Selective stimulation of murine cytotoxic T cell and antibody responses by particulate or monomeric hepatitis B virus surface (S) antigen.

abstract：:In this study we have investigated the specificity of bioassays in which interleukin (IL) 1 and/or IL 6 are active. The thymocyte assay cannot be used to discriminate between IL 1 and IL 6; both monokines are active in this assay. Moreover the detection limit for both IL 1 and IL 6 is around 100 pg/ml. IL 6 activity c...

journal_title：European journal of immunology

authors： Helle M,Boeije L,Aarden LA

更新日期：1988-10-01 00:00:00

abstract：:When cytotoxic titrations were made of rabbit anti-mouse brain and anti-Thy-1.2 sera against mouse lymphoid cells in the presence of sodium barbital or xylocaine, it was observed that a proportion of T cells were much more sensitive (50 x) than the remainder. This effect could be detected with ethidium or fluorescein ...

journal_title：European journal of immunology

authors： Lee SK,Singh J,Taylor RB

更新日期：1975-04-01 00:00:00

abstract：:Activation pathways inducing the expression of the interferon (IFN)-gamma gene in a cytotoxic T lymphocyte (CTL) clone were studied for their effects on transcription and on mRNA stability. IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein ...

journal_title：European journal of immunology

authors： Kaldy P,Schmitt-Verhulst AM

更新日期：1995-04-01 00:00:00

abstract：:The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

journal_title：European journal of immunology

authors： Nordin AA

更新日期：1978-11-01 00:00:00

abstract：:Naive T cells do not proliferate but remain alive in vivo. In contrast, naive T cells rapidly die in an in vitro culture, suggesting that some factors that are present at the sites of naive T cell circulation in vivo but missing in the bovine serum-containing culture medium, are necessary for their survival. The prese...

journal_title：European journal of immunology

authors： Endharti AT,Zhou YW,Nakashima I,Suzuki H

更新日期：2005-01-01 00:00:00

abstract：:We recently constructed IL-15 transgenic (Tg) mice using cDNA encoding a secretable isoform of the IL-15 precursor protein under the control of an MHC class I promoter. The IL-15 Tg mice exhibited resistance against a primary infection with Listeria monocytogenes. The numbers of memory CD8(+) T cells were markedly inc...

journal_title：European journal of immunology

authors： Yajima T,Nishimura H,Ishimitsu R,Yamamura K,Watase T,Busch DH,Pamer EG,Kuwano H,Yoshikai Y

更新日期：2001-03-01 00:00:00

abstract：:Defined tumor-associated antigens (TAA) are attractive targets for anti-tumor immunotherapy. Here, we describe a novel genome-wide approach to identify multiple TAA from any given tumor. A panel of transplantable thymomas was established from an inbred p53-/- mouse strain. The resulting tumors were examined for gene e...

journal_title：European journal of immunology

authors： Mathiassen S,Lauemøller SL,Ruhwald M,Claesson MH,Buus S

更新日期：2001-04-01 00:00:00

abstract：:Adoptive lymphocyte transfers between Iga, Igb and Igd allotype-congenic mouse strains revealed host barriers against the production of certain donor allotypes. First, as recipients of Igb cells, Iga and Igd mice permitted the production of donor Ig-4b but not that of Ig-1 b. The apparent mediators of this Ig-1 b barr...

journal_title：European journal of immunology

authors： Bosma MJ,Bosma GC,Owen JL

更新日期：1978-08-01 00:00:00

abstract：:Stilbene disulfonates are known to competitively inhibit Cl-/HCO3- flux through Band 3-related anion exchange (AE) proteins. To study the role of AE in lymphocyte activation, stilbene disulfonates were added to cultures of rat splenocytes (SPL). Four different stilbene derivatives were tested and each directly stimula...

journal_title：European journal of immunology

authors： Deane KH,Mannie MD

更新日期：1992-05-01 00:00:00

abstract：:The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...

journal_title：European journal of immunology

authors： Nobrega A,Grandien A,Haury M,Hecker L,Malanchère E,Coutinho A

更新日期：1998-04-01 00:00:00

abstract：:Twelve continuous rat tissue cultured mast cell (MC) lines were established by prolonged culture of rat peritoneal MC in the absence of added factors or feeder layers. Two of these lines, RCMC1 and RCMC2, have been briefly described previously, seven others are now also described. Both RCMC1 and RCMC2 lack a marker ch...

journal_title：European journal of immunology

authors： Chan BM,Ra CS,Hu WN,McNeill K,Miller HR,Befus D,Kinet JP,Froese A

更新日期：1990-01-01 00:00:00

abstract：:We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the alternative pathway (AP) of complement activation might play a role in retinal inflamma...

journal_title：European journal of immunology

authors： Chen M,Muckersie E,Luo C,Forrester JV,Xu H

更新日期：2010-10-01 00:00:00

abstract：:The entry of neutrophils into inflamed tissues is initiated by cell rolling on the blood vessel wall followed by arrest and transendothelial migration. Rolling is mediated by the selectins, while the two subsequent steps require activated beta 2-integrins. We have investigated whether the binding of P-selectin to mous...

journal_title：European journal of immunology

authors： Blanks JE,Moll T,Eytner R,Vestweber D

更新日期：1998-02-01 00:00:00

abstract：:Mouse bone marrow cells differentiate in culture in the presence of L cell-conditioned medium to macrophages (M phi). Proliferation, release of plasminogen activator, expression of transglutaminase, random motility and response to a standard preparation of purified M phi migration inhibitory factor (MIF) was recorded ...

journal_title：European journal of immunology

authors： Michels E,Stenzinger W,Sorg C

更新日期：1984-10-01 00:00:00

abstract：:Injection of incomplete Freund's adjuvant (IFA) into the footpads of BALB/c mice induced an acute inflammation. Draining popliteal lymph nodes showed major histocompatibility complex (MHC) class II-restricted proliferation when challenged in vitro with recombinant Mycobacterium bovis 65-kDa heat shock protein (hsp65)....

journal_title：European journal of immunology

authors： Anderton SM,van der Zee R,Goodacre JA

更新日期：1993-01-01 00:00:00

abstract：:Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory effects by inducing tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and IL-6. However, the cascade of events leading to induction of cytokines by IL-18 is unclear. The aim of the present study...

journal_title：European journal of immunology

authors： Netea MG,Kullberg BJ,Verschueren I,Van Der Meer JW

更新日期：2000-10-01 00:00:00

abstract：:HLA class II molecules are involved in the OKT3-induced T cell activation, since monoclonal antibodies (mAb) to monomorphic determinants of class II antigens are able to inhibit T cell proliferation. This effect involves several of the events leading to T cell activation and proliferation, i.e. interleukin (IL) 1, IL ...

journal_title：European journal of immunology

authors： Ruggiero G,Racioppi L,Manzo C,Pirozzi G,D'Oro U,Ferrone S,Zappacosta S,Fontana S

更新日期：1991-01-01 00:00:00

abstract：:Two major histocompatibility complex (MHC) class I-reactive T cell clones derived from H-2b mice, generated against the allogeneic Ld molecule, were found to recognize the H-2b class II mutant Abm12 molecule as well. In addition, these clones also recognize the class II A(s) molecule, and display a class II-dependent ...

journal_title：European journal of immunology

authors： Frangoulis B,Urbero B,Pla M

更新日期：1993-08-01 00:00:00

abstract：:Between 10 and 20% of the peripheral gammadelta T cells express cytoplasmic TCR-beta proteins, but whether such TCR-beta chains can partake in alphabeta T-cell development has never been systematically investigated. Therefore, we reconstituted the T-cell compartment of CD3epsilon-deficient mice with Pax5-TCR-beta defi...

journal_title：European journal of immunology

authors： Bosco N,Engdahl C,Bénard A,Rolink J,Ceredig R,Rolink AG

更新日期：2008-12-01 00:00:00

abstract：:In this study, we have analyzed the in vivo dynamics of the interaction between polyclonal Foxp3(+) Treg cells, effector T (Teff) cells, and DCs in order to further our understanding of the mechanisms of Treg cell-mediated suppression. Cotransfer of polyclonal activated Treg cells into healthy mice attenuated the ind...

journal_title：European journal of immunology

authors： Davidson TS,Shevach EM

更新日期：2011-10-01 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) has been described as an important autoantigen in rheumatoid arthritis (RA) since it is targeted by autoantibodies, autoreactive T cells, and is aberrantly expressed in synovial cells in patients. To identify hnRNP-A2-specific T-cell epitopes possibly associate...

journal_title：European journal of immunology

authors： Trembleau S,Hoffmann M,Meyer B,Nell V,Radner H,Zauner W,Hammer J,Aichinger G,Fischer G,Smolen J,Steiner G

更新日期：2010-06-01 00:00:00

abstract：:Development of Th1 and Th2 effector lymphocytes is driven primarily by IL-12 or IL-4, but is also influenced by the strength of antigenic stimulation. However, the mechanism by which TCR signaling contributes to T cell polarization remains elusive. We show that in the presence of IL-12 a short TCR stimulation can lead...

journal_title：European journal of immunology

authors： Iezzi G,Scotet E,Scheidegger D,Lanzavecchia A

更新日期：1999-12-01 00:00:00

abstract：:The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune ...

journal_title：European journal of immunology

authors： Wensveen FM,Šestan M,Turk Wensveen T,Polić B

更新日期：2019-07-01 00:00:00

abstract：:Somatic hypermutation in B cells undergoing T cell dependent immune responses generates high affinity antibodies that provide protective immunity. B cells also switch from the expression of immunoglobulin (Ig) M and IgD to that of other Ig classes through somatic DNA recombination. Recent work has implicated DNA stran...

journal_title：European journal of immunology

authors： Klein U,Esposito G,Baudat F,Keeney S,Jasin M

更新日期：2002-02-01 00:00:00

abstract：:In rheumatoid arthritis (RA), T cells in the inflamed joint are considered to play a crucial role in the pathogenesis. However, despite the fact that synovial T cells have an activated memory phenotype, they are functionally suppressed upon combined CD3 and CD28 stimulation. Here, we analyzed the contribution of both ...

journal_title：European journal of immunology

authors： Maurice MM,van der Voort EA,Leow A,Levarht N,Breedveld FC,Verweij CL

更新日期：1998-05-01 00:00:00

abstract：:The present report describes functional characteristics of a monoclonal antibody (mAb), TA/211, which is reactive with a common determinant of the human CD45 molecules. When added to purified testing human T cells, TA/211, which is itself not mitogenic, leads to a strong proliferative response in combination with subm...

journal_title：European journal of immunology

authors： Schraven B,Roux M,Hutmacher B,Meuer SC

更新日期：1989-02-01 00:00:00

abstract：:B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. fo...

journal_title：European journal of immunology

authors： Ceredig R,Rolink AG,Melchers F,Andersson J

更新日期：2000-03-01 00:00:00

abstract：:Limited studies have addressed the ability of gammadelta T cells to become memory populations. We previously demonstrated that WC1.1(+) gammadelta T cells from ruminants vaccinated with killed Leptospira borgpetersenii proliferate and produce IFN-gamma in recall responses. Here we show that this response is dependent ...

journal_title：European journal of immunology

authors： Blumerman SL,Herzig CT,Baldwin CL

更新日期：2007-05-01 00:00:00

abstract：:Differential screening of a subtracted cDNA library led to the detection of two distinct but homologous mouse cDNA, called CTLA-2 alpha and CTLA-2 beta. The corresponding transcripts have a tissue distribution restricted to T lymphocytes, where they are inducible upon activation, and to mast cells. The open-frame regi...

journal_title：European journal of immunology

authors： Denizot F,Brunet JF,Roustan P,Harper K,Suzan M,Luciani MF,Mattei MG,Golstein P

更新日期：1989-04-01 00:00:00

abstract：:The 4-1BB is a costimulatory molecule similar to the receptor activator of NF-kappaB ligand (RANKL), both of which are key factors for the differentiation of osteoclasts and are expressed mainly by activated T cells. The 4-1BB shares common signaling pathways with RANK, suggesting a potential role in osteoclastogenesi...

journal_title：European journal of immunology

authors： Yang J,Park OJ,Lee YJ,Jung HM,Woo KM,Choi Y

更新日期：2008-06-01 00:00:00