当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Human CD4+ T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirus.

Human CD4+ T cells stimulated by conserved adenovirus 5 hexon peptides recognize cells infected with different species of human adenovirus.

Abstract：

:The immune response against human adenovirus (HAdV) has gained interest because of the application of HAdV-based vectors in gene therapy and the high incidence of infections in pediatric recipients of allogeneic stem cell grafts. Because antiviral medication is frequently ineffective, the option of adoptive transfer of HAdV-specific donor-derived T cells in these immunocompromised patients is investigated. To generate good manufacturing practice-compatible reagents, a panel of 63 long, overlapping, peptides of the hexon protein was screened for recognition by T cells. Five conserved peptides of 30 amino acids were identified that were recognized by the majority of adult donors. CD4+ T cells from long-term cultures of PBMC, stimulated with this set of five peptides, recognized cells infected with HAdV serotypes belonging to different species. These data demonstrate that adult human T cells preferentially recognize conserved sequences of amino acid residues from a structural protein of HAdV. In the context of gene therapy, this observation may limit the beneficial effect of switching to HAdV-based vectors derived from less common serotypes of HAdV in an attempt to circumvent pre-existing immunity. However, this cross-reactivity benefits the application of HAdV-specific T cells for adoptive immunotherapy in immunocompromised transplant recipients.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Veltrop-Duits LA,Heemskerk B,Sombroek CC,van Vreeswijk T,Gubbels S,Toes RE,Melief CJ,Franken KL,Havenga M,van Tol MJ,Schilham MW

doi

10.1002/eji.200535786

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

2410-23

issue

9

eissn

0014-2980

issn

1521-4141

journal_volume

36

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40-ligand) and TNF-alpha, but strongly enhanced by interleukin-10.

    abstract：:In the lymphoid tissues, adaptive immune responses are initiated by the interaction of interdigitating dendritic cells (IDC) with naive T cells. To understand this interplay better, we used mature Langerhans cells (mLC), migrating from human epidermis, as the correlate of IDC ex vivo to evaluate the different effects ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250722

    authors： Ludewig B,Graf D,Gelderblom HR,Becker Y,Kroczek RA,Pauli G

    更新日期：1995-07-01 00:00:00

  • The repertoire of serum IgM in normal mice is largely independent of external antigenic contact.

    abstract：:Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270635

    authors： Haury M,Sundblad A,Grandien A,Barreau C,Coutinho A,Nobrega A

    更新日期：1997-06-01 00:00:00

  • Liposomes as immunological adjuvants in eliciting antibodies specific to the synthetic polypeptide poly(LTyr, LGlu)-poly(DLAla)--(LLys) with high frequency of site-associated idiotypic determinants.

    abstract：:The antibody response to the synthetic polypeptide, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), [(T,G)-A--L], injected entrapped in liposomes which served as adjuvant has been analyzed. The liposomes used were composed of phosphatidylcholine, cholesterol, dicetylphosphate and DL alpha-tocopherol (molar ratios as 4:3:0.1...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830110510

    authors： Lifshitz R,Gitler C,Mozes E

    更新日期：1981-05-01 00:00:00

  • Allelic exclusion of membrane but not secreted immunoglobulin in a mature B cell line.

    abstract：:Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210110

    authors： Picarella D,Serunian LA,Rosenberg N

    更新日期：1991-01-01 00:00:00

  • Maturation of Peyer's patch dendritic cells in vitro upon stimulation via cytokines or CD40 triggering.

    abstract：:In mouse Peyer's patches (PP), dendritic cells (DC) are localized in T cell areas as NLDC145+ CD11c+ cells, and in the dome and corona region of the follicle as NLDC145- CD11c+ cells, respectively, suggesting the presence of two different DC populations with distinct roles in antigen uptake, processing, and presentati...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270605

    authors： Ruedl C,Hubele S

    更新日期：1997-06-01 00:00:00

  • LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation.

    abstract：:The T cell-dependent differentiation and function of B lymphocytes are tightly regulated by TNF ligands (L) and receptors interactions, such as CD40/CD40L, CD27/CD70 and CD134/CD314L. The LIGHT/HVEM system [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the herpes vir...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425598

    authors： Duhen T,Pasero C,Mallet F,Barbarat B,Olive D,Costello RT

    更新日期：2004-12-01 00:00:00

  • Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19.

    abstract：:Macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19 are members of the CC chemokine subfamily which exert their effects through specific receptors, CCR6 and CCR7, respectively. Previously, we have reported that human neutrophils have the capacity to produce a number of chemokines, including I...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200107)31:7<1981::aid-immu19

    authors： Scapini P,Laudanna C,Pinardi C,Allavena P,Mantovani A,Sozzani S,Cassatella MA

    更新日期：2001-07-01 00:00:00

  • Reduced intracellular oxidative metabolism promotes firm adhesion of human polymorphonuclear leukocytes to vascular endothelium under flow conditions.

    abstract：:The interaction of polymorphonuclear leukocytes (PMN) with the vascular endothelium and their subsequent extravasation to the tissues is a key step during different physiological and pathological processes. In certain of these pathologies the oxygen tension becomes very low, leading to reduced cellular oxidative statu...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270818

    authors： Montoya MC,Luscinskas FW,del Pozo MA,Aragonés J,de Landázuri MO

    更新日期：1997-08-01 00:00:00

  • Shaping immunity in healthy and diseased tissues.

    abstract：:About one hundred immunologists recently met in Capo Caccia, Sardinia, for the first of three events that will comprise the EMBO Conference Series, organised by the ENII, on Molecular and Cellular Mechanisms of Immune Regulation. The 2007 Conference focused on how immunity is shaped in healthy and diseased tissues. ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200790031

    authors： Borst J,Ricciardi-Castagnoli P

    更新日期：2007-08-01 00:00:00

  • Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice.

    abstract：:T cells are known to play an important role in beta cell destruction in the nonobese diabetic (NOD) mouse model of Type I diabetes and islet-specific T cell clones have been demonstrated to be capable of adoptive transfer of diabetes. One important issue involves the identity of beta cell antigens that are recognized ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830250430

    authors： Daniel D,Gill RG,Schloot N,Wegmann D

    更新日期：1995-04-01 00:00:00

  • Genetic control of B cell function. III. IgVH-controlled polymorphism in the frequencies of B cells that recognize xenogeneic red blood cells.

    abstract：:Previous work has shown that the primary IgM plaque-forming cell response of inbred mice to xenogeneic red blood cells (RBC) including sheep, horse and chicken RBC is under the control of two polymorphic genes or sets of genes, one linked to the Igh linkage group and the other of unknown linkage but unlinked to H-2 an...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830150205

    authors： Saizawa KM,Melchers I,Eichmann K

    更新日期：1985-02-01 00:00:00

  • Interleukin-12 and Flt3 ligand differentially promote dendropoiesis in vivo.

    abstract：:Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on dendritic cell (DC) generation and accumulation in murine spleen, ly...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200009)30:9<2565::AID-IMMU2565>3

    authors： Esche C,Cai Q,Peron JM,Hunter O,Subbotin VM,Lotze MT,Shurin MR

    更新日期：2000-09-01 00:00:00

  • SWAP-70-deficient mast cells are impaired in development and IgE-mediated degranulation.

    abstract：:Cross-linking of the high-affinity IgE receptor (FcepsilonRI) on mast cell activates signaling pathways that trigger degranulation and the release of multiple pro-inflammatory mediators. Mature,immature and precursor mast cells are degranulation competent. We show here that the signaling protein SWAP-70 has a function...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200204)32:4<1121::AID-IMMU1121>3

    authors： Gross B,Borggrefe T,Wabl M,Sivalenka RR,Bennett M,Rossi AB,Jessberger R

    更新日期：2002-04-01 00:00:00

  • The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes.

    abstract：:The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830231117

    authors： Fung-Leung WP,Louie MC,Limmer A,Ohashi PS,Ngo K,Chen L,Kawai K,Lacy E,Loh DY,Mak TW

    更新日期：1993-11-01 00:00:00

  • Defects in signal transduction caused by a T cell receptor beta chain substitution.

    abstract：:An antigen-specific T-T hybridoma was mutagenized with ethylmethane sulfonate and negatively selected by anti-Ly-6 antibody-induced growth inhibition. One of the mutants generated, M4/8, had lost surface expression of a T cell receptor (TcR) V beta 8 epitope detected on the surface of the parental cell line. However, ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200702

    authors： Reno TA,Ley S,Sugiyama E,Cantagrel A,Blumberg R,Bonventre J,Terhorst C,Yeh ET

    更新日期：1990-07-01 00:00:00

  • Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils.

    abstract：:LL-37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL-37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down-regulated by LL-37. LL-37 functions similarly to CXCR2-specific chemokines CXCL1 and CXCL7 in terms of recept...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939496

    authors： Zhang Z,Cherryholmes G,Chang F,Rose DM,Schraufstatter I,Shively JE

    更新日期：2009-11-01 00:00:00

  • Rheumatoid factor autoantibody-binding site: a molecular analysis using monoclonal antibodies with dual anti-TNP and anti-IgG activities.

    abstract：:Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830191123

    authors： Reininger L,Spertini F,Shibata T,Jaton JC,Izui S

    更新日期：1989-11-01 00:00:00

  • Stimulation of all T cells bearing V beta 1, V beta 3, V beta 11 and V beta 12 by staphylococcal enterotoxin A.

    abstract：:To determine the molecular mechanisms of T cell stimulation by staphylococcal enterotoxin A (SEA), we examined the expression of T cell receptor (TcR) V beta on the T cells from four strains of mice stimulated in vitro with SEA, using flow cytometric analysis for the number of T cells bearing V beta 3, V beta 6, V bet...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200323

    authors： Takimoto H,Yoshikai Y,Kishihara K,Matsuzaki G,Kuga H,Otani T,Nomoto K

    更新日期：1990-03-01 00:00:00

  • Modulation of complement receptors of a human monocyte cell line, U-937, during incubation with phorbol myristate acetate: expression of an iC3b-specific receptor (CR3).

    abstract：:The human monocyte line, U-937, derived from an individual with histiocytic lymphoma was studied for the expression of surface C3 receptors, after cultivation in the presence of phorbol myristate acetate (PMA) or T lymphocyte-conditioned medium. Receptors were detected by using EAC4b, EAC3b, EC3b, EAC3bi and EAC3d int...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830151005

    authors： Gilbert D,Peulve P,Daveau M,Ripoche J,Fontaine M

    更新日期：1985-10-01 00:00:00

  • The cytosolic free calcium in anti-mu-stimulated human B cells is derived partly from extracellular medium and partly from intracellular stores.

    abstract：:The inositol phospholipid metabolism and the increase in cytosolic free Ca2+ concentration ([Ca2+]i) into the cell are recognized as two important events in the anti-mu-induced B cell activation. The anti-mu stimulation caused the [3H]inositol incorporation and also a rapid increase in [Ca2+]i from 85 nM to 285 nM. Th...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830170916

    authors： Dugas B,Calenda A,Delfraissy JF,Vazquez A,Bach JF,Galanaud P

    更新日期：1987-09-01 00:00:00

  • L3T4+ T cells able to mediate parasite-specific delayed-type hypersensitivity play a role in the pathology of experimental Chagas' disease.

    abstract：:During the chronic phase of infection with the parasite Trypanosoma cruzi, mice develop inflammatory lesions in the heart and skeletal muscles, as well as in peripheral nerves and the liver. We demonstrated the presence, in the blood of chronically infected mice, of L3T4+ T cells able to transfer a specific T. cruzi d...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830170720

    authors： Hontebeyrie-Joskowicz M,Said G,Milon G,Marchal G,Eisen H

    更新日期：1987-07-01 00:00:00

  • Selective stimulation of murine cytotoxic T cell and antibody responses by particulate or monomeric hepatitis B virus surface (S) antigen.

    abstract：:In the murine system, we tested in vivo the immunogenicity of different preparations of the yeast-derived surface antigen (S-antigen or S-protein) of hepatitis B virus (HBV). Native S-protein molecules self-assemble into stable 22-nm particles. BALB/c mice immunized with low doses of native S-particles without adjuvan...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240512

    authors： Schirmbeck R,Melber K,Mertens T,Reimann J

    更新日期：1994-05-01 00:00:00

  • Functional characterization of the antibody-mediated protection against blood stages of Plasmodium falciparum in the monkey Saimiri sciureus.

    abstract：:The squirrel monkey Saimiri sciureus is one of the World Health Organization recommended experimental models of Plasmodium falciparum blood stage infection. Anti-malaria antibodies developed by this host after a drug-controlled infection play an important part in the acquired protection against the P. falciparum blood...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830201022

    authors： Groux H,Perraut R,Garraud O,Poingt JP,Gysin J

    更新日期：1990-10-01 00:00:00

  • IL-13 and TNF-alpha inhibit dual-tropic HIV-1 in primary macrophages by reduction of surface expression of CD4, chemokine receptors CCR5, CXCR4 and post-entry viral gene expression.

    abstract：:We show that IL-13 in the presence of TNF-alpha effected an equal or greater antiviral activity against a dual-tropic HIV-1 (R5X4) in macrophages. A temporary or continued exposure of macrophages to both cytokines significantly decreased the infection and replication of R5X4 HIV-1(89.6) (median, 128-fold, n = 9, p = 0...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(200005)30:5<1340::AID-IMMU

    authors： Bailer RT,Lee B,Montaner LJ

    更新日期：2000-05-01 00:00:00

  • Murine thymic NK cells: A case of identity.

    abstract：:Just over a decade ago, it was established that NK cells in the thymus do not follow precisely the same developmental pathway as conventional NK cells that develop in the bone marrow. Subsequently, it has emerged that NK cells are one branch of a family of innate lymphoid cells (ILCs). ILC1s and thymic NK cells have, ...

    journal_title：European journal of immunology

    pub_type： 评论,杂志文章

    doi：10.1002/eji.201747038

    authors： Male V,Brady HJM

    更新日期：2017-05-01 00:00:00

  • p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

    abstract：:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation cap...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201445422

    authors： Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

    更新日期：2016-01-01 00:00:00

  • Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection.

    abstract：:We evaluated the role of regulatory T cells (CD4(+) CD25(+) Foxp3(+) cells, Tregs) in human Mycobacterium tuberculosis infection. Tregs were expanded in response to M. tuberculosis in healthy tuberculin reactors, but not in tuberculin-negative individuals. The M. tuberculosis mannose-capped lipoarabinomannan (ManLAM) ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200737268

    authors： Garg A,Barnes PF,Roy S,Quiroga MF,Wu S,García VE,Krutzik SR,Weis SE,Vankayalapati R

    更新日期：2008-02-01 00:00:00

  • Recombinant human granulocyte-macrophage colony-stimulating factor induces secretion of autoinhibitory monokines by U-937 cells.

    abstract：:Colony-stimulating factors are required for survival proliferation, differentiation and functional activation of granulocytes, macrophages and their precursor cells. In the present report, however, we demonstrate antiproliferative activity of recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830180308

    authors： Lindemann A,Riedel D,Oster W,Mertelsmann R,Herrmann F

    更新日期：1988-03-01 00:00:00

  • Physiology of murine B lymphocytes. I. Life-spans of anti-mu and haptenated Ficoll (thymus-independent antigen)-reactive B cells.

    abstract：:We have evaluated the life-span of B lymphocytes by measuring the functional reactivity of normal B cells upon transfer into xid mice, which do not respond to anti-mu, fluoresceinated-Ficoll (FL-Ficoll) and 2,4,6-trinitrophenyl aminoethylcarbamylmethyl Ficoll (TNP-Ficoll). After 4 days of transfer only 30-40% of anti-...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830181019

    authors： Udhayakumar V,Goud SN,Subbarao B

    更新日期：1988-10-01 00:00:00

  • Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function.

    abstract：:Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterized by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201948435

    authors： Boardman DA,Garcia RV,Ivison SM,Bressler B,Dhar TM,Zhao Q,Levings MK

    更新日期：2020-09-01 00:00:00