TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.

abstract：:For long-term attack on tumor cells in patients with prostate cancer, induction of cytolytic T cells is desirable. Several lineage-specific target proteins are known and algorithms have identified candidate MHC class I-binding peptides, particularly for HLA-A*0201. We have designed tolerance-breaking DNA fusion vaccin...

journal_title：European journal of immunology

authors： Vittes GE,Harden EL,Ottensmeier CH,Rice J,Stevenson FK

更新日期：2011-08-01 00:00:00

abstract：:Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated pro...

journal_title：European journal of immunology

authors： Farber DL,Acuto O,Bottomly K

更新日期：1997-08-01 00:00:00

abstract：:Empty major histocompatibility complex (MHC) class I molecules present on the surface of RMA-S (26 degrees C) cells were loaded with the iodinated peptides APGNYPAL, FAPGNYPAL (SEV-9) and RGYVYQGL (VSV-8), respectively. The thermostability of these peptide-loaded MHC class I molecules was assessed using temperature gr...

journal_title：European journal of immunology

authors： Tulp A,Verwoerd DJ

更新日期：1993-08-01 00:00:00

abstract：:Endogenous superantigens (SAg) presented by MHC class II IA molecules induce slow-evolving negative selection of alpha beta T cells. The role of both B and gamma delta T cells on the regulation of these SAg-specific alpha beta T cell responses was addressed in IA(b+)IE(b-) C57BL/6 mice bearing genetically induced B ce...

journal_title：European journal of immunology

authors： Izcue A,Morales G,Minguet S,Sánchez-Movilla A,Morales P,Martínez-M JA,Gaspar ML,Marcos MA

更新日期：2001-09-01 00:00:00

abstract：:The turnover of mature and immature B cells defined by a range of cell surface markers was investigated by feeding normal or bcl-2-transgenic (bcl-2-Tg) mice 5'-bromo-2-deoxyuridine (BrdUrd) for up to 6 weeks. In peripheral lymphoid tissue, B cells accumulated BrdUrd with a 50% labeling time of 4.3 weeks and a pattern...

journal_title：European journal of immunology

authors： Fulcher DA,Basten A

更新日期：1997-05-01 00:00:00

abstract：:Clonal deletion, anergy and suppression have all been considered mechanisms of immunological tolerance. Although adoptive transfer of immunosuppression has been shown to occur in the periphery, particularly for transplantation tolerance, it has proven difficult to characterize this phenomenon further, due to the lack ...

journal_title：European journal of immunology

authors： Teng YT,Gorczynski RM,Iwasaki S,Williams DB,Hozumi N

更新日期：1995-09-01 00:00:00

abstract：:Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception ...

journal_title：European journal of immunology

authors： Wellington D,Yin Z,Abdel-Haq A,Zhang L,Forbester J,Kite K,Rajapaksa U,Laurenson-Schafer H,Makvandi-Nejad S,Jin B,Bowes E,Manoharan K,Maldonado-Perez D,Verrill C,Humphreys IR,Dong T

更新日期：2020-10-30 00:00:00

abstract：:Twelve continuous rat tissue cultured mast cell (MC) lines were established by prolonged culture of rat peritoneal MC in the absence of added factors or feeder layers. Two of these lines, RCMC1 and RCMC2, have been briefly described previously, seven others are now also described. Both RCMC1 and RCMC2 lack a marker ch...

journal_title：European journal of immunology

authors： Chan BM,Ra CS,Hu WN,McNeill K,Miller HR,Befus D,Kinet JP,Froese A

更新日期：1990-01-01 00:00:00

abstract：:The 95-kDa antigen recognized by the anti-CD19 panel of monoclonal antibodies is found on the surface of most cells of the B cell lineage. Anti-CD19 antibodies inhibit B cell proliferation in response to anti-Ig plus interleukin 4 (IL4), but enhance the response to mitogenic concentrations of either phorbol 12-myrista...

journal_title：European journal of immunology

authors： Rigley KP,Callard RE

更新日期：1991-03-01 00:00:00

abstract：:Cells from the monoclonal B cell lymphoma I.29 expressing surface IgM (mu +) are capable of differentiating in vitro to IgM secretion and of switching to IgA or IgE production in response to lipopolysaccharide (LPS) stimulation. To determine whether a single mu + B cell is capable of undertaking both differentiative p...

journal_title：European journal of immunology

authors： Alberini C,Biassoni R,DeAmbrosis S,Vismara D,Sitia R

更新日期：1987-04-01 00:00:00

abstract：:The early activation antigen CD69 is a member of a supergene family of type II integral membrane proteins with a C-type lectin domain. In recent reports the genes encoding the natural killer (NK) cell-related molecules of this supergene family, NKR-P1, NK1.1 and Ly-49, were shown to be clustered in a chromosomal regio...

journal_title：European journal of immunology

authors： Schnittger S,Hamann J,Dannenberg C,Fiebig H,Strauss M,Fonatsch C

更新日期：1993-10-01 00:00:00

abstract：:Just over a decade ago, it was established that NK cells in the thymus do not follow precisely the same developmental pathway as conventional NK cells that develop in the bone marrow. Subsequently, it has emerged that NK cells are one branch of a family of innate lymphoid cells (ILCs). ILC1s and thymic NK cells have, ...

journal_title：European journal of immunology

authors： Male V,Brady HJM

更新日期：2017-05-01 00:00:00

abstract：:While c-myc often contributes to the generation of B cell transformation, its transgenic overexpression alone does not lead to full transformation of B-lineage cells. Synergistically acting second genes must cooperate. Here, we constructed doxycycline-inducible cDNA-libraries from pre-B cell mRNA. These libraries were...

journal_title：European journal of immunology

authors： Wolf I,Bouquet C,Melchers F

更新日期：2016-11-01 00:00:00

abstract：:The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...

journal_title：European journal of immunology

authors： Kelso A,Groves P,Troutt AB,Francis K

更新日期：1995-05-01 00:00:00

abstract：:This evidence-based clinical guideline provides consensus-recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. ...

journal_title：European journal of immunology

authors： Hanitsch L,Baumann U,Boztug K,Burkhard-Meier U,Fasshauer M,Habermehl P,Hauck F,Klock G,Liese J,Meyer O,Müller R,Pachlopnik-Schmid J,Pfeiffer-Kascha D,Warnatz K,Wehr C,Wittke K,Niehues T,von Bernuth H

更新日期：2020-10-01 00:00:00

abstract：:NKR-P1 is a type II transmembrane protein which acts as an activation receptor on natural killer (NK) cells. The cytoplasmic domains of the CD4, CD8 and 4-1BB receptors contain the sequence Cys-X-Cys-Pro which is directly involved in coupling to another pair of cysteines in the N-terminal domain of the src family tyro...

journal_title：European journal of immunology

authors： Campbell KS,Giorda R

更新日期：1997-01-01 00:00:00

abstract：:The induction of B cell tolerance to 2,4-dinitrophenyl conjugates of polysaccharide antigens (levan or dextran) was studied in mice primed with keyhole limpet hemocyanin (KLH) or 2,4,6-trinitrophenylated KLH. The relationship of the epitope density of the tolerogen with avidity of B cell receptors (as judged indirectl...

journal_title：European journal of immunology

authors： Desaymard C,Pearce B,Feldmann M

更新日期：1976-09-01 00:00:00

abstract：:Natural killer (NK) cells play an important role in early defense against viral infection. The cytotoxic activity of NK cells is increased by interferon-alpha/beta (IFN-alpha/beta), produced en masse in virally infected cells. However, the mechanism(s) by which IFN-alpha/beta contribute to the NK-cell-mediated antivir...

journal_title：European journal of immunology

authors： Sato K,Hida S,Takayanagi H,Yokochi T,Kayagaki N,Takeda K,Yagita H,Okumura K,Tanaka N,Taniguchi T,Ogasawara K

更新日期：2001-11-01 00:00:00

abstract：:Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portio...

journal_title：European journal of immunology

authors： Avraham A,Jung S,Samuels Y,Seger R,Ben-Neriah Y

更新日期：1998-08-01 00:00:00

abstract：:Transcription of the gene encoding the transcriptional coactivator Oct-binding factor 1 (OBF-1)/OCA-B/Bob.1 is largely restricted to B cells. During B cell development OBF-1 expression shows two peaks, one in immature B cells in the bone marrow and the other in germinal center B cells. Promoter analysis has identified...

journal_title：European journal of immunology

authors： Massa S,Junker S,Schubart K,Matthias G,Matthias P

更新日期：2003-10-01 00:00:00

abstract：:The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subsequent extravasation to the tissues is a key step during different physiological and pathological processes. In certain of these pathologies the oxygen tension becomes very low, leading to reduced cellular oxidative statu...

journal_title：European journal of immunology

authors： Montoya MC,Luscinskas FW,del Pozo MA,Aragonés J,de Landázuri MO

更新日期：1997-08-01 00:00:00

abstract：:A gene-encoding ligand for deletion of T cells bearing TcRV beta 6 and V beta 8.1 cosegregates a new mammary tumor provirus locus, Mtv-50 in NC mice. The sequence of the open reading frame (ORF) in the 3' long terminal repeat (LTR) of Mtv-50 was strikingly similar to those of Mtv-7, Mtv-43 and exogenous mouse mammary ...

journal_title：European journal of immunology

authors： Niimi N,Wajjwalku W,Ando Y,Tomida S,Takeuchi M,Ueda M,Kaneda T,Yoshikai Y

更新日期：1994-02-01 00:00:00

abstract：:Previous studies have suggested that T-lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS). In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell signaling, activation, and migration. ...

journal_title：European journal of immunology

authors： Kasic T,Colombo P,Soldani C,Wang CM,Miranda E,Roncalli M,Bronte V,Viola A

更新日期：2011-07-01 00:00:00

abstract：:The murine T cell response to heterologous insulins provides a good model system for studying the mechanism of immune response (Ir)-gene function, since insulin is a small, chemically well-defined molecule. H-2b mice respond predominantly to A chain loop determinants of beef insulin, presented by the I-A epitope Ia. W...

journal_title：European journal of immunology

authors： Huber BT,Hochman PS

更新日期：1984-12-01 00:00:00

abstract：:Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...

journal_title：European journal of immunology

authors： Seyerl M,Blüml S,Kirchberger S,Bochkov VN,Oskolkova O,Majdic O,Stöckl J

更新日期：2008-03-01 00:00:00

abstract：:The expression of the Pit-1/GHF-1 transcription factor (hereafter Pit-1), which controls the expression of growth hormone (GH) and prolactin (PRL) in the pituitary gland, has been documented in human and rat hemopoietic and lymphoid tissues and cell lines. Pit-1 mRNA was detected by in situ hybridization in about 1% o...

journal_title：European journal of immunology

authors： Delhase M,Vergani P,Malur A,Hooghe-Peters EL,Hooghe RJ

更新日期：1993-04-01 00:00:00

abstract：:TCR degeneracy may facilitate self-reactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC class II alleles of the DR2 haplotype DR2a (DRB5*0101) and DR2b (DRB1*1501) are associated with an increased risk for MS in Caucasian populations. In order to selectively expand an...

journal_title：European journal of immunology

authors： Zhang X,Tang Y,Sujkowska D,Wang J,Ramgolam V,Sospedra M,Adams J,Martin R,Pinilla C,Markovic-Plese S

更新日期：2008-05-01 00:00:00

abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

journal_title：European journal of immunology

authors： Ashman RF

更新日期：1976-06-01 00:00:00

abstract：:T helper cell type 2 (Th2) cells when triggered by antibodies to CD3 acquire the capacity to stimulate the polyclonal proliferation of syngeneic, resting B cells. Here, we tested the ability of various monoclonal antibodies (mAb) to block the B cell proliferation-inducing potential of such activated Th2 cells. We demo...

journal_title：European journal of immunology

authors： Lohoff M,Koch A,Röllinghoff M

更新日期：1992-02-01 00:00:00

abstract：:We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph ...

journal_title：European journal of immunology

authors： Maloy KJ,Donachie AM,Mowat AM

更新日期：1995-10-01 00:00:00