Functional characteristics of murine macrophages responding to migration inhibitory factors.

abstract：:Natural killer (NK) cells in normal mouse spleen have so far been found to lack conventional cell surface markers. Recently, neuraminidase treatment has been shown to uncover receptors for the A hemagglutinin of the snail Helix pomatia (HP) on populations (preferentially T cells) of human blood lymphocytes. We have us...

journal_title：European journal of immunology

authors： Haller O,Gidlund M,Hellström U,Hammarström S,Wigzell H

更新日期：1978-11-01 00:00:00

abstract：:The human promyelocytic U937 cells express detectable levels of MHC class II (MHC-II) molecules. Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gen...

journal_title：European journal of immunology

authors： De Lerma Barbaro A,Procopio FA,Mortara L,Tosi G,Accolla RS

更新日期：2005-02-01 00:00:00

abstract：:This study describes a CD5+ B cell that differs from the majority of the CD5+ B cells from human tonsils. This cell, isolated from in vivo activated B cells, expressed activation markers and featured a CD23-, IgMhigh, IgDlow surface phenotype, responded to T cell-independent type-2 antigens in vitro, and was detected ...

journal_title：European journal of immunology

authors： Dono M,Burgio VL,Colombo M,Sciacchitano S,Reverberi D,Tarantino V,Cutrona G,Chiorazzi N,Ferrarini M

更新日期：2007-08-01 00:00:00

abstract：:In the bone marrow, the passage of developing B cells through critical checkpoints of differentiation is associated with a reduction of specific categories of CDR3 of the Ig heavy chain (CDR-H3), particularly those with excessive hydrophobic or charged amino acids and those with a length of eight or fewer residues. To...

journal_title：European journal of immunology

authors： Schelonka RL,Tanner J,Zhuang Y,Gartland GL,Zemlin M,Schroeder HW Jr

更新日期：2007-04-01 00:00:00

abstract：:The MHC class Ib molecule H2-M3 presents N-formylated peptides from the N terminus of proteins encoded by the mitochondrial genome to CTL. A panel of CTL specific for a peptide derived from a mitochondrial protein, either COI or ND1, was used to determine the optimal peptide length for sensitizing antigen-deficient ta...

journal_title：European journal of immunology

authors： Dabhi VM,Lindahl KF

更新日期：1998-11-01 00:00:00

abstract：:The encephalitogenic peptide pMOG 35-55 from the myelin oligodendrocyte glycoprotein was used to induce experimental autoimmune encephalomyelitis (EAE) in H-2b mice with the interleukin-6 (IL-6) gene intact or disrupted. The IL-6+/+ mice developed a chronic form of EAE ascending paralysis, whereas the IL-6-/- mice wer...

journal_title：European journal of immunology

authors： Mendel I,Katz A,Kozak N,Ben-Nun A,Revel M

更新日期：1998-05-01 00:00:00

abstract：:The proliferative state of functionally defined populations of size-separated pre-B cells was investigated. The results presented here support the hypothesis that pre-B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon wool columns, unlik...

journal_title：European journal of immunology

authors： Deslauriers-Boisvert N,Mercier G,Lafleur L

更新日期：1982-04-01 00:00:00

abstract：:LIGHT is a recently identified member of the TNF superfamily that is up-regulated on activated T cells and can cooperate with CD40L to condition DC for the priming of CTL. In this report, we show that an intracellular pool of LIGHT is found selectively in some CD45RA-CD27+CD4+ "central" memory T cells and to a greater...

journal_title：European journal of immunology

authors： Morel Y,Truneh A,Costello RT,Olive D

更新日期：2003-11-01 00:00:00

abstract：:Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multip...

journal_title：European journal of immunology

authors： Jones R,Cosway EJ,Willis C,White AJ,Jenkinson WE,Fehling HJ,Anderson G,Withers DR

更新日期：2018-09-01 00:00:00

abstract：:Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...

journal_title：European journal of immunology

authors： Bluestone JA,Auchincloss H Jr,Sachs DH,Fibi M,Hämmerling GJ

更新日期：1983-06-01 00:00:00

abstract：:The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function have been identified. E+/UCHT1+ cell...

journal_title：European journal of immunology

authors： Beverley PC,Callard RE

更新日期：1981-04-01 00:00:00

abstract：:T cells from human peripheral blood were enriched in T4+ cells by lysis of T8+ cells with the monoclonal antibody OKT8 plus complement. The T4+ subset was separated into 4 fractions differing in avidity for the lectin Helix pomatia A hemagglutinin (HP). The fractions were studied for their capacity to help autologous ...

journal_title：European journal of immunology

authors： Wikén M,Hellström U,Perlmann P

更新日期：1984-11-01 00:00:00

abstract：:In the frog Xenopus, MHC class I antigen presentation and processing genes (the immunoproteasome LMP2 and LMP7 and the transporter TAP1 and TAP2) seem to be closely linked in a primordial organization. Two distinct lineages of class Ia and LMP7 loci were previously identified, thus strongly suggesting co-evolution amo...

journal_title：European journal of immunology

authors： Ohta Y,Powis SJ,Lohr RL,Nonaka M,Pasquier LD,Flajnik MF

更新日期：2003-11-01 00:00:00

abstract：:At the surface of the murine T lymphoma cell line RMA-S, the expression of "empty" class I molecules can be dramatically enhanced by culture at 26 degrees C. These class I molecules are unstable following transfer to 37 degrees C unless they are loaded with exogenously added peptides. Class I heterodimers that have fa...

journal_title：European journal of immunology

authors： Neefjes JJ,Smit L,Gehrmann M,Ploegh HL

更新日期：1992-06-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneous candidiasis (CMC...

journal_title：European journal of immunology

authors： Zheng J,van de Veerdonk FL,Crossland KL,Smeekens SP,Chan CM,Al Shehri T,Abinun M,Gennery AR,Mann J,Lendrem DW,Netea MG,Rowan AD,Lilic D

更新日期：2015-10-01 00:00:00

abstract：:During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite fre...

journal_title：European journal of immunology

authors： Kahn S,Kahn M,Eisen H

更新日期：1992-12-01 00:00:00

abstract：:Cognate interactions between major histocompatibility complex class II antigen (Ag)-reactive CD4+ T helper (Th) and Ag-presenting B cells induce first the activation of B cells and their subsequent differentiation into Ig-secreting cells (IgSC). The Th cell-associated homodimeric glycoprotein CD28 has been implicated ...

journal_title：European journal of immunology

authors： Damle NK,Linsley PS,Ledbetter JA

更新日期：1991-05-01 00:00:00

abstract：:We have investigated the role of TNF-alpha in mast cell-mediated late airway hyperresponsiveness (AHR) using mast cell-deficient WBB6F1-W/W(v) (W/W(v)) mice in a murine model of asthma, which exhibits a biphasic increase in AHR. TNF-alpha levels in the airway and magnitude of late AHR in response to airway allergen ch...

journal_title：European journal of immunology

authors： Kim YS,Ko HM,Kang NI,Song CH,Zhang X,Chung WC,Kim JH,Choi IH,Park YM,Kim GY,Im SY,Lee HK

更新日期：2007-04-01 00:00:00

abstract：:The molecular mechanism of the interleukin (IL) 2-induced differentiation of human B cells has been investigated. The experimental results show that Staphylococcus aureus Cowan strain I (SAC) activation alone induces IL6 secretion from B cells. When B cells were activated by SAC, there was an increased transcription o...

journal_title：European journal of immunology

authors： Xia X,Lee HK,Clark SC,Choi YS

更新日期：1989-12-01 00:00:00

abstract：:The contribution of T cell responses to immunity against respiratory syncytial virus (RSV) is not fully defined, but this is an important issue for vaccine design. Recent studies demonstrating RSV-induced pulmonary T cell suppression suggest that RSV may have evolved strategies to escape T cell immunity. Here we evalu...

journal_title：European journal of immunology

authors： Ostler T,Ehl S

更新日期：2002-09-01 00:00:00

abstract：:Secretion of proinflammatory mediators by activated macrophages plays an important role in the immune response to Trypanosoma cruzi. We have previously reported that AgC10, a glycosylphosphatidylinositol-anchored mucin from T. cruzi, inhibits TNF secretion by activated macrophages (de Diego, J., Punzon, C., Duarte, M....

journal_title：European journal of immunology

authors： Alcaide P,Fresno M

更新日期：2004-06-01 00:00:00

abstract：:The delivery of T-cell help to B cells is antigen-specific, MHC-restricted, and CD40L (CD154) dependent. It has been thought that when a T cell recognizes an antigen-presenting B cell, CD40L expressed on the T-cell surface engages with CD40 on the surface of B cells as long as the cells remain conjugated. By adding fl...

journal_title：European journal of immunology

authors： Gardell JL,Parker DC

更新日期：2017-01-01 00:00:00

abstract：:The present study was designed to elucidate the role of Valpha14(+) NKT cells in the host defense against pulmonary infection with Streptococcus pneumoniae using Jalpha281 gene-disrupted mice (Jalpha281KO mice) that lacked this lymphocyte subset. In these mice, pneumococcal infection was severely exacerbated, as shown...

journal_title：European journal of immunology

authors： Kawakami K,Yamamoto N,Kinjo Y,Miyagi K,Nakasone C,Uezu K,Kinjo T,Nakayama T,Taniguchi M,Saito A

更新日期：2003-12-01 00:00:00

abstract：:The F1 progeny of autoimmune NZB and normal SWR mice uniformly develop severe and accelerated lupus nephritis. The (SWR x NZB)F1 mice produce an oligoclonally expanded population of nephritogenic anti-DNA autoantibodies that share a recurrent cross-reactive idiotype (Id564), use highly homologous VH genes and surprisi...

journal_title：European journal of immunology

authors： O'Keefe TL,Datta SK,Imanishi-Kari T

更新日期：1992-03-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:IL-5 preferentially activates B1 cells to produce natural antibodies cross-reactive to self antigens. To determine the role of IL-5 in antibody-mediated autoimmune disease, we generated systemic lupus erythematosus (SLE)-prone (NZB x NZW)F1 mice congenic for IL-5 transgene (TG-F1). The transgene unexpectedly reduced t...

journal_title：European journal of immunology

authors： Wen X,Zhang D,Kikuchi Y,Jiang Y,Nakamura K,Xiu Y,Tsurui H,Takahashi K,Abe M,Ohtsuji M,Nishimura H,Takatsu K,Shirai T,Hirose S

更新日期：2004-10-01 00:00:00

abstract：:Two subpopulations of human T lymphocytes expressing different antigen receptors, alpha/beta and gamma/delta, emigrate into inflamed tissues in distinctive patterns. We compared the transmigration of alpha/beta and gamma/delta T cells to C-C and C-X-C chemokines using an in vitro transendothelial chemotaxis assay. The...

journal_title：European journal of immunology

authors： Roth SJ,Diacovo TG,Brenner MB,Rosat JP,Buccola J,Morita CT,Springer TA

更新日期：1998-01-01 00:00:00

abstract：:IL-33 is a novel cytokine of the IL-1 family and mediates its biological effect via the receptor ST2, which is selectively expressed on Th2 cells but not Th1 cells. IL-33 drives production of Th2-associated cytokines including IL-5 and IL-13 and thereby promotes defense and pathology in mucosal organs. Cell locomotion...

journal_title：European journal of immunology

authors： Komai-Koma M,Xu D,Li Y,McKenzie AN,McInnes IB,Liew FY

更新日期：2007-10-01 00:00:00

abstract：:Regulation of the development of thymocytes into mature T cells within the thymus is now known to involve antigen-induced deletion, by apoptosis, of potentially autoreactive thymocytes, and it can be mimicked either by stimulating the T cell receptor (TcR) complex by monoclonal antibody (mAb) or by ionophore-induced e...

journal_title：European journal of immunology

authors： Conroy LA,Jenkinson EJ,Owen JJ,Michell RH

更新日期：1995-07-01 00:00:00

abstract：:The interaction between activated T cells and eosinophils has been proposed to play an important role in the pathogenesis of allergic diseases. T cell-derived cytokines such as interleukin-5 and granulocyte/macrophage colony-stimulating factor inhibit eosinophil apoptosis and may therefore contribute to the developmen...

journal_title：European journal of immunology

authors： Hebestreit H,Yousefi S,Balatti I,Weber M,Crameri R,Simon D,Hartung K,Schapowal A,Blaser K,Simon HU

更新日期：1996-08-01 00:00:00