Abstract:
:T-cell death is a fundamental process that is intricately regulated at multiple phases during T-cell differentiation, tolerance induction and the decline of the immune response. Caspase 3 is a crucial molecule regulating both mitochondrial and death receptor apoptotic pathways and therefore we were interested in examining the role of caspase 3 in T cells. Using P14 and H-Y CD8(+) TCR-transgenic models, our analysis has shown that caspase 3 is not required for thymic negative selection. In addition, caspase 3 does not play a prominent role in the contraction phase following acute viral infection, nor clonal deletion of CD8(+) T cells under tolerizing conditions. Surprisingly, our studies demonstrate that caspase 3 was not required for the induction of CD8(+) T-cell anergy in vivo, contrary to published reports using CD4(+) T cells. Therefore, these results demonstrate that caspase 3 is not essential in CD8(+) T cells for multiple forms of thymic or peripheral tolerance, nor the contraction phase after an acute anti-viral response.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Murakami K,Liadis N,Sarmiento J,Elford AR,Woo M,Nguyen LT,Mak TW,Ohashi PSdoi
10.1002/eji.201040475subject
Has Abstractpub_date
2010-12-01 00:00:00pages
3372-7issue
12eissn
0014-2980issn
1521-4141journal_volume
40pub_type
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