigens upon cellular uptake by endocytosis, but has also been observed for endogenously synthesized antigens. We have studied the MHC class II-associated presentation of the endogenously synthe...

journal_title：European journal of immunology

authors： Oxenius A,Bachmann MF,Ashton-Rickardt PG,Tonegawa S,Zinkernagel RM,Hengartner H

更新日期：1995-12-01 00:00:00

abstract：:The capacity of human peripheral blood lymphocytes (PBL) to bind antigen-IgG antibody (EA(IgG)) and antigen-IgM antibody (EA(IgM)) complexes was investigated using a rosette technique with ox erythrocytes coated with rabbit IgG or IgM antibody. It was found that while EA(IgG)-rosette-forming cells (RFC) were detected ...

journal_title：European journal of immunology

authors： Moretta L,Ferrarini M,Durante ML,Mingari MC

更新日期：1975-08-01 00:00:00

abstract：:The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...

journal_title：European journal of immunology

authors： Wensveen FM,Šestan M,Turk Wensveen T,Polić B

更新日期：2019-07-01 00:00:00

abstract：:Infection with parasitic worms (helminths) alters host immune responses and can inhibit pathogenic inflammation. Helminth infection promotes a strong Th2 and T regulatory response while suppressing Th1 and Th17 function. Th2 responses are largely dependent on transcriptional programs directed by Stat6-signaling. We ex...

journal_title：European journal of immunology

authors： Metwali A,Winckler S,Urban JF Jr,Kaplan MH,Ince MN,Elliott DE

更新日期：2020-10-16 00:00:00

abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

journal_title：European journal of immunology

authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

更新日期：1996-08-01 00:00:00

abstract：:A panel of monoclonal antibodies (mAb) specific for the C gamma 2, C gamma 3 or inter C gamma 2/C gamma 3 domain epitopes was tested for inhibition of antibody-dependent cellular cytotoxicity (ADCC) specific for anti-D IgG-coated erythrocytes. Significant inhibition of ADCC was demonstrable for some antibodies having ...

journal_title：European journal of immunology

authors： Sármay G,Jefferis R,Klein E,Benczur M,Gergely J

更新日期：1985-10-01 00:00:00

abstract：:At the surface of the murine T lymphoma cell line RMA-S, the expression of "empty" class I molecules can be dramatically enhanced by culture at 26 degrees C. These class I molecules are unstable following transfer to 37 degrees C unless they are loaded with exogenously added peptides. Class I heterodimers that have fa...

journal_title：European journal of immunology

authors： Neefjes JJ,Smit L,Gehrmann M,Ploegh HL

更新日期：1992-06-01 00:00:00

abstract：:The recently discovered B6.C-H-2bm12 (bm12) histocompatibility mutant bears a mutation of the I-A subregion of the H-2b haplotype. We have studied cytotoxic T lymphocytes (CTL) generated in secondary mixed lymphocyte culture (MLC) between the bm12 mutant and the strain of origin C57BL/6 (B6). In both directions, stron...

journal_title：European journal of immunology

authors： de Waal LP,Melief CJ,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:NK cells display several killer inhibitory receptors (KIR) specific for different alleles of MHC class I molecules. A family of KIR are represented by type I transmembrane proteins belonging to the immunoglobulin superfamily (Ig-SF). Besides cDNA encoding for these KIR, additional cDNA have been identified which encod...

journal_title：European journal of immunology

authors： Cantoni C,Verdiani S,Falco M,Pessino A,Cilli M,Conte R,Pende D,Ponte M,Mikaelsson MS,Moretta L,Biassoni R

更新日期：1998-06-01 00:00:00

abstract：:Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...

journal_title：European journal of immunology

authors： Ramesh G,Alvarez AL,Roberts ED,Dennis VA,Lasater BL,Alvarez X,Philipp MT

更新日期：2003-09-01 00:00:00

abstract：:Human NK cells can be subdivided into CD56(dim) and CD56(bright) NK cells, which exhibit different phenotypical and functional characteristics. As murine NK cells lack CD56 or a distinct correlate, direct comparative studies of NK cells in mice and humans are limited. Although CD27 is currently proposed as a feasible ...

journal_title：European journal of immunology

authors： Marquardt N,Wilk E,Pokoyski C,Schmidt RE,Jacobs R

更新日期：2010-05-01 00:00:00

abstract：:Psoriasis is an inflammatory disease of the skin affecting 2-3% of the population, characterized by a thickening of the epidermis and immune infiltrates throughout the dermis and epidermis, causing skin lesions that can seriously affect quality of life. The study of psoriasis has historically been hampered by the lack...

journal_title：European journal of immunology

authors： Flutter B,Nestle FO

更新日期：2013-12-01 00:00:00

abstract：:IL-18 is involved in the pathogenesis of atopic dermatitis, psoriasis, and allergic contact dermatitis. CXCL9, CXCL10, and CXCL11 recruit type 1 T cells, and the production of these chemokines by keratinocytes is enhanced in these dermatoses. We examined the in vitro effects of IL-18 on IFN-gamma-induced CXCL9, CXCL10...

journal_title：European journal of immunology

authors： Kanda N,Shimizu T,Tada Y,Watanabe S

更新日期：2007-02-01 00:00:00

abstract：:Under physiological conditions, activation of CD4+ T cells by major histocompatibility complex (MHC)antigen complexes requires engagement of both the T cell receptor and the CD4 molecule. However, CD4 ligands binding to the CD4 molecule has also been shown to inhibit T cell proliferation and interleukin (IL)-2 product...

journal_title：European journal of immunology

authors： Jabado N,Pallier A,Jauliac S,Fischer A,Hivroz C

更新日期：1997-02-01 00:00:00

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00