Abstract：
:The encephalitogenic peptide pMOG 35-55 from the myelin oligodendrocyte glycoprotein was used to induce experimental autoimmune encephalomyelitis (EAE) in H-2b mice with the interleukin-6 (IL-6) gene intact or disrupted. The IL-6+/+ mice developed a chronic form of EAE ascending paralysis, whereas the IL-6-/- mice were resistant to the disease. Injections of recombinant IL-6 following pMOG immunization induced severe disease in the IL-6-/- mice. Histological examination of brain and spinal cord sections showed that the perivascular infiltration of inflammatory cells evident in IL-6+/+ mice was absent in the IL-6-/- animals and could be restored by exogenous IL-6 administration. Anti-MOG antibody levels were much lower in the IL-6-/- mice, but were not restored to high levels by IL-6 injections which elicited the development of pMOG 35-55-induced EAE. T lymphocytes reactive to the pMOG antigen were recovered from lymph nodes of both types of mice and Tcell lines could be established from both. Adoptive transfer of Tcell lines from IL-6+/+ mice induced EAE in the mice with the intact IL-6 gene but less in the IL-6-deficient mice, indicating that the resistant phenotype cannot be explained solely by lack of encephalitogenic Tcells. The absence of cell infiltrates in the brain and spinal cords of IL-6-/- mice upon adoptive transfer of the pathogenic Tcells from IL-6+/+ mice is consistent with a function of IL-6 in the local perivascular inflammatory process.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Mendel I,Katz A,Kozak N,Ben-Nun A,Revel Mdoi
10.1002/(SICI)1521-4141(199805)28:05<1727::AID-IMMsubject
Has Abstractpub_date
1998-05-01 00:00:00pages
1727-37issue
5eissn
0014-2980issn
1521-4141pii
10.1002/(SICI)1521-4141(199805)28:05<1727::AID-IMMjournal_volume
28pub_type
杂志文章abstract：:The lectin leucoagglutinin has been used to induce reactivity to interleukin 2 (IL2) in unseparated spleen cells and in highly purified Lyt-2+ lymph node T cells. Recombinant human IL2 and various other IL2-containing preparations, including concanavalin A-induced spleen cell supernatant, were compared for their capac...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830150405
更新日期：1985-04-01 00:00:00
abstract：:Peritoneal macrophages from C57BL/6 mice process antigens from bacteria or coated on polystyrene beads for presentation by major histocompatibility complex (MHC) class I molecules. To investigate this antigen processing pathway, peritoneal macrophages from homozygous TAP1-/- mice, which lack the transporter associated...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830261135
更新日期：1996-11-01 00:00:00
abstract：:We analyzed the avidity and CD28-mediated co-stimulatory requirements for the activation of T cells in vivo and in vitro. The strength of the T cell/antigen-presenting cell interaction was varied by using altered peptide ligands for stimulation. Co-stimulatory requirements were studied using T cells from CD28-deficien...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830260908
更新日期：1996-09-01 00:00:00
abstract：:Delivery of foreign antigens to mucosal surfaces, such as the pulmonary airways, has been shown to preferentially induce Th2-mediated responses in humans and in mice. What is not clear from these studies is whether this preferential skewing in responses is the result of the limited types of antigen being administered ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/1521-4141(200003)30:3<840::AID-IMMU840>3.0
更新日期：2000-03-01 00:00:00
abstract：:The repertoire of V regions of alpha/beta+ T cell receptor (TcR) on CD4+ and CD8+ T cells from the peripheral blood of six patients with a novel X-linked combined immunodeficiency was investigated by flow cytometry. The relative frequencies of V region subfamilies V alpha 2a on CD4+ T lymphocytes and V beta 5b and V b...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830220435
更新日期：1992-04-01 00:00:00
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journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830121202
更新日期：1982-12-01 00:00:00
abstract：:There is limited insight into the mechanisms involved in the counterregulation of TLR. Given the important role of TLR3/TIR domain-containing adaptor-inducing IFN-β (TRIF)-dependent signalling in innate immunity, novel insights into its modulation is of significance in the context of many physiological and pathologica...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201040547
更新日期：2010-11-01 00:00:00
abstract：:The biological behavior of immune cells is determined by their intrinsic properties and interactions with other cell populations within their microenvironment. Several studies have confirmed the existence of tight spatial interactions between mast cells (MCs) and Tregs in different settings. For instance, we have rece...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201041300
更新日期：2011-07-01 00:00:00
abstract：:Single-positive thymocytes are the immediate precursors of peripheral recent thymic emigrants (RTE) which develop into mature peripheral T cells. The functional ability of RTE is unclear but their state of differentiation may be relevant to the development of tolerance to peripheral "self" antigens. Since RTE are diff...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830240738
更新日期：1994-07-01 00:00:00
abstract：:Human natural killer (NK) cells can be subdivided into two populations based on the density of cell surface CD56 antigen. The great majority (approximately 90%) of NK cells express CD56 at low levels (the CD56dim phenotype), whereas a small NK cell subset (approximately 10%) exhibits approximately fivefold greater den...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830220102
更新日期：1992-01-01 00:00:00
abstract：:Although alterations in CD3-associated signal-transducing molecules in tumor-infiltrating T cells of patients with advanced cancer have been previously described, the mechanism behind these changes is not known. We demonstrate that macrophages isolated from metastatic lymph nodes of patients with malignant melanoma do...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830260620
更新日期：1996-06-01 00:00:00
abstract：:Bacterial antigens recognized by CD8(+) T cells in the context of MHC class I are thought to play a crucial role in protection against pathogenic intracellular bacteria. Here, we demonstrate the induction of HLA-A*0201-restricted CD8(+) T cell responses against six new high-affinity HLA-A*0201-binding CTL epitopes, en...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/1521-4141(200112)31:12<3602::aid-immu3602>
更新日期：2001-12-01 00:00:00
abstract：:The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells, monocytes and dendritic cells is essential for humoral immunity and for up-regulation of antigen-presenting cell (APC) functions, as a result of signaling through CD40. There are also some indications that after interaction with CD40, CD...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830260732
更新日期：1996-07-01 00:00:00
abstract：:The internalization and intracellular processing of monoclonal antibody to immunoglobulin mu heavy chain (Mamu) have been investigated in two human Burkitt lymphoma cell lines (Ramos and Raji), in a human B cell lymphoma and in normal human peripheral blood B cells. In addition to the degradation of 125I-labeled Mamu ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830160314
更新日期：1986-03-01 00:00:00
abstract：:The use of fetal bovine serum (FBS) for the culture and expansion of mesenchymal stromal cells (MSCs) limits their possible clinical applications. Although some recent studies recommended substituting FBS with human platelet lysate (HPL) for the expansion of MSCs for clinical use, the functional capacity of the expand...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201141542
更新日期：2011-11-01 00:00:00
abstract：:For homeostasis, T cells integrate non-cognate TCR-dependent and -independent signals to survive and weakly proliferate. In contrast to antigen-specific, stable, and long-lived contacts, signaling in short-lived homeostatic interactions depends upon the coordination of ongoing T-cell migration on the surface of DC and...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201040575
更新日期：2010-10-01 00:00:00
abstract：:AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 also mobilizes most mature leukocyte subsets to blood; however, their source and trafficking potential have not been fully delineated. Here, ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201445245
更新日期：2015-06-01 00:00:00
abstract：:The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine cor...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.201141683
更新日期：2011-10-01 00:00:00
abstract：:Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...
journal_title：European journal of immunology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
abstract：:Th17 cells are defined by their capacity to produce IL-17, and are important mediators of inflammation and autoimmunity. Human Th17 cells express high levels of the retinoic acid-related orphan receptor variant 2 (RORC2), but it is currently unclear whether expression of this transcription factor alone is sufficient t...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200838908
更新日期：2009-06-01 00:00:00
abstract：:Analysis of proliferation and cytokine production at the single-cell level indicated that proliferation of pre-existing type 2 cytokine(+) human peripheral naive T cells (CD4(+) and CD8(+)) accounts for the accumulation of type 2 T cells in lymphocytes cultured with IL-2, with or without IL-4, and independently from T...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200323643
更新日期：2003-04-01 00:00:00
abstract：:The effector function of activated CD4(+) T cells and secretion of cytokines are important in the establishment of productive immune responses and tolerance. We identified expression by CD4(+) T cells of Notch receptors and ligands and enhanced Notch signaling upon activation. Notch1 expression was up regulated and co...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.200425562
更新日期：2005-03-01 00:00:00
abstract：:B cells from bursa of Fabricius of newly hatched chickens are able to reconstitute the B cell compartment of chemically bursectomized chickens. The resulting B cell chimerism can be detected with monoclonal antibodies against donor B cell alloantigen. Chimeric chickens accept donor-type skin grafts and are unresponsiv...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830190303
更新日期：1989-03-01 00:00:00
abstract：:The T cell receptor (TcR) on CD8+ T lymphocytes recognizes a complex which consists of a major histocompatibility complex (MHC) heavy chain, beta 2-microglobulin (beta 2M), and peptide on the surface of antigen-presenting cells. Mutational analyses have suggested that the TcR recognizes both the alpha 1 and alpha 2 do...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830231145
更新日期：1993-11-01 00:00:00
abstract：:The genetic control of in vitro primary syngeneic sensitization on monolayers of thyroid epithelial cells was investigated both at the level of the responder lymphocytes and that of stimulator thyroid epithelial cells using congenic resistant strains of mice. It clearly appears that similar to the in vivo model of exp...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830131115
更新日期：1983-11-01 00:00:00
abstract：:Site-directed mutagenesis of a recombinant Fc hinge fragment has recently been used to localize the site of the mouse IgG1 (mIgG1) molecule that is involved in the intestinal transfer of recombinant Fc hinge fragments in neonatal mice. This site encompasses Ile-253, His-310, Gln-311, His-433 and Asn-434, localized at ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830261038
更新日期：1996-10-01 00:00:00
abstract：:The involvement of rheumatoid factor (RF)-secreting cells in normal immune responses was examined by screening hybridomas derived from 129/Sv mice during primary and secondary immune responses against foreign proteins. No RF-secreting cells were detected during primary responses, but up to 10% of the total number of c...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/eji.1830131106
更新日期：1983-11-01 00:00:00
abstract：:X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the B-cell compartment caused by a defective gene encoding for the tyrosine kinase (btk) essential for B cell differentiation. Affected males undergo recurrent pyogenic infections and deficient immunoglobulin production. Peripheral blood T cells from 6...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/1521-4141(200106)31:6<1927::aid-immu1927>3
更新日期：2001-06-01 00:00:00
abstract：:Precursor CD4-CD8- (DN) thymocytes rearrange their TCR-beta genes, and only those which succeed in beta-selection subsequently expand and differentiate into immature CD4+CD8+ (DP) thymocytes. The cell subsets corresponding to the successive steps of this transition can be defined in terms of CD44 and CD25 expression. ...
journal_title：European journal of immunology
pub_type： 杂志文章
doi：10.1002/1521-4141(2001010)31:10<3038::aid-immu3038
更新日期：2001-10-01 00:00:00
abstract：:An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic di...
journal_title：European journal of immunology
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doi：10.1002/eji.201747157
更新日期：2018-06-01 00:00:00
