当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes.

gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes.

Abstract：

:Under physiological conditions, activation of CD4+ T cells by major histocompatibility complex (MHC)antigen complexes requires engagement of both the T cell receptor and the CD4 molecule. However, CD4 ligands binding to the CD4 molecule has also been shown to inhibit T cell proliferation and interleukin (IL)-2 production in human CD4+ T cells, in an MHC-independent way. We have previously shown that this inhibition was associated with a diminished binding activity of the IL-2 transcription factors NF-AT, NF-kappaB, and AP-1. AP-1 plays a key role in the regulation of IL-2 transcription, and ERK and JNK activities are necessary for regulating AP-1 at both the transcriptional and the post-transcriptional levels. We therefore studied, in human peripheral CD4+ T cells, the regulation of the activities of extracellular signal-regulated protein kinases (ERK) and c-Jun N-terminal kinases (JNK) by two CD4 ligands, gp160 the envelope glycoprotein of human immunodeficiency virus (HIV) and an anti-CD4 monoclonal antibody (mAb). Pre-incubation of CD4+ T lymphocytes in the presence of anti-CD4 mAb or gp160 inhibits the activation of JNK in response to phorbol 12-myristate 13-acetate and ionomycin. In the same conditions, phosphorylation and activation of ERK-2 were also inhibited. Inhibition of both JNK and ERK-2 activities are specific for binding of CD4 ligands to the CD4 molecule. They were not observed in CD8+ T lymphocytes. These results suggest that a specific inhibition of JNK and ERK-2 activities contributes to defective IL-2 production in T lymphocytes pre-incubated with CD4 ligands.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Jabado N,Pallier A,Jauliac S,Fischer A,Hivroz C

doi

10.1002/eji.1830270209

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

397-404

issue

2

eissn

0014-2980

issn

1521-4141

journal_volume

27

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period.

    abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240235

    authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

    更新日期：1994-02-01 00:00:00

  • Analysis of the T cell repertoire for myelin basic protein in thymus-grafted and other types of chimera: evidence that major histocompatibility complex molecules on accessory cells rather than T cell specificity mainly regulate susceptibility to autoimmun

    abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease inducible in rodents by immunization of brain-specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200934

    authors： Matsumoto Y,Kawai K,Fujiwara M

    更新日期：1990-09-01 00:00:00

  • Update on animal models for HIV research.

    abstract：:Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939576

    authors： Haigwood NL

    更新日期：2009-08-01 00:00:00

  • Enhanced immunogenicity of aldehyde-bearing antigens: a possible link between innate and adaptive immunity.

    abstract：:Innate immunity directs the adaptive immune response by identifying antigens that are associated with infectious agents. Although some microbial antigens can be recognized by innate immune receptors, most cannot, and these require identification by some other means. The introduction of aldehydes into antigens by glyco...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200010)30:10<2881::AID-IMMU2881>

    authors： Allison ME,Fearon DT

    更新日期：2000-10-01 00:00:00

  • The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci.

    abstract：:An approach to the preparation of antigen-specific human monoclonal antibodies focuses on mice transgenic for human immunoglobulin gene miniloci; the V gene segments in these miniloci undergo productive rearrangement to yield mouse B cells expressing human immunoglobulin (Ig) chains. The general usefulness of this str...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830241116

    authors： Wagner SD,Popov AV,Davies SL,Xian J,Neuberger MS,Brüggemann M

    更新日期：1994-11-01 00:00:00

  • IL-18 enhances IFN-gamma-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes.

    abstract：:IL-18 is involved in the pathogenesis of atopic dermatitis, psoriasis, and allergic contact dermatitis. CXCL9, CXCL10, and CXCL11 recruit type 1 T cells, and the production of these chemokines by keratinocytes is enhanced in these dermatoses. We examined the in vitro effects of IL-18 on IFN-gamma-induced CXCL9, CXCL10...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200636420

    authors： Kanda N,Shimizu T,Tada Y,Watanabe S

    更新日期：2007-02-01 00:00:00

  • The stromal cell line S17 supports the growth of lipopolysaccharide-stimulated CBA/N spleen cell colonies in vitro.

    abstract：:The expression of an X-linked defect in the CBA/N strain of mice has been found to result in a number of immune abnormalities. These include low responsiveness to antigens and a greatly reduced ability to respond to many of the common B cell mitogens. An in vitro manifestation of this condition is the virtual inabilit...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220419

    authors： Narendran A,Cumano A,Dorshkind K,Paige CJ

    更新日期：1992-04-01 00:00:00

  • Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.

    abstract：:Reactive oxygen species (ROS) are implicated in the modulation of diverse processes including immune responses. To evaluate the effects of metabolic ROS produced by mitochondria on B-cell function and development, we created transgenic (Tg) mice expressing a phosphorylation-defective mutant of succinate dehydrogenase ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201646342

    authors： Ogura M,Inoue T,Yamaki J,Homma MK,Kurosaki T,Homma Y

    更新日期：2017-02-01 00:00:00

  • Activation and proliferation signals in mouse B cells. VIII. Induction of DNA synthesis in B cells by a combination of calcium ionophores and phorbol myristate acetate.

    abstract：:Mouse B cells cultured with either phorbol myristate acetate (PMA), or with Ca2+ ionophores enter a transitional activated state, between quiescence (G0) and G1, but do not synthesize DNA. It is shown here that the combination of PMA plus the ionophore ionomycin induces resting B cells to synthesize DNA, but not to se...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160118

    authors： Klaus GG,O'Garra A,Bijsterbosch MK,Holman M

    更新日期：1986-01-01 00:00:00

  • Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites.

    abstract：:Leishmaniasis is currently classified as category 1 disease, i.e. emerging and uncontrolled. Since the importance of persistent infection for maintaining an effective long-lasting protective response is controversial, the present study asks whether immunisation with non-persistent parasites leads to protection against...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200838423

    authors： Kedzierski L,Curtis JM,Doherty PC,Handman E,Kedzierska K

    更新日期：2008-11-01 00:00:00

  • The effects of B7-dependent costimulation on T cell division and survival in vivo and in vitro are dependent on antigen concentration.

    abstract：:We used 5-(and 6-) carboxyfluorescein diacetate succinimidyl ester labeled TCR-transgenic CD4(+) T cells to investigate the contribution of B7 costimulation to T cell activation and clonal expansion. B7 costimulation was blocked with the fusion protein cytotoxic T lymphocyte-associated antigen-4 (CTLA-4)-Ig, which pre...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200323929

    authors： Lumsden JM,Prasad SJ,Peach RJ,Ronchese F

    更新日期：2003-08-01 00:00:00

  • Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment.

    abstract：:The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed th...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425246

    authors： Maehr R,Kraus M,Ploegh HL

    更新日期：2004-08-01 00:00:00

  • Inhibition of clonal expansion by Foxp3 expression as a mechanism of controlled T-cell responses and autoimmune disease.

    abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939404

    authors： Guo L,Tian J,Marinova E,Zheng B,Han S

    更新日期：2010-01-01 00:00:00

  • Correlated expression of VH framework and VH idiotypic determinants on T helper cells and on functionally undefined T cells binding group A streptococcal carbohydrate.

    abstract：:Antibodies to framework determinants of the VH and V lambda fragments of MOPC 315 and antisera to the VH idiotype determinants of the A 5 A antibody were used to analyze the antigen receptors of mouse T (and B) cells. This was done by using the antibodies as inhibitors in (a) an assay in which the binding of radiolabe...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830100207

    authors： Eichmann K,Ben-Neriah Y,Hetzelberger D,Polke C,Givol D,Lonai P

    更新日期：1980-02-01 00:00:00

  • CMV and natural killer cells: shaping the response to vaccination.

    abstract：:Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can...

    journal_title：European journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1002/eji.201646762

    authors： Goodier MR,Jonjić S,Riley EM,Juranić Lisnić V

    更新日期：2018-01-01 00:00:00

  • SWAP-70-deficient mast cells are impaired in development and IgE-mediated degranulation.

    abstract：:Cross-linking of the high-affinity IgE receptor (FcepsilonRI) on mast cell activates signaling pathways that trigger degranulation and the release of multiple pro-inflammatory mediators. Mature,immature and precursor mast cells are degranulation competent. We show here that the signaling protein SWAP-70 has a function...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200204)32:4<1121::AID-IMMU1121>3

    authors： Gross B,Borggrefe T,Wabl M,Sivalenka RR,Bennett M,Rossi AB,Jessberger R

    更新日期：2002-04-01 00:00:00

  • Different cytokine production profiles of gamma delta T cell clones: relation to inflammatory arthritis.

    abstract：:This study was performed to investigate whether gamma delta T cells could also be divided into subsets, identified by a cytokine profile, as described for alpha beta T helper (Th) cell subsets. Cytokine production was studied in 22 gamma delta T cell clones obtained from the synovial fluid and peripheral blood of one ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240923

    authors： Chomarat P,Kjeldsen-Kragh J,Quayle AJ,Natvig JB,Miossec P

    更新日期：1994-09-01 00:00:00

  • Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-gamma inducible protein-10 and monocyte chemotactic protein-1.

    abstract：:In viral meningitis the inflammatory response involves activated T cells and monocytes which are recruited into the subarachnoid space. To identify the chemotactic signals attracting the cells to the site of infection in the meninges, we measured the levels of two CXC chemokines, interferon-gamma (IFN-gamma) inducible...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830271004

    authors： Lahrtz F,Piali L,Nadal D,Pfister HW,Spanaus KS,Baggiolini M,Fontana A

    更新日期：1997-10-01 00:00:00

  • Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways.

    abstract：:Immune enhancement is desirable in situations where decreased immunity results in increased morbidity. We investigated whether blocking the surface inhibitory receptor PD-1 and/or p38 MAP kinase could enhance the proliferation of the effector memory CD8(+) T-cell subset that re-expresses CD45RA (EMRA) and exhibits cha...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201445312

    authors： Henson SM,Macaulay R,Riddell NE,Nunn CJ,Akbar AN

    更新日期：2015-05-01 00:00:00

  • Binding of nucleosomes to a cell surface receptor: redistribution and endocytosis in the presence of lupus antibodies.

    abstract：:In the present study, we sought evidence for a surface nucleosome receptor in the fibroblastic cell line CV-1, and questioned whether anti-double-stranded (ds) DNA and/or anti-histone autoantibodies could recognize and influence the fate of cell surface-bound nucleosomes. 125I-labeled mononucleosomes were shown to bin...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260230

    authors： Koutouzov S,Cabrespines A,Amoura Z,Chabre H,Lotton C,Bach JF

    更新日期：1996-02-01 00:00:00

  • The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro.

    abstract：:Btk is a member of the Tec family of protein tyrosine kinases expressed in B cells. It is stimulated following cross-linking of the B cell receptor which leads to the autophosphorylation of a specific residue in the SH3 domain, Y223. Previous work using Btk-derived fusion proteins has shown that the Btk SH3 domain bin...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199907)29:07<2269::AID-IMM

    authors： Morrogh LM,Hinshelwood S,Costello P,Cory GO,Kinnon C

    更新日期：1999-07-01 00:00:00

  • Dynamic changes in intrathymic ILC populations during murine neonatal development.

    abstract：:Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multip...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201847511

    authors： Jones R,Cosway EJ,Willis C,White AJ,Jenkinson WE,Fehling HJ,Anderson G,Withers DR

    更新日期：2018-09-01 00:00:00

  • CD45RB expression defines two interconvertible subsets of human CD4+ T cells with memory function.

    abstract：:Reciprocal expression of CD45RA and CD45RO in human CD4+ T cells defines populations understood to be naive cells (CD45RA+CD45RO-) and memory cells (CD45RA-CD45RO+). We investigate two subsets of CD45RA-CD45RO+ CD4+ human T cells which differ by fourfold in their expression of the CD45RB isoform; one is CD45RBbright a...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240536

    authors： Horgan KJ,Tanaka Y,Luce GE,van Seventer GA,Nutman TB,Shaw S

    更新日期：1994-05-01 00:00:00

  • OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans.

    abstract：:The costimulatory receptor OX40 is expressed on activated T cells and regulates T-cell responses. Here, we show the efficacy and mechanism of action of an OX40 blocking antibody using the chronic house dust mite (HDM) mouse model of lung inflammation and in vitro HDM stimulation of cells from HDM allergic human donors...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201445163

    authors： Burrows KE,Dumont C,Thompson CL,Catley MC,Dixon KL,Marshall D

    更新日期：2015-04-01 00:00:00

  • HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway.

    abstract：:HLA class II molecules are involved in the OKT3-induced T cell activation, since monoclonal antibodies (mAb) to monomorphic determinants of class II antigens are able to inhibit T cell proliferation. This effect involves several of the events leading to T cell activation and proliferation, i.e. interleukin (IL) 1, IL ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210106

    authors： Ruggiero G,Racioppi L,Manzo C,Pirozzi G,D'Oro U,Ferrone S,Zappacosta S,Fontana S

    更新日期：1991-01-01 00:00:00

  • Persistence of autoreactive myelin oligodendrocyte glycoprotein (MOG)-specific T cell repertoires in MOG-expressing mice.

    abstract：:Experimental autoimmune encephalomyelitis, an experimental murine model for multiple sclerosis, is induced by stimulation of myelin-specific T lymphocytes. Myelin oligodendrocyte glycoprotein (MOG), a minor component of myelin proteins, is a potent autoantigen which contributes extensively to the anti-myelin response....

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200535021

    authors： Fazilleau N,Delarasse C,Sweenie CH,Anderton SM,Fillatreau S,Lemonnier FA,Pham-Dinh D,Kanellopoulos JM

    更新日期：2006-03-01 00:00:00

  • Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.

    abstract：:The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presen...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200737518

    authors： Denkberg G,Stronge VS,Zahavi E,Pittoni P,Oren R,Shepherd D,Salio M,McCarthy C,Illarionov PA,van der Merwe A,Besra GS,Dellabona P,Casorati G,Cerundolo V,Reiter Y

    更新日期：2008-03-01 00:00:00

  • Induction of the Igkappa 3' enhancer by distinct pathways can be inhibited by cross-linking of the CD40 receptor.

    abstract：:Upon treatment with lipopolysaccharide (LPS), primary B cells proliferate and differentiate into plasma cells with concomitant up-regulation of immunoglobulin (Ig) gene expression. Here we examine the role of the Igkappa 3' enhancer in this process using a kappa3'-enhancer-driven beta-globin reporter gene in transgeni...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199903)29:03<872::AID-IMMU

    authors： Meyer KB

    更新日期：1999-03-01 00:00:00

  • Expression of a non-DNA-binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis.

    abstract：:Ikaros is a transcriptional regulator whose function is essential for B cell development. It is expressed in the hematopoietic stem cell (HSC) through the mature B cell stage. Using genetically engineered mice in which the endogenous Ikaros gene is disrupted, it has been shown that a lack of Ikaros leads to a block in...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200637026

    authors： Wojcik H,Griffiths E,Staggs S,Hagman J,Winandy S

    更新日期：2007-04-01 00:00:00

  • Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes.

    abstract：:Myeloid dendritic cells (DC) and macrophages evolve from a common precursor. However, factors controlling monocyte differentiation toward DC or macrophages are poorly defined. We report that the surface density of the GM-CSF receptor (GM-CSFR) alpha subunit in human peripheral blood monocytes varies among donors. Alth...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200737395

    authors： Conti L,Cardone M,Varano B,Puddu P,Belardelli F,Gessani S

    更新日期：2008-03-01 00:00:00