Abstract:
:We analyzed the avidity and CD28-mediated co-stimulatory requirements for the activation of T cells in vivo and in vitro. The strength of the T cell/antigen-presenting cell interaction was varied by using altered peptide ligands for stimulation. Co-stimulatory requirements were studied using T cells from CD28-deficient mice. The results indicate that T cell activation is not an all-or-nothing event, but occurs in distinct steps. For each step, a certain avidity, co-stimulatory threshold or both, must be met. Depending upon the strength of the interaction between the T cell receptor and the major histocompatibility complex/peptide and the presence of CD28 co-stimulatory signals, T cells may undergo blast formation alone or proliferate or eventually both proliferate and differentiate to effector cells. Thus, T cell activation is governed by both avidity and co-stimulatory thresholds.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Bachmann MF,Sebzda E,Kündig TM,Shahinian A,Speiser DE,Mak TW,Ohashi PSdoi
10.1002/eji.1830260908subject
Has Abstractpub_date
1996-09-01 00:00:00pages
2017-22issue
9eissn
0014-2980issn
1521-4141journal_volume
26pub_type
杂志文章abstract::The present study was designed to elucidate the role of Valpha14(+) NKT cells in the host defense against pulmonary infection with Streptococcus pneumoniae using Jalpha281 gene-disrupted mice (Jalpha281KO mice) that lacked this lymphocyte subset. In these mice, pneumococcal infection was severely exacerbated, as shown...
journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 评论,杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230510
更新日期:1993-05-01 00:00:00
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journal_title:European journal of immunology
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doi:10.1002/(SICI)1521-4141(199801)28:01<104::AID-IMMU
更新日期:1998-01-01 00:00:00
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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journal_title:European journal of immunology
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更新日期:1994-03-01 00:00:00
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更新日期:2017-05-01 00:00:00