Localization of the site of the IgG molecule that regulates maternofetal transmission in mice.

abstract：:A novel surface molecule, Tp90, is described which appears to be involved in an antigen-independent pathway of human T lymphocyte activation. The Tp90 molecule was identified by a monoclonal antibody (mAb), MX20, obtained from a fusion using spleen cells of a mouse immunized with cells from two T cell leukemia lines, ...

journal_title：European journal of immunology

authors： Carrel S,Salvi S,Giuffrè L,Isler P,Cerottini JC

更新日期：1987-06-01 00:00:00

abstract：:The thymus is the primary organ for T-cell differentiation and maturation. Unlike other major organs, the thymus is highly dynamic, capable of undergoing multiple rounds of almost complete atrophy followed by rapid restoration. The process of thymic atrophy, or involution, results in decreased thymopoiesis and emigrat...

journal_title：European journal of immunology

authors： Dooley J,Liston A

更新日期：2012-05-01 00:00:00

abstract：:Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during s...

journal_title：European journal of immunology

authors： Lohoff M,Dirks M,Rohwer P,Röllinghoff M

更新日期：1989-01-01 00:00:00

abstract：:Whereas the role of CD4 T cells in B cell memory generation is well established and unequivocal, the role that CD4 T cells play in CD8 responses was until recently far more elusive and controversial. A series of recent reports, however, have re-assessed the role of CD4 help on CD8 responses and have given rise to surp...

journal_title：European journal of immunology

authors： Bourgeois C,Tanchot C

更新日期：2003-12-01 00:00:00

abstract：:Studies of experimental autoimmune encephalomyelitis (EAE) in rodents have revealed that encephalitogenic T cell lines reactive with myelin basic protein (BP) are frequently dominated by clones expressing a restricted T cell receptor repertoire. Using the rat EAE model, we have begun to examine the basis for clonal do...

journal_title：European journal of immunology

authors： Sun D,Hu XZ,Coleclough C

更新日期：1995-01-01 00:00:00

abstract：:CD40-CD40 ligand (CD40L) signaling plays multiple indispensable roles in cellular and humoral immunity. Impaired memory T-cell responses in the absence of CD40L have been well documented, but the requirement of this interaction for efficient priming of CD8+ T cells especially under inflammatory conditions has been und...

journal_title：European journal of immunology

authors： Durlanik S,Loyal L,Stark R,Sercan Alp Ö,Hartung A,Radbruch A,von Herrath M,Matzmohr N,Frentsch M,Thiel A

更新日期：2016-11-01 00:00:00

abstract：:Recently activated peripheral T cells treated with IL-2 for 4 days expressed Fas ligand (FasL)-mediated cytotoxicity. These IL-2-treated T cells had high nuclear expression of SP1 and NFAT, but lacked the Egr-2 and Egr-3 that could be induced by anti-CD3 stimulation and had been implicated in FasL gene activation. A m...

journal_title：European journal of immunology

authors： Xiao S,Matsui K,Fine A,Zhu B,Marshak-Rothstein A,Widom RL,Ju ST

更新日期：1999-11-01 00:00:00

abstract：:Self-glycosphingolipids bind to surface CD1 molecules and are readily displaced by other CD1 ligands. This capacity to exchange antigens at the cell surface is not common to other antigen-presenting molecules and its physiological importance is unclear. Here we show that a large pool of cell-surface CD1a, but not CD1b...

journal_title：European journal of immunology

authors： Manolova V,Kistowska M,Paoletti S,Baltariu GM,Bausinger H,Hanau D,Mori L,De Libero G

更新日期：2006-05-01 00:00:00

abstract：:The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,...

journal_title：European journal of immunology

authors： Kelso A,Groves P,Troutt AB,Francis K

更新日期：1995-05-01 00:00:00

abstract：:Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. These proteins are encoded by mutated genes which may also give rise to truncated membrane immunoglobulins. The neoplastic cells proliferate in vivo although they can...

journal_title：European journal of immunology

authors： Corcos D,Iglesias A,Dunda O,Bucchini D,Jami J

更新日期：1991-11-01 00:00:00

abstract：:The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell resp...

journal_title：European journal of immunology

authors： Frick R,Gunnarsen KS,Dahal-Koirala S,Risnes LF,Sollid LM,Sandlie I,Høydahl LS,Løset GÅ

更新日期：2020-01-01 00:00:00

abstract：:The hypothesis that distinct subsets of NK cells produce type 2 and type 1 cytokines in resting naive lymphocytes was tested analyzing cytokine production at the single-cell level. Two non-overlapping IL-13+ and IFN-gamma+ subsets were identified in adult and neonatal NK cells. IL-2 maintained their relative proportio...

journal_title：European journal of immunology

authors： Loza MJ,Peters SP,Zangrilli JG,Perussia B

更新日期：2002-02-01 00:00:00

abstract：:The immune response against human adenovirus (HAdV) has gained interest because of the application of HAdV-based vectors in gene therapy and the high incidence of infections in pediatric recipients of allogeneic stem cell grafts. Because antiviral medication is frequently ineffective, the option of adoptive transfer o...

journal_title：European journal of immunology

authors： Veltrop-Duits LA,Heemskerk B,Sombroek CC,van Vreeswijk T,Gubbels S,Toes RE,Melief CJ,Franken KL,Havenga M,van Tol MJ,Schilham MW

更新日期：2006-09-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed by memory T cells and NK cells in man and mice. It is frequently used as a cell differentiation marker and members of the cadherin family are ligands for KLRG1. The present study provides new insights into the interaction of mouse KLRG...

journal_title：European journal of immunology

authors： Rosshart S,Hofmann M,Schweier O,Pfaff AK,Yoshimoto K,Takeuchi T,Molnar E,Schamel WW,Pircher H

更新日期：2008-12-01 00:00:00

abstract：:The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may...

journal_title：European journal of immunology

authors： Siegrist CA,Barrios C,Martinez X,Brandt C,Berney M,Córdova M,Kovarik J,Lambert PH

更新日期：1998-12-01 00:00:00

abstract：:An intracellular staining procedure for the cytoskeletal marker, glial fibrillary acidic protein of astrocytes, has been developed which allows flow cytometric phenotyping of astrocytes within complex mixtures of glial cells. Employing this technique, we show here that measles virus infection of rat mixed glial cell c...

journal_title：European journal of immunology

authors： Kraus E,Schneider-Schaulies S,Miyasaka M,Tamatani T,Sedgwick J

更新日期：1992-01-01 00:00:00

abstract：:Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized by transient activation of MAPK-, NF-κB- and IRF-mediated signaling pathways and expression of pro-inflammatory genes. This activation state is inherently unstable and often transitions into a state of 'tolerance' characte...

journal_title：European journal of immunology

authors： Ivashkiv LB

更新日期：2011-09-01 00:00:00

abstract：:1Alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts several effects on the immune system, by regulating lymphocyte proliferation, differentiation of monocytes and secretion of cytokines as IL-2, granulocyte-macrophage colony-stimulating factor and IFN-gamma in T cells. Here, we analyze the effect of 1,25-(OH)2D3 on IF...

journal_title：European journal of immunology

authors： Cippitelli M,Santoni A

更新日期：1998-10-01 00:00:00

abstract：:Indirect immunofluorescence revealed that 13% of BALB/c and 33% of CBA spleen cells of B type carry specific binding sites at their surface for double-stranded poly(I).poly(C). Pretreatment of BALB/c spleen cells with anti-mouse immunoglobulin serum increased the number of B cells capable of binding poly(I).poly(C) in...

journal_title：European journal of immunology

authors： Diamantstein T,Bittstein-Willinger E

更新日期：1978-12-01 00:00:00

abstract：:The aim of this study was to investigate the effects of IL-17-producing T cells, including Th17 and Tc17 cells, on acute graft-versus-host disease (aGVHD) in patients who had undergone granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood progenitor cell (PBPC) and G-CSF-primed bone marrow (G-BM) tr...

journal_title：European journal of immunology

authors： Zhao XY,Xu LL,Lu SY,Huang XJ

更新日期：2011-02-01 00:00:00

abstract：:Crosslinking of Fc γ receptor II B (FcγRIIB) and the BCR by immune complexes (IC) can downregulate antigen-specific B-cell responses. Accordingly, FcγRIIB deficiencies have been associated with B-cell hyperactivity in patients with systemic lupus erythematosus and mouse models of lupus. However, we have previously sho...

journal_title：European journal of immunology

authors： Avalos AM,Uccellini MB,Lenert P,Viglianti GA,Marshak-Rothstein A

更新日期：2010-10-01 00:00:00

abstract：:The IFN stimulated gene 15 (ISG15) encodes a 15-kDa ubiquitin-like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an antiviral molecule possibly by being covalently conjugated to viral proteins and disturbing virus particle as...

journal_title：European journal of immunology

authors： Held T,Basler M,Knobeloch KP,Groettrup M

更新日期：2020-07-20 00:00:00

abstract：:Myeloid leukocytes form actin-based plasma membrane protrusions, called podosomes, that are implicated in myeloid cell recruitment into tissues and cell migration within the interstitium. In this study, we show that tyrosine kinases of the Abl family are present in podosomes formed by murine and human macrophages. Sil...

journal_title：European journal of immunology

authors： Baruzzi A,Berton G

更新日期：2012-10-01 00:00:00

abstract：:We examined T cell development and T cell repertoire in transgenic mice expressing a single T cell receptor (TCR) alpha chain derived from the H-2Db-lymphocytic choriomeningitis virus (LCMV)-specific cytolytic T lymphocyte (CTL) clone P14. To generate these alpha P14 mice, mice transgenic for the P14 TCR alpha chain w...

journal_title：European journal of immunology

authors： Brändle D,Brduscha-Riem K,Hayday AC,Owen MJ,Hengartner H,Pircher H

更新日期：1995-09-01 00:00:00

abstract：:Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus (EBV)-transformed B cells is mediated by CD2/lymphocyte function-associated antigen (LFA)-3 and LFA-1/intracellular adhesion molecule (ICAM)-1. Although some anti-CD4 antibodies block the antigen-independent adhesion of CD4+ T lymphocytes, the CD...

journal_title：European journal of immunology

authors： Mazerolles F,Amblard F,Lumbroso C,Lecomte O,Van de Moortele PF,Barbat C,Piatier-Tonneau D,Auffray C,Fischer A

更新日期：1990-03-01 00:00:00

abstract：:Single-positive thymocytes are the immediate precursors of peripheral recent thymic emigrants (RTE) which develop into mature peripheral T cells. The functional ability of RTE is unclear but their state of differentiation may be relevant to the development of tolerance to peripheral "self" antigens. Since RTE are diff...

journal_title：European journal of immunology

authors： Charlton B,Meltzer J,Fathman CG

更新日期：1994-07-01 00:00:00

abstract：:This is the first report on the establishment of the readily identifiable and functioning thymic nurse cell (TNC) clones from the mouse thymus. In the course of the culture of an epithelial cell line using a medium with a low concentration of Ca2+ from the spontaneous BALB/c thymic tumor, lymphocytes as well as thymic...

journal_title：European journal of immunology

authors： Itoh T,Doi H,Chin S,Nishimura T,Kasahara S

更新日期：1988-05-01 00:00:00

abstract：:To elucidate the rapid destruction of allogeneic bone marrow (BM) grafts in nonsensitized rats we have assessed: (a) the 21-h tissue localization of 51Cr-labeled allogeneic vs. syngeneic BM cells, (b) the ability of allogeneic BM cells to proliferate in the BM or irradiated recipients, (c) the survival of allogeneic v...

journal_title：European journal of immunology

authors： Rolstad B,Benestad HB

更新日期：1984-09-01 00:00:00

abstract：:It is now recognized that Th17 cells constitute the third effector arm of Th cells, complementing the Th1 and Th2 lineages. Although secretion of IL-17 is a primary defining characteristic of Th17 cells, the expression profile of specific chemokine receptors, cell surface molecules and cytokines are also part of the T...

journal_title：European journal of immunology

authors： Unutmaz D

更新日期：2009-06-01 00:00:00

abstract：:The MHC class II molecule H2-A(s), expressed in the SJL mouse strain, is the principle restriction element of autoreactive CD4(+) T cells mediating experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. We deduced the H2-A(s) ligand motif from the analysis of naturally processed self peptide...

journal_title：European journal of immunology

authors： Kalbus M,Fleckenstein BT,Offenhäusser M,Blüggel M,Melms A,Meyer HE,Rammensee HG,Martin R,Jung G,Sommer N

更新日期：2001-02-01 00:00:00